Control of Biofilm Formation: Antibiotics and Beyond.

Abstract:

:Biofilm-associated bacteria are less sensitive to antibiotics than free-living (planktonic) cells. Furthermore, with variations in the concentration of antibiotics throughout a biofilm, microbial cells are often exposed to levels below inhibitory concentrations and may develop resistance. This, as well as the irresponsible use of antibiotics, leads to the selection of pathogens that are difficult to eradicate. The Centers for Disease Control and Prevention use the terms "antibiotic" and "antimicrobial agent" interchangeably. However, a clear distinction between these two terms is required for the purpose of this assessment. Therefore, we define "antibiotics" as pharmaceutically formulated and medically administered substances and "antimicrobials" as a broad category of substances which are not regulated as drugs. This comprehensive minireview evaluates the effect of natural antimicrobials on pathogens in biofilms when used instead of, or in combination with, commonly prescribed antibiotics.

journal_name

Appl Environ Microbiol

authors

Algburi A,Comito N,Kashtanov D,Dicks LMT,Chikindas ML

doi

10.1128/AEM.02508-16

subject

Has Abstract

pub_date

2017-01-17 00:00:00

issue

3

eissn

0099-2240

issn

1098-5336

pii

AEM.02508-16

journal_volume

83

pub_type

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