Abstract:
BACKGROUND:The purpose of this study was to perform a histological comparative analysis of tibiotalar joint samples taken from areas of osteolysis adjacent to total ankle arthroplasties vs control synovial specimens to determine the reaction to and presence of polyethylene (PE) particles. METHODS:A total of 57 pathology samples were identified in the osteolysis group, while 11 were identified in the control group. For each sample, hematoxylin and eosin, Oil Red O (ORO), and macrophage marker CD163-stained slides were created. Polarized light and ORO stain were used to identify PE particles. The presence of metal particles and giant cell reaction to PE particles were also scored. RESULTS:Macrophages, PE particles, metallosis, and foreign body giant cell reaction scores were significantly higher in the osteolysis group compared with the control group. In the osteolysis group, ORO staining was positive in 93% (53/57), birefringent material was present in 96.5% (55/57), and macrophage infiltrates were present in 96.5% (55/57). Foreign body giant cell reaction with giant cells surrounding PE particles was present in 49.1% (28/57) of osteolytic specimens. The presence of foreign body giant cell reaction was associated with significantly higher macrophage, ORO, and polarizable material scores. The average time to surgery for osteolysis from the index ankle replacement was 6.0 (range, 0-15) years for the 57 patients in the osteolysis group. CONCLUSION:This study is the largest ankle arthroplasty histological analysis to show that areas of osteolysis consist of abundant polyethylene wear particles, present both intracellularly and extracellularly. Furthermore, these areas were associated with a CD163+ macrophage infiltrate and frequently a foreign body reaction with giant cells engulfing PE particles. It is likely that implant wear particles play a significant role in osteolysis based on the histopathology. LEVEL OF EVIDENCE:Level III, retrospective comparative series.
journal_name
Foot Ankle Intjournal_title
Foot & ankle internationalauthors
Schipper ON,Haddad SL,Pytel P,Zhou Ydoi
10.1177/1071100716682333subject
Has Abstractpub_date
2017-04-01 00:00:00pages
351-359issue
4eissn
1071-1007issn
1944-7876journal_volume
38pub_type
杂志文章abstract::Fifth metatarsal fractures, otherwise known as "Jones" fractures, occur commonly in athletes and nonathletes alike. While recent occurrence in the popular elite athlete has increased public knowledge and interest in the fracture, this injury is common at all levels of sport. This review will focus on all three types o...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/1071100717741856
更新日期:2018-02-01 00:00:00
abstract::Fluoroquinolone antibiotics (such as olprofloxacin, pefloxacin, ofloxacin, norfloxacin, temafloxacin, etc.) have recently been implicated in the etiology of Achilles tendinitis and subsequent tendon rupture. We report on a patient with bilateral partial Achilles tendon ruptures associated with ciprofloxacin therapy an...
journal_title:Foot & ankle international
pub_type: 杂志文章,评审
doi:10.1177/107110079601700811
更新日期:1996-08-01 00:00:00
abstract:BACKGROUND:The incidence of Achilles ruptures has been on the rise in National Collegiate Athletic Association (NCAA) football players, but the career impact of this injury is not fully understood. In this study, we analyzed a large series of Achilles tendon injuries in NCAA Football Bowl Subdivision (FBS) defensive fo...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/1071100719899072
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journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/107110070302400206
更新日期:2003-02-01 00:00:00
abstract:BACKGROUND:The aim of this study was to determine whether tightness of the posterior muscles of the lower extremity was associated with plantar fasciitis. METHODS:A total of 100 lower limbs of 100 subjects, 50 with plantar fasciitis and 50 matching controls were recruited. Hamstring and calf muscles were evaluated thr...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/1071100712459173
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to determine whether low-fidelity arthroscopic simulation training improves basic ankle arthroscopy performance and efficiency among orthopedic trainees. METHODS:Twenty-nine orthopedic surgery trainees with varying levels of experience in ankle arthroscopy were randomized into ...
