Abstract:
:Harmine is the β-carboline alkaloid with the highest concentration in the psychotropic plant decoction Ayahuasca. In rodents, classical antidepressants reverse the symptoms of depression by stimulating neuronal proliferation. It has been shown that Ayahuasca presents antidepressant effects in patients with depressive disorder. In the present study, we investigated the effects of harmine in cell cultures containing human neural progenitor cells (hNPCs, 97% nestin-positive) derived from pluripotent stem cells. After 4 days of treatment, the pool of proliferating hNPCs increased by 71.5%. Harmine has been reported as a potent inhibitor of the dual specificity tyrosine-phosphorylation-regulated kinase (DYRK1A), which regulates cell proliferation and brain development. We tested the effect of analogs of harmine, an inhibitor of DYRK1A (INDY), and an irreversible selective inhibitor of monoamine oxidase (MAO) but not DYRK1A (pargyline). INDY but not pargyline induced proliferation of hNPCs similarly to harmine, suggesting that inhibition of DYRK1A is a possible mechanism to explain harmine effects upon the proliferation of hNPCs. Our findings show that harmine enhances proliferation of hNPCs and suggest that inhibition of DYRK1A may explain its effects upon proliferation in vitro and antidepressant effects in vivo.
journal_name
PeerJjournal_title
PeerJauthors
Dakic V,Maciel RM,Drummond H,Nascimento JM,Trindade P,Rehen SKdoi
10.7717/peerj.2727subject
Has Abstractpub_date
2016-12-06 00:00:00pages
e2727issn
2167-8359pii
2727journal_volume
4pub_type
杂志文章相关文献
PeerJ文献大全abstract:Background:This systematic review aimed to investigate the psychometric properties of the school health's assessment tools in primary schools through COSMIN Risk of Bias checklist. We examined the studies that have addressed the measurement properties of school-health instruments to give a clear overview of the quality...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.9459
更新日期:2020-07-21 00:00:00
abstract:Background:Fatigue influences athletic performance and can also increase the risk of injury in sports, and most of the methods to evaluate it require an additional voluntary effort. Tensiomyography (TMG), which uses electrical stimulation and a displacement sensor to evaluate muscle contraction properties of one or mor...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.8674
更新日期:2020-02-28 00:00:00
abstract::Garden Warblers Sylvia borin were studied during autumn stopover in Crete before crossing the barrier of the Mediterranean Sea and the Sahara Desert. Birds followed with transmitters show extensive stopover periods, which were longer in first-year birds, 16 days, compared with adult birds, 14 days. The distribution of...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.319
更新日期:2014-03-25 00:00:00
abstract::We present a new supertree method that enables rapid estimation of a summary tree on the scale of millions of leaves. This supertree method summarizes a collection of input phylogenies and an input taxonomy. We introduce formal goals and criteria for such a supertree to satisfy in order to transparently and justifiabl...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.3058
更新日期:2017-03-01 00:00:00
abstract:Background:Fibroblast growth factor 2 (FGF2) is a highly pleiotropic cytokine with antifibrotic activity in wound healing. During the process of wound healing and fibrosis, fibroblasts are the key players. Although accumulating evidence has suggested the antagonistic effects of FGF2 in the activation process of fibrobl...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10671
更新日期:2021-01-15 00:00:00
abstract::Following a radiation incident, preliminary dose estimates made by γ-H2AX foci analysis can supplement the early triage of casualties based on clinical symptoms. Sample processing time is important when many individuals need to be rapidly assessed. A protocol was therefore developed for high sample throughput that req...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.282
更新日期:2014-03-06 00:00:00
abstract::Ethylene response factors (ERFs) are plant-specific transcription factors (TFs) that play important roles in plant growth and stress defense and have received a great amount of attention in recent years. In this study, seven ERF genes related to abiotic stress tolerance and response were identified in plants of the Po...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.10206
更新日期:2020-10-20 00:00:00
abstract:Background:In the predator-sea urchin-macrophyte trophic cascade, the ecological effect of sea urchins as grazers depends both on their density and the changes in foraging activity, which are influenced by various disturbing factors. However, the complete duration of the alarm reactions of echinoids has not been studie...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.8087
更新日期:2019-11-22 00:00:00
abstract:Background:Ecosystem engineers are species that transform habitats in ways that influence other species.While the impacts of many engineers have been well described, our understanding of how their impact varies along environmental gradients remains limited. Although disentangling the effects of gradients and engineers ...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.5612
更新日期:2018-10-09 00:00:00
abstract::Ocean acidification (OA) is one of the most significant threats to marine life, and is predicted to drive important changes in marine communities. Although OA impacts will be the sum of direct effects mediated by alterations of physiological rates and indirect effects mediated by shifts in species interactions and bio...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.5327
更新日期:2018-07-31 00:00:00
abstract::Body condition is an important determinant of health, and its evaluation has practical applications for the conservation and management of mammals. We developed a noninvasive method that uses photographs to assess the body condition of free-ranging brown bears (Ursus arctos) in the Shiretoko Peninsula, Hokkaido, Japan...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.9982
更新日期:2020-09-18 00:00:00
abstract::The aim of this study was to analyze the influence of smoking habits and other possibly relevant factors on dental implant survival. The study population included all patients who underwent dental implants between the years 1999 and 2008 at a large military dental clinic and were examined in the periodic medical exami...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.546
更新日期:2014-09-02 00:00:00
abstract::Solanum lycopersicum, belonging to Solanaceae, is one of the commonly used model plants. The GRAS genes are transcriptional regulators, which play a significant role in plant growth and development, and the functions of several GRAS genes have been recognized, such as, axillary shoot meristem formation, radial root pa...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.3955
更新日期:2017-11-08 00:00:00
