Abstract:
Clinical Question:Which treatments have been shown to be effective in randomized clinical trials (RCTs) for hidradenitis suppurativa (HS) in adults? Bottom Line:There is high-quality evidence of benefit from adalimumab given weekly, while every other week dosing is ineffective, with reductions in Dermatology Life Quality Index (DLQI) scores compared with placebo of 2.8 points (95% CI, -3.7 to -2.0 points) and 1.6 points (95% CI, -3.9 to 0.6 points), respectively. Moderate-quality evidence suggests that infliximab is beneficial; RCT evidence for other interventions was lower in quality or absent, limiting further conclusions.
journal_name
JAMA Dermatoljournal_title
JAMA dermatologyauthors
Ingram JRdoi
10.1001/jamadermatol.2017.0432subject
Has Abstractpub_date
2017-05-01 00:00:00pages
458-459issue
5eissn
2168-6068issn
2168-6084pii
2612719journal_volume
153pub_type
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