Traditional Chinese medicine xin-mai-jia recouples endothelial nitric oxide synthase to prevent atherosclerosis in vivo.

abstract：:The airways of individuals with cystic fibrosis (CF) are abundantly colonised by Staphylococcus aureus and Pseudomonas aeruginosa. Co-infecting hypoxic regions of static mucus within CF airways, together with decreases in pulmonary function, mucus plugging and oxygen consumption by host neutrophils gives rise to regio...

journal_title：Scientific reports

authors： Pallett R,Leslie LJ,Lambert PA,Milic I,Devitt A,Marshall LJ

更新日期：2019-05-01 00:00:00

abstract：:First-generation adenovirus vectors (FG AdVs) are widely used in basic studies and gene therapy. However, virus-associated (VA) RNAs that act as small-interference RNAs are indeed transcribed from the vector genome. These VA RNAs can trigger the innate immune response. Moreover, VA RNAs are processed to functional vir...

journal_title：Scientific reports

authors： Maekawa A,Pei Z,Suzuki M,Fukuda H,Ono Y,Kondo S,Saito I,Kanegae Y

更新日期：2013-01-01 00:00:00

abstract：:Melimine and Mel4 are chimeric cationic peptides with broad-spectrum antimicrobial activity. They have been shown to be highly biocompatible in animal models and human clinical trials. The current study examined the mechanism of action of these two antimicrobial peptides against P. aeruginosa. The effect of the peptid...

journal_title：Scientific reports

authors： Yasir M,Dutta D,Willcox MDP

更新日期：2019-05-08 00:00:00

abstract：:Single-wall carbon nanotubes (SWCNTs) and Bi2Te3 nanoplates are very promising thermoelectric materials for energy harvesting. When these two materials are combined, the resulting nanocomposites exhibit high thermoelectric performance and excellent flexibility. However, simple mixing of these materials is not effectiv...

journal_title：Scientific reports

authors： Yabuki H,Yonezawa S,Eguchi R,Takashiri M

更新日期：2020-10-12 00:00:00

abstract：:Urban climate is determined by a variety of factors, whose knowledge can help to attenuate heat stress in the context of ongoing urbanization and climate change. We study the influence of city size and urban form on the Urban Heat Island (UHI) phenomenon in Europe and find a complex interplay between UHI intensity and...

journal_title：Scientific reports

authors： Zhou B,Rybski D,Kropp JP

更新日期：2017-07-06 00:00:00

abstract：:High quality wafer-scale free-standing WS2 grown by van der Waals rheotaxy (vdWR) using Ni as a texture promoting layer is reported. The microstructure of vdWR grown WS2 was significantly modified from mixture of crystallites with their c-axes both parallel to (type I) and perpendicular to (type II) the substrate to l...

journal_title：Scientific reports

authors： Yu Y,Fong PW,Wang S,Surya C

更新日期：2016-11-29 00:00:00

abstract：:The transcription apparatus (TA) is a huge molecular machine. It detects the time-varying concentrations of transcriptional activators and initiates mRNA transcripts at appropriate rates. Based on the general structural organizations of the TA, we propose how the TA dynamically orchestrates transcriptional responses. ...

journal_title：Scientific reports

authors： Wang Y,Liu F,Wang W

更新日期：2012-01-01 00:00:00

abstract：:Epigallocatechin-3-gallate (EGCG), a green tea-derived polyphenol, exhibits antitumor activities. An EGCG nanoemulsion (nano-EGCG) was prepared to improve the stability and reduce the side effects of EGCG for treatment of human lung cancer cells, and the antitumor effects were studied. The possible molecular mechanism...

journal_title：Scientific reports

authors： Chen BH,Hsieh CH,Tsai SY,Wang CY,Wang CC

更新日期：2020-03-20 00:00:00

abstract：:The irritant receptor TRPA1 was suggested to mediate analgesic, antipyretic but also pro-inflammatory effects of the non-opioid analgesic acetaminophen, presumably due to channel activation by the reactive metabolites parabenzoquinone (pBQ) and N-acetyl-parabenzoquinonimine (NAPQI). Here we explored the effects of the...

journal_title：Scientific reports

authors： Eberhardt MJ,Schillers F,Eberhardt EM,Risser L,de la Roche J,Herzog C,Echtermeyer F,Leffler A

更新日期：2017-10-06 00:00:00

abstract：:Most large herbivores in arid landscapes need to drink which constrains their movements and makes them vulnerable to disturbance. Asiatic wild ass or khulan (Equus hemionus) were widespread and abundant throughout the arid landscapes of Central Asia and Mongolia, but have undergone dramatic population declines and ran...

