Abstract：
BACKGROUND:The liver stages of Plasmodium parasites are important targets for the discovery and development of prophylactic drugs. METHODS:A real-time in vivo imaging system was used to determine the level of luminescence measured from firefly luciferase expression by sporozoites developing in hepatocytes in different strains of mice. RESULTS:The luminescence values (photon counts/sec) measured from the anatomical liver location in the untreated mice infected with 10,000 Plasmodium berghei sporozoites were 8.15 × 105 for C57BL/6 Albino, 2.12 × 105 for C3H/HeNCrL, 0.91 × 105 for C57BL/6 WT, 0.28 × 105 for BALB/c, and 0.16 × 105 for ICR/CD-1 mice. This data suggests that the C57BL/6 Albino strain is most susceptible to luminescent photon, mainly because the less light scattering and absorption from deeper tissues and the skin in the strain of mouse. The photon count observed in black C57BL/6 wild type mice was shown to be 88.83% lower compared to C57BL/6 Albino mice. Although the highest growth rate of sporozoites in hepatocytes was found for C57BL/6 wild type mice in this study, the black skin of this mouse significantly reduced parasite-associated bioluminescence. CONCLUSIONS:The minimal light scattering and absorption and also enhanced susceptibility to liver infection of C57BL/6 Albino mice makes this strain preferable sensitivity for discovery and development of prophylactic antimalarial drugs.
journal_name
Mil Medjournal_title
Military medicineauthors
Li Q,Xie L,Caridha D,Roncal N,Zeng Q,Zhang J,Zhang P,Hickman M,Read Ldoi
10.7205/MILMED-D-16-00090subject
Has Abstractpub_date
2017-03-01 00:00:00pages
360-368issue
S1eissn
0026-4075issn
1930-613Xjournal_volume
182pub_type
杂志文章abstract：BACKGROUND:Methemoglobinemia is a potentially life-threatening complication of local anesthetic sprays employed in upper endoscopy. There is limited information available on the incidence of this complication, and no prospective trial has ever undertaken to evaluate subclinical levels of methemoglobinemia. OBJECTIVE:T...
journal_title：Military medicine
pub_type： 杂志文章,随机对照试验
doi：10.7205/MILMED-D-13-00035
更新日期：2013-06-01 00:00:00
abstract：:Goodpasture's syndrome, or anti-glomerular basement membrane (anti-GBM) disease, is a rare pulmonary-renal syndrome that results from autoantibody-mediated destruction of alveolar and glomerular basement membranes. It is defined by the triad of pulmonary hemorrhage (hemoptysis), glomerulonephritis (hematuria), and cir...
journal_title：Military medicine
pub_type： 杂志文章
doi：
更新日期：2001-09-01 00:00:00
abstract：:The Department of Defense Serum Repository (DoDSR) of the Armed Forces Health Surveillance Center (AFHSC), Silver Spring, Maryland, has over 55 million specimens. Over 80% of these specimens are linked to individual health data. In response to Congressional and Department of Defense (DoD) concern about toxic exposures...
journal_title：Military medicine
pub_type：
doi：10.7205/MILMED-D-15-00065
更新日期：2015-10-01 00:00:00
abstract：:In an attempt to overcome some of the difficulties encountered with transabdominal ultrasonography we report on 55 patients who underwent 88 transvaginally directed sonograms. In 24 patients in whom a diagnosis of an early intrauterine pregnancy was made, the mean crow-rump length (CRL) was 10.7 mm (range, 3 to 27). I...
journal_title：Military medicine
pub_type： 杂志文章
doi：
更新日期：1990-07-01 00:00:00
abstract：:The purpose of this study was to analyze the assumptions underlying the Army's Weight Control Program (AWCP) and to determine whether overweight and normal-weight soldiers differed with respect to health risk, health status, self-motivation, psychological symptomatic distress, and physical fitness. The sample consiste...
journal_title：Military medicine
pub_type： 杂志文章
doi：
更新日期：1990-09-01 00:00:00
abstract：:Cluster headaches (CHs) are one of the most debilitating of all the identified headache syndromes. Their pathogenesis is poorly understood, which has made their treatment challenging. Various medicines and modalities have been put forth in an effort to minimize the symptoms, but none have proven to be consistently rel...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.7205/MILMED-D-14-00713
更新日期：2015-10-01 00:00:00
abstract：:A 30-year review of the Armed Forces Tumor Registry revealed that of 3,126 thyroid cancers on file, 82 were in the pediatric population. All of these cases were reviewed, and the mean age was found to be 13.8 years. There as a male-to-female ratio of 1:2.3. At the time of diagnosis, 33% had regional nodes and 6% had d...
