Evaluation of the impact of polyclonal infection and heteroresistance on treatment of tuberculosis patients.

abstract：:When lightning strikes soil, it may generate a cylindrical tube of glass known as a fulgurite. The morphology of a fulgurite is ultimately a consequence of the energy of the lightning strike that formed it, and hence fulgurites may be useful in elucidating the energy distribution frequency of cloud-to-ground lightning...

journal_title：Scientific reports

authors： Pasek MA,Hurst M

更新日期：2016-07-28 00:00:00

abstract：:The PIM1 serine/threonine protein kinase mediates growth factor and survival signalling, and cooperates potently with c-MYC during tumorigenesis. PIM1 is overexpressed in many human cancers and is a promising target for drug development. PIM1 levels are regulated mainly through cytokine-induced transcription and prote...

journal_title：Scientific reports

authors： Iyer RS,Chatham L,Sleigh R,Meek DW

更新日期：2017-06-15 00:00:00

abstract：:Liquid-ordered lipid domains represent a lateral inhomogeneity in cellular membranes. These domains have elastic and physicochemical properties different from those of the surrounding membrane. In particular, their thickness exceeds that of the disordered membrane. Thus, elastic deformations arise at the domain bounda...

journal_title：Scientific reports

authors： Pinigin KV,Kondrashov OV,Jiménez-Munguía I,Alexandrova VV,Batishchev OV,Galimzyanov TR,Akimov SA

更新日期：2020-03-05 00:00:00

abstract：:In this study, we report on a new approach for remote temperature probing that provides accuracy as good as 0.017°C (0.0055% accuracy) by measuring the magnetisation curve of magnetic nanoparticles. We included here the theoretical model construction and the inverse calculation method, and explored the impact caused b...

journal_title：Scientific reports

authors： Zhong J,Liu W,Kong L,Morais PC

更新日期：2014-10-15 00:00:00

abstract：:To pattern electrical metal contacts, electron beam lithography or photolithography are commonly utilized, and these processes require polymer resists with solvents. During the patterning process the graphene surface is exposed to chemicals, and the residue on the graphene surface was unable to be completely removed b...

journal_title：Scientific reports

authors： Tien DH,Park JY,Kim KB,Lee N,Seo Y

更新日期：2016-05-12 00:00:00

abstract：:Psychiatric disorders have been widely reported to be associated with systemic inflammation upregulation and adiposity. However, there are no data that link adipose tissue inflammation to these mental disorders. The analysis of adipokines and inflammation-related markers in adipose tissue could help to elucidate the p...

journal_title：Scientific reports

authors： Coín-Aragüez L,Pavón FJ,Contreras A,Gentile AM,Lhamyani S,De Diego-Otero Y,Casado Y,Oliva Olivera W,Olveira G,Tinahones FJ,Pérez Costillas L,El Bekay R

更新日期：2018-11-30 00:00:00

abstract：:The current molecular docking study provided the Free Energy of Binding (FEB) for the interaction (nanotoxicity) between VDAC mitochondrial channels of three species (VDAC1-Mus musculus, VDAC1-Homo sapiens, VDAC2-Danio rerio) with SWCNT-H, SWCNT-OH, SWCNT-COOH carbon nanotubes. The general results showed that the FEB ...

journal_title：Scientific reports

authors： González-Durruthy M,Werhli AV,Seus V,Machado KS,Pazos A,Munteanu CR,González-Díaz H,Monserrat JM

更新日期：2017-10-16 00:00:00

abstract：:The relationship between the cuprate pseudogap (Δ(p)) and superconducting gap (Δ(s)) remains an unsolved mystery. Here, we present a temperature- and doping-dependent tunneling study of submicron Bi(2)Sr(2)CaCu(2)O(8+δ) intrinsic Josephson junctions, which provides a clear evidence that Δ(s) closes at a temperature T(...

journal_title：Scientific reports

authors： Ren JK,Zhu XB,Yu HF,Tian Y,Yang HF,Gu CZ,Wang NL,Ren YF,Zhao SP

更新日期：2012-01-01 00:00:00

abstract：:Emergence of DS-1-like-G1P[8] rotavirus in Asia have been recently reported. We report for the first time the detection and the whole genome phylogenetic analysis of DS-1-like-G1P[8] strains in America. From 2013 to 2017, a total of 4226 fecal samples were screened for rotavirus by ELISA, PAGE, RT-PCR and sequencing. ...

journal_title：Scientific reports

authors： Luchs A,da Costa AC,Cilli A,Komninakis SCV,Carmona RCC,Morillo SG,Sabino EC,Timenetsky MDCST

更新日期：2019-02-18 00:00:00

abstract：:Seagrass meadows are threatened by coastal development and global change. In the face of these pressures, molecular techniques such as reverse transcription quantitative real-time PCR (RT-qPCR) have great potential to improve management of these ecosystems by allowing early detection of chronic stress. In RT-qPCR, the...

