Abstract：
PURPOSE:The purpose of this study was to compare screening methods for the early detection of maculopathy in patients treated with chloroquine (CQ) or hydroxychloroquine (HCQ) and to identify the risk factors for the development of toxic maculopathy. METHODS:We performed a prospective study of all 217 patients taking CQ and/or HCQ and seen in our center between July 2011 and December 2013. All subjects underwent a complete ocular examination, as well as spectral domain optical coherence tomography (SD-OCT), fundus autofluorescence (FAF), and 10-2 Humphrey visual field (10-2 HVF). RESULTS:The median age of patients was 51 years, median CQ/HCQ duration was 40 months, and median cumulative dose was 180 g. The prevalence of at least two abnormal tests was 7.4% (16/217). SD-OCT had the highest sensitivity, specificity, predictive values and accuracy while 10-2 HVF showed in 30% of nonreliable results and had the lowest specificity and positive predictive value. In multivariate analysis, an age of older than 60 years (P = 0.002), CQ duration of more than 5 years (P < 0.001), and CQ dose more than 3 mg/kg/day (P = 0.005) were associated with toxicity. CONCLUSIONS:In patients with unreliable outcomes of 10-2 HVF testing, SD-OCT in combination with FAF might represent a suitable alternative screening tool for toxic maculopathy.
journal_name
Indian J Ophthalmoljournal_title
Indian journal of ophthalmologyauthors
Kunavisarut P,Chavengsaksongkram P,Rothova A,Pathanapitoon Kdoi
10.4103/0301-4738.195018subject
Has Abstractpub_date
2016-10-01 00:00:00pages
710-714issue
10eissn
0301-4738issn
1998-3689pii
IndianJOphthalmol_2016_64_10_710_195018journal_volume
64pub_type
杂志文章abstract：PURPOSE:To ascertain if the polymerization reaction also contributes additionally to the antibacterial effects of two commonly used cyanoacrylate tissue adhesives. MATERIALS AND METHODS:Fresh liquid ethyl-cyanoacrylate (EC) and N-butyl-cyanoacrylate (BC) adhesives were applied onto 6-mm sterile filter paper discs. In ...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/0301-4738.55065
更新日期：2009-09-01 00:00:00
abstract：PURPOSE:To study the time course of interface healing and its correlation with visual acuity, modulation transfer function (MTF), and aberrations after myopic small-incision lenticule extraction (SMILE) correction. METHODS:Seventy-eight eyes of 78 patients (1 eye per patient) with a mean age of 25.7 years and mean sph...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/ijo.IJO_775_17
更新日期：2018-02-01 00:00:00
abstract：:A 10-year-old girl presented to us with inferonasally displaced, non-axial proptosis of oculus dexter (OD), with ipsilateral, painless massive cervical lymphadenopathy of ten weeks duration. After a detailed hematological work-up and imaging, the histological evidence obtained on cervical lymph node biopsy established...
journal_title：Indian journal of ophthalmology
pub_type：
doi：10.4103/ijo.IJO_1596_18
更新日期：2019-07-01 00:00:00
abstract：:To describe the optical coherence tomography (OCT) and electrophysiological changes in a case of closantel toxicity. A 25-year-old patient presented with sudden painless defective vision following intake of closantel. Visual acuity (VA) was counting fingers at 5 m in both eyes (BE). OCT revealed disruption of outer re...
