Cell adhesion pattern created by OSTE polymers.

abstract：:The physical and mechanical properties of cells modulate their behavior such proliferation rate, migration and extracellular matrix remodeling. In order to study cell behavior in a tissue-like environment in vitro, it is of utmost importance to develop biologically and physically relevant 3D cell models. Here, we char...

journal_title：Biofabrication

authors： Pillet F,Gibot L,Madi M,Rols MP,Dague E

更新日期：2017-05-11 00:00:00

abstract：:Cell cultures for tissue engineering are traditionally prepared on two-dimensional or three-dimensional scaffolds with simple pores; however, this limits mass transportation, which is necessary for cell viability and function. In this paper, an innovative method is proposed for fabricating porous scaffolds with design...

journal_title：Biofabrication

authors： Liu Y,Li X,Qu X,Zhu L,He J,Zhao Q,Wu W,Li D

更新日期：2012-03-01 00:00:00

abstract：:Technical limitations of traditional electrospinning make it hard to produce three-dimensional (3D) scaffolds with hierarchical pore structures. Here, porous polycaprolactone (PCL) nanofiber meshes with different nano-hydroxyapatite (nHA) concentrations were prepared by electrospinning with stainless steel mesh as the...

journal_title：Biofabrication

authors： Song J,Zhu G,Wang L,An G,Shi X,Wang Y

更新日期：2017-02-14 00:00:00

abstract：:To overcome the drawbacks of in vitro liver testing during drug development, numerous liver-on-a-chip models have been developed. However, current liver-on-a-chip technologies are labor-intensive, lack extracellular matrix (ECM) essential for liver cells, and lack a biliary system essential for excreting bile acids, w...

journal_title：Biofabrication

authors： Lee H,Chae S,Kim JY,Han W,Kim J,Choi Y,Cho DW

更新日期：2019-01-16 00:00:00

abstract：:Laser-assisted bioprinting (LaBP) allows the realization of computer-generated 3D tissue grafts consisting of cells embedded in a hydrogel environment. In this study, human adipose-derived stem cells (hASCs) were printed in a free-scalable 3D grid pattern by means of LaBP. We demonstrate that neither the proliferation...

journal_title：Biofabrication

authors： Gruene M,Pflaum M,Deiwick A,Koch L,Schlie S,Unger C,Wilhelmi M,Haverich A,Chichkov BN

更新日期：2011-03-01 00:00:00

abstract：:We report on the fabrication of silicon-reinforced carbon (C:Si) structures by combinatorial pulsed laser deposition to search for the best design for a new generation of multi-functional coated implants. The synthesized films were characterized from the morphological, structural, compositional, mechanical and microbi...

journal_title：Biofabrication

authors： Mihailescu IN,Bociaga D,Popescu-Pelin G,Stan GE,Duta L,Socol G,Chifiriuc MC,Bleotu C,Lazar V,Husanu MA,Zgura I,Miculescu F,Negut I,Hapenciuc C

更新日期：2017-06-01 00:00:00

abstract：:The inkjet ejection technology used in printers has been adopted and research has been conducted on manufacturing artificial tissue by patterning cells through micronozzle ejection of small droplets containing multiple cells. However, stable injection of cells has proven difficult, owing to the frequent occurrence of ...

journal_title：Biofabrication

authors： Yamaguchi S,Ueno A,Akiyama Y,Morishima K

更新日期：2012-12-01 00:00:00

abstract：:Despite the widespread use as platforms for various biomedical applications, engineering hydrogels to impart multifunctionality and control physical properties, while closely mimicking the native cellular microenvironment, is still a significant challenge. Herein, nanofibers consisting of hydrophilic and photocrosslin...

journal_title：Biofabrication

authors： Kim S,Cha C

更新日期：2019-12-19 00:00:00

abstract：:Advances in three-dimensional cell cultures offer new opportunities in biomedical research and drug development. However, there are still challenges to overcome, including the lack of reliability, repeatability and complexity of tissues obtained by these techniques. In this study, we describe a new bioprinting system ...

journal_title：Biofabrication

authors： da Conceicao Ribeiro R,Pal D,Ferreira AM,Gentile P,Benning M,Dalgarno K

更新日期：2018-12-27 00:00:00

abstract：:Bone healing is regulated by multiple microenvironmental signals provided by the extracellular matrix (ECM). This study aimed to mimic the native osteoinductive microenvironment by developing an ECM using gene-transduced cells. The LIM mineralization protein-1 (LMP-1) gene was transferred to murine pre-osteoblast cell...

