Baseline Characteristics Predict the Presence of Amyloid on Endomyocardial Biopsy.

Abstract:

BACKGROUND:Recent studies have suggested a high prevalence of cardiac amyloidosis (CAm) in heart failure (HF) patients. CAm might be underdiagnosed owing to low clinical suspicion. METHODS AND RESULTS:We performed retrospective analysis of 259 patients with HF and ejection fraction (EF) ≥50% referred for endomyocardial biopsy. Seventy-three (28%) had CAm. Multivariable independent predictors of CAm were identified. Over a mean follow-up of 2.6 ± 3.3 years, CAm patients had worse survival than those without (1.5 y vs 6.3 y; log rank P < .0001). CONCLUSIONS:Clinicians should be suspicious of CAm in patients with EF 50%-75%, >50 years of age, BMI <30 kg/m2, peripheral neuropathy, Sokolow-Lyon index ≤15 mm, and septal wall thickness ≥1.4 cm.

journal_name

J Card Fail

authors

Ton VK,Bhonsale A,Gilotra NA,Halushka MK,Steenbergen C,Almansa J,Brown E,Tedford RJ,Wittstein I,Sharma K,Russell SD,Judge DP

doi

10.1016/j.cardfail.2016.12.006

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

340-344

issue

4

eissn

1071-9164

issn

1532-8414

pii

S1071-9164(16)31243-X

journal_volume

23

pub_type

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