当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Downregulation of oncogenic RAS and c-Myc expression in MOLT-4 leukaemia cells by a salicylaldehyde semicarbazone copper(II) complex.

Downregulation of oncogenic RAS and c-Myc expression in MOLT-4 leukaemia cells by a salicylaldehyde semicarbazone copper(II) complex.

Abstract：

:Copper complexes with potent anti-tumor effect have been extensively developed. Most investigations of their modes of action focused on the biomolecular targets but not the signal transduction between target binding and cell death. We have previously shown that the cytotoxic complex pyridine(2,4-dihydroxybenzaldehyde dibenzyl semicarbazone)copper(II) (complex 1) shows selective binding to human telomeric G-quadruplex DNA over double-stranded DNA in vitro. Herein, we elucidate the mechanism of action by which complex 1 induces apoptosis in MOLT-4 cells. Complex 1 accumulates in the nuclei and differentially downregulates the expression of c-Myc, c-Kit and KRAS oncogenes. Chemical affinity capture assay results show that the complex is associated with c-Myc and KRAS quadruplex sequences in MOLT-4 cells. We further showed that the reduction in Ras protein expression resulted in attenuated MEK-ERK and PI3K-Akt signalling activities, leading to the activation of caspase-dependent apoptosis. Notably, complex 1 increased the sensitivity of MOLT-4 cells to cisplatin and vice versa. Overall, we demonstrated that complex 1 induces apoptosis, at least in part, by suppressing KRAS, c-Kit and c-Myc oncogene expression and the pro-survival MEK-ERK and PI3K-Akt signalling pathways.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Goh YY,Yan YK,Tan NS,Goh SA,Li S,Teoh YC,Lee PP

doi

10.1038/srep36868

subject

Has Abstract

pub_date

2016-11-14 00:00:00

pages

36868

issn

2045-2322

pii

srep36868

journal_volume

6

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Disease-free monoculture farming by fungus-growing termites.

    abstract：:Fungus-growing termites engage in an obligate mutualistic relationship with Termitomyces fungi, which they maintain in monocultures on specialised fungus comb structures, without apparent problems with infectious diseases. While other fungi have been reported in the symbiosis, detailed comb fungal community analyses h...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-45364-z

    authors： Otani S,Challinor VL,Kreuzenbeck NB,Kildgaard S,Krath Christensen S,Larsen LLM,Aanen DK,Rasmussen SA,Beemelmanns C,Poulsen M

    更新日期：2019-06-19 00:00:00

  • Heart rate acceleration at relative workloads during treadmill and overground running for tracking exercise performance during functional overreaching.

    abstract：:Maximal rate of heart rate (HR) increase (rHRI) as a measure of HR acceleration during the transition from rest to exercise, or during an increase in workload, tracks exercise performance. rHRI assessed at relative rather than absolute workloads may track performance better, and a field test would increase applicabili...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-71597-4

    authors： Bellenger CR,Thomson RL,Robertson EY,Davison K,Nelson MJ,Karavirta L,Buckley JD

    更新日期：2020-09-03 00:00:00

  • Quantum control and characterization of ultrafast ionization with orthogonal two-color laser pulses.

    abstract：:We study ultrafast ionization dynamics using orthogonally polarized two-color (OTC) laser pulses involving the resonant "first plus second" (ω + 2ω) scheme. The scheme is illustrated by numerical simulations of the time-dependent Schrödinger equation and recording the photoelectron momentum distribution. On the basis ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-57125-z

    authors： Agueny H

    更新日期：2020-01-14 00:00:00

  • Climate- and gateway-driven cooling of Late Eocene to earliest Oligocene sea surface temperatures in the North Sea Basin.