journal_title：Scientific reports

authors： Payne JC,Buuveibaatar B,Bowler DE,Olson KA,Walzer C,Kaczensky P

更新日期：2020-02-19 00:00:00

abstract：:Equine athletes have a pattern of exercise which is analogous to human athletes and the cardiovascular risks in both species are similar. Both species have a propensity for atrial fibrillation (AF), which is challenging to detect by ECG analysis when in paroxysmal form. We hypothesised that the proarrhythmic backgroun...

journal_title：Scientific reports

authors： Alexeenko V,Fraser JA,Bowen M,Huang CL,Marr CM,Jeevaratnam K

更新日期：2020-04-22 00:00:00

abstract：:Unlike mammals, in palmipedes de novo lipogenesis from diet takes place mostly in the liver. The French Landes Goose is famous for its high capacity and susceptibility to fatty liver production. While miRNAs play a critical role in the posttranscriptional regulation of gene expression, miRNAs that are involved in the ...

journal_title：Scientific reports

authors： Chen F,Zhang H,Li J,Tian Y,Xu J,Chen L,Wei J,Zhao N,Yang X,Zhang W,Lu L

更新日期：2017-11-24 00:00:00

abstract：:Parasite death via ion channel activations is the hallmark of anthelmintic and antiparasitic drugs. Glutamate gated chloride channel (GluCl) is a prominent targets for drug selection and design in parasitology. We report several iodine-fluorine based lead activators of GluCl by computational studies and structure-acti...

journal_title：Scientific reports

authors： Rajasekharan SK,Lee JH,Ravichandran V,Kim JC,Park JG,Lee J

更新日期：2019-02-14 00:00:00

abstract：:The Sansha Yongle Blue Hole (SYBH) is the deepest blue hole found anywhere to date. Study of the SYBH can provide insight into the interactions between hole wall morphology and many geological/hydrological mechanisms. A comprehensive investigation of the SYBH was carried out for the first time in 2017 using a professi...

journal_title：Scientific reports

authors： Li T,Feng A,Liu Y,Li Z,Guo K,Jiang W,Du J,Tian Z,Xu W,Liu Y,Wang Y

更新日期：2018-11-20 00:00:00

abstract：:Human cardiac stem/progenitor cells (hCPCs) may serve in regenerative medicine to repair the infarcted heart. However, this approach is severely limited by the poor survival of donor cells. Recent studies suggest that the mammalian globin cytoglobin (CYGB) regulates nitric oxide (NO) metabolism and cell death. In the ...

journal_title：Scientific reports

authors： Zhang S,Li X,Jourd'heuil FL,Qu S,Devejian N,Bennett E,Jourd'heuil D,Cai C

更新日期：2017-09-07 00:00:00

abstract：:Obstacles to widespread deployments of direct air capture of CO2 (DAC) lie in high material and energy costs. By grafting quaternary ammonium (QA) functional group to mesoporous polymers with high surface area, a unique DAC adsorbent with moisture swing adsorption (MSA) ability and ultra-high kinetics was developed in...

journal_title：Scientific reports

authors： Wang T,Wang X,Hou C,Liu J

更新日期：2020-12-08 00:00:00

abstract：:Different grazing strategies impact grassland plant production and may also regulate the soil carbon formation. For a site in semiarid temperate steppe, we studied the effect of combinations of rest, high and moderate grazing pressure over three stages of the growing season, on the process involved in soil carbon sequ...

journal_title：Scientific reports

authors： Chen W,Huang D,Liu N,Zhang Y,Badgery WB,Wang X,Shen Y

更新日期：2015-07-03 00:00:00

abstract：:To realize the economical production of ethanol and other bio-based chemicals from lignocellulosic biomass by consolidated bioprocessing (CBP), various cellulases from different sources were tested to improve the level of cellulase secretion in the yeast Saccharomyces cerevisiae by screening an optimal translational f...

journal_title：Scientific reports

authors： Lee CR,Sung BH,Lim KM,Kim MJ,Sohn MJ,Bae JH,Sohn JH

更新日期：2017-06-30 00:00:00

abstract：:The patterns of evolution and expression of tissue-specific genes are poorly understood beyond sex-specific genes. Accordingly, we identified 3,191 tissue-specific genes and 38,745 common genes using 22 RNA-seq datasets from cultivated peanut. The expression levels of tissue-specific genes were significantly lower tha...

journal_title：Scientific reports

authors： Song H,Zhang Q,Tian P,Nan Z

更新日期：2017-08-21 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Altair T,de Avellar MGB,Rodrigues F,Galante D

更新日期：2020-07-30 00:00:00

abstract：:The hepatic asialoglycoprotein receptor (ASGP-R) is posttranslationally modified in the Golgi en route to the plasma membrane, where it mediates clearance of desialylated serum glycoproteins. It is known that content of plasma membrane-associated ASGP-R is decreased after ethanol exposure, although the mechanisms rema...