journal_title：Biofabrication

authors： Ma J,Guo W,Gao M,Huang B,Qi Q,Ling Z,Chen Y,Hu H,Zhou H,Yu F,Chen K,Richards G,Lin J,Zhou Z,Xiao D,Zou X

更新日期：2017-11-14 00:00:00

abstract：:Native small intestine possesses distinct multi-scale structures (e.g., crypts, villi) not included in traditional 2D intestinal culture models for drug delivery and regenerative medicine. The known impact of structure on cell function motivates exploration of the influence of intestinal topography on the phenotype of...

journal_title：Biofabrication

authors： Koppes AN,Kamath M,Pfluger CA,Burkey DD,Dokmeci M,Wang L,Carrier RL

更新日期：2016-08-22 00:00:00

abstract：:Tissue engineering has been developed with the ultimate aim of manufacturing human organs, but success has been limited to only thin tissues and tissues with no significant structures. In order to construct more complicated tissues, we have developed a three-dimensional (3D) fabrication technology in which 3D structur...

journal_title：Biofabrication

authors： Arai K,Iwanaga S,Toda H,Genci C,Nishiyama Y,Nakamura M

更新日期：2011-09-01 00:00:00

abstract：:Nerve tissues contain hierarchically ordered nerve fibers, while each of the nerve fibers has nano-oriented fibrous extracellular matrix and a core-shell structure of tubular myelin sheath with elongated axons encapsulated. Here, we report, for the first time, a ready approach to fabricate biomimetic nerve fibers whic...

journal_title：Biofabrication

authors： Chen S,Wu C,Liu A,Wei D,Xiao Y,Guo Z,Chen L,Zhu Y,Sun J,Luo H,Fan H

更新日期：2020-05-12 00:00:00

abstract：:We have developed cell sheet technology as a modern method for the fabrication of functional tissue-like and organ-like structures. This technology allows for a sheet of interconnected cells and cells in full contact with their natural extracellular environment to be obtained. A cell sheet can be patterned and compose...

journal_title：Biofabrication

authors： Hannachi IE,Yamato M,Okano T

更新日期：2009-06-01 00:00:00

abstract：:Cell mechanical microenvironment (CMM) significantly affects cell behaviors such as spreading, migration, proliferation and differentiation. However, most studies on cell response to mechanical stimulation are based on two-dimensional (2D) planar substrates, which cannot mimic native three-dimensional (3D) CMM. Accumu...

journal_title：Biofabrication

authors： Huang G,Wang L,Wang S,Han Y,Wu J,Zhang Q,Xu F,Lu TJ

更新日期：2012-12-01 00:00:00

abstract：:Tissue engineering aims to create implantable biomaterials for the repair and regeneration of damaged tissues. In vitro tissue engineering is generally based on static culture, which limits access to nutrients and lacks mechanical signaling. Using shear stress is controversial because in some cases it can lead to cell...

journal_title：Biofabrication

authors： Salinas EY,Aryaei A,Paschos N,Berson E,Kwon H,Hu JC,Athanasiou KA

更新日期：2020-08-10 00:00:00

abstract：:Bioprinting of living cells is rapidly developing as an advanced biofabrication approach to engineer tissues. Bioinks can be extruded in three-dimensions (3D) to fabricate complex and hierarchical constructs for implantation. However, a lack of functionality can often be attributed to poor bioink properties. Indeed, a...

journal_title：Biofabrication

authors： Cidonio G,Alcala-Orozco CR,Lim KS,Glinka M,Mutreja I,Kim YH,Dawson JI,Woodfield TBF,Oreffo ROC

更新日期：2019-06-12 00:00:00

abstract：:Electrospinning has been widely used to produce ultrafine fibers in microscale and nanoscale; however, traditional electrospinning processes are currently beset by troublesome limitations in fabrication of 3D periodic porous structures because of the chaotic nature of the electrospinning jet. Here we report a novel st...

journal_title：Biofabrication

authors： Yuan H,Zhou Q,Li B,Bao M,Lou X,Zhang Y

更新日期：2015-11-05 00:00:00

abstract：:Calcified cartilage regeneration plays an important role in successful osteochondral repair, since it provides a biological and mechanical transition from the unmineralized cartilage at the articulating surface to the underlying mineralized bone. To biomimic native calcified cartilage in engineered constructs, here we...

journal_title：Biofabrication

authors： You F,Chen X,Cooper DML,Chang T,Eames BF

更新日期：2018-12-27 00:00:00

abstract：:In the past few decades, 3D printing has played a significant role in fabricating scaffolds with consistent, complex structure that meet patient-specific needs in future clinical applications. Although many studies have contributed to this emerging field of additive manufacturing, which includes material development a...