    abstract：:During the late Eocene, the Earth's climate experienced several transient temperature fluctuations including the Vonhof cooling event (C16n.1n; ~35.8 Ma) hitherto known mainly from the southern oceans. Here we reconstruct sea-surface temperatures (SST) and provide δ18O and δ13C foraminiferal records for the late Eocen...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-41013-7

    authors： Śliwińska KK,Thomsen E,Schouten S,Schoon PL,Heilmann-Clausen C

    更新日期：2019-03-14 00:00:00

  • Carbon Redox-Polymer-Gel Hybrid Supercapacitors.

    abstract：:Energy storage devices that provide high specific power without compromising on specific energy are highly desirable for many electric-powered applications. Here, we demonstrate that polymer organic radical gel materials support fast bulk-redox charge storage, commensurate to surface double layer ion exchange at carbo...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep22194

    authors： Vlad A,Singh N,Melinte S,Gohy JF,Ajayan PM

    更新日期：2016-02-26 00:00:00

  • Catalytic performance of the Ce-doped LaCoO3 perovskite nanoparticles.

    abstract：:A series of La1-xCexCoO3 perovskite nanoparticles with rhombohedral phases was synthesized via sol-gel chemical process. X-ray diffraction (XRD), Transmission Electron Microscopy (TEM), Electron Diffraction Spectroscopy (EDS), Thermogravimetric Analysis (TGA), UV-Vis spectroscopy, Fourier Transform Infrared spectra (F...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-71869-z

    authors： Ansari AA,Adil SF,Alam M,Ahmad N,Assal ME,Labis JP,Alwarthan A

    更新日期：2020-09-14 00:00:00

  • Appropriate reference region selection of 18F-florbetaben and 18F-flutemetamol beta-amyloid PET expressed in Centiloid.

    abstract：:The Centiloid (CL) is a method for standardizing amyloid beta (Aβ) quantification through different ligands and methods. To find the most appropriate reference region to reduce the variance in the Aβ CL unit between 18F-florbetaben (FBB) and 18F-flutemetamol (FMM), we conducted head-to-head comparisons from 56 partici...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-70978-z

    authors： Cho SH,Choe YS,Park S,Kim YJ,Kim HJ,Jang H,Kim SJ,Kim JP,Jung YH,Kim BC,Na DL,Moon SH,Seo SW

    更新日期：2020-09-11 00:00:00

  • Quality of non-expert citizen science data collected for habitat type conservation status assessment in Natura 2000 protected areas.

    abstract：:EU biodiversity conservation policy is based on the Habitats Directive (92/43/EC), which aims that habitat types and species of Community interest should reach 'favourable conservation status'. To this end, Member States are obliged to perform periodic assessment of species and habitat conservation status through biod...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-09316-9

    authors： Kallimanis AS,Panitsa M,Dimopoulos P

    更新日期：2017-08-21 00:00:00

  • Suspending effect on low-frequency charge noise in graphene quantum dot.

    abstract：:Charge noise is critical in the performance of gate-controlled quantum dots (QDs). Such information is not yet available for QDs made out of the new material graphene, where both substrate and edge states are known to have important effects. Here we show the 1/f noise for a microscopic graphene QD is substantially lar...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep08142

    authors： Song XX,Li HO,You J,Han TY,Cao G,Tu T,Xiao M,Guo GC,Jiang HW,Guo GP

    更新日期：2015-01-30 00:00:00

  • Entropic uncertainty relations for Markovian and non-Markovian processes under a structured bosonic reservoir.

    abstract：:The uncertainty relation is a fundamental limit in quantum mechanics and is of great importance to quantum information processing as it relates to quantum precision measurement. Due to interactions with the surrounding environment, a quantum system will unavoidably suffer from decoherence. Here, we investigate the dyn...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-01094-8

    authors： Wang D,Huang AJ,Hoehn RD,Ming F,Sun WY,Shi JD,Ye L,Kais S

    更新日期：2017-04-21 00:00:00

  • Active dynamics of colloidal particles in time-varying laser speckle patterns.

