Association between C4, C4A, and C4B copy number variations and susceptibility to autoimmune diseases: a meta-analysis.

Abstract:

:Although several studies have investigated the association between C4, C4A, and C4B gene copy number variations (CNVs) and susceptibility to autoimmune diseases, the results remain inconsistency for those diseases. Thus, in this study, a comprehensive meta-analysis was conducted to assess the role of C4, C4A, and C4B CNVs in autoimmune diseases in different ethnic groups. A total of 16 case-control studies described in 12 articles (8663 cases and 11099 controls) were included in this study. The pooled analyses showed that a low C4 gene copy number (GCN) (<4) was treated as a significant risk factor (odds ratio [OR] = 1.46, 95% confidence interval [CI] = 1.19-1.78) for autoimmune diseases compared with a higher GCN (>4). The pooled statistical results revealed that low C4 (<4) and low C4A (<2) GCNs could be risk factors for systemic lupus erythematosus (SLE) in Caucasian populations. Additionally, the correlation between C4B CNVs and all type of autoimmune diseases could not be confirmed by the current meta-analysis (OR = 1.07, 95% CI = 0.93-1.24). These data suggest that deficiency or absence of C4 and C4A CNVs may cause susceptibility to SLE.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Li N,Zhang J,Liao D,Yang L,Wang Y,Hou S

doi

10.1038/srep42628

subject

Has Abstract

pub_date

2017-02-16 00:00:00

pages

42628

issn

2045-2322

pii

10.1038/srep42628

journal_volume

7

pub_type

杂志文章
  • Transferrin as a thermosensitizer in radiofrequency hyperthermia for cancer treatment.

    abstract::One of the main characteristics of cancer tissues is poor development of neovascularization that results in a limited blood circulation. Because of this phenomenon, it is harder for cancer tissues to diffuse their elevated heat into other parts of the body. The scientific principle of radiofrequency hyperthermia relie...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-31232-9

    authors: Chung HJ,Lee HK,Kwon KB,Kim HJ,Hong ST

    更新日期:2018-09-10 00:00:00

  • A general-purpose Monte Carlo particle transport code based on inverse transform sampling for radiotherapy dose calculation.

    abstract::The Monte Carlo (MC) method is widely used to solve various problems in radiotherapy. There has been an impetus to accelerate MC simulation on GPUs whereas thread divergence remains a major issue for MC codes based on acceptance-rejection sampling. Inverse transform sampling has the potential to eliminate thread diver...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-66844-7

    authors: Liang Y,Muhammad W,Hart GR,Nartowt BJ,Chen ZJ,Yu JB,Roberts KB,Duncan JS,Deng J

    更新日期:2020-06-17 00:00:00

  • Growth of high quality and uniformity AlGaN/GaN heterostructures on Si substrates using a single AlGaN layer with low Al composition.

    abstract::By employing a single AlGaN layer with low Al composition, high quality and uniformity AlGaN/GaN heterostructures have been successfully grown on Si substrates by metal-organic chemical vapor deposition (MOCVD). The heterostructures exhibit a high electron mobility of 2150 cm(2)/Vs with an electron density of 9.3 × 10...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep23020

    authors: Cheng J,Yang X,Sang L,Guo L,Zhang J,Wang J,He C,Zhang L,Wang M,Xu F,Tang N,Qin Z,Wang X,Shen B

    更新日期:2016-03-10 00:00:00

  • Identification of a phosphinothricin-resistant mutant of rice glutamine synthetase using DNA shuffling.

    abstract::To date, only bar/pat gene derived from Streptomyces has been used to generate the commercial PPT-resistant crops currently available in the market. The limited source of bar/pat gene is probably what has caused the decrease in PPT-tolerance, which has become the main concern of those involved in field management prog...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep15495

    authors: Tian YS,Xu J,Zhao W,Xing XJ,Fu XY,Peng RH,Yao QH

    更新日期:2015-10-23 00:00:00

  • A Novel Lubricant Based on Covalent Functionalized Graphene Oxide Quantum Dots.

    abstract::Dodecyl amine edge functionalized few-layer graphene oxide quantum dots were synthesized in good yields. The covalent functionalization was demonstrated with NMR and AFM-IR. The resulting structure and particle size was measured with AFM and HRTEM. The thermal stability of the compound was investigated and showed a st...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-24062-2

    authors: Wolk A,Rosenthal M,Neuhaus S,Huber K,Brassat K,Lindner JKN,Grothe R,Grundmeier G,Bremser W,Wilhelm R

    更新日期:2018-04-11 00:00:00

  • Intrinsic and extrinsic noise of gene expression in lineage trees.

