Abstract：
:Folic acid is a member of the B-vitamin family and is essential for amino acid metabolism. Adequate intake of folic acid is vital for metabolism, cellular homeostasis, and DNA synthesis. Since the initial discovery of folic acid in the 1940s, folate deficiency has been implicated in numerous disease states, primarily those associated with neural tube defects in utero and neurological degeneration later in life. However, in the past decade, epidemiological studies have identified an inverse relation between both folic acid intake and blood folate concentration and cardiovascular health. This association inspired a number of clinical studies that suggested that folic acid supplementation could reverse endothelial dysfunction in patients with cardiovascular disease (CVD). Recently, in vitro and in vivo studies have begun to elucidate the mechanism(s) through which folic acid improves vascular endothelial function. These studies, which are the focus of this review, suggest that folic acid and its active metabolite 5-methyl tetrahydrofolate improve nitric oxide (NO) bioavailability by increasing endothelial NO synthase coupling and NO production as well as by directly scavenging superoxide radicals. By improving NO bioavailability, folic acid may protect or improve endothelial function, thereby preventing or reversing the progression of CVD in those with overt disease or elevated CVD risk.
journal_name
Nutr Revjournal_title
Nutrition reviewsauthors
Stanhewicz AE,Kenney WLdoi
10.1093/nutrit/nuw053subject
Has Abstractpub_date
2017-01-01 00:00:00pages
61-70issue
1eissn
0029-6643issn
1753-4887pii
nuw053journal_volume
75pub_type
杂志文章,评审abstract：:Iron is essential for oxygen transport, oxidative metabolism, and cellular growth. Interactions between iron and other dietary factors play a significant role in determining the adequacy of iron nutrition and have important implications for food fortification in developing countries. Vitamin A and vitamin C deficiency...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1997.tb06461.x
更新日期：1997-04-01 00:00:00
abstract：:Combining data from two large-scale prospective observational studies in women and men, investigators link the consumption of fruits and vegetables to the risk of ischemic stroke. Of interest is their breakdown of these foods into cruciferous vegetables and citrus fruit juice, which confer the greatest protection. ...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2001.tb01902.x
更新日期：2001-01-01 00:00:00
abstract：:The glucocorticoid dexamethasone (dex) stimulates differentiation of cultured preadipocytes of the 3T3-L1 cell line to adipocytes. The preadipocytes express a gene termed preadipocyte factor 1 (pref-1). The pref-1 gene product is abundant in preadipocytes but completely absent in adipocytes. Constitutive expression of...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1999.tb06907.x
更新日期：1999-10-01 00:00:00
abstract：CONTEXT:Contrary to nutritional guidelines, accumulating evidence shows that pregnant women's energy intakes remain stable throughout trimesters. Although pregnant women may eat below their needs or underreport their energy intakes, it is also relevant to question how energy requirements - estimated through measurement...
journal_title：Nutrition reviews
pub_type： 杂志文章
doi：10.1093/nutrit/nuaa093
更新日期：2020-09-25 00:00:00
abstract：:Lipases are key enzymes in the hydrolysis of triglycerides, phospholipids, and cholesteryl esters, including those of dietary origin. Their actions are essential to maintain lipid homeostasis and cardiovascular health. This report describes the finding and characterization of a new lipase of endothelial origin, one th...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1999.tb01814.x
更新日期：1999-09-01 00:00:00
abstract：:The aim of this article is to review the definitions and regulations for dietary fiber and whole grains worldwide and to discuss barriers to meeting recommended intake levels. Plant foods, such as whole grains, that are rich in dietary fiber are universally recommended in dietary guidance. Foods rich in dietary fiber ...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1093/nutrit/nuz061
更新日期：2020-08-01 00:00:00
abstract：:This review shows how some transcription factors respond to alterations in macronutrients. Carbohydrates induce enzymes for their metabolism and fatty acid synthesis. Fatty acids reduce carbohydrate processing, induce enzymes for their metabolism, and increase both gluconeogenesis and storage of fat. Fat stores help c...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2008.00039.x
更新日期：2008-06-01 00:00:00
