当前位置： SCI文献检索 > Asian Pacific Journal of Tropical Medicine期刊下所有文献 > The role of heme-oxygenase-1 in pathogenesis of cerebral malaria in the co-culture model of human brain microvascular endothelial cell and ITG Plasmodium falciparum-infected red blood cells.

The role of heme-oxygenase-1 in pathogenesis of cerebral malaria in the co-culture model of human brain microvascular endothelial cell and ITG Plasmodium falciparum-infected red blood cells.

Abstract：

OBJECTIVE:To investigate the role of human host heme-oxygenase-1 (HO-1) in pathogenesis of cerebral malaria in the in vitro model. METHODS:The effect of human host HO-1 [human brain microvascular endothelial cell (HBMEC)] on hemoglobin degradation in the co-culture model of HBMEC and ITG Plasmodium falciparum-infected red cells (iRBC) through measurement of the enzymatic products iron and bilirubin. RESULTS:Following exposure to the HO-1 inducer CoPPIX at all concentrations, the HBMEC cells apoptosis occurred, which could be prominently observed at 15 μM of 3 h exposure. In contrast, there was no significant change in the morphology in the non-exposed iRBC at all concentrations and exposure time. This observation was in agreement with the levels of the enzymatic degradation products iron and bilirubin, of which the highest levels (106.03 and 1753.54% of baseline level, respectively) were observed at 15 μM vs. 20 μM at 3 h vs. 24 h exposure. For the effect of the HO-1 inhibitor ZnPPIX, HBMEC cell morphology was mostly unchanged, but significant inhibitory effect on cell apoptosis was seen at 10 μM for the exposure period of 3 h (37.17% of baseline level). The degree of the inhibitory effect as reflected by the level of iron produced was not clearly observed (highest effect at 10 μM and 3 h exposure). CONCLUSIONS:Results provide at least in part, insight into the contribution of HO-1 on CM pathogenesis and need to be confirmed in animal model.

journal_name

Asian Pac J Trop Med

journal_title

Asian Pacific journal of tropical medicine

authors

Thongdee P,Na-Bangchang K

doi

10.1016/j.apjtm.2016.11.011

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

20-24

issue

1

eissn

1995-7645

issn

2352-4146

pii

S1995-7645(16)30727-1

journal_volume

10

pub_type

杂志文章

相关文献

Asian Pacific Journal of Tropical Medicine文献大全
  • Efficiency of HAART in the prevention of mother to children HIV-1 transmission at Saint Camille medical centre in Burkina Faso, West Africa.

    abstract：OBJECTIVE:To evaluate efficiency of HAART in the prevention of mother to child HIV transmission. METHODS:A longitudinal study was conducted on 1 300 women attending the antenatal service at Saint Camille Medical Centre from September 2010 to July 2011. The HIV status of mothers was determined by rapid tests and ELISA....

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(12)60188-6

    authors： Linguissi LS,Bisseye C,Sagna T,Nagalo BM,Ouermi D,Djigma FW,Pignatelli S,Sia JD,Pietra V,Moret R,Nikiema JB,Simpore J

    更新日期：2012-12-01 00:00:00

  • Isolation and characterization of anti-diabetic component (bioactivity-guided fractionation) from Ocimum sanctum L. (Lamiaceae) aerial part.

    abstract：OBJECTIVE:To isolate and characterize antidiabetic component (bioactivity-guided fractionation) from hydro alcoholic extract of Ocimum sanctum (O. sanctum) aerial part. METHODS:Ten fractions (F1-F10) were isolated from hydro alcoholic extract of O. sanctum aerial part by column chromatography. All the fractions F1 to ...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(11)60086-2

    authors： Patil R,Patil R,Ahirwar B,Ahirwar D

    更新日期：2011-04-01 00:00:00

  • RETRACTED: Effect of thioredoxin-interacting protein on Wnt/β-catenin signaling pathway and diabetic myocardial infarction.

