Adrenal disorders and non-alcoholic fatty liver disease.

Abstract:

:Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the developed world and its pathogenesis is complex and multifactorial. It is considered the hepatic manifestation of the metabolic syndrome and is the leading cause of hepatic cirrhosis. This review aims to present current knowledge on the involvement of the adrenal glands in the development of NAFLD. Clinical and animal studies have shown that excess glucocorticoids (GC) have been implicated in the pathogenesis of NAFLD. Patients with NAFLD seem to have a subtle chronic activation of the hypothalamic pituitary adrenal axis leading to a state of subclinical hypercortisolism. Regulators of GC such as 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), an enzyme that regenerates cortisol from inactive cortisone, and 5α/5β-reductases, enzymes that increase cortisol clearance, are implicated in the development of NAFLD by amplifying local GC action. Adrenal androgen (dehydroepiandrosterone) abnormalities and increased aldosterone levels may also have a role in the development of NAFLD whereas the contribution of adrenergic signaling in NAFLD pathogenesis remains unclear.

journal_name

Minerva Endocrinol

journal_title

Minerva endocrinologica

authors

Papanastasiou L,Fountoulakis S,Vatalas IA

doi

10.23736/S0391-1977.16.02583-9

subject

Has Abstract

pub_date

2017-06-01 00:00:00

pages

151-163

issue

2

eissn

0391-1977

issn

1827-1634

pii

S0391197716025839

journal_volume

42

pub_type

杂志文章,评审
  • Growth hormone-releasing hormone and pituitary somatotrope proliferation.

    abstract::Growth hormone-releasing hormone (GHRH) is a hypothalamic hormone that is essential for normal expansion of the somatotrope lineage during pituitary development. Decreased GHRH secretion and/or action leads to impairment of this process and somatotrope hypoplasia in both humans and experimental animals. Excessive GHRH...

    journal_title:Minerva endocrinologica

    pub_type: 杂志文章,评审

    doi:

    authors: Frohman LA,Kineman RD

    更新日期:2002-12-01 00:00:00

  • Pituitary expansive adenoma. A report of a case and differential diagnosis.

    abstract::Notwithstanding recent neuroendocrinological and neuroradiological findings, about 40% of carriers of pituitary adenoma still reach clinical observation and, consequently, the surgeon, in the stage of suffering from extrasellar extension to a varying degree, especially when the volumetric growth of the lesion is not a...

    journal_title:Minerva endocrinologica

    pub_type: 杂志文章

    doi:

    authors: Russo A

    更新日期:2006-09-01 00:00:00

  • [The role of the endogenous opioid system in the pathogenesis of polycystic ovary syndrome: the altered neuroendocrine regulation of GnRH-LH is corrected after clomiphene therapy].

    abstract::To investigate whether inappropriate LH secretion in Polycystic Ovary Syndrome (PCO) was related to a reduction of inhibitory opioid control on the GnRH-LH system, 23 women affected by PCO (12 obese, BMI: 37.1 +/- 3.9 and 11 non obese, BMI: 21.5 + 2.4) and 19 fertile women (10 obese, BMI: 38.8 + 1.8 and 9 non obese, B...

    journal_title:Minerva endocrinologica

    pub_type: 杂志文章

    doi:

    authors: Barletta C,Vagiri D,Scavo D

    更新日期:1992-07-01 00:00:00

  • New technologies for treating obesity.

    abstract::Obesity has become a national epidemic and a disease of global magnitude. The numbers of patients with obesity have grown exponentially in the last 10 years to the degree that the Centers for Disease Control and Prevention reports that one third of the US population is obese. The prevalence of diabetes has grown by mo...

    journal_title:Minerva endocrinologica

    pub_type: 杂志文章,评审

    doi:

    authors: Bermudez DM,Pories WJ

    更新日期:2013-06-01 00:00:00

  • [Differentiated carcinoma of the thyroid in the young. Clinical and histopathologic aspects].

