Abstract:
:Surface-enhanced Raman spectroscopy (SERS) is an ultrasensitive analytical technique with molecular specificity, making it an ideal candidate for therapeutic drug monitoring (TDM). However, in critical diagnostic media including blood, nonspecific protein adsorption coupled with weak surface affinities and small Raman activities of many analytes hinder the TDM application of SERS. Here we report a hierarchical surface modification strategy, first by coating a gold surface with a self-assembled monolayer (SAM) designed to attract or probe for analytes and then by grafting a non-fouling zwitterionic polymer brush layer to effectively repel protein fouling. We demonstrate how this modification can enable TDM applications by quantitatively and dynamically measuring the concentrations of several analytes-including an anticancer drug (doxorubicin), several TDM-requiring antidepressant and anti-seizure drugs, fructose and blood pH-in undiluted plasma. This hierarchical surface chemistry is widely applicable to many analytes and provides a generalized platform for SERS-based biosensing in complex real-world media.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Sun F,Hung HC,Sinclair A,Zhang P,Bai T,Galvan DD,Jain P,Li B,Jiang S,Yu Qdoi
10.1038/ncomms13437subject
Has Abstractpub_date
2016-11-11 00:00:00pages
13437issn
2041-1723pii
ncomms13437journal_volume
7pub_type
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