Abstract:
OBJECTIVES:The current treatment options for neuropathic pain due to nerve injuries are limited and largely unsatisfactory. Mesenchymal stem cell transplantation (MSC) has shown promise as an emerging therapy for neuropathic pain. However, a number of critical parameters, including the sources of cells, the number of cells, and routes of transplantation, need to be elucidated before it can be tested clinically. METHODS:MSCs were isolated from rat bone marrow (rBM-MSCs) and adipose tissue (rAD-MSCs) and characterized by flow cytometry and functional differentiation. Rats with chronic constriction injury of the sciatic nerve were transplanted either intravenously or intrathecally with rBM-MSCs or rAD-MSCs in two different doses. The effects were evaluated by using paw withdrawal thresholds in response to noxious stimulation. The MSCs labeled with Dil dye were traced. A total of 75 Sprague-Dawley rats were used for these experiments. RESULTS:Both intravenous and intrathecal transplantation of MSCs significantly attenuated neuropathic pain. Comparable results were achieved by either rBM-MSCs or rAD-MSCs. No differences were noted between the two doses of cell transplantation. MSCs were found on the surface of the spinal cord and dorsal root ganglia. The animals did not show any signs of toxicity throughout the whole course of the experiments. CONCLUSIONS:Both intravenous and intrathecal MSC transplantations were safe and efficacious and both rBM-MSCs and rAD-MSCs are suitable for transplantation.
journal_name
Mil Medjournal_title
Military medicineauthors
Liu L,Hua Z,Shen J,Yin Y,Yang J,Cheng K,Liu A,Wang L,Cheng Jdoi
10.7205/MILMED-D-16-00096subject
Has Abstractpub_date
2017-03-01 00:00:00pages
175-184issue
S1eissn
0026-4075issn
1930-613Xjournal_volume
182pub_type
杂志文章abstract:INTRODUCTION:Military personnel must remain physically active to meet operational requirements. Military physical training not only provides the performance capabilities required for performing occupational tasks but also fosters the development of sport. Thus, Armed Forces across the world have historically invested i...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.1093/milmed/usz003
更新日期:2019-12-01 00:00:00
abstract::The objective of the present study was to compare three specialized treatment programs for post-traumatic stress disorder (PTSD) in different Veterans Affairs medical centers, in terms of the format of therapeutic services and the medications prescribed for PTSD. Chart review methods were used to examine medical recor...
journal_title:Military medicine
pub_type: 杂志文章,多中心研究
doi:10.7205/milmed.170.4.305
更新日期:2005-04-01 00:00:00
abstract::A 22-year-old active duty E1 Nepalese male who recently emigrated from Nepal suddenly exhibited strange behaviors and mutism during Advanced Individual Training. After receiving care from a hospital near his unit, he was transferred to Walter Reed Army Medical Center Inpatient Psychiatry for further evaluation and tre...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/milmed.172.11.1213
更新日期:2007-11-01 00:00:00
abstract::This study evaluated the noise attenuation of earplugs and earmuffs or their combined use against heavy weapon noise in field conditions for military personnel. The noise attenuation was measured with a miniature microphone inserted into the ear canal. The subjects (13) were tested against pink noise and against the n...
journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:2000-09-01 00:00:00
abstract:Introduction:Bioelectrical impedance analysis (BIA) is a practical and rapid method for making a longitudinal analysis of changes in body composition. However, most BIA validation studies have been performed in a clinical population and only at one moment, or point in time (cross-sectional study). The aim of this study...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.1093/milmed/usx223
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVE:The purpose of this study is to report the device lessons learned from an emergency tourniquet program and, in particular, to emphasize analysis of discarded devices recovered after clinical use. METHODS:Discarded tourniquet devices were analyzed after use in emergency care of war casualties to determine wea...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/milmed-d-11-00114
更新日期:2011-10-01 00:00:00
abstract:INTRODUCTION:Prolonged field care for junctional wounds is challenging and involves limb movement to facilitate transport. No studies to date have explored the efficacy of gauze products to limit rebleeding in these scenarios. MATERIALS AND METHODS:We randomly assigned 48 swine to QuikClot Combat Gauze, ChitoGauze, Nu...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.1093/milmed/usaa403
更新日期:2021-01-25 00:00:00
abstract::Receipt of public support payments is associated with beneficial outcomes for homeless people with mental illness. The purpose of this study was to identify factors associated with receipt of Department of Veterans Affairs (VA) pension and compensation benefits among homeless veterans after their initial contact with ...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/milmed.172.5.461
更新日期:2007-05-01 00:00:00
abstract::This paper describes the results of a nonexperimental descriptive research study in which specific positive and negative health behaviors used by soldiers in a medical reserve unit to ensure compliance with the Army Weight Control standards were surveyed using a questionnaire. The findings of the survey, particularly ...
journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:1990-06-01 00:00:00
abstract::A diminution in the anticoagulant effect of IV heparin with concomitant use of IV nitroglycerin has been reported. However, recent reports have disputed the existence of this interaction. The objective of this study was to assess the potential interaction of these agents in a clinical setting. Forty-five patients hosp...
journal_title:Military medicine
pub_type: 临床试验,杂志文章
doi:
更新日期:1994-08-01 00:00:00
abstract:INTRODUCTION:With more than 370,000 military and civilian personnel stationed across Pacific Command (PACOM), medical evacuation in this largest command presents unique challenges. The authors describe medical evacuations analyzed from the U.S. Air Force Transportation Command Regulating and Command & Control Evacuatio...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.1093/milmed/usaa289
更新日期:2020-11-21 00:00:00
abstract::Substantial research has demonstrated an association between post-traumatic stress disorder (PTSD) and quality of sleep, particularly in veteran populations. The exact nature of this relationship, however, is not clear. The possibility that poor sleep is a more general experience among veterans has not been explored t...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/milmed-d-04-0208
更新日期:2009-09-01 00:00:00
abstract::The effects on hearing thresholds, sound attenuation, and consonant discrimination of wearing a balaclava under hearing-protecting earmuffs were studied. This combination is commonly worn during cold weather military operations. One group of 20 normal-hearing adults (10 male and 10 female subjects) was tested. Within-...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/milmed.171.10.976
更新日期:2006-10-01 00:00:00
abstract::Lean Six Sigma (LSS) is a process improvement methodology developed in the manufacturing industry to increase process efficiency while maintaining product quality. The efficacy of LSS application to the health care setting has not been adequately studied. This article presents a quality improvement project at the U.S....
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/MILMED-D-15-00247
更新日期:2016-06-01 00:00:00
abstract:INTRODUCTION:Deployment-related mild traumatic brain injury (mTBI) affects a significant proportion of those who served in Post-9/11 combat operations. The prevalence of head injuries, including those that lead to mTBI, is often reported quantitatively. However, service member (SM) and Veteran firsthand accounts of the...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.1093/milmed/usaa308
更新日期:2021-01-25 00:00:00
abstract:INTRODUCTION:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) belonging to the family Coronaviridae and genus Betacoronavirus is the causative agent of COVID-19 disease and was first identified in Wuhan, China. SARS-CoV-2 spread globally with >28 million cases and 911,000 deaths recorded worldwide as of Sep...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.1093/milmed/usaa525
更新日期:2020-11-30 00:00:00
abstract::This paper reports a survey of routine admission and preoperative diagnostic studies required by regulation at fifteen USAF hospitals. The results show that each hospital differs from the others on studies required. Clinical reports show that routine diagnostic studies are inappropriate on hospital admission. Clinical...
journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:1989-03-01 00:00:00
abstract::Foreign bodies, in particular sand and soil particles, can cause considerable reaction in wounds and remain in tissues indefinitely. The introduction of foreign material as a contaminant in wounds and intracavitary injuries to military personnel deployed in the Persian Gulf region can be a complicating factor in treat...
journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:1992-07-01 00:00:00
abstract::The efficacy of ultraviolet C (UVC) light (100-280 nm) in the decontamination of three hospital-related surfaces, namely, unpainted/painted aluminum (bed railings), stainless steel (operating tables), and scrubs (laboratory coats), was investigated. Acinetobacter baumannii cells were inoculated (10(5) or 10(3) cells) ...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/milmed.172.11.1166
更新日期:2007-11-01 00:00:00
abstract::Mental health problems are a well-known consequence of combat exposure, and the problem of barriers to receiving mental health care for veterans is well known. The current heavy reliance on reserve component soldiers may aggravate this problem. This study tries to characterize problems with access to mental health car...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/milmed-d-10-00219
更新日期:2011-03-01 00:00:00
abstract::Streptococcus pneumoniae causes severe morbidity and mortality worldwide and poses a significant threat to the health and readiness of U.S. military personnel. Although a vaccine to prevent pneumococcal infections has been available for almost 25 years, its use has been limited. Recently, increasing antibiotic resista...
journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:2001-12-01 00:00:00
abstract:Introduction:This review summarizes the research conducted on botulinum toxin (BoTx) from 1943 to 1956 by a small group of Camp Detrick investigators and their staff. A systematic, cross-disciplinary approach was used to develop effective vaccines against this biological warfare threat agent. In response to the potenti...
journal_title:Military medicine
pub_type: 历史文章,杂志文章,评审
doi:10.1093/milmed/usx047
更新日期:2018-05-01 00:00:00
abstract:INTRODUCTION:Despite greater than 60,000 nonfatal firearm injuries per year in the United States, retained shrapnel is a relatively rare cause of systemic lead toxicity with less than 100 cases reported in the medical literature since 1867. While intra-articular retained shrapnel as a cause of lead toxicity is well-des...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/MILMED-D-16-00231
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVE:To determine whether the presence of insulin resistance in obese subjects would adversely affect the rate of ovulation induction by clomiphene citrate. RESULTS:Fasting hyperinsulinemia was associated with the failure to ovulate in response to clomiphene. In addition, other parameters found to correlate with ...
journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:1996-12-01 00:00:00
abstract::The Department of Defense Serum Repository (DoDSR) of the Armed Forces Health Surveillance Center (AFHSC), Silver Spring, Maryland, has over 55 million specimens. Over 80% of these specimens are linked to individual health data. In response to Congressional and Department of Defense (DoD) concern about toxic exposures...
journal_title:Military medicine
pub_type:
doi:10.7205/MILMED-D-15-00065
更新日期:2015-10-01 00:00:00
abstract::Manufacturers' recommended temperatures for pharmaceuticals were compared with actual field temperatures that the medications were exposed to during the winter months of December and February in the Republic of Korea. Two daily temperatures of field pharmaceuticals were taken in a M577 armored aid station. These tempe...
journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:2001-08-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to describe the epidemiology of suicides among U.S. Air Force, Army, Marine Corps, and Navy recruits from 1980 through 2004. METHODS:Recruit suicides were identified through the Department of Defense Recruit Mortality Registry. We calculated crude, category-specific, and age-adj...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/milmed.172.10.1024
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND:Tourniquets are issued to deployed members of both the United States (U.S. military and the Australian Defence Force (ADF). The ease of removing the tourniquet from the pocket of the combat uniform may influence its time to application. The ADF uniform uses buttons to secure the pocket, whereas the U.S. unif...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/MILMED-D-15-00028
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:The Medical College Admissions Test (MCAT) is a high-stakes test required for entry to most U. S. medical schools; admissions committees use this test to predict future accomplishment. Although there is evidence that the MCAT predicts success on multiple choice-based assessments, there is little information ...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/MILMED-D-14-00550
更新日期:2015-04-01 00:00:00
abstract::Prior to recent advances in the field of molecular biology, prenatal diagnosis of hemoglobinopathies was accomplished by direct analysis of the gene product(s) in samples obtained by fetoscopy or, more recently, percutaneous umbilical blood sampling. The use of the polymerase chain reaction enables quicker diagnosis t...
journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:1991-12-01 00:00:00