Abstract:
RATIONALE:Pseudoprogression, that is, initial tumor growth followed by subsequent tumor regression, has been well described for immunomodulation therapy in melanoma patients. This phenomenon is not well defined in lung cancer. Nivolumab, an anti-PD-1 monoclonal antibody, was recently approved for nonsmall cell lung cancer (NSCLC) as a second-line therapy. PATIENT CONCERNS AND DIAGNOSIS:We present a patient with squamous NSCLC, suffering from multiple bone and subcutaneous metastases. INTERVENTIONS:The patient was treated with nivolumab. OUTCOMES:A subcutaneous lesion in her upper back grew substantially after the first cycle of nivolumab, and later regressed, with marked improvement in all cancer sites. LESSONS:Such pseudoprogression may serve to predict subsequent clinical response.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Sarfaty M,Moore A,Dudnik E,Peled Ndoi
10.1097/MD.0000000000005951subject
Has Abstractpub_date
2017-01-01 00:00:00pages
e5951issue
4eissn
0025-7974issn
1536-5964pii
00005792-201701270-00029journal_volume
96pub_type
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