Automatic prediction of tumour malignancy in breast cancer with fractal dimension.

Abstract:

:Breast cancer is one of the most prevalent types of cancer today in women. The main avenue of diagnosis is through manual examination of histopathology tissue slides. Such a process is often subjective and error-ridden, suffering from both inter- and intraobserver variability. Our objective is to develop an automatic algorithm for analysing histopathology slides free of human subjectivity. Here, we calculate the fractal dimension of images of numerous breast cancer slides, at magnifications of 40×, 100×, 200× and 400×. Using machine learning, specifically, the support vector machine (SVM) method, the F1 score for classification accuracy of the 40× slides was found to be 0.979. Multiclass classification on the 40× slides yielded an accuracy of 0.556. A reduction of the size and scope of the SVM training set gave an average F1 score of 0.964. Taken together, these results show great promise in the use of fractal dimension to predict tumour malignancy.

journal_name

R Soc Open Sci

authors

Chan A,Tuszynski JA

doi

10.1098/rsos.160558

subject

Has Abstract

pub_date

2016-12-07 00:00:00

pages

160558

issue

12

issn

2054-5703

pii

rsos160558

journal_volume

3

pub_type

杂志文章
  • Geometric models to explore mechanisms of dynamic shape change in skeletal muscle.

    abstract::Skeletal muscle bulges when it contracts. These three-dimensional (3D) dynamic shape changes play an important role in muscle performance by altering the range of fascicle velocities over which a muscle operates. However traditional muscle models are one-dimensional (1D) and cannot fully explain in vivo shape changes....

    journal_title:Royal Society open science

    pub_type: 杂志文章

    doi:10.1098/rsos.172371

    authors: Dick TJM,Wakeling JM

    更新日期:2018-05-16 00:00:00

  • Anastasis: recovery from the brink of cell death.

    abstract::Anastasis is a natural cell recovery phenomenon that rescues cells from the brink of death. Programmed cell death such as apoptosis has been traditionally assumed to be an intrinsically irreversible cascade that commits cells to a rapid and massive demolition. Interestingly, recent studies have demonstrated recovery o...

    journal_title:Royal Society open science

    pub_type: 杂志文章,评审

    doi:10.1098/rsos.180442

    authors: Tang HM,Tang HL

    更新日期:2018-09-19 00:00:00

  • Dynamics and biases of online attention: the case of aircraft crashes.

    abstract::The Internet not only has changed the dynamics of our collective attention but also through the transactional log of online activities, provides us with the opportunity to study attention dynamics at scale. In this paper, we particularly study attention to aircraft incidents and accidents using Wikipedia transactional...

    journal_title:Royal Society open science

    pub_type: 杂志文章

    doi:10.1098/rsos.160460

    authors: García-Gavilanes R,Tsvetkova M,Yasseri T

    更新日期:2016-10-12 00:00:00

  • Performance improvement of miniaturized ZnO nanowire accelerometer fabricated by refresh hydrothermal synthesis.

    abstract::Miniaturized accelerometers are necessary for evaluating the performance of small devices, such as haptics, robotics and simulators. In this study, we fabricated miniaturized accelerometers using well-aligned ZnO nanowires. The layer of ZnO nanowires is used for active piezoelectric layer of the accelerometer, and cop...

    journal_title:Royal Society open science

    pub_type: 杂志文章

    doi:10.1098/rsos.170557

    authors: Song S,Kim HC,Kim JW,Kim D,Kim J

    更新日期:2017-09-13 00:00:00

  • Value of species and the evolution of conservation ethics.

    abstract::The theory of evolution by natural selection can help explain why people care about other species. Building upon recent insights that morality evolves to secure fitness advantages of cooperation, we propose that conservation ethics (moral beliefs, attitudes, intuitions and norms regarding other species) could be adapt...

    journal_title:Royal Society open science

    pub_type: 杂志文章

    doi:10.1098/rsos.181038

    authors: Hare D,Blossey B,Reeve HK

    更新日期:2018-11-21 00:00:00

  • Differential loss of components of traditional ecological knowledge following a primate extinction event.

    abstract::Traditional ecological knowledge (TEK), an important component of the modern conservation toolkit, is being eroded in indigenous communities around the world. However, the dynamics of TEK loss in response to ecosystem change and disruption to social-ecological systems, and patterns of variation in vulnerability and re...

    journal_title:Royal Society open science

    pub_type: 杂志文章

    doi:10.1098/rsos.172352

    authors: Turvey ST,Bryant JV,McClune KA

    更新日期:2018-06-13 00:00:00

  • Correction to: 'Anastasis: recovery from the brink of cell death'.

    abstract::[This corrects the article DOI: 10.1098/rsos.180442.]. ...

