Hierarchical zwitterionic modification of a SERS substrate enables real-time drug monitoring in blood plasma.

Abstract:

:Surface-enhanced Raman spectroscopy (SERS) is an ultrasensitive analytical technique with molecular specificity, making it an ideal candidate for therapeutic drug monitoring (TDM). However, in critical diagnostic media including blood, nonspecific protein adsorption coupled with weak surface affinities and small Raman activities of many analytes hinder the TDM application of SERS. Here we report a hierarchical surface modification strategy, first by coating a gold surface with a self-assembled monolayer (SAM) designed to attract or probe for analytes and then by grafting a non-fouling zwitterionic polymer brush layer to effectively repel protein fouling. We demonstrate how this modification can enable TDM applications by quantitatively and dynamically measuring the concentrations of several analytes-including an anticancer drug (doxorubicin), several TDM-requiring antidepressant and anti-seizure drugs, fructose and blood pH-in undiluted plasma. This hierarchical surface chemistry is widely applicable to many analytes and provides a generalized platform for SERS-based biosensing in complex real-world media.

journal_name

Nat Commun

journal_title

Nature communications

authors

Sun F,Hung HC,Sinclair A,Zhang P,Bai T,Galvan DD,Jain P,Li B,Jiang S,Yu Q

doi

10.1038/ncomms13437

subject

Has Abstract

pub_date

2016-11-11 00:00:00

pages

13437

issn

2041-1723

pii

ncomms13437

journal_volume

7

pub_type

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