journal_title：Scientific reports

authors： Schliep M,Pernice M,Sinutok S,Bryant CV,York PH,Rasheed MA,Ralph PJ

更新日期：2015-11-23 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) represent a vast unexplored genetic space that may hold missing drivers of tumourigenesis, but few such "driver lncRNAs" are known. Until now, they have been discovered through changes in expression, leading to problems in distinguishing between causative roles and passenger effects. We h...

journal_title：Scientific reports

authors： Lanzós A,Carlevaro-Fita J,Mularoni L,Reverter F,Palumbo E,Guigó R,Johnson R

更新日期：2017-01-27 00:00:00

abstract：:The formation and motion features of self interstitial atom (SIA) clusters in tungsten are studied by molecular dynamics (MD) simulations. The static calculations show that the SIA clusters are stable with binding energy over 2 eV. The SIA clusters exhibit a fast one dimensional (1D) motion along 〈111〉. Through analys...

journal_title：Scientific reports

authors： Zhou WH,Zhang CG,Li YG,Zeng Z

更新日期：2014-05-28 00:00:00

abstract：:It remains a grand challenge to achieve both high activity and durability in Pt electrocatalysts for oxygen reduction reaction (ORR) in fuel cells. Here we develop a class of Pt highly concave cubic (HCC) nanocrystals, which are enriched with high-index facets, to enable high ORR activity. The durability of HCC nanocr...

journal_title：Scientific reports

authors： Wang C,Ma L,Liao L,Bai S,Long R,Zuo M,Xiong Y

更新日期：2013-01-01 00:00:00

abstract：:Kashin-Beck disease (KBD) is a chronic osteoarthropathy, which manifests as joint deformities and growth retardation. Only a few genetic studies of growth retardation associated with the KBD have been carried out by now. In this study, we conducted a two-stage bivariate genome-wide association study (BGWAS) of the KBD...

journal_title：Scientific reports

authors： Hao J,Wang W,Wen Y,Xiao X,He A,Guo X,Yang T,Liu X,Shen H,Chen X,Tian Q,Deng HW,Zhang F

更新日期：2016-08-22 00:00:00

abstract：:Magnetic skyrmions are hailed as a potential technology for data storage and other data processing devices. However, their stability against thermal fluctuations is an open question that must be answered before skyrmion-based devices can be designed. In this work, we study paths in the energy landscape via which the t...

journal_title：Scientific reports

authors： Cortés-Ortuño D,Wang W,Beg M,Pepper RA,Bisotti MA,Carey R,Vousden M,Kluyver T,Hovorka O,Fangohr H

更新日期：2017-06-22 00:00:00

abstract：:The identification of clinically-relevant early diagnostic and prognostic protein biomarkers is essential to maximize therapeutic efficacy and prevent cancer progression. The aim of the current study is to determine whether aberrant plasma protein profile can be applied as a surrogate tool for early diagnosis of bladd...

journal_title：Scientific reports

authors： Nedjadi T,Benabdelkamal H,Albarakati N,Masood A,Al-Sayyad A,Alfadda AA,Alanazi IO,Al-Ammari A,Al-Maghrabi J

更新日期：2020-07-03 00:00:00

abstract：:Molecular behaviour of liquid water under proton irradiation is of great importance to a number of technological and medical applications. The highly energetic proton generates a time-varying field that is highly localized and heterogeneous at the molecular scale, and massive electronic excitations are produced as a r...

journal_title：Scientific reports

authors： Reeves KG,Kanai Y

更新日期：2017-01-13 00:00:00

abstract：:The strong adhesion of sub-micron sized particles to surfaces is a nuisance, both for removing contaminating colloids from surfaces and for conscious manipulation of particles to create and test novel micro/nano-scale assemblies. The obvious idea of using detergents to ease these processes suffers from a lack of contr...

journal_title：Scientific reports

authors： Feldmann D,Maduar SR,Santer M,Lomadze N,Vinogradova OI,Santer S

更新日期：2016-11-03 00:00:00

abstract：:The sensitivity of many ion channels to phosphatidylinositol-4,5-bisphosphate (PIP2) levels in the cell membrane suggests that PIP2 fluctuations are important and general signals modulating neuronal excitability. Yet the PIP2 dynamics of central neurons in their native environment remained largely unexplored. Here, we...

journal_title：Scientific reports

authors： Hackelberg S,Oliver D

更新日期：2018-08-28 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Liu Z,Kemp TJ,Gao YT,Corbel A,McGee EE,Roa JC,Wang B,Araya JC,Shen MC,Rashid A,Hsing AW,Hildesheim A,Ferreccio C,Pfeiffer RM,Pinto LA,Koshiol J

