Challenges and opportunities to enhance global drug development in neonates.

abstract：PURPOSE OF REVIEW:Physical activity has been highlighted internationally as a beneficial intervention for weight control and the improvement of physical and mental health. This review highlights findings from recent literature to guide office-based promotion of physical activity for obesity treatment and prevention. R...

journal_title：Current opinion in pediatrics

authors： Floriani V,Kennedy C

更新日期：2007-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Recently, recommendations from the American Heart Association regarding treatment of streptococcal tonsillo-pharyngitis were revised. This review provides the background for changes that were made in comparison with the group's 1995 recommendations. Recent papers on other issues relating to group A St...

journal_title：Current opinion in pediatrics

authors： Baltimore RS

更新日期：2010-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Urinary tract infections are the most common serious bacterial infections in infants and young children. This review focuses on new additions to the literature for the period August 22, 2002, to August 21, 2003. RECENT FINDINGS:There is still considerable interest in determining which test is best to...

journal_title：Current opinion in pediatrics

authors： Wald E

更新日期：2004-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent literature regarding assessment, management and prevention of child maltreatment will be considered. Unexplained infant and child death will also be reviewed. RECENT FINDINGS:Controversies in the evaluation of unexpected infant death and inflicted traumatic brain injury are ongoing. Evidence c...

journal_title：Current opinion in pediatrics

authors： Newton AW,Vandeven AM

更新日期：2007-04-01 00:00:00

abstract：:Medical informatics is both a science, which seeks to understand the information requirements of medical practice, research, and education, and an engineering discipline, which applies new technologies to help manage the explosion of data and new knowledge that confront contemporary physicians. Computerization of the ...

journal_title：Current opinion in pediatrics

authors： Shiffman RN

更新日期：1994-10-01 00:00:00

abstract：:Recent neonatal intensive care outcome studies are asking more focused research questions and incorporating, at least implicitly, pathogenetic models. A few have grappled with the complex issues of health-related quality of life and functional outcomes and the many factors that affect these outcomes. The need to evalu...

journal_title：Current opinion in pediatrics

authors： Allen MC

更新日期：2000-04-01 00:00:00

abstract：:Advances in pediatric anesthesia can contribute to improved care of children in other environments. As an example, drugs and dosages established in preoperative sedation of children provide a base for their application in sedation and pain relief of children undergoing painful procedures in the emergency unit, oncolog...

journal_title：Current opinion in pediatrics

authors： Broennle AM,Cohen DE

更新日期：1993-06-01 00:00:00

abstract：:In the 7 years since the cystic fibrosis (CF) gene has been cloned, many experimental trials of population screening for CF heterozygotes have been reported. Targeting young adults near reproductive age has shown that the method in which screening is offered is a major determinant of acceptance rates: personal invitat...

journal_title：Current opinion in pediatrics

authors： Brock DJ

更新日期：1996-12-01 00:00:00

abstract：:Preimplantation genetic diagnosis now represents an alternative reproductive option for parents at high risk of having offspring affected with certain genetic diseases. Progress in the past year has included increasing reliability in embryo sexing by both polymerase chain reaction and fluorescent in situ hybridization...

journal_title：Current opinion in pediatrics

authors： Black SH

更新日期：1994-12-01 00:00:00

abstract：:Now known as a Garrodian inborn error caused by the homozygous state of many different autosomal recessive mutations of the 7-dehydrocholesterol reductase gene leading to deficient conversion of 7-dehydrocholesterol to cholesterol, the RSH (so-called Smith-Lemli-Opitz) syndrome has become a paradigmatic metabolic malf...

journal_title：Current opinion in pediatrics

authors： Opitz JM

更新日期：1999-08-01 00:00:00

abstract：PURPOSE OF REVIEW:The goal of this review is to provide updates on the evolution of conceptual definitions as they relate to quality in healthcare, existing measurement platforms for performance benchmarking in pediatric surgery, and available tools for quality improvement that are relevant to care of the pediatric sur...

journal_title：Current opinion in pediatrics

authors： Cameron DB,Rangel SJ

更新日期：2016-06-01 00:00:00

abstract：:Lemierre's disease, also known as 'postanginal sepsis', 'necrobacillosis', or 'internal jugular vein thrombosis', is a rare but serious emerging infection. Although Lemierre's disease remains rare, the number of reported cases has risen in recent years as more judicious antimicrobial prescribing practices for viral up...

journal_title：Current opinion in pediatrics

authors： Sharma D,Rouphael N

更新日期：2009-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The term 'dual diagnosis' most commonly refers to the combination of severe mental illness and substance-use disorder (SUD). It is estimated that 7-10 million people in the USA alone have at a minimum one psychiatric disorder in addition to a SUD. As many of the psychiatric illnesses implicated have t...

journal_title：Current opinion in pediatrics

authors： Santucci K

更新日期：2012-04-01 00:00:00

abstract：:This review highlights the most significant progress in treatment of constipation occurring in the last year, underlying the advances in pathophysiology, clinical presentation, diagnosis, and treatment of both organic and functional constipation. Recent developments in the field of the pathophysiology of idiopathic ch...

journal_title：Current opinion in pediatrics

authors： Staiano A,Tozzi A

更新日期：1998-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Exposure to traffic-related air pollutants (TRAPs) has been implicated in asthma development, persistence, and exacerbation. This exposure is highly significant because increasingly large segments of the population worldwide reside in zones that have high levels of TRAP, including children, as schools...

journal_title：Current opinion in pediatrics

authors： Brandt EB,Myers JM,Ryan PH,Hershey GK

更新日期：2015-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The present coronavirus disease 2019 (COVID-19) pandemic has created additional challenges with an increased number of presumed healthy, full-term newborns being discharged at 24 h after delivery. Short lengths of stay raise the possibility of mother-infant dyads being less ready for discharge, define...

