Galanin contributes to monoaminergic dysfunction and to dependent neurobehavioral comorbidities of epilepsy.

abstract：:Locally generating new proteins in subcellular regions provide means to spatially and temporally modify protein content in polarized cells. Recent years have seen resurgence of the concept that axonal processes of neurons can locally synthesize proteins. Experiments from a number of groups have now shown that axonal p...

journal_title：Experimental neurology

authors： Yoo S,van Niekerk EA,Merianda TT,Twiss JL

更新日期：2010-05-01 00:00:00

abstract：:Wistar rats (n = 58) were injected subcutaneously during the lactation period with fluoxetine (5, 10, 20 or 40 mg/kg/day) and cortical spreading depression (SD) was recorded immediately after weaning (25-30 days of life). An additional group (10 mg/kg; n = 8) was SD-recorded at 60-70 days. As compared to the saline-in...

journal_title：Experimental neurology

authors： dos Santos AA,Pinheiro PC,de Lima DS,Ozias MG,de Oliveira MB,Guimarães NX,Guedes RC

更新日期：2006-08-01 00:00:00

abstract：:We demonstrated previously that the hypothalamic supraoptic nucleus (SON) undergoes a robust axonal sprouting response following unilateral transection of the hypothalamo-neurohypophysial tract. Concomitant with this response is an increase in ciliary neurotrophic factor (CNTF) and CNTF receptor alpha (CNTFRα) express...

journal_title：Experimental neurology

authors： Askvig JM,Leiphon LJ,Watt JA

更新日期：2012-01-01 00:00:00

abstract：:Axons are the anatomical link between neuronal cell bodies and their target organs, and thus axonal degeneration is the pathological substrate that underlies neurological dysfunction in a large number of neurological conditions. Recent advances in the field of axonal biology demonstrate that axons possess programs for...

journal_title：Experimental neurology

authors： Fischer-Hayes LR,Brotherton T,Glass JD

更新日期：2013-08-01 00:00:00

abstract：:Wnt5b, a member of Wnt family, plays multiple roles in tumor progression and metastasis. However, whether Wnt5b contributes to the sensitization of dorsal root ganglia (DRG) neurons and pathogenesis of bone cancer pain still remains unclear. Here, we found that the protein expression of Wnt5b and its atypical tyrosine...

journal_title：Experimental neurology

authors： He JJ,Wang X,Liang C,Yao X,Zhang ZS,Yang RH,Fang D

更新日期：2020-12-01 00:00:00

abstract：:Our primary aim was to determine if there exists a preferential involvement of the fast-twitch or slow-twitch skeletal muscle fibers in the dy2J/dy2J strain of murine dystrophy. The changes in the contractile properties of the slow-twitch soleus (SOL) and the fast-twitch extensor digitorum longus (EDL) muscles of norm...

journal_title：Experimental neurology

authors： Bressler BH,Jasch LG,Ovalle WK,Slonecker CE

更新日期：1983-05-01 00:00:00

abstract：:The role of 5-HT2 and opioid receptors in pudendal inhibition of bladder activity induced by intravesical infusion of saline or 0.25% acetic acid (AA) was investigated in anesthetized cats using methysergide (a 5-HT2 receptor antagonist) and naloxone (an opioid receptor antagonist). AA irritated the bladder and signif...

journal_title：Experimental neurology

authors： Matsuta Y,Schwen Z,Mally AD,Shen B,Wang J,Roppolo JR,de Groat WC,Tai C

更新日期：2013-09-01 00:00:00

abstract：:Here, we describe a bilateral cervical contusion model for mice. Adult female mice received graded bilateral contusion injuries at cervical level 5 (C5) using a commercially available impactor (the IH device). Three separate experiments were carried out to define conditions that produce impairments in forelimb functio...

journal_title：Experimental neurology

authors： Aguilar RM,Steward O

更新日期：2010-01-01 00:00:00

abstract：:We present here an example case of neuropathic pain with heat allodynia as a major symptom to illustrate how the functional imaging of pain may provide new insights into the pathophysiology of painful sensory disorders. Tissue injury of almost any kind, but especially peripheral or central neural tissue injury, can le...

journal_title：Experimental neurology

authors： Casey KL,Lorenz J,Minoshima S

更新日期：2003-11-01 00:00:00

abstract：:Recent in vitro studies have shown that the periventricular subependymal zone (SEZ) of the rodent brain is capable of de novo generation of neurons and glia. There is less information available on neurogenesis in the adult human brain, and no study has shown the clonal generation of neurons and glia from in vitro-gene...

journal_title：Experimental neurology

authors： Kukekov VG,Laywell ED,Suslov O,Davies K,Scheffler B,Thomas LB,O'Brien TF,Kusakabe M,Steindler DA