abstract：:Based on the fact that energy content in 1 gram of alcohol is 29 kJ or 7.1 kcal, alcohol consumption can lead to weight gain. The present review was conducted to analyze the effects of alcohol consumption on body weight. A search of the Medline database for the period 1984 to March 2010 was conducted to identify cross...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2011.00403.x
更新日期：2011-08-01 00:00:00
abstract：:Several studies have indicated that omega-3 poly-unsaturated fatty acids in fish oil have protective effects on cardiovascular disease by reducing vascular endothelial inflammation in atherosclerosis. In a recent study, supplementation of patients with fish oil following coronary angioplasty elevated levels of lipid p...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2000.tb07812.x
更新日期：2000-02-01 00:00:00
abstract：:Although body weight is considered to positively affect bones of children and adults, recent studies suggest that overweight and obesity in childhood and adolescence reduce bone mineral content below what would be predicted based on weight and are associated with an increase in incidence of childhood fractures. ...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1301/002966402760240327
更新日期：2002-01-01 00:00:00
abstract：:The identity of the protein responsible for hemochromatosis, the iron overload disease, has eluded scientists for years. However, a recent report identifies the gene where the hemochromatosis defect lies. It is a gene that encodes a major histocompatibility complex (MHC) class-1-like protein called HLA-H. The mechanis...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1996.tb03949.x
更新日期：1996-09-01 00:00:00
abstract：:The increasing prevalence of overweight and obesity highlight the need for improved intervention strategies to counteract this significant public health problem. To this end, it appears that increases in energy expenditure through exercise and other forms of physical activity may be an important component of effective...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2006.tb00235.x
更新日期：2006-02-01 00:00:00
abstract：:Perchlorate inhibits the uptake of iodide into the thyroid gland, thereby possibly affecting the synthesis of thyroid hormones. Pregnant women and their fetuses and newborns have the greatest potential for risk of adverse health effects following exposure to perchlorate. Perchlorate is present in some foods and in dri...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2009.00260.x
更新日期：2010-01-01 00:00:00
abstract：:In vitro studies and some clinical studies suggest that vitamin D plays an important role in reducing inflammation. The objective of this review was to examine recent evidence that vitamin D status influences the level of inflammation in adults without acute illness or injury. Five large cross-sectional studies and tw...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/nure.12095
更新日期：2014-02-01 00:00:00
abstract：:Observational studies document a positive relationship between vitamin D from the environment (sunlight or diet), circulating vitamin D status, and improved symptoms or prevention of multiple sclerosis (MS). Experimental animal models of MS reproduce the beneficial effects of vitamin D and 1,25(OH)(2)D(3). The geograp...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2008.00097.x
更新日期：2008-10-01 00:00:00
abstract：:Although low-income youth are likely to have low or less frequent fruit and vegetable intake, current understanding of the influences on intake in youth is limited. A systematic review of quantitative research on determinants of fruit and vegetable intake among low-income youth (i.e., persons aged <20 years) was condu...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/nure.12126
更新日期：2014-09-01 00:00:00
abstract：:A meta-analysis of 13 case-control studies suggests that intakes of dietary fiber and risk of colon cancer are inversely associated. Weaker associations were observed between risk of colon cancer and dietary intake of ascorbic acid and beta-carotene. ...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1993.tb03091.x
更新日期：1993-05-01 00:00:00
abstract：:In a recent case-control study of 164 patients with clinically diagnosed Alzheimer's disease (AD), including 76 patients with the AD diagnosis confirmed postmortem, mean total serum homocysteine concentration was found to be significantly higher than that of a control group of elderly individuals with no evidence of c...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1999.tb06936.x
更新日期：1999-04-01 00:00:00
abstract：:Reported here is a summary of the proceedings of the Symposium on Plant Polyphenols: Nutrition, Health and Innovations, which was cosponsored by the Southeast Asia Region branch of the International Life Sciences Institute and the Nutrition Society of Malaysia in Kuala Lumpur, Malaysia, June 22-23, 2009. The symposium...
