Loss of tricellular tight junction protein LSR promotes cell invasion and migration via upregulation of TEAD1/AREG in human endometrial cancer.

abstract：:Exposure to stress during early life affects subsequent behaviors and increases the vulnerability to adult pathologies, a phenomenon that has been well documented in humans and rodents. In this study, we introduce a chronic unpredictable stress protocol adapted to young zebrafish, which is an increasingly popular vert...

journal_title：Scientific reports

authors： Golla A,Østby H,Kermen F

更新日期：2020-06-25 00:00:00

abstract：:DEMETER-like DNA glycosylases (DMLs) initiate the base excision repair-dependent DNA demethylation to regulate a wide range of biological processes in plants. Six putative SmDML genes, termed SmDML1-SmDML6, were identified from the genome of S. miltiorrhiza, an emerging model plant for Traditional Chinese Medicine (TC...

journal_title：Scientific reports

authors： Li J,Li C,Lu S

更新日期：2018-05-08 00:00:00

abstract：:The synthesis of a new series of Gd(III)-arylphosphonium complexes is described and the solution stability of selected compounds is reported. Their lipophilicity and uptake in human glial (SVG p12) and human glioblastoma multiforme (T98G) cell lines are presented. The in vitro cytotoxicity of all complexes was determi...

journal_title：Scientific reports

authors： Hall AJ,Robertson AG,Hill LR,Rendina LM

更新日期：2021-01-12 00:00:00

abstract：:For accurate micro-scale quantification of a specific protein in biological fluids, immunoaffinity chromatography (IAC) and isoelectric focusing (IEF) were combined in a single fused-silica capillary. The inner wall of the capillary was coated with an anti-E-tag antibody at the inlet side to form an IAC column, and po...

journal_title：Scientific reports

authors： Shimura K,Nagai T

更新日期：2016-12-15 00:00:00

abstract：:Spin-polarized triangular graphene nanoflakes (t-GNFs) serve as ideal building blocks for the long-desired ferromagnetic graphene superlattices, but they are always assembled to planar structures which reduce its mechanical properties. Here, by joining t-GNFs in a spiral way, we propose one-dimensional graphene spiral...

journal_title：Scientific reports

authors： Zhang X,Zhao M

更新日期：2014-07-16 00:00:00

abstract：:Glial fibrillary acidic protein expressing (GFAP+) glia modulate nociceptive neuronal activity in both the peripheral nervous system (PNS) and the central nervous system (CNS). Resident GFAP+ glia in dorsal root ganglia (DRG) known as satellite glial cells (SGCs) potentiate neuronal activity by releasing pro-inflammat...

journal_title：Scientific reports

authors： Xie AX,Madayag A,Minton SK,McCarthy KD,Malykhina AP

更新日期：2020-08-25 00:00:00

abstract：:Electroceutical wound dressings, especially those involving current flow with silver based electrodes, show promise for treating biofilm infections. However, their mechanism of action is poorly understood. We have developed an in vitro agar based model using a bioluminescent strain of Pseudomonas aeruginosa to measure...

journal_title：Scientific reports

authors： Dusane DH,Lochab V,Jones T,Peters CW,Sindeldecker D,Das A,Roy S,Sen CK,Subramaniam VV,Wozniak DJ,Prakash S,Stoodley P

更新日期：2019-02-14 00:00:00

abstract：:In recent years many monoclonal antibodies (mAb) have entered the biotherapeutics market, offering new treatments for chronic and life-threatening diseases. Protein A resin captures monoclonal antibody (mAb) effectively, but the binding capacity decays over repeated purification cycles. On an industrial scale, replaci...

journal_title：Scientific reports

authors： Boulet-Audet M,Kazarian SG,Byrne B

更新日期：2016-07-29 00:00:00

abstract：:Rapid integration of high-quality functional devices in microchannels is in highly demand for miniature lab-on-a-chip applications. This paper demonstrates the embellishment of existing microfluidic devices with integrated micropatterns via femtosecond laser MRAF-based holographic patterning (MHP) microfabrication, wh...

journal_title：Scientific reports

authors： Zhang C,Hu Y,Du W,Wu P,Rao S,Cai Z,Lao Z,Xu B,Ni J,Li J,Zhao G,Wu D,Chu J,Sugioka K

更新日期：2016-09-13 00:00:00

abstract：:The crystallization characteristics in supercooled liquid Zn during isothermal relaxation were investigated using molecular dynamics simulations by adopting the cluster-type index method (CTIM) and the tracing method. Results showed that the crystallization process undergo three different stages. The size of the criti...

journal_title：Scientific reports

authors： Zhou LL,Liu RS,Tian ZA,Liu HR,Hou ZY,Peng P

更新日期：2016-08-16 00:00:00

abstract：:Dysfunctional epicardial adipose tissue (EAT) secretome can influence the heart's stretch response. However, the molecular mechanisms are still poorly understood. The aim of this study was to clarify how dysfunctional EAT promotes maladaptive heart remodeling in cardiovascular disease (CVD) through ST2 production asso...