    abstract:BACKGROUND:The surgical approach to Differentiated Thyroid Carcinoma (DTC) is controversial. Aim of this study is to evaluate the opportunity of total thyroidectomy as treatment of choice for DTC in children. METHODS:We examined the tumor features at diagnosis, the complications of surgery and the clinical outcome in ...

    journal_title:Minerva endocrinologica

    pub_type: 杂志文章

    doi:

    authors: Iurato MP,Scollo C,Belfiore A,Pellegriti G,Salice P,Pezzino V,Giuffrida D

    更新日期:2000-06-01 00:00:00

  • The relationship between phthalates and obesity: serum and urine concentrations of phthalates.

    abstract:BACKGROUND:A limited number of human and animal studies suggest that a relationship exists between phthalates and obesity, although this is not supported by all research. The purpose of this study was to investigate the relationship between Body Mass Index (BMI) and the levels of phthalates in human blood and urine sam...

    journal_title:Minerva endocrinologica

    pub_type: 杂志文章

    doi:10.23736/S0391-1977.16.02295-1

    authors: Oktar S,Sungur S,Okur R,Yilmaz N,Ustun I,Gokce C

    更新日期:2017-03-01 00:00:00

  • [Medical treatment of Cushing syndrome].

    abstract::Cushing's syndrome is a serious endocrine condition for which no treatment has been proven fully satisfactory at least for its pituitary dependent form (Cushing's disease). Indeed, despite some advances in pharmacology (cyproheptadine, bromocriptine, lisuride) and in surgical and radiation procedures at pituitary leve...

    journal_title:Minerva endocrinologica

    pub_type: 杂志文章,评审

    doi:

    authors: Mantero F,Sonino N

    更新日期:1990-01-01 00:00:00

  • Androgens and the skeleton.

    abstract::Loss of estrogens or androgens causes bone loss by increasing the rate of bone remodeling, and also causes an imbalance between resorption and formation by prolonging the lifespan of osteoclasts and shortening the lifespan of osteoblasts. Conversely, treatment with androgens, as well as estrogens, maintains cancellous...

    journal_title:Minerva endocrinologica

    pub_type: 杂志文章,评审

    doi:

    authors: Lindberg MK,Vandenput L,Movèrare Skrtic S,Vanderschueren D,Boonen S,Bouillon R,Ohlsson C

    更新日期:2005-03-01 00:00:00

  • The complex genetic basis of congenital hypogonadotropic hypogonadism.

    abstract::Congenital hypogonadotropic hypogonadism (CHH) is a rare disease characterized by delayed/absent puberty and infertility due to an inadequate secretion or action of gonadotrophin-releasing hormone (GnRH), with an otherwise structurally and functionally normal hypothalamic-pituitary-gonadal (HPG) axis. CHH is genetical...

    journal_title:Minerva endocrinologica

    pub_type: 杂志文章,评审

    doi:

    authors: Vezzoli V,Duminuco P,Bassi I,Guizzardi F,Persani L,Bonomi M

    更新日期:2016-06-01 00:00:00

  • Diagnosis, treatment, clinical course, and prognosis of childhood-onset craniopharyngioma patients.

    abstract::For decades gross-total resection was the preferred treatment option in childhood-onset craniopharyngioma, assuming that radical strategies at the time of initial diagnosis and treatment would result in cure. Recent reports on long-term prognosis, novel treatment approaches, and molecular genetics provide new insights...

    journal_title:Minerva endocrinologica

    pub_type: 杂志文章,meta分析,评审

    doi:10.23736/S0391-1977.17.02615-3

    authors: Müller HL

    更新日期:2017-12-01 00:00:00

  • [Nuclear medicine methods for the diagnosis of adrenal tumors].