更新日期：1999-04-01 00:00:00

abstract：:The present study was carried out to determine if augmentation of phrenic nerve activity during the crossed phrenic phenomenon temporally coincides with the morphological changes in the phrenic nucleus that we have observed in previous studies. This investigation consisted of two experiments in spinal cord hemisected ...

journal_title：Experimental neurology

authors： O'Hara TE Jr,Goshgarian HG

更新日期：1991-02-01 00:00:00

abstract：:MicroRNA-21 (miR-21) is consistently up-regulated in various neurological disorders, including epilepsy. Here, we show that the biogenesis of miR-21 is altered following pilocarpine-induced status epilepticus (SE) with an increase in precursor miR-21 (pre-miR-21) in rats. We demonstrate that pre-miR-21 has an energeti...

journal_title：Experimental neurology

authors： Chak K,Roy-Chaudhuri B,Kim HK,Kemp KC,Porter BE,Kay MA

更新日期：2016-12-01 00:00:00

abstract：:When adrenal medullary cells are cultured in vitro, tyrosine hydroxylase (TH) mRNA, preproenkephalin (PPEnk) mRNA, and methionine enkephalin (Mek) immunoreactivity was markedly increased compared with intact adrenal medullary cells in situ, suggesting an increased biosynthesis of catecholamines and enkephalin-containi...

journal_title：Experimental neurology

authors： Wang XT,Unnerstall JR,Ibuki T,Wang H,Pappas GD

更新日期：2000-01-01 00:00:00

abstract：:The olfactory bulb is the target of neural progenitor cells that are generated in the subventricular zone of the lateral ventricle in the adult brain. This permanent neurogenesis is likely influenced by olfactory input to the bulb since previous studies have shown that cell proliferation and/or apoptotic death are sti...

journal_title：Experimental neurology

authors： Veyrac A,Didier A,Colpaert F,Jourdan F,Marien M

更新日期：2005-08-01 00:00:00

abstract：:Noninvasive, targeted drug delivery to the brain can be achieved using transcranial focused ultrasound (FUS), which transiently increases the permeability of the blood-brain barrier (BBB) for localized delivery of therapeutics from the blood to the brain. Previously, we have demonstrated that FUS can deliver intraveno...

journal_title：Experimental neurology

authors： Jordão JF,Thévenot E,Markham-Coultes K,Scarcelli T,Weng YQ,Xhima K,O'Reilly M,Huang Y,McLaurin J,Hynynen K,Aubert I

更新日期：2013-10-01 00:00:00

abstract：:Although transgenic expression of oncogenes typically leads to tumorigenesis, oncogene expression directed to the rod photoreceptors leads to cell death without tumor formation. To evaluate the cellular and functional changes induced in cone photoreceptors by an oncogene, the Mas1 protooncogene was targeted to the con...

journal_title：Experimental neurology

authors： Xu X,Quiambao AB,Roveri L,Pardue MT,Marx JL,Röhlich P,Peachey NS,Al-Ubaidi MR

更新日期：2000-05-01 00:00:00

abstract：:Previously injured dorsal roots were electrically stimulated to determine if regenerating sensory axons can form physiologically active synaptic contacts with neurons within fetal spinal cord tissue transplants. Dorsal rootlets, sectioned at their spinal cord entry zone, were apposed to intraspinal transplants of feta...

journal_title：Experimental neurology

authors： Houle JD,Skinner RD,Garcia-Rill E,Turner KL

更新日期：1996-06-01 00:00:00

abstract：:Typical antipsychotic drugs (APDs) with D2antagonistic properties impede functional outcome after experimental traumatic brain injury (TBI) and reduce the effectiveness of environmental enrichment (EE). Here we test the hypothesis that aripiprazole (ARIP), an atypical APD with partial D2and 5-HT1Areceptor agonist acti...

journal_title：Experimental neurology

authors： Besagar S,Radabaugh HL,Bleimeister IH,Meyer EA,Niesman PJ,Cheng JP,Bondi CO,Kline AE

更新日期：2019-04-01 00:00:00

abstract：:GAP-43 is a neuronal protein whose synthesis is elevated during developmental and regenerative axon growth. We propose that one consequence of this increased synthesis may be the delivery of calmodulin-like proteins to the distal portions of the growing axon at an increased velocity; this is because calmodulin, which ...

journal_title：Experimental neurology

authors： Spencer S,Willard MB

更新日期：1992-01-01 00:00:00

abstract：:Sympathetic axons have been shown to invade the rat hippocampal formation after lesions of the septohippocampal (cholinergic) projection. To test the generality of this type of transmitter-specific sprouting within the central nervous system, lesions were placed within the horizontal limb of the diagonal band in order...