    abstract：OBJECTIVE:To explore the regulatory role of thioredoxin-interacting protein (TXNIP) in Wnt/β-catenin signaling pathway and therefore to elucidate its function in diabetic myocardial infarction. METHODS:Diabetic myocardial infarction models were generated in mice. The expression levels of TXNIP and β-catenin and level ...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章,撤回出版物

    doi：10.1016/j.apjtm.2015.10.010

    authors： Yu H,Zhao XX,Shan XH,Li P,Chen T

    更新日期：2015-11-01 00:00:00

  • GC-MS analysis of volatile compounds of Perilla frutescens Britton var. Japonica accessions: Morphological and seasonal variability.

    abstract：OBJECTIVE:To investigate the composition of volatile compounds in the different accessions of Perilla frutescens (P. frutescens) collected from various habitats of China and Japan. METHODS:In the present study, the essential oil from the leaves of P. frutescens cultivars from China and Japan was extracted by hydro-dis...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/j.apjtm.2017.07.004

    authors： Ghimire BK,Yoo JH,Yu CY,Chung IM

    更新日期：2017-07-01 00:00:00

  • Malaria helminth co-infections and their contribution for aneamia in febrile patients attending Azzezo health center, Gondar, Northwest Ethiopia: a cross sectional study.

    abstract：OBJECTIVE:To assess the prevalence of malaria helminth co-infections and their contribution for aneamia in febrile patients attending Azzezo health center, Gondar, Northwest Ethiopia. METHODS:A cross section study was conducted among febrile patients attending Azezo health center from February-March 30, 2011. Convenie...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(12)60147-3

    authors： Alemu A,Shiferaw Y,Ambachew A,Hamid H

    更新日期：2012-10-01 00:00:00

  • Protective effect of omeprazole on gastric mucosal of cirrhotic portal hypertension rats.

    abstract：OBJECTIVE:To observe the protective effect of omeprazole on gastric mucosal of cirrhotic portal hypertension rats. METHODS:All rats were randomly divided into normal control group, cirrhosis and treatment group. Thioacetamide was used to establish rat model of cirrhotic portal hypertension. The necrotic tissue of gast...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(14)60065-1

    authors： Gao W,Li HY,Wang LX,Hao LJ,Gao JL,Zheng RJ,Cai CJ,Si YL

    更新日期：2014-05-01 00:00:00

  • Overt gastrointestinal bleeding because of hookworm infection.

    abstract：:Hookworm infection is a relatively common cause of anemia in endemic areas. The most common hookworm species are Ancylostoma duodenale and Necator americanus. In this report we present a case of overt gastrointestinal bleeding because of hookworm infection. Capsule endoscopy revealed many hookworms in the lumen of pro...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(12)60051-0

    authors： Chen JM,Zhang XM,Wang LJ,Chen Y,Du Q,Cai JT

    更新日期：2012-04-01 00:00:00

  • RETRACTED: Effect of transplantation of BMMSCs on pathological change of gastric precancerous lesions of rats.

    abstract：OBJECTIVE:To build the rat model of gastric precancerous lesions and discuss the effect of transplantation of mesenchymal stem cells (BMMSCs) on the pathological change. METHODS:The rat model of gastric precancerous lesions was built using N-methyl-N'-nitro-N'-nitrosoguanidine. After the intravenous transplantation of...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章,撤回出版物

    doi：10.1016/j.apjtm.2015.11.006

    authors： Lin ZL,Zheng GW,Zhang L,Zheng JT,Chen H

    更新日期：2015-12-01 00:00:00

  • Establishment and identification of induced pluripotent stem cells in liver cancer patients.

    abstract：OBJECTIVE:To induce pluripotent stem (IPS) cells from fibrocytes that are separated from liver cancer patients. METHODS:The fibrocytes were reprogrammed to IPS cells by lentiviral vector, stained and identified by immunohistochemistry. RESULTS:The IPS cells were successfully established from fibrocytes after infectio...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(14)60032-8

    authors： Zhang DM,Li JJ,Yan P,Hu JT

    更新日期：2014-04-01 00:00:00

  • First report on natural Leishmania infection of Phlebotomus sergenti due Leishmania tropica by high resolution melting curve method in South-eastern Iran.