    abstract：:Colloidal particles immersed in a dynamic speckle pattern experience an optical force that fluctuates both in space and time. The resulting dynamics presents many interesting analogies with a broad class of non-equilibrium systems like: active colloids, self propelled microorganisms, transport in dynamical intracellul...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep27681

    authors： Bianchi S,Pruner R,Vizsnyiczai G,Maggi C,Di Leonardo R

    更新日期：2016-06-09 00:00:00

  • Oxygen consumption rate of Caenorhabditis elegans as a high-throughput endpoint of toxicity testing using the Seahorse XFe96 Extracellular Flux Analyzer.

    abstract：:Caenorhabditis elegans presents functioning, biologically relevant phenotypes and is frequently used as a bioindicator of toxicity. However, most C. elegans in vivo effect-assessment methods are laborious and time consuming. Therefore, we developed a novel method to measure the oxygen consumption rate of C. elegans as...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-61054-7

    authors： Preez GD,Fourie H,Daneel M,Miller H,Höss S,Ricci C,Engelbrecht G,Zouhar M,Wepener V

    更新日期：2020-03-06 00:00:00

  • Discovery of human-like L-asparaginases with potential clinical use by directed evolution.

    abstract：:L-asparaginase is a chemotherapy drug used to treat acute lymphoblastic leukemia (ALL). The main prerequisite for clinical efficacy of L-asparaginases is micromolar KM for asparagine to allow for complete depletion of this amino acid in the blood. Since currently approved L-asparaginases are of bacterial origin, immun...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-10758-4

    authors： Rigouin C,Nguyen HA,Schalk AM,Lavie A

    更新日期：2017-08-31 00:00:00

  • Fermionic order by disorder in a van der Waals antiferromagnet.

    abstract：:CeTe3 is a unique platform to investigate the itinerant magnetism in a van der Waals (vdW) coupled metal. Despite chemical pressure being a promising route to boost quantum fluctuation in this system, a systematic study on the chemical pressure effect on Ce3+(4f1) states is absent. Here, we report on the successful gr...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-72300-3

    authors： Okuma R,Ueta D,Kuniyoshi S,Fujisawa Y,Smith B,Hsu CH,Inagaki Y,Si W,Kawae T,Lin H,Chuang FC,Masuda T,Kobayashi R,Okada Y

    更新日期：2020-09-17 00:00:00

  • The dorsal arcopallium of chicks displays the expression of orthologs of mammalian fear related serotonin receptor subfamily genes.

    abstract：:Fear is an adaptive emotion that elicits defensive behavioural responses against aversive threats in animals. In mammals, serotonin receptors (5-HTRs) have been shown to modulate fear-related neural circuits in the basolateral amygdala complex (BLA). To understand the phylogenetic continuity of the neural basis for fe...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-78247-9

    authors： Fujita T,Aoki N,Mori C,Fujita E,Matsushima T,Homma KJ,Yamaguchi S

    更新日期：2020-12-03 00:00:00

  • Low-temperature remote plasma enhanced atomic layer deposition of ZrO2/zircone nanolaminate film for efficient encapsulation of flexible organic light-emitting diodes.

    abstract：:Encapsulation is essential to protect the air-sensitive components of organic light-emitting diodes (OLEDs) such as active layers and cathode electrodes. In this study, hybrid zirconium inorganic/organic nanolaminates were fabricated using remote plasma enhanced atomic layer deposition (PEALD) and molecular layer depo...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep40061

    authors： Chen Z,Wang H,Wang X,Chen P,Liu Y,Zhao H,Zhao Y,Duan Y

    更新日期：2017-01-06 00:00:00

  • The Effect of Rotational Disorder on the Microwave Transmission of Checkerboard Metal Square Arrays.

    abstract：:The effect of rotational disorder on the microwave transmission through thin metallic checkerboard arrays has been experimentally studied. Broad resonant features below the onset of diffraction, attributed to electromagnetic radiation coupling through the structure via the evanescent fields of bound surface waves, are...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep16608

    authors： Tremain B,Durrant CJ,Carter IE,Hibbins AP,Sambles JR

    更新日期：2015-11-16 00:00:00

  • Evolutionary dynamics of the chloroplast genome sequences of six Colobanthus species.

