Abstract：
:Background Chronic Rheumatic Heart disease (RHD) continues to be a health problem in many low and middle income countries and especially in sub-Saharan Africa. Echocardiography has shown that the disease is far more widespread than may be detected by clinical assessment, but data are lacking on the prevalence and epidemiological features in rural Africa. Design Community-based prevalence survey Methods We used transthoracic echocardiography to carry out a population-based study of RHD in a rural area of Ethiopia. A total of 987 participants aged 6 to 25 were selected by cluster sampling. The prevalence of RHD was assessed by the current consensus World Heart Federation criteria. Results There were 37 definite cases of RHD and a further 19 borderline cases giving an overall prevalence of 37.5 cases per 1000 population (95% CI 26.9-51.8) rising to 56.7 (95% CI 43.9-73.5) if the borderline cases are included. The prevalence of definite disease rose to a peak of 60 cases per 1000 in those aged 16-20 years before falling to 11 cases per 1000 in subjects aged 21-25 years. Of the 37 with definite disease, 36 had evidence of mitral valve and seven evidence of aortic valve disease. Conclusions RHD has a high prevalence in rural Ethiopia. Although follow-up is needed to determine how the disease develops with advancing age, the data provide evidence that the disease is an important health problem in rural sub-Saharan Africa requiring urgent concerted action.
journal_name
Eur J Prev Cardioljournal_title
European journal of preventive cardiologyauthors
Gemechu T,Mahmoud H,Parry EH,Phillips DI,Yacoub MHdoi
10.1177/2047487316687104subject
Has Abstractpub_date
2017-05-01 00:00:00pages
717-723issue
7eissn
2047-4873issn
2047-4881journal_volume
24pub_type
杂志文章abstract：BACKGROUND:Adiponectin is viewed as an insulin-sensitizing hormone with anti-inflammatory effects. In accordance, plasma adiponectin is decreased in metabolic disorders including type 2 diabetes mellitus (T2DM). However, in spite of the apparently beneficially effects, recent data from large prospective studies have co...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487313514894
更新日期：2015-03-01 00:00:00
abstract：BACKGROUND:The aim of the study was to investigate the effects of sesame oil on endothelial function and to detect the underlying mechanisms, both in the postprandial state and after long-term consumption. DESIGN:We enrolled 30 hypertensive men in a two-phase study. In the first phase, 26 volunteers consumed 35 g of e...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487312437625
更新日期：2013-04-01 00:00:00
abstract：:Excessive or inappropriate use of non-steroidal anti-inflammatory drugs can affect cardiovascular and renal function. Non-steroidal anti-inflammatory drugs, both non-selective and selective cyclooxygenase 2 inhibitors, are among the most widely used drugs, especially in the elderly, with multiple comorbidities. Exposi...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,评审
doi：10.1177/2047487319848105
更新日期：2020-05-01 00:00:00
abstract：AIMS:To investigate whether levels of thyroid-stimulating hormone (TSH) within the normal range are associated with an increased risk of new vascular events and mortality in patients with clinical manifest vascular diseases and whether this relation is influenced by adiposity. METHODS AND RESULTS:Prospective cohort st...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/1741826711416045
更新日期：2012-08-01 00:00:00
abstract：BACKGROUND:Hyperammonemia during rest periods is a dysfunction in heart failure (HF). The low formation of ammonia during exercise reflects an inefficiency of purine metabolism. Hyperkalemia in response to physical exercise is common in HF and may contribute to a contractile inefficiency in type II fibers, leading to e...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,随机对照试验
doi：10.1177/2047487312460520
更新日期：2014-02-01 00:00:00
abstract：BACKGROUND:The test-retest reliability for multiple cardiopulmonary exercise test (CPX) variables has not been compared in a single study and the influence of different diseases on test-retest reliability has not been examined. We investigated different measures of test-retest reliability for multiple variables and com...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487313518474
更新日期：2014-04-01 00:00:00
abstract：BACKGROUND:In western populations, high-sensitivity C-reactive protein (hsCRP), and to a lesser degree serum creatinine and haemoglobin A1c, predict risk of coronary heart disease (CHD). However, data on Asian populations that are increasingly affected by CHD are sparse and it is not clear whether these biomarkers can ...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,多中心研究
doi：10.1177/2047487315626547
更新日期：2016-08-01 00:00:00