    abstract：OBJECTIVE:To identify the Leishmania species in infected sand flies by Real-time PCR coupled with HRM analysis. METHODS:Real-time PCR coupled with HRM analysis targeting the first internal transcribed spacer (ITS1) of nuclear ribosomal DNA as the genetic marker was used to identify and distinguish Leishmania species i...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(14)60002-X

    authors： Aghaei AA,Rassi Y,Sharifi I,Vatandoost H,Mollaie H,Oshaghi MA,Abai M,Rafizadeh S

    更新日期：2014-02-01 00:00:00

  • Comparison on serum biomarkers for anovulatory and ovulatory dysfunctional uterine bleeding in Lizu females.

    abstract：OBJECTIVE:To screen, identify, and compare the serum biomarkers between anovulatory dysfunctional uterine bleeding (ADUB) and ovulatory dysfunctional uterine bleeding (ODUB) in Lizu females. METHODS:The subjects included 128 ADUB patients, 63 ODUB patients, and 93 controls. The serum and supernate of the subjects' men...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(14)60012-2

    authors： Bao S,Yang SY,Li ZR,Wen GB

    更新日期：2014-02-01 00:00:00

  • Efficacy evaluation of the protein isolated from Peganum harmala seeds as an antioxidant in liver of rats.

    abstract：OBJECTIVE:To evaluate the curative effect of the 132 KD protein isolated from the seeds of Peganum harmala (P. harmala) L. against carbon tetrachloride (CCl(4)) induced oxidative stress in rats. METHODS:Animals were post treated intraperitoneally with 132 KD isolated protein at doses of 4 and 8 mg/kg body weight and b...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(13)60058-9

    authors： Soliman AM,Abu-El-Zahab HS,Alswiai GA

    更新日期：2013-04-13 00:00:00

  • Salmonella-salmonellosis-rare presentations of a common pathogen.

    abstract：:Salmonella are most commonly associated with gastroenteritis and enteric fever in humans. Occasionally, dissemination of bacilli throughout the body results in establishment of localized foci of persistent infection especially in patients with debilitating diseases and immunosuppressive states. Infection at various ab...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(11)60117-X

    authors： Kaistha N,Gupta V,Sidhu S,Chander J

    更新日期：2011-05-01 00:00:00

  • Profile and geographical distribution of reported cutaneous leishmaniasis cases in Northwestern Saudi Arabia, from 2010 to 2013.

    abstract：OBJECTIVE:To describe the profile and geographical distribution of reported cases of cutaneous leishmaniasis (CL) in the province of Hail, Saudi Arabia from 2010 to 2013. METHODS:Human data were collected from the dermatology service of both King Khaled and General Hail hospitals. RESULTS:A total of 483 confirmed CL ...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(14)60332-1

    authors： Haouas N,Amer O,Ishankyty A,Alazmi A,Ishankyty I

    更新日期：2015-04-01 00:00:00

  • An update on prodrugs from natural products.

    abstract：:A natural prodrug is a chemical compound or substance obtained from plants, microorganism, animal and marine sources. Natural products are small molecule source for Food and Drug Administration approved drugs and major sources for drug discovery. Most of the drugs for different ailment diseases undergo first pass meta...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(14)60203-0

    authors： Kumar SV,Saravanan D,Kumar B,Jayakumar A

    更新日期：2014-09-01 00:00:00

  • Immunomodulatory activity of a lupane triterpenoid ester isolated from the eastern Nigeria mistletoe, Loranthus micranthus (Linn).

    abstract：OBJECTIVE:To provide further evidence for the ethnomedicinal use of the Eastern Nigeria mistletoe, Loranthus micranthus (L. micranthus), as an immunostimulant. METHODS:Solvent fractions from the crude extract of the mistletoe plant was obtained and screened by the cell mediated delayed type hypersensitivity reaction (...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(11)60137-5

    authors： Ogechukwu OE,Ogoamaka OP,Sylvester NC,Kawamura A,Proksch P

    更新日期：2011-07-01 00:00:00

  • Asymptomatic malaria parasitemia does not induce additional oxidative stress in pregnant women of South East Nigeria.

