Abstract:
BACKGROUND:In the Guadeloupe and Saint Martin islands, Aedes aegypti mosquitoes are the only recognized vectors of dengue, chikungunya, and Zika viruses. For around 40 years, malathion was used as a mosquito adulticide and temephos as a larvicide. Since the European Union banned the use of these two insecticide molecules in the first decade of the 21st century, deltamethrin and Bacillus thuringiensis var. israelensis are the remaining adulticide and larvicide, respectively, used in Guadeloupe. In order to improve the management of vector control activities in Guadeloupe and Saint Martin, we investigated Ae. aegypti resistance to and mechanisms associated with deltamethrin, malathion, and temephos. METHODS:Ae. aegypti mosquitoes were collected from six different localities of Guadeloupe and Saint Martin. Larvae were used for malathion and temephos bioassays, and adult mosquitoes for deltamethrin bioassays, following World Health Organization recommendations. Knockdown resistance (Kdr) genotyping for V1016I and F1534C mutations, and expression levels of eight enzymes involved in detoxification mechanisms were examined in comparison with the susceptible reference Bora Bora strain. RESULTS:Resistance ratios (RR50) calculated for Ae. aegypti larvae showed high resistance levels to temephos (from 8.9 to 33.1-fold) and low resistance levels to malathion (from 1.7 to 4.4-fold). Adult females displayed moderate resistance levels to deltamethrin regarding the time necessary to affect 50% of individuals, varying from 8.0 to 28.1-fold. Molecular investigations on adult mosquitoes showed high resistant allele frequencies for V1016I and F1534C (from 85 to 96% and from 90 to 98%, respectively), as well as an overexpression of the glutathione S-transferase gene, GSTe2, the carboxylesterase CCEae3a, and the cytochrome genes 014614, CYP6BB2, CYP6M11, and CYP9J23. CONCLUSIONS:Ae. aegypti populations from Guadeloupe and Saint Martin exhibit multiple resistance to organophosphates (temephos and malathion), and pyrethroids (deltamethrin). The mechanisms associated with these resistance patterns show strong frequencies of F1534C and V1016I Kdr mutations, and an over-expression of CCEae3a, GSTe2, and four cytochrome P450 genes (014614, CYP9J23, CYP6M11, CYP6BB2). These results will form the baseline for a deeper understanding of the insecticide resistance levels and associated mechanisms of Ae. aegypti populations and will be used to improve vector control strategies in Guadeloupe and Saint Martin.
journal_name
Infect Dis Povertyjournal_title
Infectious diseases of povertyauthors
Goindin D,Delannay C,Gelasse A,Ramdini C,Gaude T,Faucon F,David JP,Gustave J,Vega-Rua A,Fouque Fdoi
10.1186/s40249-017-0254-xsubject
Has Abstractpub_date
2017-02-10 00:00:00pages
38issue
1eissn
2095-5162issn
2049-9957pii
10.1186/s40249-017-0254-xjournal_volume
6pub_type
杂志文章abstract::Recently, the mortality of 240 causes in China including a subnational analysis during 1990-2013 was published in The Lancet. This comprehensive analysis will undoubtedly impact policymaking regarding public health in China. However, it is unfavourable in some degree to neglected tropical diseases, which is the subjec...
journal_title:Infectious diseases of poverty
pub_type: 信件
doi:10.1186/s40249-017-0237-y
更新日期:2017-02-03 00:00:00
abstract:BACKGROUND:Malaria is a major world health issue and its continued burden is due, in part, to difficulties in the diagnosis of the illness. The World Health Organization recommends confirmatory testing using microscopy-based techniques or rapid diagnostic tests (RDT) for all cases of suspected malaria. In regions where...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-017-0251-0
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journal_title:Infectious diseases of poverty
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journal_title:Infectious diseases of poverty
pub_type: 杂志文章,评审
doi:10.1186/s40249-018-0477-5
更新日期:2018-09-03 00:00:00
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journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-018-0498-0
更新日期:2018-12-04 00:00:00
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journal_title:Infectious diseases of poverty
pub_type: 信件
doi:10.1186/s40249-019-0588-7
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journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-018-0458-8
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journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/2049-9957-1-2
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journal_title:Infectious diseases of poverty
pub_type: 杂志文章
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journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-020-00788-y
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journal_title:Infectious diseases of poverty
pub_type: 杂志文章,评审
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更新日期:2017-04-07 00:00:00
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journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-018-0486-4
更新日期:2018-11-02 00:00:00
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journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-017-0260-z
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:Tuberculosis infection still places a great burden on HIV-infected individuals in China and other developing countries. Knowledge of the survival of HIV-infected patients with pulmonary tuberculosis (PTB) would provide important insights for the clinical management of this population, which remains to be wel...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-018-0405-8
更新日期:2018-03-24 00:00:00
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journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-017-0339-6
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journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-016-0095-z
更新日期:2016-01-13 00:00:00
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journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-020-00652-z
更新日期:2020-04-16 00:00:00
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journal_title:Infectious diseases of poverty
pub_type: 杂志文章
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journal_title:Infectious diseases of poverty
pub_type: 杂志文章
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journal_title:Infectious diseases of poverty
pub_type: 杂志文章,评审
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更新日期:2018-11-05 00:00:00
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journal_title:Infectious diseases of poverty
pub_type: 杂志文章,已发布勘误
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更新日期:2018-04-20 00:00:00
abstract:BACKGROUND:Aedes borne viral diseases, notably dengue, are increasingly reported in Cameroon with Aedes aegypti being a major vector. Data on insecticide resistance of this vector and underlying mechanisms needed for outbreak preparedness remain scarce in Cameroon. Here, we present the nationwide distribution of insect...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-020-00769-1
更新日期:2020-11-02 00:00:00
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journal_title:Infectious diseases of poverty
pub_type: 社论
doi:10.1186/s40249-018-0400-0
更新日期:2018-03-22 00:00:00
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journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/2049-9957-1-8
更新日期:2012-11-01 00:00:00
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journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/2049-9957-3-19
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journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-019-0591-z
更新日期:2019-10-03 00:00:00
abstract::Schistosomiasis is an important zoonotic parasitic disease that causes serious harms to humans and animals. Surveillance and diagnosis play key roles in schistosomiasis control, however, current techniques for surveillance and diagnosis of the disease have limitations. As genome data for parasites are increasing, nove...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章,评审
doi:10.1186/s40249-016-0116-y
更新日期:2016-03-30 00:00:00
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journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-020-00759-3
更新日期:2020-10-12 00:00:00
abstract:BACKGROUND:Interventions are currently being used against 'infectious diseases of poverty', which remain highly debilitating and deadly in most endemic countries, especially malaria, schistosomiasis, echinococcosis and African sleeping sickness. However, major limitations of current 'traditional' methods for diagnosis ...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-017-0344-9
更新日期:2017-10-02 00:00:00
abstract:BACKGROUND:Before 2014 (the year of closure of the two largest needle exchange programs in Hungary, which halved the number of available syringes in the country despite increased injecting risk practices) no HIV was reportedly acquired in Hungary among people who inject drugs (PWIDs) who were not also men who had sex w...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-017-0360-9
更新日期:2017-10-11 00:00:00