Abstract:
:Human Papilloma Virus infection is very frequent in humans and is mainly transmitted sexually. The majority of infections are transient and asymptomatic, however, if the infection persists, it can occur with a variety of injuries to skin and mucous membranes, depending on the type of HPV involved. Some types of HPV are classified as high oncogenic risk as associated with the onset of cancer. The tumors most commonly associated with HPV are cervical and oropharyngeal cancer, epigenetic mechanisms related to HPV infection include methylation changes to host and viral DNA and chromatin modification in host species. This review is focused about epigenethic mechanism, such as MiRNAs expression, related to cervix and oral cancer. Specifically it discuss about molecular markers associated to a more aggressive phenotype. In this way we will analyze genes involved in meiotic sinaptonemal complex, transcriptional factors, of orthokeratins, sinaptogirin, they are all expressed in cancer in a way not more dependent on cell differentiation but HPV-dependent.
journal_name
Cancer Biol Therjournal_title
Cancer biology & therapyauthors
Di Domenico M,Giovane G,Kouidhi S,Iorio R,Romano M,De Francesco F,Feola A,Siciliano C,Califano L,Giordano Adoi
10.1080/15384047.2017.1310349subject
Has Abstractpub_date
2018-01-01 00:00:00pages
850-857issue
10eissn
1538-4047issn
1555-8576journal_volume
19pub_type
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