journal_title：Indian journal of ophthalmology
pub_type：
doi：10.4103/ijo.IJO_2070_18
更新日期：2019-10-01 00:00:00
abstract：:Simultaneous corneal cross-linking (CXL) has been proposed as an adjunct therapy to corneal refractive procedures to prevent future ectasia, especially when performed in borderline corneas. This review analyses the currently available literature (minimum follow-up 6 months) on corneal refractive surgery and simultaneo...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.4103/ijo.IJO_1709_20
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:Retinopathy of prematurity (ROP) is an important cause of childhood blindness in developing countries. AIM:To report the spectrum of ROP and associated risk factors in babies weighing > 1250 g at birth in a developing country. SETTING AND DESIGN:Institutional, retrospective, non-randomized, observational c...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/0301-4738.33817
更新日期：2007-09-01 00:00:00
abstract：PURPOSE:The objective of the study was to assess the awareness and health-seeking practices related to cataract in urban slums of Delhi. METHODS:This study design was a population-based cross-sectional study. Participants aged 18-60 years were recruited from randomly selected five slums of South Delhi. They were inter...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章,多中心研究
doi：10.4103/ijo.IJO_585_16
更新日期：2017-12-01 00:00:00
abstract：CONTEXT:There are few reports on the management of extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type (MALT), which are based on the experience of a single institution, as opposed to large multicenter randomized trials. AIM:The aim of this study was to report on the clinical experience ...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/0301-4738.81993
更新日期：2011-07-01 00:00:00
abstract：:Juvenile diabetics have severe loss of beta cell function and require replacement therapy with insulin. Insulin antigenicity can produce anti-insulin antibodies resulting in allergic reactions and insulin resistance. The role of insulin-anti-insulin antibody complexes in the development and progress of chronic diabeti...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：1991-10-01 00:00:00
abstract：:A 15-year-old female child with history of bilateral poor vision since childhood presented with sudden onset pain, photophobia, and diminution of vision OD for 10 days. Visual acuity was hand motion OD and 1/60 OS. Slit lamp examination revealed microcornea OU with multiple intrastromal fluid clefts OD and an irregula...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/ijo.IJO_1671_18
更新日期：2019-08-01 00:00:00
abstract：: ...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/ijo.IJO_469_18
更新日期：2018-11-01 00:00:00
abstract：BACKGROUND AND AIM:Central corneal thickness (CCT) of term and preterm infants in Indian population is not known. We did a prospective noninterventional study to measure the CCT in term and preterm infants. MATERIALS AND METHODS:An ultrasonic pachymeter was used. The data regarding the date of birth, expected date of ...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/0301-4738.162601
更新日期：2015-06-01 00:00:00
abstract：:We describe a case of neurotrophic keratitis in association with dihydroxypyrimidine dehydrogenase (DHPD) deficiency. Ocular manifestations in patients with DHPD are rare and neurotrophic keratitis has never been reported before. A six-year-old boy who was a known case of DHPD deficiency and born of a consanguineous m...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/0301-4738.41422
更新日期：2008-07-01 00:00:00
abstract：BACKGROUND:India is a signatory to the World Health Organization resolution on Vision 2020: The right to sight. Efforts of all stakeholders have resulted in increased number of cataract surgeries performed in India, but the impact of these efforts on the elimination of avoidable blindness is unknown. AIMS:Projection o...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/0301-4738.42774
更新日期：2008-11-01 00:00:00
abstract：:This study was conducted to determine awareness and practices relating to diabetic retinopathy among non-medical persons in a south Indian population. In this population-based cross-sectional study, trained social workers conducted face-to-face interviews using a semi-structured questionnaire with 200 randomly selecte...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：
更新日期：2004-09-01 00:00:00
abstract：PURPOSE:This study aims to investigate the levels of aqueous vascular endothelial growth factor (VEGF) in diabetic patient groups in comparison to normal subjects, and to correlate elevated VEGF with the severity of diabetic retinopathy (DR). MATERIALS AND METHODS:Aqueous samples were obtained from 78 eyes of 74 patie...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/0301-4738.67042
更新日期：2010-09-01 00:00:00
abstract：: ...
journal_title：Indian journal of ophthalmology
pub_type： 社论
doi：10.4103/ijo.IJO_1894_18
更新日期：2018-12-01 00:00:00
abstract：:New treatment modalities for the management of central serous chorioretinopathy (CSC) now exist. While acute CSC generally resolves without the requirement for intervention, chronic CSC has been associated with persistent disruption in visual function. Current treatment approaches include photodynamic therapy, oral al...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.4103/ijo.IJO_1077_18
更新日期：2018-12-01 00:00:00
abstract：:Toric intraocular lenses (IOLs) are the procedure of choice to correct corneal astigmatism of 1 D or more in cases undergoing cataract surgery. Comprehensive literature search was performed in MEDLINE using "toric intraocular lenses," "astigmatism," and "cataract surgery" as keywords. The outcomes after toric IOL impl...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.4103/ijo.IJO_810_17
更新日期：2017-12-01 00:00:00
abstract：:Globe luxation is a rare clinical event. Most of the cases are usually traumatic, although spontaneous globe luxation has also been reported. The majority of the posttraumatic cases are usually associated with the injury or fracture of the bony orbit. We report here a case of globe luxation that occurred per se withou...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/0301-4738.169795
更新日期：2015-08-01 00:00:00
abstract：:Retinal racemose hemangiomas (RRH) are vascular malformations comprising of direct arteriovenous communications in the retina. Exudation and neurosensory detachment are some of the complications which may cause decreased visual acuity. Herein, we describe a case of a 38-year-old male presenting with unilateral Group I...