journal_title：Military medicine
pub_type： 杂志文章
doi：
更新日期：1997-07-01 00:00:00
abstract：Objectives:Greater serum levels and dietary intake of vitamin D have been inversely associated with the risk of multiple cancers including colon cancer. Most colorectal cancers are thought to arise from adenomatous polyps, which become dysplastic under the influence of numerous factors. Prospective data are needed to d...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.1093/milmed/usx152
更新日期：2018-03-01 00:00:00
abstract：:This study examined the infleunce of three types of boot-sock systems on incidence and severity of foot blisters. Participants were 357 men undergoing U.S. Marine recruit training at Parris Island, South Carolina. Each participant was assigned to one of three treatment groups. The first group wore the standard militar...
journal_title：Military medicine
pub_type： 杂志文章
doi：
更新日期：1996-10-01 00:00:00
abstract：INTRODUCTION:We assessed potential racial or ethnic differences in the degree to which veterans with pharmaceutically treated hypertension report experiences with their primary care system that are consistent with optimal chronic illness care as suggested by Wagner's Chronic Care Model (CCM). MATERIALS AND METHODS:A c...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.1093/milmed/usx111
更新日期：2018-09-01 00:00:00
abstract：UNLABELLED:The Department of Defense spends more than $50 million dollars a year on humanitarian assistance (HA) projects. Although the projects are perceived as beneficial, demonstrating sustainable long-term impact is not possible. METHODS:A seven-step monitoring and evaluation (M&E) process was adapted for this stu...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.7205/milmed.172.4.339
更新日期：2007-04-01 00:00:00
abstract：Introduction:This review summarizes the research conducted on botulinum toxin (BoTx) from 1943 to 1956 by a small group of Camp Detrick investigators and their staff. A systematic, cross-disciplinary approach was used to develop effective vaccines against this biological warfare threat agent. In response to the potenti...
journal_title：Military medicine
pub_type： 历史文章,杂志文章,评审
doi：10.1093/milmed/usx047
更新日期：2018-05-01 00:00:00
abstract：INTRODUCTION:The aims of this study were as follows: first to quantify and review the types of surgical procedures performed by military surgeons assigned to a Forward Surgical Team (FST) providing medical support to the population (MSP) in the Ivory Coast (IC), and second to analyze how this MSP was achieved. METHODS...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.7205/MILMED-D-14-00688
更新日期：2015-10-01 00:00:00
abstract：:The results of a drug use evaluation of lisinopril at a large teaching military medical center are reported. Indicators and thresholds were developed and approved by the Pharmacy and Therapeutics Committee. The medical charts of 227 patients for whom lisinopril was prescribed from June 1991 to June 1992 were reviewed ...
journal_title：Military medicine
pub_type： 杂志文章
doi：
更新日期：1997-02-01 00:00:00
abstract：:A case of primary squamous cell carcinoma of the thyroid is presented. Squamous epithelium is normally not present in the thyroid gland, and this tumor is exceedingly rare. Proper workup is described, including the differentiation from metastatic disease. The case reported is of a 64-year-old woman who presented with ...
journal_title：Military medicine
pub_type： 杂志文章
doi：
更新日期：2003-02-01 00:00:00
abstract：:Cutaneous leishmaniasis typically presents as a painless papule progressing to an ulcer or plaque. In this case study of the ear, the disease manifested as a small painful bump progressing into redness and swelling about the ear with purulent drainage. After multiple oral/intravenous antipseudomonal, antistaphylococca...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.7205/MILMED-D-17-00054
更新日期：2017-07-01 00:00:00
abstract：OBJECTIVE:Problematic anger is a significant clinical issue in military personnel, and is further complicated by comorbid post-traumatic stress disorder (PTSD). Despite increasing numbers of military personnel returning from deployment with anger and aggression difficulties, the treatment of problematic anger has recei...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.1093/milmed/usx115
更新日期：2018-09-01 00:00:00
abstract：:A study of ambulatory mental health services on a U.S. Army post where logistic support personnel are stationed compared utilization of psychiatric services before, during, and after the Persian Gulf War. Rates were calculated for service utilization for the at-risk groups from consecutive cases presenting at the post...
