Activin A is increased in the nucleus accumbens following a cocaine binge.

abstract：:We introduce a polarization-resolved terahertz time-domain spectrometer with a broadband (0.3-2.5 THz), rotatable THz polarization state, and which exhibits minimal change in the electric field amplitude and polarization state upon rotation. This was achieved by rotating an interdigitated photoconductive emitter, and ...

journal_title：Scientific reports

authors： Mosley CDW,Failla M,Prabhakaran D,Lloyd-Hughes J

更新日期：2017-09-26 00:00:00

abstract：:Hepcidin, a cysteine-rich peptide hormone, secreted mainly by the liver, plays a central role in iron metabolism regulation. Emerging evidence suggests that disordered iron metabolism is a risk factor for various types of diseases including cancers. However, it remains challenging to apply current mass spectrometry (M...

journal_title：Scientific reports

authors： Moghieb A,Tesfay L,Nie S,Gritsenko M,Fillmore TL,Jacobs JM,Smith RD,Torti FM,Torti SV,Shi T,Ansong C

更新日期：2019-05-13 00:00:00

abstract：:The mammalian AlkB homolog (ALKBH) family of proteins possess a 2-oxoglutarate- and Fe(II)-dependent oxygenase domain. A similar domain in the Escherichia coli AlkB protein catalyzes the oxidative demethylation of 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) in both DNA and RNA. AlkB homolog 3 (ALKBH3) was als...

journal_title：Scientific reports

authors： Ueda Y,Ooshio I,Fusamae Y,Kitae K,Kawaguchi M,Jingushi K,Hase H,Harada K,Hirata K,Tsujikawa K

更新日期：2017-02-13 00:00:00

abstract：:The ability of the cerebellar cortex to learn from experience ensures the accuracy of movements and reflex adaptation, processes which require long-term plasticity at granule cell (GC) to Purkinje neuron (PN) excitatory synapses. PNs also receive GABAergic inhibitory inputs via GCs activation of interneurons; despite ...

journal_title：Scientific reports

authors： Binda F,Dorgans K,Reibel S,Sakimura K,Kano M,Poulain B,Isope P

更新日期：2016-09-19 00:00:00

abstract：:Next generation sequencing is transforming clinical medicine and genome research, providing a powerful route to establishing molecular diagnoses for genetic conditions; however, challenges remain given the volume and complexity of genetic variation. A number of methods integrate patient phenotype and genotypic data to...

journal_title：Scientific reports

authors： Pengelly RJ,Alom T,Zhang Z,Hunt D,Ennis S,Collins A

更新日期：2017-10-18 00:00:00

abstract：:The present study investigates the biostimulant effects of 18 Crude Bio-Extracts (CBEs) obtained from Microalgae and Cyanobacteria on tomato plant growth, chlorophyll content, nutrient uptake and metabolite profile. Significant root and shoot length improvement (112.65%, 53.70%); was recorded at treatment with Aphanot...

journal_title：Scientific reports

authors： Mutale-Joan C,Redouane B,Najib E,Yassine K,Lyamlouli K,Laila S,Zeroual Y,Hicham EA

更新日期：2020-02-18 00:00:00

abstract：:Effects of elevated seawater temperatures on deep-water benthos has been poorly studied, despite reports of increased seawater temperature (up to 4 °C over 24 hrs) coinciding with mass mortality events of the sponge Geodia barretti at Tisler Reef, Norway. While the mechanisms driving these mortality events are unclear...

journal_title：Scientific reports

authors： Strand R,Whalan S,Webster NS,Kutti T,Fang JKH,Luter HM,Bannister RJ

更新日期：2017-05-22 00:00:00

abstract：:Up to 40% of congenital diseases present disturbances of brain and craniofacial development resulting in simultaneous alterations of both systems. Currently, the best available method to preclinically visualize the brain and the bones simultaneously is to co-register micro-magnetic resonance (µMR) and micro-computed t...

journal_title：Scientific reports

authors： Llambrich S,Wouters J,Himmelreich U,Dierssen M,Sharpe J,Gsell W,Martínez-Abadías N,Vande Velde G

更新日期：2020-10-30 00:00:00

abstract：:Light-sheet microscopy enables considerable speed and phototoxicity gains, while quantitative-phase imaging confers label-free recognition of cells and organelles, and quantifies their number-density that, thermodynamically, is more representative of metabolism than size. Here, we report the fusion of these two imagin...

journal_title：Scientific reports

authors： Subedi NR,Jung PS,Bredeweg EL,Nemati S,Baker SE,Christodoulides DN,Vasdekis AE

更新日期：2020-11-19 00:00:00

abstract：:Pericytes regulate vessel stability and pericyte dysfunction contributes to retinopathies, stroke, and cancer. Here we define Notch as a key regulator of pericyte function during angiogenesis. In Notch1(+/-); Notch3(-/-) mice, combined deficiency of Notch1 and Notch3 altered pericyte interaction with the endothelium a...