journal_title：Indian journal of ophthalmology
pub_type：
doi：10.4103/ijo.IJO_293_20
更新日期：2020-10-01 00:00:00
abstract：:Aripiprazole is a new drug for the treatment of adults with schizophrenia. Ocular side effects of aripiprazole are very rare. Review of literature revealed few cases of aripiprazole-induced myopia. We report a rare case of aripiprazole-induced transient myopia. A 22-year-old female patient presented to the department ...
journal_title：Indian journal of ophthalmology
pub_type：
doi：10.4103/ijo.IJO_907_16
更新日期：2018-01-01 00:00:00
abstract：:Many of the causes of childhood blindness are avoidable, being either preventable or treatable. Retinopathy of prematurity (ROP) remains one of the most preventable causes of childhood blindness worldwide. Currently, India is facing the third epidemic of ROP. In India, the health system involving the mother and child ...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.4103/ijo.IJO_700_18
更新日期：2019-06-01 00:00:00
abstract：:Calcinosis cutis is a rare metabolic disorder characterized by cutaneous and subcutaneous deposition of insoluble calcium salts. Ocular adnexal involvement is uncommon but mostly seen in males and in the upper eyelid. Solitary lesions are more common than multiple. The treatment of choice is excision biopsy. Histopath...
journal_title：Indian journal of ophthalmology
pub_type：
doi：10.4103/ijo.IJO_1185_17
更新日期：2018-05-01 00:00:00
abstract：:The case report incorporates a Fourier-domain optical coherence tomography (OCT) examination for demonstration of the existence of pre-Descemet's layer (PDL; Dua's layer) overlying a descemetocele and demonstrates predescemetocele as a separate clinical entity. The prospective analysis was done in two cases that had d...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/ijo.IJO_492_17
更新日期：2017-11-01 00:00:00
abstract：:Cutaneous lupus erythematosus is a previously undiagnosed side-effect of ranibizumab. Here, we present a case of an 82-year-old female Caucasian patient with wet age-related macular degeneration. Following a single intraocular injection of Lucentis (ranibizumab), she developed a subacute cutaneous lupus erythematosus ...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/0301-4738.121133
更新日期：2013-12-01 00:00:00
abstract：:We conducted an institutional-based retrospective study on 308 uveitic patients and analyzed the pattern of uveitis in Northeastern India. Anterior uveitis was the most common type (47.07%) followed by posterior (29.87%), intermediate (12.98%) and panuveitis (10.06%). Toxoplasmosis (40.21%) had the highest incidence a...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/0301-4738.45506
更新日期：2009-03-01 00:00:00
abstract：OBJECTIVE:Evaluation of the clinical profile and distribution of different sub-types of amblyopia in a referral eye hospital in India. METHODS:This was a prospective hospital-based observational study, evaluating the clinical profile of patients with amblyopia presenting to a referral strabismology practice. The exami...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/0301-4738.18903
更新日期：2005-12-01 00:00:00
abstract：:Keratoconus is a progressive corneal thinning disease associated with significant tissue remodeling activities and activation of a variety of signaling networks. However, it is not understood how differential gene and protein expression direct function in keratoconus corneas to drive the underlying pathology, ectasia....
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章,评审
doi：10.4103/0301-4738.116056
更新日期：2013-08-01 00:00:00
abstract：Purpose:To analyze the outcome of cataract surgery in patients with ocular tuberculosis (OTB). Methods:Medical records of patients with OTB who underwent cataract surgery between 2005 and 2018 were retrospectively reviewed. The primary outcome measure was corrected distant visual acuity (CDVA), and a good outcome was ...
journal_title：Indian journal of ophthalmology
pub_type： 杂志文章
doi：10.4103/ijo.IJO_428_20
更新日期：2020-09-01 00:00:00