    abstract：OBJECTIVE:To determine the relationship between asymptomatic malaria parasitemia and some oxidative stress parameters in pregnant Nigerian women. METHODS:This is a cross-sectional study involving 130 normal pregnant women at various trimesters, who were attending antenatal clinic at the University of Nigeria Teaching ...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(11)60076-X

    authors： Nwagha UI,Okeke TC,Nwagha TU,Ejezie FE,Ogbodo SO,Dim CC,Anyaehie BU

    更新日期：2011-03-01 00:00:00

  • Current perspectives on dengue episode in Malaysia.

    abstract：:Prevalence of dengue transmission has been alarmed by an estimate of 390 million infections per annum. Urban encroachment, ecological disruption and poor sanitation are all contributory factors of increased epidemiology. Complication however arises from the fact that dengue virus inherently exists as four different se...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.apjtm.2016.03.004

    authors： Pang EL,Loh HS

    更新日期：2016-04-01 00:00:00

  • Antioxidant, anti-inflammatory and antinociceptive potential of Ternstroemia sylvatica Schltdl. & Cham.

    abstract：OBJECTIVE:To evaluate the anti-inflammatory, analgesic, antioxidant and acute toxicity of extracts obtained from a successive extraction with solvents of ascending polarity [hexane, hex; chloroform, CHCl3 and ethanol (EtOH)] of Ternstroemia sylvatica Schltdl. & Cham. METHODS:The antioxidant potential was evaluated by ...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/j.apjtm.2017.10.007

    authors： Moreno-Quirós CV,Sánchez-Medina A,Vázquez-Hernández M,Hernández Reyes AG,García-Rodríguez RV

    更新日期：2017-11-01 00:00:00

  • Free radical scavenging property and antiproliferative activity of Rhodiola imbricata Edgew extracts in HT-29 human colon cancer cells.

    abstract：OBJECTIVE:To investigate the in vitro antioxidant and antiproliferative activity of rhizome extracts of Rhodiola imbricata (R. imbricata) in HT-29 human colon cancer cell line. METHODS:The successively extracted rhizome of R. imbricata using various solvents was analyzed for their total phenolics, tannins and flavonoi...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(12)60194-1

    authors： Senthilkumar R,Parimelazhagan T,Chaurasia OP,Srivastava RB

    更新日期：2013-01-01 00:00:00

  • Effect of Chinese herbal compound on liver fibrosis in rabbits with schistosomiasis by B-ultrasound.

    abstract：OBJECTIVE:To explore the value of B-ultrasound on the evaluation of the effects of traditional Chinese medicine compound of Radix astragali, Salvia miltiorrhiza and Angelica sinensis, and TCM + praziquantel on liver fibrosis in rabbits with schistosomiasis. METHODS:The hepatic fibrosis model in rabbits with schistosom...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(13)60114-5

    authors： Liang XL,Yuan JY

    更新日期：2013-08-01 00:00:00

  • Induction of deletion mutation on ompR gene of Salmonella enterica serovar Typhi isolates from asymptomatic typhoid carriers to evolve attenuated strains for vaccine development.

    abstract：OBJECTIVE:To develop attenuated strains of Salmonella enterica serovar Typhi (S. typhi) for the candidate vaccine by osmolar stress. METHODS:S. typhi SS3 and SS5 strains were isolated from asymptomatic typhoid carriers in Namakkal, Tamil Nadu, India. Both strains were grown in LB (Luria Bertani) medium supplemented wi...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(14)60165-6

    authors： Senthilkumar B,Anbarasu K,Senbagam D,Rajasekarapandian M

    更新日期：2014-12-01 00:00:00

  • Potentiating activity of luteolin on membrane permeabilizing agent and ATPase inhibitor against methicillin-resistant Staphylococcus aureus.

    abstract：OBJECTIVE:To investigate the mechanism of antibacterial activity of luteolin (LUT) against methicillin-resistant Staphylococcus aureus (MRSA). METHODS:The mechanism of anti-MRSA activity of LUT was analyzed by the viability assay in membrane permeabilizing agent, ATPase inhibitors, and peptidoglycan (PGN) derived from...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/j.apjtm.2015.12.004

    authors： Joung DK,Lee YS,Han SH,Lee SW,Cha SW,Mun SH,Kong R,Kang OH,Song HJ,Shin DW,Kwon DY

    更新日期：2016-01-01 00:00:00

  • Escherichia coli tetracycline efflux determinants in relation to tetracycline residues in chicken.