journal_title：Scientific reports

authors： Kofler NM,Cuervo H,Uh MK,Murtomäki A,Kitajewski J

更新日期：2015-11-13 00:00:00

abstract：:Spotted seal (Phoca largha) is a critically endangered pinniped in China and South Korea. The conventional method to protect and maintain the P. largha population is to keep them captive in artificially controlled environments. However, little is known about the physiological differences between wild and captive P. la...

journal_title：Scientific reports

authors： Tian J,Du J,Han J,Bao X,Song X,Lu Z

更新日期：2020-10-30 00:00:00

abstract：:In community ecology, it is important to understand the distribution of communities along environmental and spatial gradients. However, it is common for the residuals of models investigating those relationships to be very high (> 50%). It is believed that species' intrinsic characteristics such as rarity can contribut...

journal_title：Scientific reports

authors： Brasil LS,Vieira TB,Andrade AFA,Bastos RC,Montag LFA,Juen L

更新日期：2020-11-13 00:00:00

abstract：:The mechanism of droplet drying is a widely concerned fundamental issue since controlling the deposition morphology of droplet has significant influence on printing, biology pattern, self-assembling and other solution-based devices fabrication. Here we reveal a striking different kinetics-controlled deposition regime ...

journal_title：Scientific reports

authors： Li Y,Yang Q,Li M,Song Y

更新日期：2016-04-19 00:00:00

abstract：:Cardiovascular risk rapidly increased following exposure to air pollution. Changes in human autonomic regulation have been implicated based on epidemiological associations between exposure estimates and indirect autonomic nervous system measurements. We conducted a mechanistic study to test the hypothesis that, in hea...

journal_title：Scientific reports

authors： Heusser K,Tank J,Holz O,May M,Brinkmann J,Engeli S,Diedrich A,Framke T,Koch A,Großhennig A,Jan Danser AH,Sweep FCGJ,Schindler C,Schwarz K,Krug N,Jordan J,Hohlfeld JM

更新日期：2019-03-06 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Sharman GR,Sylvester Z,Covault JA

更新日期：2020-11-02 00:00:00

abstract：:Work stress is a risk factor for cardio-metabolic diseases, but few large-scale studies have examined the clinical profile of individuals with work stress. To address this limitation, we conducted a cross-sectional study including 43,593 working adults from a French population-based sample aged 18-72 years (the CONSTA...

journal_title：Scientific reports

authors： Magnusson Hanson LL,Westerlund H,Goldberg M,Zins M,Vahtera J,Hulvej Rod N,Stenholm S,Steptoe A,Kivimäki M

更新日期：2017-08-24 00:00:00

abstract：:The aim of this study was to investigate rheumatoid arthritis (RA), and systemic lupus erythematous (SLE) as risk factors for stroke. The study was analyzed by Using the Taiwan Longitudinal Health Insurance Database 2005 (LHID2005), this cohort study investigated patients with a recorded diagnosis of RA (N = 6114), an...

journal_title：Scientific reports

authors： Liou TH,Huang SW,Lin JW,Chang YS,Wu CW,Lin HW

更新日期：2014-06-05 00:00:00

abstract：:The genetic data of 17 Y chromosome short tandem repeats in 146 unrelated donor residents in the provinces of Granada, Málaga, and Almería (GMA) were analyzed to determine the genetic legacy of the male inhabitants of the former Kingdom of Granada. A total of 139 unique haplotypes were identified. Observed allele freq...

journal_title：Scientific reports

authors： Saiz M,Alvarez-Cubero MJ,Lorente JA,Alvarez JC,Martinez-Gonzalez LJ

更新日期：2019-03-26 00:00:00

abstract：:Large (>10 kb) palindromic sequences are enriched on mammalian sex chromosomes. In mice, these palindromes harbor gene families (≥2 gene copies) expressed exclusively in post-meiotic testicular germ cells, a time when most single-copy sex-linked genes are transcriptionally repressed. This observation led to the hypoth...

journal_title：Scientific reports

authors： Kruger AN,Ellison Q,Brogley MA,Gerlinger ER,Mueller JL

更新日期：2018-06-12 00:00:00

abstract：:In East Greenland, a dramatic increase of tuberculosis (TB) incidence has been observed in recent years. Classical genotyping suggests a genetically similar Mycobacterium tuberculosis (Mtb) strain population as cause, however, precise transmission patterns are unclear. We performed whole genome sequencing (WGS) of Mtb...

journal_title：Scientific reports

authors： Bjorn-Mortensen K,Soborg B,Koch A,Ladefoged K,Merker M,Lillebaek T,Andersen AB,Niemann S,Kohl TA