    abstract::Cell-to-cell heterogeneity is driven by stochasticity in intracellular reactions and the population dynamics. While these sources are usually studied separately, we develop an agent-based framework that accounts for both factors while tracking every single cell of a growing population. Apart from the common intrinsic ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-35927-x

    authors: Thomas P

    更新日期:2019-01-24 00:00:00

  • Using already-solved cases of a mass disaster event for prioritizing the search among remaining victims: a Bayesian approach.

    abstract::This work presents a new method for assisting in the identification process of missing persons in several contexts, such as enforced disappearances. We apply a Bayesian technique to incorporate non-genetic variables in the construction of prior information. In that way, we can learn from the already-solved cases of a ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-59841-3

    authors: Caridi I,Alvarez EE,Somigliana C,Puerto MS

    更新日期:2020-03-19 00:00:00

  • Protein-protein interaction network analysis applied to DNA copy number profiling suggests new perspectives on the aetiology of Mayer-Rokitansky-Küster-Hauser syndrome.

    abstract::Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a rare disease, characterised by the aplasia of vagina and uterus in women with a 46,XX karyotype. Most cases are sporadic, but familial recurrence has also been described. Herein, we investigated an Italian cohort of 36 unrelated MRKH patients to explore the presence ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-79827-5

    authors: Pontecorvi P,Bernardini L,Capalbo A,Ceccarelli S,Megiorni F,Vescarelli E,Bottillo I,Preziosi N,Fabbretti M,Perniola G,Benedetti Panici P,Pizzuti A,Grammatico P,Marchese C

    更新日期:2021-01-11 00:00:00

  • Zolpidem is a potent stoichiometry-selective modulator of α1β3 GABAA receptors: evidence of a novel benzodiazepine site in the α1-α1 interface.

    abstract::Zolpidem is not a typical GABAA receptor hypnotic. Unlike benzodiazepines, zolpidem modulates tonic GABA currents in the rat dorsal motor nucleus of the vagus, exhibits residual effects in mice lacking the benzodiazepine binding site, and improves speech, cognitive and motor function in human patients with severe brai...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep28674

    authors: Che Has AT,Absalom N,van Nieuwenhuijzen PS,Clarkson AN,Ahring PK,Chebib M

    更新日期:2016-06-27 00:00:00

  • Hematocrit, hemoglobin and red blood cells are associated with vascular function and vascular structure in men.

    abstract::High and low hematocrit (Hct) and hemoglobin (Hb) levels are associated with the risk of cardiovascular disease. The purpose of this study was to determine the relationships of Hct, Hb and red blood cells (RBCs) with vascular function and structure. We measured flow-mediated vasodilation (FMD), nitroglycerin-induced v...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-68319-1

    authors: Kishimoto S,Maruhashi T,Kajikawa M,Matsui S,Hashimoto H,Takaeko Y,Harada T,Yamaji T,Han Y,Kihara Y,Chayama K,Goto C,Yusoff FM,Nakashima A,Higashi Y

    更新日期:2020-07-10 00:00:00

  • Radiotherapy-Compatible Robotic System for Multi-Landmark Positioning in Head and Neck Cancer Treatments.

    abstract::The spine flexibility creates one of the most significant challenges to proper positioning in radiation therapy of head and neck cancers. Even though existing immobilization techniques can reduce the positioning uncertainty, residual errors (2-3 mm along the cervical spine) cannot be mitigated by single translation-ba...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-50797-7

    authors: Ostyn M,Wang S,Kim YS,Kim S,Yeo WH

    更新日期:2019-10-07 00:00:00

  • A 'hidden' 18O-enriched reservoir in the sub-arc mantle.

    abstract::Plate subduction continuously transports crustal materials with high-δ(18)O values down to the mantle wedge, where mantle peridotites are expected to achieve the high-δ(18)O features. Elevated δ(18)O values relative to the upper mantle value have been reported for magmas from some subduction zones. However, peridotite...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep04232

    authors: Liu CZ,Wu FY,Chung SL,Li QL,Sun WD,Ji WQ

    更新日期:2014-02-28 00:00:00

  • Collision of millimetre droplets induces DNA and protein transfection into cells.

    abstract::Nonperturbing and simple transfection methods are important for modern techniques used in biotechnology. Recently, we reported that electrospraying can be applied to DNA transfection in cell lines, bacteria, and chicken embryos. However, the transfection efficiency was only about 2%. To improve the transfection rate, ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep00289

    authors: Ikemoto K,Sakata I,Sakai T

    更新日期:2012-01-01 00:00:00

  • Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84.

    abstract::Medium chain fatty acids can activate the pro-inflammatory receptor GPR84 but so also can molecules related to 3,3'-diindolylmethane. 3,3'-Diindolylmethane and decanoic acid acted as strong positive allosteric modulators of the function of each other and analysis showed the affinity of 3,3'-diindolylmethane to be at l...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-18159-3

    authors: Mahmud ZA,Jenkins L,Ulven T,Labéguère F,Gosmini R,De Vos S,Hudson BD,Tikhonova IG,Milligan G

