Abstract:
:Operating at multiple levels of control, mesenchymal stem cells from adipose tissue (ADSCs) communicate with organ systems to adjust immune response, provide signals for differentiation, migration, enzymatic reactions, and to equilibrate the regenerative demands of balanced tissue homeostasis. The identification of the mechanisms by which ADSCs accomplish these functions for dermatological rejuvenation and wound healing has great potential to identify novel targets for the treatment of disorders and combat aging. Herein, we review new insights into the role of adipose-derived stem cells in the maintenance of dermal and epidermal homeostasis, and recent advances in clinical applications of ADSCs related to dermatology.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Gaur M,Dobke M,Lunyak VVdoi
10.3390/ijms18010208subject
Has Abstractpub_date
2017-01-20 00:00:00issue
1issn
1422-0067pii
ijms18010208journal_volume
18pub_type
杂志文章,评审abstract::Hypoxic-ischemic encephalopathy (HIE) resulting from asphyxia in the peripartum period is the most common cause of neonatal brain damage and can result in significant neurologic sequelae, including cerebral palsy. Currently therapeutic hypothermia is the only accepted treatment in addition to supportive care for infan...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18010017
更新日期:2016-12-22 00:00:00
abstract::Monoclonal and recombinant antibodies are widely used for the diagnostics and therapy of cancer. They are generated to interact with cell surface proteins which are usually involved in the development and progression of cancer. Carbonic anhydrase XII (CA XII) contributes to the survival of tumors under hypoxic conditi...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21249411
更新日期:2020-12-10 00:00:00
abstract::Tacrolimus is widely used as an immunosuppressant in liver transplantation, and tacrolimus-induced acute kidney injury (AKI) is a serious complication. The urinary neutrophil gelatinase-associated lipocalin (NGAL) level has been linked to tacrolimus-induced AKI in patients starting tacrolimus treatment the morning aft...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20123103
更新日期:2019-06-25 00:00:00
abstract::The effect of palmitoylethanolamide (PEA), an endogenous fatty acid amide displaying neuroprotective actions, on glutamate release from rat cerebrocortical nerve terminals (synaptosomes) was investigated. PEA inhibited the Ca²⁺-dependent release of glutamate, which was triggered by exposing synaptosomes to the potassi...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms16035555
更新日期:2015-03-11 00:00:00
abstract::Scrapie infection, which converts cellular prion protein (PrPC) into the pathological and infectious isoform (PrPSc), leads to neuronal cell death, glial cell activation and PrPSc accumulation. Previous studies reported that PrPC regulates RhoA/Rho-associated kinase (ROCK) signaling and that connexin 43 (Cx43) express...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21041255
更新日期:2020-02-13 00:00:00
abstract::Hypoxia, which is common during tumor progression, plays important roles in tumor biology. Failure in cell death in response to hypoxia contributes to progression and metastasis of tumors. On the one hand, the metabolic and oxidative stress following hypoxia could lead to cell death by triggering signal cascades, like...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms161025536
更新日期:2015-10-23 00:00:00
abstract::Fe3O4-Au hybrid nanoparticles (HNPs) have shown increasing potential for biomedical applications such as image guided stimuli responsive drug delivery. Incorporation of the unique properties of HNPs into thermally responsive scaffolds holds great potential for future biomedical applications. Here we successfully fabri...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms14048585
更新日期:2013-04-19 00:00:00
abstract::A T-maze test is an experimental approach that is used in congenital research. However, the food reward-based protocol for the T-maze test in fish has low efficiency and a long training period. The aim of this study is to facilitate the T-maze conditions by using a combination of the principles of passive avoidance an...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21041464
更新日期:2020-02-21 00:00:00
abstract::Alpha-synuclein (SNCA) is a small membrane protein that plays an important role in neuro-psychiatric diseases. It is best known for its abnormal subcellular aggregation in Lewy bodies that serves as a hallmark of Parkinson's disease (PD). Due to the high comorbidity of PD with depression, we investigated the role of S...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20082029
更新日期:2019-04-25 00:00:00
abstract::Arachidonic acid (AA) is a phospholipase A2 metabolite that has been reported to mediate a plethora of cellular mechanisms involved in healthy and pathological states such as platelet aggregation, lymphocyte activation, and tissue inflammation. AA has been described to activate Ca2+ entry through the arachidonate-regu...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21093315
更新日期:2020-05-07 00:00:00
abstract::Effect of H2O and NH3 on the synergistic oxidation reaction of SO2 and NO2 is investigated by theoretical calculation using the molecule system SO2-2NO2-nH2O (n = 0, 1, 2, 3) and SO2-2NO2-nH2O-mNH3 (n = 0, 1, 2; m = 1, 2). Calculated results show that SO2 is oxidized to SO3 by N2O4 intermediate. The additional H2O in ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20153746
更新日期:2019-07-31 00:00:00
abstract::Given the ability of molecular chaperones and chaperone-like proteins to inhibit the formation of pathological amyloid fibrils, the chaperone-based therapy of amyloidosis has recently been proposed. However, since these diseases are often diagnosed at the stages when a large amount of amyloids is already accumulated i...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21207659
更新日期:2020-10-16 00:00:00
abstract::Kentucky bluegrass (KB, Poa pratensis) is one of the most widely used cool-season turfgrass species, but it is sensitive to drought stress. Molecular studies in KB are hindered by its large and complex genome structure. In this study, a comparative transcriptomic study was conducted between a short and long period of ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20061289
更新日期:2019-03-14 00:00:00
abstract::Genistein has been reported to stimulate luminal HCO3(-) secretion. We hypothesized that genistein mediates this effect via SLC26A6 and SLC4A4 (NBCe1) transporters. Our study aimed to: investigate changes in uterine fluid pH, Na+ and HCO3(-) concentration and expression of uterine SLC26A6 and NBCe1 under genistein eff...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms15010958