更新日期：2016-09-12 00:00:00

abstract：:We herein present a novel and sustainable technology for mercury recycling, with the maximum observed uptake capacity. Facile synthesis of the most efficient (~1.9 gg-1) nano-trap, made of montmorillonite-Fe-iron oxides, was performed to instantaneously remove mercury(II) ions from water. Elemental Hg was recovered fr...

journal_title：Scientific reports

authors： Ganguly M,Dib S,Ariya PA

更新日期：2018-11-02 00:00:00

abstract：:The non-invasive high-resolution spatial mapping of cell metabolism within tissues could provide substantial advancements in assessing the efficacy of stem cell therapy and understanding tissue development. Here, using two-photon excited fluorescence microscopy, we elucidate the relationships among endogenous cell flu...

journal_title：Scientific reports

authors： Quinn KP,Sridharan GV,Hayden RS,Kaplan DL,Lee K,Georgakoudi I

更新日期：2013-12-05 00:00:00

abstract：:Thrombosis has proven to be extremely difficult to predict. Measuring the generation of thrombin is a very sensitive method to detect changes in the hemostatic system. We developed a method based on the generation of thrombin to further fingerprint hemostasis, which we have named thrombin dynamics. Via this method we ...

journal_title：Scientific reports

authors： de Laat-Kremers RMW,Yan Q,Ninivaggi M,de Maat M,de Laat B

更新日期：2020-07-27 00:00:00

abstract：:GLP-1 receptor agonists (GLP-1RA) and SGLT2 inhibitors (SGLT2i) have been associated with improved glycemic control, body weight loss and favorable changes in cardiovascular risk factors and outcomes. We conducted a systematic review and meta-analysis to evaluate the effects of the addition of GLP-1RA to SGLT2i in pat...

journal_title：Scientific reports

authors： Castellana M,Cignarelli A,Brescia F,Perrini S,Natalicchio A,Laviola L,Giorgino F

更新日期：2019-12-18 00:00:00

abstract：:Three dimensional hierarchical nanostructures have attracted great attention for electrochemical energy storage applications. In this work, self-supported TiO2@Ni(OH)2 core-shell nanowire arrays are prepared on carbon fiber paper via the combination of hydrothermal synthesis and chemical bath deposition. In this core-...

journal_title：Scientific reports

authors： Ke Q,Zheng M,Liu H,Guan C,Mao L,Wang J

更新日期：2015-09-10 00:00:00

abstract：:Siglec-2 undergoes constitutive endocytosis and is a drug target for autoimmune diseases and B cell-derived malignancies, including hairy cell leukaemia, marginal zone lymphoma, chronic lymphocytic leukaemia and non-Hodgkin's lymphoma (NHL). An alternative to current antibody-based therapies is the use of liposomal na...

journal_title：Scientific reports

authors： Madge PD,Maggioni A,Pascolutti M,Amin M,Waespy M,Bellette B,Thomson RJ,Kelm S,von Itzstein M,Haselhorst T

更新日期：2016-11-03 00:00:00

abstract：:The intensity and frequency of precipitation events are predicted to change over the coming decades. For many areas, longer periods without rainfall are expected. We investigated the importance of irrigation frequency under water deficit conditions for growth, physiology and chemistry of wheat (Triticum aestivum). Dro...

journal_title：Scientific reports

authors： Stallmann J,Schweiger R,Pons CAA,Müller C

更新日期：2020-06-22 00:00:00

abstract：:The concept of milk as a healthy food has opened the way for studies on milk components, from nutrients to microRNAs, molecules with broad regulatory properties present in large quantities in milk. Characterization of these components has been performed in several species, such as humans and bovine, depending on the s...

journal_title：Scientific reports

authors： Le Guillou S,Leduc A,Laubier J,Barbey S,Rossignol MN,Lefebvre R,Marthey S,Laloë D,Le Provost F

更新日期：2019-12-30 00:00:00

abstract：:The housefly (Musca domestica L.) lives in close association with its microbiota and its symbionts are suggested to have pivotal roles in processes such as metabolism and immune response, but it is unclear how the profound physiological changes during ontogeny affect the housefly's associated microbiota and their meta...

journal_title：Scientific reports

authors： de Jonge N,Michaelsen TY,Ejbye-Ernst R,Jensen A,Nielsen ME,Bahrndorff S,Nielsen JL

更新日期：2020-05-12 00:00:00

abstract：:Misuse of antibiotics in the clinical and agricultural sectors has caused the emergence of multidrug-resistant (MDR) Klebsiella pneumoniae which contributes a threat to human health. In this study, we assessed the feasibility of lavender essential oil (LVO) as an antimicrobial agent in combinatory therapy with meropen...

journal_title：Scientific reports

authors： Yang SK,Yusoff K,Thomas W,Akseer R,Alhosani MS,Abushelaibi A,Lim SH,Lai KS

更新日期：2020-01-21 00:00:00