    abstract：:The complete plastome sequences of six species were sequenced to better understand the evolutionary relationships and mutation patterns in the chloroplast genome of the genus Colobanthus. The length of the chloroplast genome sequences of C. acicularis, C. affinis, C. lycopodioides, C. nivicola, C. pulvinatus and C. su...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-68563-5

    authors： Androsiuk P,Jastrzębski JP,Paukszto Ł,Makowczenko K,Okorski A,Pszczółkowska A,Chwedorzewska KJ,Górecki R,Giełwanowska I

    更新日期：2020-07-13 00:00:00

  • Grafting alters tomato transcriptome and enhances tolerance to an airborne virus infection.

    abstract：:Grafting of commercial tomato varieties and hybrids on the tomato ecotype Manduria resulted in high levels of tolerance to the infection of Sw5 resistance-breaking strains of tomato spotted wilt virus and of severe cucumber mosaic virus strains supporting hypervirulent satellite RNAs that co-determine stunting and nec...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-59421-5

    authors： Spanò R,Ferrara M,Montemurro C,Mulè G,Gallitelli D,Mascia T

    更新日期：2020-02-13 00:00:00

  • Differential parameters between activity flare and acute infection in pediatric patients with systemic lupus erythematosus.

    abstract：:Systemic lupus erythematosus (SLE) patients are vulnerable to infections. We aim to explore the approach to differentiate active infection from disease activity in pediatric SLE patients. Fifty pediatric SLE patients presenting with 185 clinical visits were collected. The associations between both clinical and laborat...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-76789-6

    authors： Luo KL,Yang YH,Lin YT,Hu YC,Yu HH,Wang LC,Chiang BL,Lee JH

    更新日期：2020-11-16 00:00:00

  • Post-glacial biogeography of trembling aspen inferred from habitat models and genetic variance in quantitative traits.

    abstract：:Using species distribution models and information on genetic structure and within-population variance observed in a series of common garden trials, we reconstructed a historical biogeography of trembling aspen in North America. We used an ensemble classifier modelling approach (RandomForest) to reconstruct palaeoclima...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-04871-7

    authors： Ding C,Schreiber SG,Roberts DR,Hamann A,Brouard JS

    更新日期：2017-07-05 00:00:00

  • The effect of dielectric constants on noble metal/semiconductor SERS enhancement: FDTD simulation and experiment validation of Ag/Ge and Ag/Si substrates.

    abstract：:The finite-difference time-domain (FDTD) method was employed to simulate the electric field distribution for noble metal (Au or Ag)/semiconductor (Ge or Si) substrates. The simulation showed that noble metal/Ge had stronger SERS enhancement than noble metal/Si, which was mainly attributed to the different dielectric c...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep04052

    authors： Wang T,Zhang Z,Liao F,Cai Q,Li Y,Lee ST,Shao M

    更新日期：2014-02-11 00:00:00

  • Security of a kind of quantum secret sharing with entangled states.

    abstract：:We present a new collusion attack to a kind of quantum secret sharing schemes with entangled states. Using this attack, an unauthorized set of agents can gain access to the shared secret without the others' cooperation. Furthermore, we establish a general model for this kind of quantum secret sharing schemes and then ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-02543-0

    authors： Wang TY,Liu YZ,Wei CY,Cai XQ,Ma JF

    更新日期：2017-05-30 00:00:00

  • A Faraday laser lasing on Rb 1529 nm transition.

    abstract：:We present the design and performance characterization of a Faraday laser directly lasing on the Rb 1529 nm transition (Rb, 5P 3/2 - 4D 5/2) with high stability, narrow spectral linewidth and low cost. This system does not need an additional frequency-stabilized pump laser as a prerequisite to preparing Rb atom from 5...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-09501-w

    authors： Chang P,Peng H,Zhang S,Chen Z,Luo B,Chen J,Guo H

    更新日期：2017-08-21 00:00:00

  • Genome-wide atlas of alternative polyadenylation in the forage legume red clover.

