Not only for melanoma. Subcutaneous pseudoprogression in lung squamous-cell carcinoma treated with nivolumab: A case report.

Abstract:

RATIONALE:Pseudoprogression, that is, initial tumor growth followed by subsequent tumor regression, has been well described for immunomodulation therapy in melanoma patients. This phenomenon is not well defined in lung cancer. Nivolumab, an anti-PD-1 monoclonal antibody, was recently approved for nonsmall cell lung cancer (NSCLC) as a second-line therapy. PATIENT CONCERNS AND DIAGNOSIS:We present a patient with squamous NSCLC, suffering from multiple bone and subcutaneous metastases. INTERVENTIONS:The patient was treated with nivolumab. OUTCOMES:A subcutaneous lesion in her upper back grew substantially after the first cycle of nivolumab, and later regressed, with marked improvement in all cancer sites. LESSONS:Such pseudoprogression may serve to predict subsequent clinical response.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Sarfaty M,Moore A,Dudnik E,Peled N

doi

10.1097/MD.0000000000005951

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

e5951

issue

4

eissn

0025-7974

issn

1536-5964

pii

00005792-201701270-00029

journal_volume

96

pub_type

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