abstract：BACKGROUND:As with ischaemic heart disease, cardiac rehabilitation (CR) is recommended for patients undergoing heart valve surgery; recommendations are based on limited evidence. The organization of CR programmes and factors associated with uptake among patients undergoing heart valve surgery have not been studied. Thi...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487314536364
更新日期：2015-06-01 00:00:00
abstract：:Background Epidemiological studies on smoking and atrial fibrillation have been inconsistent, with some studies showing a positive association while others have found no association. It is also unclear whether there is a dose-response relationship between the number of cigarettes smoked or pack-years and the risk of a...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,meta分析
doi：10.1177/2047487318780435
更新日期：2018-09-01 00:00:00
abstract：BACKGROUND:International guidelines recommend pharmacotherapy combinations for chronic coronary syndromes (CCSs) but medical management remains suboptimal. DESIGN:The CICD-LT registry is investigating short- and long-term outcomes and management in patients in European Society of Cardiology (ESC) member countries, in ...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487320912491
更新日期：2020-03-31 00:00:00
abstract：BACKGROUND:The prevalence of undetected left ventricular diastolic dysfunction is high, especially in the elderly with comorbidities. Left ventricular diastolic dysfunction is a prognostic indicator of heart failure, in particularly of heart failure with preserved ejection fraction and of future cardiovascular and all-...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487318816774
更新日期：2019-04-01 00:00:00
abstract：AIMS:Reviews of clinical practice guidelines have repeatedly concluded that only a minority of guideline recommendations are supported by high-quality evidence from randomised controlled trials. The aim of this study is to evaluate whether these findings apply to the whole cardiovascular evidence base or specific recom...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487319868540
更新日期：2019-12-01 00:00:00
abstract：:Exercise-induced ischemic preconditioning (IPC) can be assessed with the second exercise stress test during sequential testing. Exercise-induced IPC is defined as the time to 1 mm ST segment depression (STD), the rate-pressure product (RPP) at 1 mm STD, the maximal ST depression and the rate-pressure product at peak e...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,meta分析,评审
doi：10.1177/2047487313502447
更新日期：2015-01-01 00:00:00
abstract：:Background Smartphone manufacturers offer mobile health monitoring technology to their customers, including apps using the built-in camera for heart rate assessment. This study aimed to test the diagnostic accuracy of such heart rate measuring apps in clinical practice. Methods The feasibility and accuracy of measurin...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,随机对照试验
doi：10.1177/2047487317702044
更新日期：2017-08-01 00:00:00
abstract：AIMS:To determine the effect of ticagrelor compared to clopidogrel in patients with peripheral artery disease (PAD) and acute coronary syndromes (ACS). METHODS AND RESULTS:PLATO (n = 18,624) was a multicentre, double-blind, randomized trial in ACS, that showed a 16% reduction in cardiovascular death (CV-death), myocar...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1177/2047487314533215
更新日期：2015-06-01 00:00:00
abstract：BACKGROUND:The purpose of this investigation was to identify a quantitative dose-response relationship for enhancing maximal oxygen consumption (VO2max) in healthy sedentary older adults after controlled endurance training. METHODS AND RESULTS:This meta-analysis of controlled clinical trials included 1257 exercisers a...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,meta分析
doi：10.1177/2047487315582322
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:Heart failure (HF) continues to be an illness of daunting proportions with a four- year mortality touching 50%. Biomarkers for prognosticating patients with heart failure have generated immense interest. Several studies have been conducted on a novel biomarker, galectin-3 to assess its prognostic effect in h...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,评审
doi：10.1177/2047487314552797
更新日期：2015-09-01 00:00:00
abstract：:Aims HIV-infected persons may have elevated risks for heart failure, but factors associated with heart failure in the modern era of HIV therapy are insufficiently understood. Despite substantial disagreement between physician-adjudicated heart failure and heart failure diagnosis codes, few studies of HIV cohorts have ...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487317732432
更新日期：2017-11-01 00:00:00
abstract：AIMS:European Society of Cardiology/European Atherosclerosis Society 2019 guidelines recommend more aggressive lipid targets in high- and very high-risk patients and the addition of adjuvant treatments to statins in uncontrolled patients. We aimed to assess (a) achievement of prior and new European Society of Cardiolog...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487320914115