journal_title：Scientific reports

authors： Petrosyan A,Cheng PW,Clemens DL,Casey CA

更新日期：2015-11-26 00:00:00

abstract：:The recent surge in research on metal-halide-perovskite solar cells has led to a seven-fold increase of efficiency, from ~3% in early devices to over 22% in research prototypes. Oft-cited reasons for this increase are: (i) a carrier diffusion length reaching hundreds of microns; (ii) a low exciton binding energy; and ...

journal_title：Scientific reports

authors： Grånäs O,Vinichenko D,Kaxiras E

更新日期：2016-11-08 00:00:00

abstract：:Understanding factors associated with tie strength in social networks is essential in a wide variety of settings. With the internet and cellular phones providing additional avenues of communication, measuring and inferring tie strength has become much more complex. We introduce the social bow tie framework, which cons...

journal_title：Scientific reports

authors： Mattie H,Engø-Monsen K,Ling R,Onnela JP

更新日期：2018-06-19 00:00:00

abstract：:Formation-free multi-level resistive switching characteristics by using 10 nm-thick polycrystalline GeOx film in a simple W/GeOx/W structure and understanding of switching mechanism through redox reaction in H2O2/sarcosine sensing (or changing Ge°/Ge4+ oxidation states under external bias) have been reported for the f...

journal_title：Scientific reports

authors： Samanta S,Rahaman SZ,Roy A,Jana S,Chakrabarti S,Panja R,Roy S,Dutta M,Ginnaram S,Prakash A,Maikap S,Cheng HM,Tsai LN,Qiu JT,Ray SK

更新日期：2017-09-11 00:00:00

abstract：:Immunoproteasomes are known for their involvement in antigen presentation. However, their broad tissue presence and other evidence are indicative of nonimmune functions. We examined a role for immunoproteasomes in cellular responses to the endogenous and environmental carcinogen formaldehyde (FA) that binds to cytosol...

journal_title：Scientific reports

authors： Ortega-Atienza S,Krawic C,Watts L,McCarthy C,Luczak MW,Zhitkovich A

更新日期：2017-04-05 00:00:00

abstract：:Facial mimicry has been suggested to be a behavioral index for emotional empathy. The present study is the first to investigate the link between facial muscle activity and empathy for pain by facial electromyographic (EMG) recording while observers watched videos depicting real-life painful events. Three types of visu...

journal_title：Scientific reports

authors： Sun YB,Wang YZ,Wang JY,Luo F

更新日期：2015-12-09 00:00:00

abstract：:The anhydrofructose pathway is an alternate pathway for glycogen degradation by α-1,4-glucan lyase. The sugar 1,5-anhydro-D-fructose (1,5-AF) acts as the central intermediate of this pathway, but its physiological role of in mammals is unclear. Glycation reactions forming advanced glycation end-products (AGEs) are imp...

journal_title：Scientific reports

authors： Sakasai-Sakai A,Takata T,Suzuki H,Maruyama I,Motomiya Y,Takeuchi M

更新日期：2019-07-15 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is closely associated with obesity, metabolic syndrome, and type II diabetes mellitus. Recently, circulating microRNAs (miRNAs) have been proposed as useful disease biomarkers. We examined whether circulating miRNAs, such as miR-20a, miR-27a, and miR-126, were useful biomarker...

journal_title：Scientific reports

authors： Ando Y,Yamazaki M,Yamada H,Munetsuna E,Fujii R,Mizuno G,Ichino N,Osakabe K,Sugimoto K,Ishikawa H,Ohashi K,Teradaira R,Ohta Y,Hamajima N,Hashimoto S,Suzuki K

更新日期：2019-12-11 00:00:00

abstract：:Early detection of breast cancer and its correct stage determination are important for prognosis and rendering appropriate personalized clinical treatment to breast cancer patients. However, despite considerable efforts and progress, there is a need to identify the specific genomic factors responsible for, or accompan...

journal_title：Scientific reports

authors： Roy S,Kumar R,Mittal V,Gupta D

更新日期：2020-03-05 00:00:00

abstract：:Brazil's large land base is important for global food security but its high dependency on inorganic phosphorus (P) fertilizer for crop production (2.2 Tg rising up to 4.6 Tg in 2050) is not a sustainable use of a critical and price-volatile resource. A new strategic analysis of current and future P demand/supply concl...

journal_title：Scientific reports

authors： Withers PJA,Rodrigues M,Soltangheisi A,de Carvalho TS,Guilherme LRG,Benites VM,Gatiboni LC,de Sousa DMG,Nunes RS,Rosolem CA,Andreote FD,Oliveira A Jr,Coutinho ELM,Pavinato PS

更新日期：2018-02-07 00:00:00