journal_title:Foot & ankle international
pub_type: 杂志文章,随机对照试验
doi:10.1177/1071100715576369
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Insufficiency fractures occur in bones with low elastic resistance. In contrast to stress fractures, which affect normal bones and have been extensively studied, insufficiency fractures of the foot and ankle have been the subject of little research. The objective of this study was to identify risk factors as...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/1071100720969654
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abstract:BACKGROUND:In this retrospective study, both the patients' and surgeons' satisfaction with resection of the first through fifth metatarsal heads for long-standing rheumatoid forefoot deformity was evaluated. METHODS:Thirty-four patients (56 feet) had first through fifth metatarsal head resection. After a mean time of ...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/107110070602700804
更新日期:2006-08-01 00:00:00
abstract::The purpose of this study was to evaluate the biomechanical properties of commonly used autogenous transplants for the surgical stabilization of chronic lateral ankle instability. We dissected the transplants (peroneus longus, peroneus brevis, Achilles and plantaris tendon, periosteal flap, fascia, corium) and the ant...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/107110070202300714
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abstract:BACKGROUND:Fixed equinovarus deformities can be challenging to treat especially in medically debilitated patients. The purpose of this study was to evaluate Achilles lengthening with posterior tibial tenotomy and immediate weightbearing in this difficult group of patients. MATERIALS AND METHODS:Thirteen extremities in...
journal_title:Foot & ankle international
pub_type: 杂志文章
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abstract:BACKGROUND:Morton's neuroma is a common primary diagnosis for referral to foot and ankle surgeons. On presentation, many patients have had an ultrasound reporting the presence of Morton's neuroma, which may not correlate with the clinical examination findings. The prevalence of such sonographic findings in the general ...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.3113/FAI.2012.0543
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:The structural importance of the spring ligament complex in arch stability has been described. Furthermore, the pathology of this complex is often noted in patients with posterior tibial tendon dysfunction. The purpose of this biomechanical study was to evaluate spring ligament repair alone versus augmentati...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/1071100719828373
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abstract:RECOMMENDATION:The optimal antibiotic treatment after foot/ankle fractures or fusion should be determined based on the result of culture. In the absence of culture results, administered antibiotics should include coverage against common pathogens such as Staphylococcus aureus. LEVEL OF EVIDENCE:Strong. DELEGATE VOTE:...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/1071100719861644
更新日期:2019-07-01 00:00:00
abstract::The capability for discrimination of vibratory stimuli of the sole of the foot was tested on 12 subjects (6 men, 6 women). Two vibratory stimuli (sinusoidal impulse: frequency, 200 Hz; amplitude, 0.1 mm; duration, 2 sec) were applied at different sites to the sole of the foot. Subjects were asked whether they detected...
journal_title:Foot & ankle international
pub_type: 杂志文章
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更新日期:1996-10-01 00:00:00
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abstract:BACKGROUND:Deep infection after open reduction internal fixation (ORIF) of ankle fractures represents a challenge to the orthopaedic surgeon, particularly in patients in whom conventional surgical treatments have failed. The aim of this study was to assess the results of a modified technique of tibiotalocalcaneal fusio...
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journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/107110070402500505
更新日期:2004-05-01 00:00:00
abstract::Twenty-nine feet in 28 patients who underwent subtalar distraction bone block fusion for the treatment of subtalar deformities associated with symptomatic arthrosis were evaluated. All patients were assessed with the American Orthopaedic Foot and Ankle Society (AOFAS) Ankle-Hindfoot Scale score. Eighteen men and 10 wo...
journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/107110079701801206
更新日期:1997-12-01 00:00:00
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journal_title:Foot & ankle international
pub_type: 杂志文章
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更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:We hypothesized that patients undergoing nonoperative treatment for asymptomatic or minimally symptomatic osteochondral lesions of the talus (OLTs) would not deteriorate clinically or radiologically over time. METHODS:Forty-eight patients (mean age = 48 years; range, 13-78 years) with an OLT confirmed by ma...
journal_title:Foot & ankle international
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journal_title:Foot & ankle international
pub_type: 杂志文章
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更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:Transfer of the flexor hallucis longus (FHL) tendon is an established method to replace a dysfunctional Achilles tendon. When using a single incision, the FHL tendon has to be transferred as a single stranded graft into the calcaneus and the distal FHL stump cannot be directly attached to the flexor digitoru...
journal_title:Foot & ankle international
pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
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journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.3113/FAI.2011.0300
更新日期:2011-03-01 00:00:00
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journal_title:Foot & ankle international
pub_type: 杂志文章
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更新日期:2019-07-01 00:00:00
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journal_title:Foot & ankle international
pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
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journal_title:Foot & ankle international
pub_type: 杂志文章
doi:10.1177/107110079801900713
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