journal_title：Biofabrication

authors： Guo T,Holzberg TR,Lim CG,Gao F,Gargava A,Trachtenberg JE,Mikos AG,Fisher JP

更新日期：2017-04-12 00:00:00

abstract：:In clinical islet transplantation, allogeneic islets of Langerhans are transplanted into the portal vein of patients with type 1 diabetes, enabling the restoration of normoglycemia. After intra-hepatic transplantation several factors are involved in the decay in islet mass and function mainly caused by an immediate bl...

journal_title：Biofabrication

authors： Marchioli G,van Gurp L,van Krieken PP,Stamatialis D,Engelse M,van Blitterswijk CA,Karperien MB,de Koning E,Alblas J,Moroni L,van Apeldoorn AA

更新日期：2015-05-28 00:00:00

abstract：:Electrospun fibers of natural polymers are desirable for biomedical applications such as tissue engineering. Crosslinking of electrospun fibers of natural polymers is needed to prevent dissolution in water and to enhance mechanical strength. In this study, an in situ UV-crosslinking method was developed for crosslinki...

journal_title：Biofabrication

authors： Lin WH,Tsai WB

更新日期：2013-09-01 00:00:00

abstract：:One of the major issues in tissue engineering has been the development of three-dimensional (3D) scaffolds, which serve as a structural template for cell growth and extracellular matrix formation. In scaffold-based tissue engineering, 3D printing (3DP) technology has been successfully applied for the fabrication of co...

journal_title：Biofabrication

authors： Park JH,Jung JW,Kang HW,Cho DW

更新日期：2014-06-01 00:00:00

abstract：:A recently emerged approach for tissue engineering is to biofabricate tissues using cellular spheroids as building blocks. Human pluripotent stem cells (hPSCs), including human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs), can be cultured to generate large numbers of cells and can presumably...

journal_title：Biofabrication

authors： Lin H,Li Q,Lei Y

更新日期：2017-04-24 00:00:00

abstract：:We previously developed the Bio-Pick, Place, and Perfuse (Bio-P3) instrument to fabricate large perfusable tissue constructs by stacking and aligning scaffold-free living microtissues with integrated lumens. The Bio-P3 required an actuating mechanism to manipulate living microtissues of various sizes and shapes that a...

journal_title：Biofabrication

authors： Ip BC,Cui F,Tripathi A,Morgan JR

更新日期：2016-05-25 00:00:00

abstract：:A bio-inspired hydrogel for 3D bioprinting of soft free-standing neural tissues is presented. The novel filler-free bioinks were designed by combining natural polymers for extracellular matrix biomimicry with synthetic polymers to endow desirable rheological properties for 3D bioprinting. Crosslinking of thiolated Plu...

journal_title：Biofabrication

authors： Haring AP,Thompson EG,Tong Y,Laheri S,Cesewski E,Sontheimer H,Johnson BN

更新日期：2019-02-25 00:00:00

abstract：:We demonstrate a simple, accurate and versatile method to manipulate Parylene C, a material widely known for its high biocompatibility, and transform it to a substrate that can effectively control the cellular microenvironment and consequently affect the morphology and function of the cells in vitro. The Parylene C sc...

journal_title：Biofabrication

authors： Trantidou T,Rao C,Barrett H,Camelliti P,Pinto K,Yacoub MH,Athanasiou T,Toumazou C,Terracciano CM,Prodromakis T

更新日期：2014-06-01 00:00:00

abstract：:As an alternative to conventional cell culture and animal testing, an organ-on-a-chip is applied to study the biological phenomena of organ development and disease, as well as the interactions between human tissues and external stimuli such as chemicals, forces and electricity. The pattern design of a microfluidic cha...

journal_title：Biofabrication

authors： Mao M,He J,Lu Y,Li X,Li T,Zhou W,Li D

更新日期：2018-02-05 00:00:00

abstract：:How to pack materials into well-defined volumes efficiently has been a longstanding question of interest to physicists, material scientists, and mathematicians as these materials have broad applications ranging from shipping goods in commerce to seeds in agriculture and to spheroids in tissue engineering. How many mar...

journal_title：Biofabrication

authors： Ren T,Steiger W,Chen P,Ovsianikov A,Demirci U

更新日期：2020-03-31 00:00:00

abstract：:In the pharmaceutical industry, new drugs are tested to find appropriate compounds for therapeutic purposes for contemporary diseases. Unfortunately, novel compounds emerge at expensive prices and current target evaluation processes have limited throughput, thus leading to an increase of cost and time for drug develop...

journal_title：Biofabrication

authors： Rodríguez-Dévora JI,Zhang B,Reyna D,Shi ZD,Xu T

更新日期：2012-09-01 00:00:00