journal_title：Scientific reports

authors： Vianello E,Dozio E,Bandera F,Schmitz G,Nebuloni M,Longhi E,Tacchini L,Guazzi M,Corsi Romanelli MM

更新日期：2019-07-17 00:00:00

abstract：:Even when speakers are not actively doing another task, they can be interfered in their speech planning by concurrent auditory stimuli. In this study, we used picture naming with passive hearing, or active listening, combined to high-density electroencephalographic (EEG) recordings to investigate the locus and origin ...

journal_title：Scientific reports

authors： Fargier R,Laganaro M

更新日期：2019-03-29 00:00:00

abstract：:Metapristone is the primary metabolite of the abortifacient mifepristone (RU486), and is being developed as a safe and effective cancer metastatic chemopreventive agent for both sexes. Here, we systematically investigated the sex-related pharmacokinetics of metapristone in both rats and dogs, and explored the related ...

journal_title：Scientific reports

authors： Chen W,Xiao Y,Chen J,Liu J,Shao J,Li T,Zhu Y,Ma J,Gao Y,Wang J,Xu J,Lu Y,Jia L

更新日期：2017-12-07 00:00:00

abstract：:Non-functioning pituitary adenomas (NFPAs) are the most frequent pituitary tumors. The elucidation of the mechanisms of aggressive NFPAs in bone destruction is required in order to guide the clinical diagnosis and treatment of NFPAs. In the present study, we investigated the differential proteomics of fibroblasts isol...

journal_title：Scientific reports

authors： Zhang LY,Ge XL,Li Z,Tang YJ,Xiong YY,Li XJ,Liu JF,Wanggou SY,Li CT,Yang K,Chen X,Hu ZL,Liu YS,Liu ZX

更新日期：2017-12-13 00:00:00

abstract：:This paper describes a Functional Electrical Stimulation (FES) standing system for rehabilitation of bone mineral density (BMD) in people with Spinal Cord Injury (SCI). BMD recovery offers an increased quality of life for people with SCI by reducing their risk of fractures. The standing system developed comprises an i...

journal_title：Scientific reports

authors： Zoulias ID,Armengol M,Poulton A,Andrews B,Gibbons R,Harwin WS,Holderbaum W

更新日期：2019-09-10 00:00:00

abstract：:Recessive mutations in the Mlo gene confer broad spectrum resistance in barley (Hordeum vulgare) to powdery mildew (Blumeria graminis f. sp. hordei), a widespread and damaging disease. However, all alleles discovered to date also display deleterious pleiotropic effects, including the naturally occurring mlo-11 mutant ...

journal_title：Scientific reports

authors： Ge X,Deng W,Lee ZZ,Lopez-Ruiz FJ,Schweizer P,Ellwood SR

更新日期：2016-07-12 00:00:00

abstract：:Critically endangered sturgeons, having undergone three whole genome duplication events, represent an exceptional example of ploidy plasticity in vertebrates. Three extant ploidy groups, combined with autopolyploidization, interspecific hybridization and the fertility of hybrids are important issues in sturgeon conser...

journal_title：Scientific reports

authors： Lebeda I,Ráb P,Majtánová Z,Flajšhans M

更新日期：2020-11-12 00:00:00

abstract：:The photo-reduction of metal ions in solution induced by femtosecond laser is an important and novel method for fabricating three-dimensional metal microstructures. However, the nonlinear absorption cross section of metal ions remains unknown because its measurement is difficult. In the present study, a method based o...

journal_title：Scientific reports

authors： Ma ZC,Chen QD,Han B,Liu XQ,Song JF,Sun HB

更新日期：2015-12-11 00:00:00

abstract：:Centrioles are essential for forming cilia, flagella and centrosomes. Successful centriole assembly requires proteins of the SAS-6 family, which can form oligomeric ring structures with ninefold symmetry in vitro. While important progress has been made in understanding SAS-6 protein biophysics, the mechanisms enabling...

journal_title：Scientific reports

authors： Klein HC,Guichard P,Hamel V,Gönczy P,Schwarz US

更新日期：2016-06-08 00:00:00

abstract：:Carbonaceous particulate matter (PM), comprising black carbon (BC), primary organic aerosol (POA) and secondary organic aerosol (SOA, from atmospheric aging of precursors), is a highly toxic vehicle exhaust component. Therefore, understanding vehicle pollution requires knowledge of both primary emissions, and how thes...

journal_title：Scientific reports

authors： Platt SM,El Haddad I,Pieber SM,Zardini AA,Suarez-Bertoa R,Clairotte M,Daellenbach KR,Huang RJ,Slowik JG,Hellebust S,Temime-Roussel B,Marchand N,de Gouw J,Jimenez JL,Hayes PL,Robinson AL,Baltensperger U,Astorga C,Prévô

