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Determining the Limitations and Benefits of Noise in Gene Regulation and Signal Transduction through Single Cell, Microscopy-Based Analysis.

Abstract：

:Stochastic fluctuations, termed "noise," in the level of biological molecules can greatly impact cellular functions. While biological noise can sometimes be detrimental, recent studies have provided an increasing number of examples in which biological noise can be functionally beneficial. Rather than provide an exhaustive review of the growing literature in this field, in this review, we focus on single-cell studies based on quantitative microscopy that have generated a deeper understanding of the sources, characteristics, limitations, and benefits of biological noise. Specifically, we highlight studies showing how noise can help coordinate the expression of multiple downstream target genes, impact the channel capacity of signaling networks, and interact synergistically with oscillatory dynamics to enhance the sensitivity of signal processing. We conclude with a discussion of current challenges and future opportunities.

journal_name

J Mol Biol

journal_title

Journal of molecular biology

authors

Harton MD,Batchelor E

doi

10.1016/j.jmb.2017.03.007

subject

Has Abstract

pub_date

2017-04-21 00:00:00

pages

1143-1154

issue

8

eissn

0022-2836

issn

1089-8638

pii

S0022-2836(17)30111-0

journal_volume

429

pub_type

杂志文章,评审

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