Abstract:
:Dopamine (DA) plays significant roles in regulation of social behavior. In social groups of humans and other animals, social hierarchy exists, which is determined by several behavioral characteristics such as aggression and impulsivity as well as social affiliations. In this study, we investigated the effects of pharmacological blockade of DA D2 receptor on social hierarchy of Japanese macaque and mouse social groups. We found acute administration of the D2 antagonist, sulpiride, in socially housed Japanese macaques attenuated social dominance when the drug was given to high social class macaques. A similar attenuation of social dominance was observed in high social class mice with D2 antagonist administration. In contrast, D2 antagonist administration in low social class macaque resulted in more stable social hierarchy of the group, whereas such effect was not observed in mouse social group. These results suggest that D2 receptor signaling may play important roles in establishment and maintenance of social hierarchy in social groups of several species of animals.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Yamaguchi Y,Lee YA,Kato A,Jas E,Goto Ydoi
10.1038/srep43348subject
Has Abstractpub_date
2017-02-24 00:00:00pages
43348issn
2045-2322pii
srep43348journal_volume
7pub_type
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