更新日期：2020-03-31 00:00:00
abstract：:Background Statin treatment in association with physical exercise can substantially reduce mortality in dyslipidaemic individuals. However, the available data to compare the efficacy and safety of statins and exercise combination therapy with statin monotherapy are limited. Design Systematic review and meta-analysis. ...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,meta分析,评审
doi：10.1177/2047487317691874
更新日期：2017-06-01 00:00:00
abstract：:Background Studies have shown significant associations of chronic kidney disease (CKD) and diabetes mellitus (DM) with cardiovascular disease (CVD) mortality. The impact on the general population is an important public health issue. However, the population attributable fraction (PAF) of CVD because of CKD and/or DM in...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487316679904
更新日期：2017-03-01 00:00:00
abstract：BACKGROUND:Statin intolerance is a barrier to effective lipid-lowering treatment. A significant number of patients stop prescribed statins, or can take only a reduced dose, because of adverse events attributed to the statin, and are then considered statin-intolerant. METHODS:Examination of differences between statin a...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,评审
doi：10.1177/2047487315602861
更新日期：2016-05-01 00:00:00
abstract：BACKGROUND:Patients with coronary heart disease often suffer from an impaired health-related quality of life (HRQoL). A healthier lifestyle not only extends individuals' lengths of life but might also improve their HRQoL. The aim of this study was to explore the relation between self-reported lifestyle changes and HRQo...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,多中心研究
doi：10.1177/2047487312473846
更新日期：2014-07-01 00:00:00
abstract：BACKGROUND:Intermittent claudication, defined as fatigue or pain in the legs while walking, is a common symptom in peripheral arterial disease. Although exercise effectively improves function and manages symptoms, adherence rates are not ideal. The high levels of pain experienced in traditional exercise programmes may ...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487319846997
更新日期：2019-10-01 00:00:00
abstract：AIMS:Functional capacity is an important endpoint for therapies oriented to older adults with cardiovascular diseases. The literature on predictors of exercise capacity is sparse in the elderly population. In a longitudinal European study on effectiveness of cardiac rehabilitation of seven European countries in elderly...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487319894676
更新日期：2020-11-01 00:00:00
abstract：:The beneficial effect of exercise training and exercise-based cardiac rehabilitation on symptom-free exercise capacity,cardiovascular and skeletal muscle function, quality of life, general healthy lifestyle, and reduction of depressive symptoms and psychosocial stress is nowadays well recognized. However, it remains l...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,评审
doi：10.1177/2047487312437063
更新日期：2012-12-01 00:00:00
abstract：AIM:We aimed to clarify the strength of the association between conventional and metabolic risk factors to coronary heart disease (CHD) mortality across short, intermediate, and long periods of follow-up and whether the effects of risk factors are heterogeneous across serum cholesterol levels. METHODS:The Oslo Study p...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/1741826711432514
更新日期：2013-02-01 00:00:00
abstract：INTRODUCTION:While there is evidence of poor health behaviours in anxious and depressed cardiac patients, it is possible that sociodemographic factors explain these associations. Few previous studies have adequately controlled for confounders. The present study investigated health behaviours in anxious and depressed ca...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1177/2047487312449593
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND:The association between abdominal obesity and recurrent atherosclerotic cardiovascular disease after myocardial infarction remains unknown. OBJECTIVE:The purpose of this study was to investigate the prevalence of abdominal obesity and its association with recurrent atherosclerotic cardiovascular disease in ...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487319898019
更新日期：2020-12-01 00:00:00
abstract：AIMS:To investigate the clinical relevance of contemporary cut-offs of left ventricular ejection fraction (LVEF) including an intermediate phenotype with mid-range reduced ejection fraction among patients with coronary artery disease undergoing percutaneous coronary intervention. METHODS AND RESULTS:Patient-level data...
journal_title：European journal of preventive cardiology
pub_type： 杂志文章
doi：10.1177/2047487319841939
更新日期：2019-08-01 00:00:00