journal_title：Current opinion in pediatrics

authors： Harriel KL,Nolt D,Moore S,Kressly S,Bernstein HH

更新日期：2020-08-01 00:00:00

abstract：PURPOSE OF REVIEW:In this review, recent advances in the epidemiology, genetics, clinical associations and management of idiopathic hypercalciuria will be discussed. RECENT FINDINGS:A significant genetic contribution exists in the pathophysiology of hypercalciuria. Although several candidate genes and genetic alterati...

journal_title：Current opinion in pediatrics

authors： Srivastava T,Schwaderer A

更新日期：2009-04-01 00:00:00

abstract：:Osteochondritis dissecans is a term used to describe the separation of an articular cartilage subchondral bone segment from the remaining articular surface. Juvenile osteochondritis dissecans describes an osteochondritis dissecans lesion found in skeletally immature children with a maximum incidence occurring between ...

journal_title：Current opinion in pediatrics

authors： Robertson W,Kelly BT,Green DW

更新日期：2003-02-01 00:00:00

abstract：PURPOSE OF REVIEW:This review highlights recent publications on the use of the Internet as it relates to pediatric primary care, including its application to the pediatrician, teen, pediatric patient, and patients' parents. A brief overview of early work is introduced. RECENT FINDINGS:The Internet has become a tool to...

journal_title：Current opinion in pediatrics

authors： Kind T

更新日期：2009-12-01 00:00:00

abstract：PURPOSE OF REVIEW:In fiscally challenging times, scientists must seek creative strategies and leverage existing resources to advance research. RECENT FINDINGS:This review describes programmes supported by the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (NIH) to promote resear...

journal_title：Current opinion in pediatrics

authors： Burns KM,Pearson GD,Kaltman JR

更新日期：2013-10-01 00:00:00

abstract：PURPOSE OF REVIEW:This review will outline the screening, diagnosis and management of cystic fibrosis related diabetes (CFRD). It will also discuss advances in the detection of early glucose abnormalities, their clinical significance and the emerging role for early insulin therapy. RECENT FINDINGS:Before the onset of ...

journal_title：Current opinion in pediatrics

authors： Hameed S,Jaffé A,Verge CF

更新日期：2015-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Pulmonary vascular disease (PVD) complicates the course of many cardiovascular, pulmonary and other systemic diseases in children. The physiological sequelae (pulmonary hypertension and elevated pulmonary vascular resistance) can overwhelm the right ventricle and lead to circulatory collapse. Despite ...

journal_title：Current opinion in pediatrics

authors： Brown G,Humpl T

更新日期：2018-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The obesity epidemic confronts the pediatrician every day in the office. Pediatricians should help curb the epidemic through prevention and the usual pediatric primary care tasks of screening, communication and anticipatory counseling. This review highlights findings from recent literature to guide of...

journal_title：Current opinion in pediatrics

authors： Perrin EM,Finkle JP,Benjamin JT

更新日期：2007-06-01 00:00:00

abstract：:A rapidly accelerating number of transplantations of hematopoietic stem cells from human umbilical cord blood have been performed for malignancies and for congenital disorders. Umbilical cord blood presents multiple advantages over bone marrow as a source of stem cells. Harvesting presents no donor risk or discomfort,...

journal_title：Current opinion in pediatrics

authors： Newburger PE,Quesenberry PJ

更新日期：1996-02-01 00:00:00

abstract：:Complete deficiency of one of the early components (C1, C4, or C2) of the classical pathway of the complement cascade is one of the strongest genetic risk factors for systemic lupus erythematosus that has been recognized. The lupus that occurs in complement-deficient individuals typically presents in early childhood. ...

journal_title：Current opinion in pediatrics

authors： Sullivan KE

更新日期：1998-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Environmental factors, such as drugs, chemicals, or abnormal concentrations of natural metabolites, induce birth defects. Environmental effects on cardiogenesis have been little studied in contrast to neurogenesis. This review presents evidence on three environmental factors: alcohol, the drug lithium...

journal_title：Current opinion in pediatrics

authors： Linask KK,Huhta J

更新日期：2010-10-01 00:00:00

abstract：PURPOSE OF REVIEW:This article reviews three common abnormalities requiring surgical treatment in adults with congenital heart disease (CHD): Ebstein's anomaly, the failing Fontan, and pulmonary valve disease. RECENT FINDINGS:As of 2000, more adults than children are alive with CHD. Each year, more of these adults wit...

journal_title：Current opinion in pediatrics

authors： Dearani JA,Mavroudis C,Quintessenza J,Deal BJ,Backer CL,Fitzgerald P,Connolly HM,Jacobs JP

更新日期：2009-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Complement mediated hemolytic uremic syndrome (aHUS) accounts for a significant proportion of non-shiga toxin HUS. The purpose of this review is to outline the pathophysiology, clinical features and therapeutic options for aHUS. RECENT FINDINGS:In the last decade, strides have been made in identifyin...

journal_title：Current opinion in pediatrics

authors： Joseph C,Gattineni J

更新日期：2013-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has become increasingly important as a cause of skin and soft tissue infections (SSTIs), particularly abscesses, in patients seen in the emergency department setting. The antibiotic sensitivity profile of Staphylococcus aureus ...

journal_title：Current opinion in pediatrics

authors： Odell CA

更新日期：2010-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Pediatric-onset multiple sclerosis (MS) is increasingly recognized. Conversely, MS diagnosis in the pediatric population continues to be challenging, particularly in the youngest group of patients. An interesting amount of data has been recently published concerning immunopathogenesis, environmental f...

journal_title：Current opinion in pediatrics

authors： Tenembaum SN

更新日期：2010-12-01 00:00:00