    abstract：:Studies on prevalence and significance of alternative polyadenylation (APA) in plants have been so far limited mostly to the model plants. Here, a genome-wide analysis of APA was carried out in different tissue types in the non-model forage legume red clover (Trifolium pratense L). A profile of poly(A) sites in differ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-29699-7

    authors： Chakrabarti M,Dinkins RD,Hunt AG

    更新日期：2018-07-27 00:00:00

  • On-target action of anti-tropomyosin drugs regulates glucose metabolism.

    abstract：:The development of novel small molecule inhibitors of the cancer-associated tropomyosin 3.1 (Tpm3.1) provides the ability to examine the metabolic function of specific actin filament populations. We have determined the ability of these anti-Tpm (ATM) compounds to regulate glucose metabolism in mice. Acute treatment (1...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-22946-x

    authors： Kee AJ,Chagan J,Chan JY,Bryce NS,Lucas CA,Zeng J,Hook J,Treutlein H,Laybutt DR,Stehn JR,Gunning PW,Hardeman EC

    更新日期：2018-03-15 00:00:00

  • Conformation-dependent binding of a Tetrastatin peptide to αvβ3 integrin decreases melanoma progression through FAK/PI3K/Akt pathway inhibition.

    abstract：:Tetrastatin, a 230 amino acid sequence from collagen IV, was previously demonstrated to inhibit melanoma progression. In the present paper, we identified the minimal active sequence (QKISRCQVCVKYS: QS-13) that reproduced the anti-tumor effects of whole Tetrastatin in vivo and in vitro on melanoma cell proliferation, m...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-28003-x

    authors： Lambert E,Fuselier E,Ramont L,Brassart B,Dukic S,Oudart JB,Dupont-Deshorgue A,Sellier C,Machado C,Dauchez M,Monboisse JC,Maquart FX,Baud S,Brassart-Pasco S

    更新日期：2018-06-29 00:00:00

  • Regulatory role of G9a and LSD1 in the Transcription of Olfactory Receptors during Leukaemia Cell Differentiation.

    abstract：:Recent studies have reported the ectopic expression of olfactory receptors (ORs) in non-olfactory tissues, however, their physiological roles were not well elucidated. ORs are expressed in and function in different types of cancers. Here, we identified that the H3K9me2 levels of several OR promoters decreased during d...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep46182

    authors： Jung H,Chae YC,Kim JY,Jeong OS,Kook H,Seo SB

    更新日期：2017-04-07 00:00:00

  • Assessment of pharmacokinetic compatibility of short acting CDRI candidate trioxane derivative, 99-411, with long acting prescription antimalarials, lumefantrine and piperaquine.

    abstract：:The pharmacokinetic compatibility of short-acting CDRI candidate antimalarial trioxane derivative, 99-411, was tested with long-acting prescription antimalarials, lumefantrine and piperaquine. LC-ESI-MS/MS methods were validated for simultaneous bioanalysis of lumefantrine and 99-411 and of piperaquine and 99-411 comb...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep17264

    authors： Taneja I,Raju KS,Singh SP,Wahajuddin M

    更新日期：2015-11-25 00:00:00

  • Growth and development of the third permanent molar in Paranthropus robustus from Swartkrans, South Africa.

    abstract：:Third permanent molars (M3s) are the last tooth to form but have not been used to estimate age at dental maturation in early fossil hominins because direct histological evidence for the timing of their growth has been lacking. We investigated an isolated maxillary M3 (SK 835) from the 1.5 to 1.8-million-year-old (Mya)...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-76032-2

    authors： Dean C,Zanolli C,Le Cabec A,Tawane M,Garrevoet J,Mazurier A,Macchiarelli R

    更新日期：2020-11-04 00:00:00