Abstract:
:The retinal degeneration 11 (rd11) mouse is a new animal model with rapid photoreceptor degeneration. The long-term efficacy of gene therapy has a direct relationship with the onset of photoreceptor degeneration or apoptosis, whereas the degeneration or apoptosis patterns of photoreceptors are still unclear in rd11 mice. The distribution patterns of cone function-related L- and S-opsin were examined by immunofluorescence staining, and the apoptosis was performed by TUNEL assay in rd11 mice. The expression pattern of L-opsin or S-opsin in rd11 retina at postnatal day (P) 14 was similar to the pattern observed in wildtype retina. With increasing age, the expression of L-opsin and S-opsin, especially S-opsin, decreased significantly in rd11 mice. The degeneration of L-opsin began around the optic nerve and expanded to the periphery of the retina, from the ventral/nasal to dorsal/temporal retina, whereas the expression of S-opsin gradually decreased from the dorsal/temporal to ventral/nasal retina. Apoptotic signal appeared at P14 and was strongest at P28 of rd11 mice. The key genes associated with apoptosis confirmed those changes. These indicated that the degeneration and apoptosis of cone photoreceptors began at P14 of rd11 mice, which was a key point for gene therapy.
journal_name
J Ophthalmoljournal_title
Journal of ophthalmologyauthors
Zhang H,Li X,Dai X,Han J,Zhang Y,Qi Y,He Y,Liu Y,Chang B,Pang JJdoi
10.1155/2017/9721362subject
Has Abstractpub_date
2017-01-01 00:00:00pages
9721362eissn
2090-004Xissn
2090-0058journal_volume
2017pub_type
杂志文章abstract:PURPOSE:To investigate neovascular age-related macular degeneration (AMD) in patients aged ≥90 years from several perspectives for a comprehensive overview: prevalence, presenting characteristics, treatment adherence, reasons for discontinuation, and efficacy of antivascular endothelial growth factor (VEGF) treatment c...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/7194927
更新日期:2017-01-01 00:00:00
abstract::Purpose. The aim of this study is to investigate the etiology and the clinical, microbiological, histopathological, and radiological findings of acquired dacryocystoceles. Methods. In this retrospective study, we reviewed the clinical records of 10 eyes of 8 patients with dacryocystoceles who underwent external dacryo...
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doi:10.1155/2014/396782
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doi:10.1155/2015/329819
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doi:10.1155/2015/193078
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pub_type: 杂志文章
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doi:10.1155/2019/1345683
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doi:10.1155/2020/2670153
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pub_type: 杂志文章
doi:10.1155/2016/8656301
更新日期:2016-01-01 00:00:00
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doi:10.1155/2016/4353957
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pub_type: 杂志文章
doi:10.1155/2015/132417
更新日期:2015-01-01 00:00:00
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journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2010/106384
更新日期:2010-01-01 00:00:00
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doi:10.1155/2020/3781249
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pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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doi:10.1155/2017/2371032
更新日期:2017-01-01 00:00:00
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doi:10.1155/2017/2370969
更新日期:2017-01-01 00:00:00
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pub_type:
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更新日期:2010-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-01-10 00:00:00
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