Abstract:
:The strong age dependency of neonatal systemic infection with Escherichia coli K1 can be replicated in the neonatal rat. Gastrointestinal (GI) colonization of two-day-old (P2) rats leads to invasion of the blood within 48 h of initiation of colonization; pups become progressively less susceptible to infection over the P2-P9 period. We show that, in animals colonized at P2 but not at P9, E. coli K1 bacteria gain access to the enterocyte surface in the mid-region of the small intestine and translocate through the epithelial cell monolayer by an intracellular pathway to the submucosa. In this region of the GI tract, the protective mucus barrier is poorly developed but matures to full thickness over P2-P9, coincident with the development of resistance to invasion. At P9, E. coli K1 bacteria are physically separated from villi by the mucus layer and their numbers controlled by mucus-embedded antimicrobial peptides, preventing invasion of host tissues.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Birchenough GM,Dalgakiran F,Witcomb LA,Johansson ME,McCarthy AJ,Hansson GC,Taylor PWdoi
10.1038/s41598-017-00123-wsubject
Has Abstractpub_date
2017-03-06 00:00:00pages
83issue
1issn
2045-2322pii
10.1038/s41598-017-00123-wjournal_volume
7pub_type
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