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Age-related alterations in the genetics and genomics of the male germ line.

Abstract：

:Paternal aging is associated with increased risk of genetic disease transmission to the offspring. The changes associated with aging arise predominantly through formation of single nucleotide variation through DNA replication errors, as well as possibly chronic exposure to environmental toxins and reactive oxygen species exposure. Several age-related reproductive factors are also contributory, including the systemic hormonal milieu, accumulation of environmental toxin exposure, aging germ cells, and accumulation of de novo genetic and genomic abnormalities in germ cells. In this article we review the age-related genetic and genomic changes that occur in the male germ line.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Herati AS,Zhelyazkova BH,Butler PR,Lamb DJ

doi

10.1016/j.fertnstert.2016.12.021

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

319-323

issue

2

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)63093-5

journal_volume

107

pub_type

杂志文章,评审

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