    abstract：OBJECTIVE:To screen for Escherichia coli (E. coli) resistant to tetracycline, followed by identification of tet efflux genes by polymerase chain reaction (PCR). In addition, detection of tetracycline residues in chicken livers and kidneys were conducted using high performance liquid chromatography-tandem quadrupole mas...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(13)60125-X

    authors： S N AB,B M AM,A S AA,A E E,I Y M

    更新日期：2013-09-01 00:00:00

  • Antitumor effect of thymoquinone combined with resveratrol on mice transplanted with breast cancer.

    abstract：OBJECTIVE:To test the anticancer potential activity of the combination of thymoquinone (TQ) and resveratrol (RES) against breast cancer in mice. METHODS:The antiproliferative activity of TQ, RES and their combination was assessed against three breast cancer cell lines and one normal cells using MTT assay. The combinat...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/j.apjtm.2017.03.026

    authors： Alobaedi OH,Talib WH,Basheti IA

    更新日期：2017-04-01 00:00:00

  • Hepatoprotective and cytoprotective properties of Hyptis suaveolens against oxidative stress-induced damage by CCl(4) and H(2)O(2).

    abstract：OBJECTIVE:To investigate capacity of Hyptis suaveolens (H. suaveolens) methanol extract as an antioxidant to protect against carbon tetrachloride (CCl(4))-induced oxidative stress, hepatotoxicity in Albino Wistar rats and cytoprotective effect of hydrogen peroxide (H(2)O(2)) induced cell death in HepG(2) cell line. ME...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(12)60162-X

    authors： Ghaffari H,Ghassam BJ,Prakash HS

    更新日期：2012-11-01 00:00:00

  • Screening, phylogenetic analysis and antibiotic sensitivity pattern of Salmonella enterica serovar Typhi isolates from typhoid asymptomatic carriers.

    abstract：OBJECTIVE:To isolate the Salmonella enterica serovar Typhi (S. typhi) from asymptomatic typhoid carriers in the local population. To assess the antibiotic sensitivity and resistant pattern of S. typhi isolates against viable antibiotics and phylogenetic analysis of S. typhi isolates on the basis of 16S rDNA gene. METH...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(11)60191-0

    authors： Chandrasekaran B,Balakrishnan S

    更新日期：2011-10-01 00:00:00

  • Duffy blood group genotypes among malaria Plasmodium vivax patients of Baoulch population in Southeastern Iran.

    abstract：OBJECTIVE:To determine the distribution of Duffy blood group genotypes in Balouch population as a major ethnic group that living in a sub-tropical area in south East of Iran. METHODS:In this study, the Duffy blood group FY phenotypes were determined using indirect anti-globulin technique and also genotype by PCR-RFLP ...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(14)60021-3

    authors： Miri-Moghaddam E,Bameri Z,Mohamadi M

    更新日期：2014-03-01 00:00:00

  • Antibacterial activity of selected ethnomedicinal plants from South India.

    abstract：OBJECTIVE:To screen the antimicrobial potential of three ethnomedicinal plants Chassalia curviflora Thw. (C. curviflora), Cyclea peltata Hook. F. & Thomson (C. peltata) and Euphorbia hirta L (E. hirta) used in folk medicines in Aarukani hills Kani tribe, Tamil Nadu, India against human bacterial pathogens. METHODS:Ant...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章

    doi：10.1016/S1995-7645(11)60107-7

    authors： Raja RD,Jeeva S,Prakash JW,Antonisamy JM,Irudayaraj V

    更新日期：2011-05-01 00:00:00

  • Anti-tubercular peptides: A quest of future therapeutic weapon to combat tuberculosis.

    abstract：:Tuberculosis (TB) is a symbolic menace to mankind, infecting almost one third of the world's populace and causing over a million mortalities annually. Mycobacterium tuberculosis (Mtb) is the key pathogen of TB that invades and replicates inside the host's macrophage. With the emerging dilemma of multi-drug resistant t...

    journal_title：Asian Pacific journal of tropical medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.apjtm.2016.09.005

    authors： Khusro A,Aarti C,Agastian P

    更新日期：2016-11-01 00:00:00