更新日期：2017-07-13 00:00:00

abstract：:High-altitude-adapted ectotherms can escape competition from dominant species by tolerating low temperatures at cooler elevations, but climate change is eroding such advantages. Studies evaluating broad-scale impacts of global change for high-altitude organisms often overlook the mitigating role of biotic factors. Yet...

journal_title：Scientific reports

authors： Muluvhahothe MM,Joseph GS,Seymour CL,Munyai TC,Foord SH

更新日期：2021-01-08 00:00:00

abstract：:Emergence and time evolution of micro-structured new-phase domains play a crucial role in determining the macroscopic physical and mechanical behaviors of iron under shock compression. Here, we investigate, through molecular dynamics simulations and theoretical modelings, shock-induced phase transition process of iron...

journal_title：Scientific reports

authors： Pang WW,Zhang P,Zhang GC,Xu AG,Zhao XG

更新日期：2014-01-10 00:00:00

abstract：:Using census data we identify geographic patterns in residency changes in Lesotho over a decade. Using kriging to spatially interpolate data from 8,510 households we identify regions where households have members temporarily living away from home (divided households). Further, using a multivariate analysis and data fr...

journal_title：Scientific reports

authors： Palk L,Blower S

更新日期：2015-12-02 00:00:00

abstract：:Natural arches, pillars and other exotic sandstone formations have always been attracting attention for their unusual shapes and amazing mechanical balance that leave a strong impression of intelligent design rather than the result of a stochastic process. It has been recently demonstrated that these shapes could have...

journal_title：Scientific reports

authors： Ostanin I,Safonov A,Oseledets I

更新日期：2017-12-11 00:00:00

abstract：:The peptidyl nucleoside blasticidin S (BS) isolated from Streptomyces griseochromogenes was the first non-mercurial fungicide used on a large scale to prevent rice blast. In the biosynthesis of BS, leucylblasticidin S (LBS) was suggested as the penultimate metabolite with 20-fold less inhibitory activity than the fina...

journal_title：Scientific reports

authors： Yu G,Li L,Liu X,Liu G,Deng Z,Zabriskie MT,Jiang M,He X

更新日期：2015-12-01 00:00:00

abstract：:Norovirus is one of the most common causes of gastroenteritis. Following infection, anti-norovirus salivary immunoglobulin G (IgG) rises steeply within 2 weeks and remains elevated for several months; this immunoconversion can serve as an indicator of infection. We used a multiplex salivary immunoassay to study norovi...

journal_title：Scientific reports

authors： Wade TJ,Griffin SM,Egorov AI,Sams E,Hudgens E,Augustine S,DeFlorio-Barker S,Plunkett T,Dufour AP,Styles JN,Oshima K

更新日期：2019-12-20 00:00:00

abstract：:Free-living animals must make dietary choices in terms of chemical and physical properties, depending on their digestive physiology and availability of food resources. Here we comprehensively evaluated the dietary choices of proboscis monkeys (Nasalis larvatus) consuming young leaves. We analysed the data for leaf tou...

journal_title：Scientific reports

authors： Matsuda I,Clauss M,Tuuga A,Sugau J,Hanya G,Yumoto T,Bernard H,Hummel J

更新日期：2017-02-17 00:00:00

abstract：:V2O5 based materials are attractive cathode alternatives due to the many oxidation state switches of vanadium bringing about a high theoretical specific capacity. However, significant capacity losses are eminent for crystalline V2O5 phases related to the irreversible phase transformations and/or vanadium dissolution s...

journal_title：Scientific reports

authors： Afyon S,Krumeich F,Mensing C,Borgschulte A,Nesper R

更新日期：2014-11-19 00:00:00

abstract：:The architecture of the genome influences the functions of DNA from bacteria to eukaryotes. Intrinsically disordered regions (IDR) of eukaryotic histones have pivotal roles in various processes of gene expression. IDR is rare in bacteria, but interestingly, mycobacteria produce a unique histone-like protein, MDP1 that...

journal_title：Scientific reports

authors： Savitskaya A,Nishiyama A,Yamaguchi T,Tateishi Y,Ozeki Y,Nameta M,Kon T,Kaboso SA,Ohara N,Peryanova OV,Matsumoto S

更新日期：2018-05-29 00:00:00

abstract：:Traumatic brain injury (TBI) has been associated with atherosclerosis and cardiovascular mortality in humans. However the causal relationship between TBI and vascular disease is unclear. This study investigated the direct role of TBI on vascular disease using a murine model of atherosclerosis. Apolipoprotein E deficie...

journal_title：Scientific reports

authors： Wang J,Su E,Wang H,Guo C,Lawrence DA,Eitzman DT

更新日期：2018-04-04 00:00:00