journal_title：Experimental neurology

authors： Gibby WA,Crutcher KA

更新日期：1984-05-01 00:00:00

abstract：:Second-order neurons in trigeminal subnucleus caudalis (Vc) and upper cervical spinal cord (C1) are critical for craniofacial pain processing and project rostrally to terminate in: ventral posteromedial thalamic nucleus (VPM), medial thalamic nuclei (MTN) and parabrachial nuclei (PBN). The contribution of each region ...

journal_title：Experimental neurology

authors： Saito H,Katagiri A,Okada S,Mikuzuki L,Kubo A,Suzuki T,Ohara K,Lee J,Gionhaku N,Iinuma T,Bereiter DA,Iwata K

更新日期：2017-07-01 00:00:00

abstract：:The extracellular signal-regulated kinase 1 and 2 (ERK) pathway, regulated by phosphorylation on specific amino acids, is emerging as an important signaling cascade in neurones, transducing sensory input into cellular responses. In the mammalian nervous system, the ERK pathway has been found to mediate plasticity even...

journal_title：Experimental neurology

authors： Cruz CD,McMahon SB,Cruz F

更新日期：2006-07-01 00:00:00

abstract：:It has been reported that the severe cerebral edema produced in experimental animals by Clostridium perfringens (Cl p) type D epsilon toxin can be prevented by prior treatment with its precursor prototoxin due to competitive binding to endothelial cells (ECs) at the blood-brain barrier (BBB). In this study we investig...

journal_title：Experimental neurology

authors： Zhu C,Ghabriel MN,Blumbergs PC,Reilly PL,Manavis J,Youssef J,Hatami S,Finnie JW

更新日期：2001-05-01 00:00:00

abstract：:Previous work utilizing the 2-deoxyglucose (2-DG) technique demonstrated that denervation, both direct (enucleation) or indirect (retinal receptor destruction, leaving ganglion cells intact), resulted in a depression followed by an increase in glucose metabolism in the superior colliculus (SC) of the mature hooded rat...

journal_title：Experimental neurology

authors： Thurlow GA,Cooper RM

更新日期：1989-06-01 00:00:00

abstract：:The left external auditory meatus was removed in 4-day-old CBA/J mice; after killing at 45 days, serial sections of the cochleae and brain stem were prepared. From these, the cross-sectional areas of spiral ganglion neurons and of 14 auditory brain stem neuronal types were measured, using a total of 210 neurons of eac...

journal_title：Experimental neurology

authors： Webster DB

更新日期：1983-01-01 00:00:00

abstract：:Because vitamin D hormone deficiency (VDHdef) can worsen severity and outcome for ischemic stroke, we examined the role of VDH in maintaining blood-brain-barrier (BBB integrity) in a rat model of stroke. In most types of stroke, the BBB is markedly compromised, potentially leading to a cascade of injury processes and ...

journal_title：Experimental neurology

authors： Sayeed I,Turan N,Stein DG,Wali B

更新日期：2019-02-01 00:00:00

abstract：:In the neocortex, the effectiveness of potential transplantation therapy for diseases involving neuronal loss may depend upon whether donor neurons can reestablish the precise long-distance projections that form the basis of sensory, motor, and cognitive function. During corticogenesis, the formation of these connecti...

journal_title：Experimental neurology

authors： Hernit-Grant CS,Macklis JD

更新日期：1996-05-01 00:00:00

abstract：:Estrogens and N-methyl-D-aspartate (NMDA) receptors regulate multiple aspects of morphological and functional plasticity in young animals. For example, estrogens increase spine density in the hippocampus, and NMDA antagonists block these effects. Few studies have examined the effects of age, postovariectomy interval, ...

journal_title：Experimental neurology

authors： Adams MM,Oung T,Morrison JH,Gore AC

更新日期：2001-08-01 00:00:00

abstract：:Subarachnoid hemorrhage (SAH) is the most devastating form of stroke. Reducing neuronal apoptosis is an important countermeasure against early brain injury (EBI) after SAH. Recent evidence indicates that OX40-OX40L coupling is critical for cell survival and proliferation. Current study was performed to detect the role...

journal_title：Experimental neurology

authors： Wu LY,Enkhjargal B,Xie ZY,Travis ZD,Sun CM,Zhou KR,Zhang TY,Zhu QQ,Hang CH,Zhang JH

更新日期：2020-04-01 00:00:00

abstract：:A sample of 504 single neurons isolated in three curvilinear arrays of 10 closely spaced tracks in primary somatosensory and in pericruciate sensorimotor cortex was studied in two awake, restrained domestic cats. Modality sensitivity and receptive field size and location were assessed for each neuron, along with respo...

journal_title：Experimental neurology

authors： Slimp JC,Towe AL

更新日期：1990-01-01 00:00:00