    abstract::Adrenal scintigraphy using 131I-6-beta-iodomethyl-19-norcholesterol or 6-methyl-75Se-methyl-19-norcholesterol is a function-dependent imaging method which, in association with high-resolution spatial imaging techniques, plays an essential role in the study of adrenocortical hyperfunction. It can distinguish between bi...

    journal_title:Minerva endocrinologica

    pub_type: 杂志文章,评审

    doi:

    authors: Gregianin M,Bui F,Varotto L,Zucchetta P,Macri C

    更新日期:1995-03-01 00:00:00

  • The cell cycle in steroid hormone regulated proliferation and differentiation.

    abstract::Steroid hormones mediate pleiotropic cellular processes involved in metabolism, cellular proliferation, and differentiation. The ability of the cell to respond to its hormonal environment is transduced by nuclear receptors (NRs) that bind both hormone and DNA. Hence, NRs represent a link between the external hormonal ...

    journal_title:Minerva endocrinologica

    pub_type: 杂志文章,评审

    doi:

    authors: Amanatullah DF,Zafonte BT,Pestell RG

    更新日期:2002-03-01 00:00:00

  • [Changes in hormonal and biochemical parameters in gastric adenocarcinoma].

    abstract::In 51 patients with gastric adenocarcinoma the fasting blood concentrations of hCG, beta hCG, alpha subunits, ADH, calcitonin, enteroglucagon, gastrin, GH, melatonin, somatostatin, estradiol, CEA and pepsinogen I in the peripheral vein were estimated by radioimmunoassay at the time of diagnosis and, in those who under...

    journal_title:Minerva endocrinologica

    pub_type: 杂志文章

    doi:

    authors: Colombo F,Iannotta F,Fachinetti A,Giuliani F,Cornaggia M,Finzi G,Mantero G,Fraschini F,Malesci A,Bersani M

    更新日期:1991-07-01 00:00:00

  • Predicting, managing and preventing new-onset diabetes after transplantation.

    abstract::New-onset diabetes after transplantation (NODAT) or posttransplant diabetes mellitus is a frequent metabolic complication of organ transplantation. Diabetes incidence rates among transplant recipients are higher than in the general population. The estimated rates are 9-18% after kidney, 20-33% after liver, 26-40% afte...

    journal_title:Minerva endocrinologica

    pub_type: 杂志文章,评审

    doi:

    authors: Gosmanov AR,Dagogo-Jack S

    更新日期:2012-09-01 00:00:00

  • The beta-cell death in long-term type 2 diabetes mellitus: never say never again.

    abstract:: ...

    journal_title:Minerva endocrinologica

    pub_type: 杂志文章

    doi:10.23736/S0391-1977.18.02852-3

    authors: Koufakis T,Ioannidis I,Zebekakis P,Kotsa K

    更新日期:2019-03-01 00:00:00

  • Very-low-calorie ketogenic diet for the management of obesity, overweight and related disorders.

    abstract::Very-low-calorie ketogenic diet (VLCKD) is a promising lifestyle intervention for the management of overweight and obesity. It is characterized by a restriction of both calories and carbohydrates, while assuring the adequate proteins, fats and micronutrients intake. Significant results in terms of excess body weight l...

    journal_title:Minerva endocrinologica

    pub_type: 杂志文章

    doi:10.23736/S0391-1977.20.03356-8

    authors: Castellana M,Biacchi E,Procino F,Casanueva FF,Trimboli P

    更新日期:2020-11-19 00:00:00

  • The possible role of endocrine dysfunction of adipose tissue in gestational diabetes mellitus.

    abstract::Gestational diabetes mellitus (GDM) is diabetes that is first diagnosed in the second or third trimester of pregnancy in patients who did not have a history of diabetes before pregnancy. Consequences of GDM include increased risk of macrosomia and birth complications in the infant and an increased risk of maternal typ...

