Abstract:
:Recent studies have revealed that the sensory nervous system is involved in bone metabolism. However, the mechanism of communication between neurons and osteoblasts is yet to be elucidated. In this study, we investigated the signaling pathways between sensory neurons of the dorsal root ganglion (DRG) and the osteoblast-like MC3T3-E1 cells using an in vitro coculture system. Our findings indicate that signal transduction from DRG-derived neurons to MC3T3-E1 cells is suppressed by antagonists of the AMPA receptor and the NK1 receptor. Conversely, signal transduction from MC3T3-E1 cells to DRG-derived neurons is suppressed by a P2X7 receptor antagonist. Our results suggest that these cells communicate with each other by exocytosis of glutamate, substance P in the efferent signal, and ATP in the afferent signal.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Kodama D,Hirai T,Kondo H,Hamamura K,Togari Adoi
10.1002/1873-3468.12561subject
Has Abstractpub_date
2017-02-01 00:00:00pages
527-539issue
3eissn
0014-5793issn
1873-3468journal_volume
591pub_type
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