abstract::Background. Recurrent pain is a common experience in childhood, but only few children with recurrent pain attend a physician. Previous studies yielded conflicting findings with regard to predictors of health care utilization in children with recurrent pain. Methods. The present study analyzes data from the German Heal...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.916
更新日期:2015-04-28 00:00:00
abstract::Wing pigmentation in Calopteryx damselflies, caused by the deposition of melanin, is energetically expensive to produce and enhances predation risk. However, patterns of melanisation are used in species identification, greater pigmentation is an accurate signal of male immune function in at least some species, and the...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.438
更新日期:2014-06-10 00:00:00
abstract:Background:Hair follicles in cashmere goats are divided into primary and secondary hair follicles (HFs). HF development, which determines the morphological structure, is regulated by a large number of vital genes; however, the key functional genes and their interaction networks are still unclear. Although the vitamin D...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.7230
更新日期:2019-07-03 00:00:00
abstract::The ubiquitin-proteasome system targets misfolded proteins for degradation. Since the accumulation of such proteins is potentially harmful for the cell, their prompt removal is important. E3 ubiquitin-protein ligases mediate substrate ubiquitination by bringing together the substrate with an E2 ubiquitin-conjugating e...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.1725
更新日期:2016-02-25 00:00:00
abstract:Background:Banteng (Bos javanicus d'Alton 1823) are an endangered species, highly sensitive to habitat structure and quality. In many areas, banteng were extinct and needed to be reintroduced to restore their population. Thus, understanding the responses of body condition of reintroduced banteng to their habitat was im...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.9041
更新日期:2020-04-23 00:00:00
abstract::Lead (Pb) is a ubiquitous pollutant which poses serious threats to plants, animals and humans once entered into the food chain via contaminated industrial effluents on their discharge into the surface of water bodies and/or geological materials. This study aimed to examine and compare the biosorption potential of natu...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.5672
更新日期:2018-09-28 00:00:00
abstract:BACKGROUND:With their Pan-American distribution, long-nosed armadillos (genus Dasypus) constitute an understudied model for Neotropical biogeography. This genus currently comprises seven recognized species, the nine-banded armadillo (D. novemcinctus) having the widest distribution ranging from Northern Argentina to the...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.3593
更新日期:2017-08-15 00:00:00
abstract::Insulin-like growth factor 2 (IGF2) and dopamine receptor 2 (DRD2) play important roles in ovarian follicular development. In this study, we analyzed tissue-specific expression of the Muscovy duck IGF2 and DRD2 genes and cloned those genes transcripts. Polymorphisms in these genes were tightly linked with egg producti...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.4083
更新日期:2017-11-23 00:00:00
abstract::A new species of freshwater crab, Fredius ibiapaba, is described and illustrated from a mid-altitude forested patch in Ipú (Ibiapaba plateau, Ceará, northeastern Brazil), between 635 to 782 m. The new species can be separated from its congeners by the morphology of its first gonopod: proximal half remarkably swollen, ...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.9370
更新日期:2020-06-29 00:00:00
abstract:BACKGROUND:Information on cardiovascular gene transcription is fragmented and far behind the present requirements of the systems biology field. To create a comprehensive source of data for cardiovascular gene regulation and to facilitate a deeper understanding of genomic data, the CardioTF database was constructed. The...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.2339
更新日期:2016-08-23 00:00:00
abstract:Purpose:To explore whether unilateral relapse of Bechet's disease-associated uveitis (BDU) causes differences in the tear proteome between the diseased and the contralateral quiescent eye and potential tear biomarkers for uveitis recurrence and disease monitoring. Method:To minimize interindividual variations, bilater...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.9250
更新日期:2020-06-19 00:00:00
abstract::Microbes ubiquitously inhabit animals and plants, often affecting their host's phenotype. As a result, even in a constant genetic background, the host's phenotype may evolve through indirect selection on the microbiome. 'Microbiome engineering' offers a promising novel approach for attaining desired host traits but ha...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.9350
更新日期:2020-07-01 00:00:00
abstract::Motor unit synchronization is the tendency of motor neurons and their associated muscle fibers to discharge near-simultaneously. It has been theorized as a control mechanism for force generation by common excitatory inputs to these motor neurons. Magnitude of synchronization is calculated from peaks in cross-correlati...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.7907
更新日期:2019-12-10 00:00:00
abstract:BACKGROUND:Habitat selection and its adaptive outcomes are crucial features for animal life-history strategies. Nevertheless, congruence between habitat preferences and breeding success has been rarely demonstrated, which may result from the single-scale evaluation of animal choices. As habitat selection is a complex m...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.3164
更新日期:2017-03-28 00:00:00
abstract::Genome sequencing is rapidly being adopted in reference labs and hospitals for bacterial outbreak investigation and diagnostics where time is critical. Seven gene multi-locus sequence typing is a standard tool for broadly classifying samples into sequence types (STs), allowing, in many cases, to rule a sample out of a...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.5233
更新日期:2018-07-31 00:00:00
abstract::Previous research has shown that odorants consistently evoke associations with textures and their tactile properties like smoothness and roughness. Also, it has been observed that olfaction can modulate tactile perception. We therefore hypothesized that tactile roughness perception may be biased towards the somatosens...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.955
更新日期:2015-05-12 00:00:00
abstract::Two forms of the monstrilloid copepod, one represented by males, the other by females, were dominant among the monstrilloids collected while sampling zooplankton with a light trap in southern coastal waters of Korea. Morphological examination revealed that the males are conspecific with the previously reported and rat...
journal_title:PeerJ
pub_type: 杂志文章
doi:10.7717/peerj.4938
更新日期:2018-06-13 00:00:00