    journal_title:Royal Society open science

    pub_type: 杂志文章,已发布勘误

    doi:10.1098/rsos.181629

    authors: Tang HM,Tang HL

    更新日期:2018-10-10 00:00:00

  • Muscle-tendon unit length changes differ between young and adult sprinters in the first stance phase of sprint running.

    abstract::The aim of this study was to compare young and adult sprinters on several biomechanical parameters that were previously highlighted as performance-related and to determine the behaviour of several muscle-tendon units (MTU) in the first stance phase following a block start in sprint running. The ground reaction force (...

    journal_title:Royal Society open science

    pub_type: 杂志文章

    doi:10.1098/rsos.180332

    authors: Aeles J,Jonkers I,Debaere S,Delecluse C,Vanwanseele B

    更新日期:2018-06-13 00:00:00

  • Neopterygian phylogeny: the merger assay.

    abstract::The phylogenetic relationships of the recently described genus †Ticinolepis from the Middle Triassic of the Monte San Giorgio are explored through cladistic analyses of the so far largest morphological dataset for fossil actinopterygians, including representatives of the crown-neopterygian clades Halecomorphi, Ginglym...

    journal_title:Royal Society open science

    pub_type: 杂志文章

    doi:10.1098/rsos.172337

    authors: López-Arbarello A,Sferco E

    更新日期:2018-03-21 00:00:00

  • Genetics of a de novo origin of undifferentiated multicellularity.

    abstract::The evolution of multicellularity was a major transition in evolution and set the stage for unprecedented increases in complexity, especially in land plants and animals. Here, we explore the genetics underlying a de novo origin of multicellularity in a microbial evolution experiment carried out on the green alga Chlam...

    journal_title:Royal Society open science

    pub_type: 杂志文章

    doi:10.1098/rsos.180912

    authors: Herron MD,Ratcliff WC,Boswell J,Rosenzweig F

    更新日期:2018-08-29 00:00:00

  • Initiation and spread of escape waves within animal groups.

    abstract::The exceptional reactivity of animal collectives to predatory attacks is thought to be owing to rapid, but local, transfer of information between group members. These groups turn together in unison and produce escape waves. However, it is not clear how escape waves are created from local interactions, nor is it unders...

    journal_title:Royal Society open science

    pub_type: 杂志文章

    doi:10.1098/rsos.140355

    authors: Herbert-Read JE,Buhl J,Hu F,Ward AJ,Sumpter DJ

    更新日期:2015-04-01 00:00:00

  • Group size and visitor numbers predict faecal glucocorticoid concentrations in zoo meerkats.

    abstract::Measures of physiological stress in zoo animals can give important insights into how they are affected by aspects of their captive environment. We analysed the factors influencing variation in glucocorticoid metabolites in faeces (fGCs) from zoo meerkats as a proxy for blood cortisol concentration, high levels of whic...

    journal_title:Royal Society open science

    pub_type: 杂志文章

    doi:10.1098/rsos.161017

    authors: Scott K,Heistermann M,Cant MA,Vitikainen EIK

    更新日期:2017-04-19 00:00:00

  • Native and invasive squirrels show different behavioural responses to scent of a shared native predator.

    abstract::Invasive species pose a serious threat to native species. In Europe, invasive grey squirrels (Sciurus carolinensis) have replaced native red squirrels (Sciurus vulgaris) in locations across Britain, Ireland and Italy. The European pine marten (Martes martes) can reverse the replacement of red squirrels by grey squirre...

    journal_title:Royal Society open science

    pub_type: 杂志文章

    doi:10.1098/rsos.191841

    authors: Twining JP,Ian Montgomery W,Price L,Kunc HP,Tosh DG

    更新日期:2020-02-26 00:00:00

  • Comparative osteohistology of Hesperornis with reference to pygoscelid penguins: the effects of climate and behaviour on avian bone microstructure.

    abstract::The broad biogeographic distribution of Hesperornis fossils in Late Cretaceous Western Interior Seaway deposits has prompted questions about whether they endured polar winters or migrated between mid- and high latitudes. Here, we compare microstructures of hesperornithiform long bones from Kansas and the Arctic to inv...

    journal_title:Royal Society open science

    pub_type: 杂志文章

    doi:10.1098/rsos.140245

    authors: Wilson LE,Chin K

    更新日期:2014-11-19 00:00:00

  • Comprehensive diagnosis of PCDD/F emission from three hazardous waste incinerators.

    abstract::Comprehensive diagnosis of polychlorinated dibenzo-p-dioxin and dibenzofuran (PCDD/F) emissions was systematically conducted on three hazardous waste incinerators (HWIs). Results indicated that PCDD/F mainly existed in the solid phase before the bag filter. This was especially true for higher chlorinated dioxin and fu...