journal_title：Military medicine
pub_type： 杂志文章
doi：
更新日期：1995-10-01 00:00:00
abstract：:Stress fractures are caused by repetitive low-impact activities. It is important to have a high index of suspicion in diagnosing and treating stress fractures early for remodeling to occur. This is a case report of a 19-year-old female military recruit with stress fractures of the right foot. The patient had an extend...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.7205/milmed-d-10-00087
更新日期：2011-01-01 00:00:00
abstract：OBJECTIVES:Little is known about the numbers of children who will be left without one or both parents because of human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome. This report evaluates childbearing patterns among U.S. Army reserve component members, a group largely made up of men with limited conta...
journal_title：Military medicine
pub_type： 杂志文章
doi：
更新日期：1997-12-01 00:00:00
abstract：:Acutely sprained ankles represent a frequent and common injury among active duty troops in training, and are a significant source of morbidity with respect to days lost to training. Swelling in the form of periarticular edema limits motion, causes pain, prevents wearing of normal foot gear, and slows the healing proce...
journal_title：Military medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1993-02-01 00:00:00
abstract：INTRODUCTION:Each year, a substantial proportion of trainees who enter the U.S. Air Force (USAF) Basic Military Training (BMT) are unable to complete training. Reentry to civilian life poses significant challenges, including finding employment, establishing a new career path, and paying for education. To our knowledge,...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.1093/milmed/usaa110
更新日期：2020-09-18 00:00:00
abstract：INTRODUCTION:Computer-aided design/computer-aided manufacturing (CAD/CAM) has gained increasing popularity since the first commercially viable dental system was introduced in the mid-1980s. Digitally milled dental restorations can be fabricated chairside in the course of one dental appointment, reducing time, cost, and...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.1093/milmed/usy260
更新日期：2019-05-01 00:00:00
abstract：:Prevention strategies for coronary artery disease among hypertensive patients require assessment of other modifiable risk factors in the target population. In this article, we describe the prevalence of other cardiovascular risk factors in military beneficiaries with high blood pressure (HBP). Baseline data from an on...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.7205/milmed.169.10.777
更新日期：2004-10-01 00:00:00
abstract：INTRODUCTION:Repetitive transcranial magnetic stimulation (rTMS) as a treatment for depression has been studied for over two decades. Repetitive TMS was approved by the Food and Drug Administration in 2008 for the treatment of depression after at least one failed trial of an antidepressant medication of adequate dose a...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.1093/milmed/usaa148
更新日期：2020-09-18 00:00:00
abstract：OBJECTIVE:To optimally practice medicine, and to live healthy lives, providers and patients need convenient access to authoritative information. The goal of this study was to determine the information needs of naval primary care providers and patients at sea to aid development of a digital health sciences library for n...
journal_title：Military medicine
pub_type： 杂志文章
doi：
更新日期：1999-02-01 00:00:00
abstract：:A cluster-randomized trial evaluating the effectiveness of chlorhexidine gluconate-impregnated wipes against skin and soft tissue infections (SSTIs) and colonization with methicillin-resistant Staphylococcus aureus (MRSA) was conducted among military recruits attending Officer Candidate School at Marine Corps Base Qua...
journal_title：Military medicine
pub_type： 杂志文章,随机对照试验
doi：10.7205/milmed-d-12-00145
更新日期：2012-11-01 00:00:00
abstract：:The aim of this study was to document risk factors for any injury and sports- and exercise-related injuries, including personal and occupational stress among active duty service members (SMs) in the Air Force, Army, Marine Corps, and Navy. A total of 10,692 SMs completed the April 2008 Status of Forces Survey of Activ...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.7205/MILMED-D-14-00080
更新日期：2014-11-01 00:00:00
abstract：:Anthrax is occasionally encountered by U.S. military physicians in the deployed setting, where limited resources make it difficult to obtain laboratory confirmation. We present a case of cutaneous anthrax diagnosed using a ruggedized polymerase chain reaction device in austere combat conditions. ...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.7205/MILMED-D-13-00062
更新日期：2013-08-01 00:00:00
abstract：OBJECTIVE:This study describes and categorizes the cultural frictions and conflicts within a successfully implemented Internal Medicine Patient-Centered Medical Home (PCMH) clinic at the National Naval Medical Center, and provides lessons learned for combating these concerns. METHODS:A semistructured interview protoco...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.7205/milmed-d-12-00146
更新日期：2013-02-01 00:00:00