    更新日期:2017-12-20 00:00:00

  • Anti-inflammatory role of 15-lipoxygenase contributes to the maintenance of skin integrity in mice.

    abstract::15-lipoxygenase is involved in the generation of specialized pro-resolving lipid mediators that play essential roles in resolution and inflammatory responses. Here, we investigated anti-inflammatory role of Alox15 in skin homeostasis. We demonstrated that knockout (KO) of Alox15 led to hair loss and disrupted the stru...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-27221-7

    authors: Kim SN,Akindehin S,Kwon HJ,Son YH,Saha A,Jung YS,Seong JK,Lim KM,Sung JH,Maddipati KR,Lee YH

    更新日期:2018-06-11 00:00:00

  • MicroRNA Profiling Reveals Distinct Profiles for Tissue-Derived and Cultured Endothelial Cells.

    abstract::Endothelial plasticity enables the cells to switch their phenotype according to the surrounding vascular microenvironment. MicroRNAs (miRNAs) are small noncoding RNAs that control endothelial plasticity. The objective of this study was to investigate the differences in miRNA profiles of tissue-derived cells and cultur...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-11487-4

    authors: Kuosmanen SM,Kansanen E,Sihvola V,Levonen AL

    更新日期:2017-09-08 00:00:00

  • Fine mapping of a leaf flattening gene Bralcm through BSR-Seq in Chinese cabbage (Brassica rapa L. ssp. pekinensis).

    abstract::Leaf flattening influences plant photosynthesis, thereby affecting product yield and quality. Here, we obtained a stably inherited leaf crinkled mutant (lcm), derived from the Chinese cabbage doubled haploid (DH) 'FT' line using EMS mutagenesis combined with isolated microspore culture. The crinkled phenotype was cont...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-70975-2

    authors: Zhang M,Huang S,Gao Y,Fu W,Qu G,Zhao Y,Shi F,Liu Z,Feng H

    更新日期:2020-08-18 00:00:00

  • Co-expression of Dorsal and Rel2 Negatively Regulates Antimicrobial Peptide Expression in the Tobacco Hornworm Manduca sexta.

    abstract::Nuclear factor κB (NF-κB) plays an essential role in regulation of innate immunity. In mammals, NF-κB factors can form homodimers and heterodimers to activate gene expression. In insects, three NF-κB factors, Dorsal, Dif and Relish, have been identified to activate antimicrobial peptide (AMP) gene expression. However,...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep20654

    authors: Zhong X,Rao XJ,Yi HY,Lin XY,Huang XH,Yu XQ

    更新日期:2016-02-05 00:00:00

  • Secular trends in overweight and obesity among urban children and adolescents, 2003-2012: A serial cross-sectional study in Guangzhou, China.

    abstract::Childhood and adolescent overweight and obesity are increasing in China, but limited information is available on its secular trends in Guangzhou. In this cross-sectional study, ten-wave successive data were obtained from the physical fitness surveillance for students in Guangzhou from 2003 to 2012. A total of 2,619,15...

    journal_title:Scientific reports

    pub_type: 临床试验,杂志文章

    doi:10.1038/s41598-017-12094-z

    authors: Zong Y,Xie R,Deng N,Liu L,Tan W,Gao Y,Yang J,Yang Y

    更新日期:2017-09-21 00:00:00

  • Cross-sectional study of Staphyloccus lugdunensis prevalence in cats.

    abstract::Staphylococcus lugdunensis is a commensal bacterium in humans and other animals that can cause serious infections. The aim of this research was to estimate the frequency of S. lugdunensis in pet cats and to characterize the S. lugdunensis isolates obtained. The prevalence of S. lugdunensis was 0.77% (4/523) in healthy...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-72395-8

    authors: Bierowiec K

    更新日期:2020-09-22 00:00:00

  • Exploring source differences on diet-tissue discrimination factors in the analysis of stable isotope mixing models.

    abstract::Stable isotope mixing models are regularly used to provide probabilistic estimates of source contributions to dietary mixtures. Whilst Bayesian implementations of isotope mixing models have become prominent, the use of appropriate diet-tissue discrimination factors (DTDFs) remains as the least resolved aspect. The DTD...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-73019-x

    authors: Kadye WT,Redelinghuys S,Parnell AC,Booth AJ

    更新日期:2020-09-25 00:00:00

  • Activated boron nitride as an effective adsorbent for metal ions and organic pollutants.