    journal_title:Royal Society open science

    pub_type: 杂志文章

    doi:10.1098/rsos.172056

    authors: Cao X,Ji L,Lin X,Stevens WR,Tang M,Shang F,Tang S,Lu S

    更新日期:2018-07-11 00:00:00

  • The positive side of a negative reference: the delay between linguistic processing and common ground.

    abstract::Interlocutors converge on names to refer to entities. For example, a speaker might refer to a novel looking object as the jellyfish and, once identified, the listener will too. The hypothesized mechanism behind such referential precedents is a subject of debate. The common ground view claims that listeners register th...

    journal_title:Royal Society open science

    pub_type: 杂志文章

    doi:10.1098/rsos.160827

    authors: Kronmüller E,Noveck I,Rivera N,Jaume-Guazzini F,Barr D

    更新日期:2017-02-08 00:00:00

  • Large batoid fishes frequently consume stingrays despite skeletal damage.

    abstract::The shapes of vertebrate teeth are often used as hallmarks of diet. Here, however, we demonstrate evidence of frequent piscivory by cartilaginous fishes with pebble-like teeth that are typically associated with durophagy, the eating of hard-shelled prey. High-resolution micro-computed tomography observation of a jaw s...

    journal_title:Royal Society open science

    pub_type: 杂志文章

    doi:10.1098/rsos.170674

    authors: Dean MN,Bizzarro JJ,Clark B,Underwood CJ,Johanson Z

    更新日期:2017-09-06 00:00:00

  • Family ties: the multilevel effects of households and kinship on the networks of individuals.

    abstract::Among social mammals, humans uniquely organize themselves into communities of households that are centred around enduring, predominantly monogamous unions of men and women. As a consequence of this social organization, individuals maintain social relationships both within and across households, and potentially there i...

    journal_title:Royal Society open science

    pub_type: 杂志文章

    doi:10.1098/rsos.172159

    authors: Koster J

    更新日期:2018-04-18 00:00:00

  • RGS5 plays a significant role in renal cell carcinoma.

    abstract::Recent advances in biotechnology led to generation of large complex biological and clinical datasets that can be used to infer the underlying mechanism of many diseases and arrive at personalized treatments. One of these datasets are the whole genome profiles, including a good collection of publicly available human ge...

    journal_title:Royal Society open science

    pub_type: 杂志文章

    doi:10.1098/rsos.191422

    authors: Su S,Shahriyari L

    更新日期:2020-04-29 00:00:00

  • C,N-codoped MoSi2 ceramic with excellent heat resistance for microwaves absorption application.

    abstract::Microwave absorption (MA) materials with high heat resistance have a wide range of applications in many fields. In this work, a C,N-codoped MoSi2 ceramic was prepared via a facile solid-phase reaction method and its MA properties was investigated. On the one hand, the results indicate that this ceramic possesses excel...

    journal_title:Royal Society open science

    pub_type: 杂志文章

    doi:10.1098/rsos.200740

    authors: Yang Z,Xu C,Xia Y,Xiong Z

    更新日期:2020-07-29 00:00:00

  • Synthesis and structure/properties characterizations of four polyurethane model hard segments.

    abstract::Four model polyurethane (PU) hard segments were synthesized by reaction of butanol with four typical diisocyanates. The four diisocyanates were aromatic 4,4'-diphenylmethane diisocyanate (4,4'-MDI) and MDI-50 (50% mixture of 2,4'-MDI and 4,4'-MDI), cycloaliphatic 4,4'-dicyclohexylmethane diisocyanate (HMDI) and linear...

    journal_title:Royal Society open science

    pub_type: 杂志文章

    doi:10.1098/rsos.180536

    authors: Jiang L,Ren Z,Zhao W,Liu W,Liu H,Zhu C

    更新日期:2018-07-25 00:00:00

  • Behavioural responses of spinner dolphins to human interactions.

    abstract::There is increasing evidence that whale and dolphin watching activities have detrimental effects on targeted cetacean populations. In Egypt, spinner dolphins regularly occur in the resting areas of Samadai, Satayah and Qubbat'Isa reefs. In-water human interactions with dolphins are regulated with a time-area closure s...

    journal_title:Royal Society open science

    pub_type: 杂志文章

    doi:10.1098/rsos.172044

    authors: Fumagalli M,Cesario A,Costa M,Harraway J,Notarbartolo di Sciara G,Slooten E

    更新日期:2018-04-25 00:00:00

  • Microwave-assisted synthesis, computational studies and antibacterial/ anti-inflammatory activities of compounds based on coumarin-pyrazole hybrid.