    journal_title:Minerva endocrinologica

    pub_type: 杂志文章

    doi:10.23736/S0391-1977.20.03192-2

    authors: Šimják P,Anderlová K,Cinkajzlová A,Pařízek A,Kršek M,Haluzík M

    更新日期:2020-09-01 00:00:00

  • Effects of adult growth hormone deficiency and growth hormone replacement on circadian rhythmicity.

    abstract::In health, growth hormone (GH) is secreted in a circadian rhythm with superimposed pulsatility. Temporal fluctuations of hormone concentrations are essential for physiological action, and loss of diurnal rhythm is important in the development of disease. GH feedback occurs through the hypothalamus and involves neurope...

    journal_title:Minerva endocrinologica

    pub_type: 杂志文章,评审

    doi:

    authors: White HD,Ahmad AM,Vora JP

    更新日期:2003-03-01 00:00:00

  • Cardiovascular risk factors, carotid artery intima media thickness, and HSCRP levels in patients with impaired glucose metabolism.

    abstract:AIM:The aim of this paper was to compare serum high sensitivity C-reactive protein (HsCRP) levels and carotid artery intima-media thickness (CIMT) of patients with impaired glucose tolerance (IGT) or impaired fasting glucose (IFG) with that in control subjects. METHODS:Ninety-six subjects with prediabetes, 48 with IFG...

    journal_title:Minerva endocrinologica

    pub_type: 杂志文章

    doi:

    authors: Karbek B,Cakal E,Cakir E,Bozkurt N,Unsal I,Sahin M,Delibaşi T

    更新日期:2013-09-01 00:00:00

  • Familial non-medullary thyroid carcinoma: clinico-pathological features, current knowledge and novelty regarding genetic risk factors.

    abstract::Familial non-medullary thyroid cancer (FNMTC) constitutes 3-9% of all thyroid cancers and occur in two or more first-degree relatives in the absence of predisposing environmental factors. Out of all FNMTC cases, only 5% are represented by syndromic forms (Gardner's syndrome, familial adenomatous polyposis, Cowden's sy...

    journal_title:Minerva endocrinologica

    pub_type: 杂志文章

    doi:10.23736/S0391-1977.20.03338-6

    authors: Cirello V

    更新日期:2020-10-12 00:00:00

  • Sleep apnea and cardiovascular complications of the acromegaly. Response to the medical treatment.

    abstract::Acromegaly is a rare disease characterized by high levels of growth hormone (GH) and insulin-like growth factor 1 (IGF-1). The excess of GH leads to the development of different manifestations in different organs, from subtle signs in the bones and soft tissues to the development of respiratory and cardiac insufficien...

    journal_title:Minerva endocrinologica

    pub_type: 杂志文章,评审

    doi:10.23736/S0391-1977.18.02930-9

    authors: García-Álvarez M,Climent V

    更新日期:2019-06-01 00:00:00

  • Measuring ovarian function in young cancer survivors.

    abstract::It is known that young female cancer survivors are at higher risk for decreased fertility and early menopause. Because the risk of these outcomes varies by age, cancer type, treatment regimen and other patient-specific characteristics, there is a need for valid tools for measuring and predicting reproductive function ...

    journal_title:Minerva endocrinologica

    pub_type: 杂志文章,评审

    doi:

    authors: Su HI

    更新日期:2010-12-01 00:00:00

  • Diabetes mellitus and the risk of cancer.

    abstract::Although diabetes has been known to increase the risk of cancer for over a century, it was not until recently when this area gained momentum and generated a lot of interest. That is in- part because of the rising global diabetes epidemic and the wide spread use of insulin analogues, metformin and other anti-diabetic a...

    journal_title:Minerva endocrinologica

    pub_type: 杂志文章,评审

    doi:

    authors: Pandey A,Forte V,Abdallah M,Alickaj A,Mahmud S,Asad S,McFarlane SI

    更新日期:2011-09-01 00:00:00

  • A case of primary hydatidosis of the thyroid gland.