更新日期：2020-02-11 00:00:00

abstract：:We report an integrated system for accelerating assays with concentrators in a standard 12-well plate (ISAAC-12) and demonstrate its versatility for rapid detection of matrix metalloproteinase (MMP)-9 expression in the cell culture supernatant of breast cancer cell line MDA-MB-231 by accelerating the enzymatic reactio...

journal_title：Scientific reports

authors： Wei X,Do VQ,Pham SV,Martins D,Song YA

更新日期：2018-07-17 00:00:00

abstract：:High-throughput RNA sequencing is a powerful tool that allows us to perform gene prediction and analyze tissue-specific overexpression of genes, but also at species level comparisons can be performed, although in a more restricted manner. In the present study complete liver transcriptomes of five tropical bat species ...

journal_title：Scientific reports

authors： Moreno-Santillán DD,Machain-Williams C,Hernández-Montes G,Ortega J

更新日期：2019-04-17 00:00:00

abstract：:We investigated the clinical characteristics of cilioretinal arteries (CAs) and cilioretinal veins (CVs) in eyes with pathologic myopia. Ninety-five eyes with pathologic myopia and CAs were studied. The retrobulbar vessels from which the CAs originated were identified by indocyanine green angiography (ICGA). The resul...

journal_title：Scientific reports

authors： Watanabe T,Kasahara K,Futagami S,Fang Y,Du R,Moriyama M,Uramoto K,Yokoi T,Onishi Y,Yoshida T,Kamoi K,Jonas JB,Ohno-Matsui K

更新日期：2019-02-21 00:00:00

abstract：:Chemotherapy can cause cachexia, which consists of weight loss associated with muscle atrophy. The exact mechanisms underlying this skeletal muscle toxicity are largely unknown and co-therapies to attenuate chemotherapy-induced side effects are lacking. By using a rat model of cisplatin-induced cachexia, we here chara...

journal_title：Scientific reports

authors： Sirago G,Conte E,Fracasso F,Cormio A,Fehrentz JA,Martinez J,Musicco C,Camerino GM,Fonzino A,Rizzi L,Torsello A,Lezza AMS,Liantonio A,Cantatore P,Pesce V

更新日期：2017-10-12 00:00:00

abstract：:Refractive index sensors based on surface plasmon resonance (SPR) promise to deliver high sensitivities. However, these sensitivities depend on the derivative of the monitored SPR parameters near resonance, so this dependency leads to a relatively narrow detection range for refractive index changes. Herein, we introdu...

journal_title：Scientific reports

authors： Cheng YC,Chang YJ,Chuang YC,Huang BZ,Chen CC

更新日期：2019-03-26 00:00:00

abstract：:Subsea hypersaline anoxic brine pools are among the most extreme habitable environments on Earth that offer clues to life on other planets. Brine is toxic to macrofauna as remotely operated vehicles commonly observe dead and preserved remains in brine pools. While brine pools are often assumed to be stable stratified ...

journal_title：Scientific reports

authors： Sawyer DE,Mason RA,Cook AE,Portnov A

更新日期：2019-01-15 00:00:00

abstract：:HLA-haploidentical hematopoietic stem cell transplantation (HSCT) may be an option for severe aplastic anemia (SAA) patients. However, to date, no large-sample studies have been performed to determine which types of SAA patients are suitable for HLA-haploidentical HSCT. We retrospectively studied 189 consecutive patie...

journal_title：Scientific reports

authors： Zeng Y,Wang S,Wang J,Liu L,Su Y,Lu Z,Zhang X,Zhang Y,Zhong JF,Peng L,Liu Q,Lu Y,Gao L,Zhang X

更新日期：2018-02-06 00:00:00

abstract：:To what extent deep-time dispersal limitation shapes present-day biodiversity at broad spatial scales remains elusive. Here, we compiled a continental dataset on the distributions of African lizard species in the reptile subfamily Agaminae (a relatively young, Neogene radiation of agamid lizards which ancestors coloni...

journal_title：Scientific reports

authors： Kissling WD,Blach-Overgaard A,Zwaan RE,Wagner P

更新日期：2016-09-27 00:00:00

abstract：:Tumor cells tend to behave differently in response to immune selective conditions. Contrary to those in therapeutic antitumor conditions, tumor cells in prophylactic antitumor conditions lose antigen expression for antitumor immune escape. Here, using a CT26/HER2 tumor model, we investigate the underlying mechanism(s)...

journal_title：Scientific reports

authors： Han BS,Ji S,Woo S,Lee JH,Sin JI

更新日期：2019-02-27 00:00:00

abstract：:Given the complex nature of the interaction between gas and solid atoms, the development of nanoscale science and technology has engendered a need for further understanding of gas transport behavior through nanopores and more tractable models for large-scale simulations. In the present paper, we utilize molecular dyna...

journal_title：Scientific reports

authors： Wu T,Zhang D

更新日期：2016-03-29 00:00:00