    abstract::An efficient, high-yield and rapid synthesis of (E)-1,5-dimethyl-4-((2-((substituted-2-oxo-2H-chromen-4-yl)methoxy)naphthalen-1-yl)methyleneamino)-2-phenyl-1,2-dihydropyrazol-3-one derivatives (3a-3i) containing Schiff base structures under microwave-irradiation has been described. Schiff base is a potential target to...

    journal_title:Royal Society open science

    pub_type: 杂志文章

    doi:10.1098/rsos.172435

    authors: Chavan RR,Hosamani KM

    更新日期:2018-05-02 00:00:00

  • Effect of the second-step voltages on the structural and corrosion properties of silicon-calcium-phosphate (Si-CaP) coatings on Mg-Zn-Ca alloy.

    abstract::The applications of magnesium (Mg) alloys as biodegradable orthopedic implants are mainly restricted due to their rapid degradation rate in the physiological environment. In this study, Si-CaP micro-arc oxidation (MAO) coatings were prepared on a Mg-Zn-Ca alloy by a second-step MAO process at different voltages in ord...

    journal_title:Royal Society open science

    pub_type: 杂志文章

    doi:10.1098/rsos.172410

    authors: Dou J,Zhao Y,Lu L,Gu G,Yu H,Chen C

    更新日期:2018-10-10 00:00:00

  • No evidence for individual recognition in threespine or ninespine sticklebacks (Gasterosteus aculeatus or Pungitius pungitius).

    abstract::Recognition plays an important role in the formation and organization of animal groups. Many animals are capable of class-level recognition, discriminating, for example, on the basis of species, kinship or familiarity. Individual recognition requires that animals recognize distinct cues, and learn to associate these w...

    journal_title:Royal Society open science

    pub_type: 杂志文章

    doi:10.1098/rsos.191703

    authors: Webster MM,Laland KN

    更新日期:2020-07-08 00:00:00

  • The relationship between substrate morphology and biological performances of nano-silver-loaded dopamine coatings on titanium surfaces.

    abstract::Biomedical device-associated infection (BAI) and lack of osseointegration are the main causes of implant failure. Therefore, it is imperative for implants not only to depress microbial activity and biofilm colonization but also to prompt osteoblast functions and osseointegration. As part of the coating development for...

    journal_title:Royal Society open science

    pub_type: 杂志文章

    doi:10.1098/rsos.172310

    authors: Zhang W,Wang S,Ge S,Chen J,Ji P

    更新日期:2018-04-11 00:00:00

  • Subliminal influence on preferences? A test of evaluative conditioning for brief visual conditioned stimuli using auditory unconditioned stimuli.

    abstract::In the field of evaluative conditioning (EC), two opposing theories-propositional single-process theory versus dual-process theory-are currently being discussed in the literature. The present set of experiments test a crucial prediction to adjudicate between these two theories: Dual-process theory postulates that eval...

    journal_title:Royal Society open science

    pub_type: 杂志文章

    doi:10.1098/rsos.160935

    authors: Heycke T,Aust F,Stahl C

    更新日期:2017-09-20 00:00:00

  • The direction after-effect is a global motion phenomenon.

    abstract::Prior experience influences visual perception. For example, extended viewing of a moving stimulus results in the misperception of a subsequent stimulus's motion direction-the direction after-effect (DAE). There has been an ongoing debate regarding the locus of the neural mechanisms underlying the DAE. We know the mech...

    journal_title:Royal Society open science

    pub_type: 杂志文章

    doi:10.1098/rsos.190114

    authors: Curran W,Beattie L,Bilello D,Coulter LA,Currie JA,Pimentel Leon JM

    更新日期:2019-03-27 00:00:00

  • In situ investigations of the phase change behaviour of tungsten oxide nanostructures.

    abstract::This study uses two in situ techniques to investigate the geometry and phase change behaviour of bundled ultrathin W18O49 nanowires and WO3 nanoparticles. The in situ X-ray diffraction (XRD) results have shown that the phase transition of WO3 nanoparticles occurs in sequence from monoclinic (room temperature) → orthor...

    journal_title:Royal Society open science

    pub_type: 杂志文章

    doi:10.1098/rsos.171932

    authors: Thummavichai K,Wang N,Xu F,Rance G,Xia Y,Zhu Y

    更新日期:2018-04-25 00:00:00

  • Magnonic band spectrum of spin waves in an elliptical helix.

    abstract::We show that the spin-wave spectrum in an elliptical helix has a band character. The size of the first band gap calculated using the perturbation theory is shown to scale as square root of the eccentricity. Curved magnonic waveguides of the kind considered here could be used as structural elements of future three-dime...

    journal_title:Royal Society open science

    pub_type: 杂志文章

    doi:10.1098/rsos.172285

    authors: Golovchan AV,Kruglyak VV,Tkachenko VS,Kuchko AN

    更新日期:2018-01-31 00:00:00