    abstract::A 54-year-old woman presented with an expansive mass in the anterior cervical region (front of the neck) with abscess. Laboratory tests and thyroid profile proved normal. Surgical exploration revealed a hydatid cyst in the left lobe of the thyroid gland with parasitic metastasis of the left lateral cervical lymph node...

    journal_title:Minerva endocrinologica

    pub_type: 杂志文章

    doi:

    authors: Cossu ML,Palermo M,Coppola M,Fais E,Ruggiu M,Tanda F,Cossu Rocca P,Noya G

    更新日期:1999-06-01 00:00:00

  • Tumor and normal thyroid spheroids: from tissues to zebrafish.

    abstract:BACKGROUND:Multicellular spheroids represent an interesting experimental model with promising applications in the pre-clinical studies on anticancer drugs. We recently demonstrated that thyroid spheroids recapitulate the features of the original tissues, in either the differentiated and "stem-like" components. Here we ...

    journal_title:Minerva endocrinologica

    pub_type: 杂志文章

    doi:10.23736/S0391-1977.17.02610-4

    authors: Cirello V,Gaudenzi G,Grassi ES,Colombo C,Vicentini L,Ferrero S,Persani L,Vitale G,Fugazzola L

    更新日期:2018-03-01 00:00:00

  • Neuroprotection of sex steroids.

    abstract::Sex steroids are essential for reproduction and development in animals and humans, and sex steroids also play an important role in neuroprotection following brain injury. New data indicate that sex-specific responses to brain injury occur at the cellular and molecular levels. This review summarizes the current underst...

    journal_title:Minerva endocrinologica

    pub_type: 杂志文章,评审

    doi:

    authors: Liu M,Kelley MH,Herson PS,Hurn PD

    更新日期:2010-06-01 00:00:00

  • Treatment of early breast cancer.

    abstract::Surgical intervention for breast cancer has continually evolved. The current review reports on updates from the pivotal trials, examines areas of controversy, and explores possible future directions. ...

    journal_title:Minerva endocrinologica

    pub_type: 杂志文章,评审

    doi:

    authors: Rao R,Wiechmann L

    更新日期:2009-12-01 00:00:00

  • Effectiveness and safety of liraglutide after three years of treatment.

    abstract:BACKGROUND:The aim of this study was to evaluate long-term effectiveness and safety of liraglutide in real world. METHODS:A diabetes clinic in Italy systematically collected data of all patients treated with liraglutide. Generalized hierarchical linear regression models for repeated measures were applied to assess tre...

    journal_title:Minerva endocrinologica

    pub_type: 杂志文章

    doi:

    authors: Ponzani P,Scardapane M,Nicolucci A,Rossi MC

    更新日期:2016-03-01 00:00:00

  • Diagnosis and treatment of multiple endocrine neoplasia type 1 (MEN1).

    abstract::Multiple endocrine neoplasia type 1 (MEN1; formerly known as Wermer syndrome) is a rare disorder characterized by the combined occurrence of two or more tumors involving parathyroid, pancreatic islets and anterior pituitary glands; some other tumors have also been described. In most cases it is inherited in an autosom...

    journal_title:Minerva endocrinologica

    pub_type: 杂志文章,评审

    doi:

    authors: Gaztambide S,Vazquez F,Castaño L

    更新日期:2013-03-01 00:00:00

  • Bariatric surgery as an option for diabetes mellitus prevention and treatment in obese persons.

    abstract::Bariatric surgery has been found to be very useful in treating established type-2 diabetes in obese persons, as well as in borderline diabetics, besides giving a good weight loss. Various modifications of the primary bariatric procedures have been introduced, with differ advantages and better efficacy. Good incretin r...

    journal_title:Minerva endocrinologica

    pub_type: 杂志文章,评审

    doi:

    authors: Ugale S,Agarwal D,Satwalekar V,Rao N,Ugale A

    更新日期:2016-12-01 00:00:00