journal_title：Nutrition reviews
pub_type：
doi：10.1111/j.1753-4887.2010.00283.x
更新日期：2010-04-01 00:00:00
abstract：:In cell cultures of carcinogen-initiated fibroblasts, a number of retinoids and carotenoids can reversibly inhibit progression to the transformed state. The anticarcinogenic action of retinoids and carotenoids is closely correlated with enhanced gap-junction cell-to-cell communication and with increased synthesis of t...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1992.tb01345.x
更新日期：1992-09-01 00:00:00
abstract：CONTEXT:Serotonergic dysfunction, including reduced central serotonin levels, is associated with different psychiatric syndromes, including depression. As a serotonin precursor, 5-hydroxytryptophan has long been used as a nonpharmacological treatment for depression. OBJECTIVE:A systematic review and meta-analysis was ...
journal_title：Nutrition reviews
pub_type： 杂志文章,meta分析
doi：10.1093/nutrit/nuz039
更新日期：2020-01-01 00:00:00
abstract：:Innovative approaches are needed to impact obesity and other diet-related chronic diseases, including interventions at the environmental and policy levels. Such interventions are promising due to their wide reach. This article reports on 10 multilevel community trials that the present authors either led (n = 8) or pla...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1093/nutrit/nuw038
更新日期：2017-01-01 00:00:00
abstract：:Patients in the intensive care unit are at high risk of glutamine depletion and subsequent complications. Several controlled studies and a meta-analysis have concluded that glutamine supplementation has beneficial effects on the clinical outcome of critically ill and surgical patients. These results may be explained b...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2005.tb00123.x
更新日期：2005-02-01 00:00:00
abstract：:In response to recent studies from India suggesting that malnutrition, as assessed by anthropometric indexes, affects metabolism of oral progestogens, this study administered a mini-pill containing .35 mg of norethindrone (NET) and combination pills containing 250 or 150 mcg of d-norgestrel (d-NG) and either 50 or 30 ...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1984.tb02317.x
更新日期：1984-05-01 00:00:00
abstract：:The national health promotion program, Health Japan 21 (second term), began in 2013. This program has set 5 basic goals: to extend healthy life expectancy and reduce health disparity, to prevent noncommunicable disease, to improve function for social life, to establish a social environment for health, and to improve l...
journal_title：Nutrition reviews
pub_type： 杂志文章
doi：10.1093/nutrit/nuaa079
更新日期：2020-12-01 00:00:00
abstract：:A recent study indicates that lowering homocysteine with folic acid and vitamin B6 significantly reduces the incidence of abnormal exercise electrocardiography tests and thus decreases the risk of atherosclerotic disease. Questions about study design and sample size, however, suggest that this conclusion may be premat...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2001.tb07016.x
更新日期：2001-07-01 00:00:00
abstract：:Fetal malnutrition has been associated with maturational defect in cell metabolism. A series of studies on anthropometric and clinical aspects of patients with intrauterine malnutrition was conducted to establish the relationship between intrauterine growth failure and cell function. The 1st study assessed intrauter...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1973.tb05171.x
更新日期：1973-06-01 00:00:00
abstract：:A food intake pattern specifying amounts and types of food was created for Canada's revised food guide, Eating Well with Canada's Food Guide (2007), using a two-step modeling process. In step one, food composites were manipulated to develop a food intake pattern. The second step used the step one food intake pattern t...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.2007.tb00295.x
更新日期：2007-04-01 00:00:00
abstract：:Results from human feeding studies and recent large-scale epidemiologic surveys suggest that dietary trans fatty acids enhance the risk of developing coronary heart diseases. Despite a lack of accurate data regarding dietary intake of trans fatty acids, existing epidemiologic data and evidence from experimental feedin...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1111/j.1753-4887.1998.tb01758.x
更新日期：1998-08-01 00:00:00
abstract：:Obesity is an established risk factor for postmenopausal, but not premenopausal, development of breast cancer. Evidence for a positive association between obesity and breast cancer mortality is mounting. Avoiding adult weight gain and maintaining a healthy body weight may contribute importantly to decreasing breast ca...
journal_title：Nutrition reviews
pub_type： 杂志文章,评审
doi：10.1301/nr.2003.febr.73-76
更新日期：2003-02-01 00:00:00
