Abstract:
:The Risk of Malignancy Algorithm (ROMA) combines the diagnostic power of the CA125 and HE4 markers with menopausal status to predict the risk for developing epithelial ovarian cancer (EOC). The aim of this study was to evaluate the association between 25-OH vitamin D levels and ROMA score in obese women. One hundred and eighteen patients with a Body Mass Index (BMI) > 30 kg/m2 (Group 1) and 80 women with a BMI less than 25 kg / m² (Group 2) were studied. The 25-OH vitamin D was quantified with LUMIPULSE® G 1200. As a threshold value, identified by ROC curve analysis, 20.2 ng/ mL (sensitivity 73.3%, specificity 84%) was chosen corresponding to the limit between sufficient and insufficient 25-OH vitamin D according to the World Health Organization (WHO). Low 25-OH vitamin D levels were observed in 64% of obese women and in 11% of normal-weight women (p less than 0.001). ROMA score above 13% was detected only in obese women (19%). An association between low levels of 25-OH vitamin D and ROMA score was observed. Indeed, 64% of obese women with ROMA score >13% had concomitant insufficient levels of 25-OH vitamin D, while only 36% of obese women with ROMA score >13% had sufficient 25-OH vitamin D levels (p less than 0.0001). This study suggests that the deficiency of 25- OH vitamin D in obese women has a possible correlation with high ROMA score.
journal_name
J Biol Regul Homeost Agentsjournal_title
Journal of biological regulators and homeostatic agentsauthors
Anastasi E,Capoccia D,Granato T,Viggiani V,Tartaglione S,Manganaro L,Angeloni A,Leonetti Fsubject
Has Abstractpub_date
2016-10-01 00:00:00pages
1165-1171issue
4eissn
0393-974Xissn
1724-6083pii
32journal_volume
30pub_type
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章,评审
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abstract::Scleroderma is a chronic systemic autoimmune disease (primarily of the skin) characterized by fibrosis (or hardening), vascular alterations and autoantibodies production.There are currently no effective therapies against this devastating and often lethal disorder. Despite the interest for the immunomodulatory effects ...
journal_title:Journal of biological regulators and homeostatic agents
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
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journal_title:Journal of biological regulators and homeostatic agents
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abstract::Cerebral small vessel disease (CSVD) is a leading cause of progressive decline of cognition and a major risk factor for stroke. Thymoquinone (TQ) is the major biological component of Nigella sativa (N. sativa) and its extracts. We explored the possible protective effect of TQ against CSVD in strokeprone spontaneously ...
journal_title:Journal of biological regulators and homeostatic agents
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journal_title:Journal of biological regulators and homeostatic agents
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 信件
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journal_title:Journal of biological regulators and homeostatic agents
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
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更新日期:1990-04-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 信件
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
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更新日期:2016-04-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
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doi:
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
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更新日期:2020-07-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
doi:
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journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
doi:
更新日期:2016-10-01 00:00:00
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journal_title:Journal of biological regulators and homeostatic agents
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abstract::Mast cells (MCs) are mediators of allergy and inflammation and participate in the growth of cancer cells. MCs can promote both neoangiogenesis and tumor growth. They increase in the stroma of certain tumors where they can be recruited by tumor-derived chemoattractants, such as monocyte chemotactic protein-1 (MCP-1), R...
journal_title:Journal of biological regulators and homeostatic agents
pub_type: 社论
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journal_title:Journal of biological regulators and homeostatic agents
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journal_title:Journal of biological regulators and homeostatic agents
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abstract::A high heterogeneity is found in the HIV-1 genome in vivo, not only between individuals, but also within a single individual. Different types of genetic heterogeneity of HIV-1 can be analyzed: the extension and the evolution of the viral quasispecies in blood, the variation between the virus obtained from different bo...
journal_title:Journal of biological regulators and homeostatic agents
pub_type: 杂志文章
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journal_title:Journal of biological regulators and homeostatic agents
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journal_title:Journal of biological regulators and homeostatic agents
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journal_title:Journal of biological regulators and homeostatic agents
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journal_title:Journal of biological regulators and homeostatic agents
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journal_title:Journal of biological regulators and homeostatic agents
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