    abstract::Novel activated boron nitride (BN) as an effective adsorbent for pollutants in water and air has been reported in the present work. The activated BN was synthesized by a simple structure-directed method that enabled us to control the surface area, pore volume, crystal defects and surface groups. The obtained BN exhibi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep03208

    authors: Li J,Xiao X,Xu X,Lin J,Huang Y,Xue Y,Jin P,Zou J,Tang C

    更新日期:2013-11-13 00:00:00

  • Author Correction: Artocarpus altilis extracts as a food-borne pathogen and oxidation inhibitors: RSM, COSMO RS, and molecular docking approaches.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-020-76567-4

    authors: Ahmad MN,Karim NU,Normaya E,Piah BM,Iqbal A,Bulat KHK

    更新日期:2020-11-05 00:00:00

  • Fracturing in coals with different fluids: an experimental comparison between water, liquid CO2, and supercritical CO2.

    abstract::The present work conducted laboratory experiments of fracturing in fat coals, anthracites, and mudstones. Three different fluids were selected as the fracturing fluids, including water, liquid CO2 (L-CO2), and supercritical CO2 (Sc-CO2). The resulting fracture morphologies and fracture apertures of the coal specimens ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-75787-y

    authors: Yang J,Lian H,Li L

    更新日期:2020-10-29 00:00:00

  • Different extent in decline of infant mortality by region and cause in Shenyang, China.

    abstract::To compare the pattern of cause of death of infant mortality rates by urban/rural areas as well as to generate knowledge for potential strategies to decrease this mortality, we carried out a study by analyzing the infant mortality data from the Shenyang Women and Children Health Care Centre. From 1997 to 2014, 970,583...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep24527

    authors: Huang YH,Wu QJ,Li LL,Li D,Li J,Zhou C,Wu L,Zhu J,Gong TT

    更新日期:2016-04-14 00:00:00

  • Morphological, physiological and anatomical traits of plant functional types in temperate grasslands along a large-scale aridity gradient in northeastern China.

    abstract::At the species level, plants can respond to climate changes by changing their leaf traits; however, there is scant information regarding the responses of morphological, physiological and anatomical traits of plant functional types (PFTs) to aridity. Herein, the leaf traits of five PFTs representing 17 plant species in...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep40900

    authors: Guo C,Ma L,Yuan S,Wang R

    更新日期:2017-01-20 00:00:00

  • Effects of Black Raspberries and Their Ellagic Acid and Anthocyanin Constituents on Taxane Chemotherapy of Castration-Resistant Prostate Cancer Cells.

    abstract::Cancer patients often use dietary supplements while on therapy, but little is known about interactions of supplements with cancer chemotherapy. Black raspberries (BRB) have anti-cancer effects, but have not been evaluated for interference with chemotherapy for castrate-resistant prostate cancer (CRPC). Here we studied...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-39589-1

    authors: Eskra JN,Schlicht MJ,Bosland MC

    更新日期:2019-03-13 00:00:00

  • The ocular surface after successful glaucoma filtration surgery: a clinical, in vivo confocal microscopy, and immune-cytology study.

    abstract::We investigated the ocular surface (OS) system modifications after completely successful glaucoma surgery in thirty-eight patients undergoing trabeculectomy (surgical group), using laser scanning confocal microscopy (LSCM) and impression cytology (IC). Twenty-six medically controlled glaucomatous patients served as co...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-47823-z

    authors: Agnifili L,Brescia L,Oddone F,Sacchi M,D'Ugo E,Di Marzio G,Perna F,Costagliola C,Mastropasqua R

    更新日期:2019-08-05 00:00:00

  • Optimal donor for severe aplastic anemia patient requiring allogeneic hematopoietic stem cell transplantation: A large-sample study from China.

    abstract::HLA-haploidentical hematopoietic stem cell transplantation (HSCT) may be an option for severe aplastic anemia (SAA) patients. However, to date, no large-sample studies have been performed to determine which types of SAA patients are suitable for HLA-haploidentical HSCT. We retrospectively studied 189 consecutive patie...

    journal_title:Scientific reports

    pub_type: 杂志文章,多中心研究

    doi:10.1038/s41598-018-20853-9

    authors: Zeng Y,Wang S,Wang J,Liu L,Su Y,Lu Z,Zhang X,Zhang Y,Zhong JF,Peng L,Liu Q,Lu Y,Gao L,Zhang X

    更新日期:2018-02-06 00:00:00

  • Evolution of the dense packings of spherotetrahedral particles: from ideal tetrahedra to spheres.

    abstract::Particle shape plays a crucial role in determining packing characteristics. Real particles in nature usually have rounded corners. In this work, we systematically investigate the rounded corner effect on the dense packings of spherotetrahedral particles. The evolution of dense packing structure as the particle shape c...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep15640

    authors: Jin W,Lu P,Li S

    更新日期:2015-10-22 00:00:00