Abstract：
:Corticotropin-releasing hormone (CRH) is a key component of the neuroendocrine response to stress. In animal models, CRH has been shown to modulate dopamine release, and this interaction is believed to contribute to stress-induced relapse in neuropsychiatric disorders. Here we investigated whether CRH administration induces dopamine release in humans, using positron emission tomography (PET). Eight healthy volunteers (5 female, 22-48 years old) completed two PET scans with the dopamine D2/3 receptor radioligand [11C]-(+)-PHNO: once after saline injection, and once after injection of corticorelin (synthetic human CRH). We also assessed subjective reports and measured plasma levels of endocrine hormones (adrenocorticotropic hormone and cortisol). Relative to saline, corticorelin administration decreased binding of the D2/3 PET probe [11C]-(+)-PHNO, suggesting dopamine release. Endocrine stress markers were also elevated, in line with activation of the hypothalamic-pituitary-adrenal axis, but we detected no changes in subjective ratings. Preliminary results from this proof-of-concept study suggests that CRH challenge in combination with [11C]-(+)-PHNO PET may serve as an assay of dopamine release, presenting a potential platform for evaluating CRH/dopamine interactions in neuropsychiatric disorders and CRH antagonists as potential treatment avenues.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Payer D,Williams B,Mansouri E,Stevanovski S,Nakajima S,Le Foll B,Kish S,Houle S,Mizrahi R,George SR,George TP,Boileau Idoi
10.1016/j.psyneuen.2016.11.034subject
Has Abstractpub_date
2017-02-01 00:00:00pages
192-196eissn
0306-4530issn
1873-3360pii
S0306-4530(16)30965-9journal_volume
76pub_type
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