更新日期:2014-01-10 00:00:00
abstract::Unloading leads to skeletal muscle atrophy via the upregulation of MuRF-1 and MAFbx E3-ligases expression. Reportedly, histone deacetylases (HDACs) 4 and 5 may regulate the expression of MuRF1 and MAFbx. To examine the HDAC-dependent mechanisms involved in the control of E3-ubiquitin ligases expression at the early st...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21134815
更新日期:2020-07-07 00:00:00
abstract::It has recently been recognized that inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), upregulate the secretion of matrix metalloproteinase-9 (MMP-9) from cancer cells and thereby promote peritoneal dissemination. In this study, we found that TNF-α also stimulated peritoneal mesothelial cells to secrete...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19123961
更新日期:2018-12-09 00:00:00
abstract::Two mesenchymal zinc transporters, ZIP7 and ZIP13, play critical roles in dermal development. ZIP7 and ZIP13 are the closest among the conserved mammalian zinc transporters. However, whether their functions are complementary remains a controversial issue. In the present study, we found that the expression of ZIP13, bu...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20163941
更新日期:2019-08-13 00:00:00
abstract::Pulmonary vascular remodeling is a pathophysiological feature that common to all classes of pulmonary hypertension (PH) and right ventricular dysfunction, which is the major prognosis-limiting factor. Vascular, as well as cardiac tissue remodeling are associated with a re-expression of fetal variants of cellular adhes...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18112371
更新日期:2017-11-08 00:00:00
abstract::Due to a typesetting error during layout, several references were incorrectly listed in [...]. ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,已发布勘误
doi:10.3390/ijms20112651
更新日期:2019-05-29 00:00:00
abstract::Fresh produce is often a source of enterohaemorrhagic Escherichia coli (EHEC) outbreaks. Fimbriae are extracellular structures involved in cell-to-cell attachment and surface colonisation. F9 (Fml) fimbriae have been shown to be expressed at temperatures lower than 37 °C, implying a function beyond the mammalian host....
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21249720
更新日期:2020-12-19 00:00:00
abstract::Cytochrome P450 17A1 (CYP17A1) catalyses the formation and metabolism of steroid hormones. They are involved in blood pressure (BP) regulation and in the pathogenesis of left ventricular hypertrophy. Therefore, altered function of CYP17A1 due to genetic variants may influence BP and left ventricular mass. Notably, gen...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms160817456
更新日期:2015-07-30 00:00:00
abstract::Nuclear β-dystroglycan (β-DG) is involved in the maintenance of nuclear architecture and function. Nonetheless, its relevance in defined nuclear processes remains to be determined. In this study we generated a C2C12 cell-based DG-null model using CRISPR-Cas9 technology to provide insights into the role of β-DG on nucl...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21144961
更新日期:2020-07-14 00:00:00
abstract::Galectins are a family of animal lectins with high affinity for β-galactosides. Galectins are able to bind to bacteria, and a few mammalian galectins are known to kill the bound bacteria. In fish, no galectins with direct bactericidal effect have been reported. In the present study, we identified and characterized a t...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms22010376
更新日期:2020-12-31 00:00:00
abstract::MnTE-2-PyP, a superoxide dismutase mimetic, inhibited OVA-induced airway inflammation in mice suggesting an effect on Th2 responsiveness. Thus, we hypothesized that MnTE-2-PyP may alter dendritic cell-Th2 interactions. Bone marrow derived dendritic cells (DC) and OVA(323-339)-specific Th2 cells were cultured separatel...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms13089785
更新日期:2012-01-01 00:00:00
abstract::Previous studies have shown that germin-like proteins (GLPs) are present ubiquitously in rice and Arabidopsis. However, the understanding regarding their role in development and abiotic/biotic stress resistance remains limited. In the present study, we report genome-wide identification, characterisation, subcellular l...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms17101622
更新日期:2016-09-23 00:00:00
abstract::Excess energy is stored primarily as triglycerides, which are mobilized when demand for energy arises. Dysfunction of energy balance by excess food intake leads to metabolic diseases, such as obesity and diabetes. Free fatty acids (FFAs) provided by dietary fat are not only important nutrients, but also contribute key...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms17040450
更新日期:2016-03-25 00:00:00
abstract::Mechanistic approaches to modeling the effects of ionizing radiation on cells are on the rise, promising a better understanding of predictions and higher flexibility concerning conditions to be accounted for. In this work we modified and extended a previously published mechanistic model of cell survival after photon i...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20236054
更新日期:2019-11-30 00:00:00
abstract::One of the hallmarks of the acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a drastically reduced feed intake by an unknown mechanism. To further elucidate this wasting syndrome, we followed the effects of a single large dose (100 μg/kg) of TCDD on the serum levels of several energy balance-influencing...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms150813938
更新日期:2014-08-12 00:00:00
abstract::Granulocytic myeloid-derived suppressor cells (Gr-MDSCs) promote immune evasion and resistance to immunotherapeutics in a variety of malignancies. Our previous study showed that dual PI3K/mTOR inhibitor Dactolisib impaired the viability and immunosuppressive function of Gr-MDSCs, and significantly synergized with immu...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21072337
更新日期:2020-03-27 00:00:00
abstract::The use of gentamicin for the treatment of bacterial infection has always been an interesting and highly speculated issue for the scientific community. Conversely, its effect on cancer cells has been very little investigated. We studied the effect of high doses of gentamicin on non-Hodgkin's T-cell human lymphoblastic...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms16022307
更新日期:2015-01-22 00:00:00