Abstract:
:The objective of this study was to investigate the influence of the genes encoding the KIR receptors and their HLA ligands in the susceptibility of ocular toxoplasmosis. A total of 297 patients serologically-diagnosed with toxoplasmosis were selected and stratified according to the presence (n = 148) or absence (n = 149) of ocular scars/lesions due to toxoplasmosis. The group of patients with scars/lesions was further subdivided into two groups according to the type of ocular manifestation observed: primary (n = 120) or recurrent (n = 28). Genotyping was performed by PCR-SSOP. Statistical analyses were conducted using the Chi-square test, and odds ratio with a 95% confidence interval was also calculated to evaluate the risk association. The activating KIR3DS1 gene was associated with increased susceptibility for ocular toxoplasmosis. The activating KIR together with their HLA ligands (KIR3DS1-Bw4-80Ile and KIR2DS1+/C2++ KIR3DS1+/Bw4-80Ile+) were associated with increased susceptibility for ocular toxoplasmosis and its clinical manifestations. KIR-HLA inhibitory pairs -KIR2DL3/2DL3-C1/C1 and KIR2DL3/2DL3-C1- were associated with decreased susceptibility for ocular toxoplasmosis and its clinical forms, while the KIR3DS1-/KIR3DL1+/Bw4-80Ile+ combination was associated as a protective factor against the development of ocular toxoplasmosis and, in particular, against recurrent manifestations. Our data demonstrate that activating and inhibitory KIR genes may influence the development of ocular toxoplasmosis.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ayo CM,Frederico FB,Siqueira RC,Brandão de Mattos CC,Previato M,Barbosa AP,Murata FH,Silveira-Carvalho AP,de Mattos LCdoi
10.1038/srep36632subject
Has Abstractpub_date
2016-11-09 00:00:00pages
36632issn
2045-2322pii
srep36632journal_volume
6pub_type
临床试验,杂志文章abstract::Atropine eye drops and myopic retinal defocus each slow progression of myopia (short-sight). They also cause thickening of the choroid, and it has been suggested that the thickening is a precursor for reduced eye growth and slowed myopia progression. We investigated whether choroidal thickening due to optical defocus ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75342-9
更新日期:2020-10-27 00:00:00
abstract::Mankind is on the verge of a postantibiotic era. New concepts are needed in our battle to attenuate infectious diseases around the world and broad spectrum plant-inspired synergistic pharmaceutical preparations should find their place in the global fight against pathogenic microorganisms. To progress towards the disco...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45222-y
更新日期:2019-06-19 00:00:00
abstract::The nitrogen-vacancy (NV) centre in diamond is a promising candidate for quantum computing applications and magnetic sensing applications, because it is an atomic-scale defect with stable coherence time (T2) and reliable accessibility at room temperature. We demonstrated a method for improving the NV spin properties (...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34158-4
更新日期:2018-10-26 00:00:00
abstract::High-throughput technology can now provide rich information on a person's biological makeup and environmental surroundings. Important discoveries have been made by relating these data to various health outcomes in fields such as genomics, proteomics, and medical imaging. However, cross-investigations between several h...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36076
更新日期:2016-10-26 00:00:00
abstract::The efficacy of prospective cancer treatments is routinely estimated by in vitro cell-line proliferation screens. However, it is unclear whether tumor aggressiveness and patient survival are influenced more by the proliferative or the migratory properties of cancer cells. To address this question, we experimentally me...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47440-w
更新日期:2019-07-29 00:00:00
abstract::Increasing the thermostability of proteins is often crucial for their successful use as analytic, synthetic or therapeutic tools. Most rational thermostabilization strategies were developed on small two-state proteins and, unsurprisingly, they tend to fail when applied to the much more abundant, larger, non-fully coop...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09129
更新日期:2015-03-16 00:00:00
abstract::We employed RNA sequencing analysis to reveal dysregulated lncRNAs in lung cancer utilizing 461 lung adenocarcinomas and 156 normal lung tissues from 3 separate cohorts. We found that LINC00152 was highly overexpressed in lung tumors as compared to their adjacent normal tissues. Patients with high LINC00152 expression...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03043-x
更新日期:2017-06-07 00:00:00
abstract::We demonstrated modulation of charge carrier densities in all-solution-processed organic field-effect transistors (OFETs) by modifying the injection properties with self-assembled monolayers (SAMs). The all-solution-processed OFETs based on an n-type polymer with inkjet-printed Ag electrodes were fabricated as a test ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep46365
更新日期:2017-04-12 00:00:00
abstract::Enhancement of endogenous neurogenesis after ischemic stroke may improve functional recovery. We previously demonstrated that medium B, which is a combination with epidermal growth factor (EGF) and fibronectin, can promote neural stem/progenitor cell (NSPC) proliferation and migration. Here, we showed that medium B pr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63598-0
更新日期:2020-04-20 00:00:00
abstract::The lateral movement of soil carbon has a profound effect on the carbon budget of terrestrial ecosystems; however, it has never been quantified in China, which is one of the strongest soil erosion areas in the world. In this study, we estimated that the overall soil erosion in China varies from 11.27 to 18.17 Pg yr(-1...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07247
更新日期:2014-11-28 00:00:00
abstract::Mitochondria-targeted antioxidants are known to alleviate mitochondrial oxidative damage that is associated with a variety of diseases. Here, we showed that SkQ1, a decyltriphenyl phosphonium cation conjugated to a quinone moiety, exhibited strong antibacterial activity towards Gram-positive Bacillus subtilis, Mycobac...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00802-8
更新日期:2017-05-03 00:00:00
abstract::Melting is considered to be one of the most fundamental problems in physical science. Generally, dimensionality plays an important role in melting. In three-dimension, it's well known that a crystal melts directly into a liquid via a first-order transition. In two-dimension (2D), however, the melting process has been ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24056
更新日期:2016-04-07 00:00:00
abstract::The extracellular matrix (ECM) impacts stem cell differentiation, but identifying formulations supportive of differentiation is challenging in 3D models. Prior efforts involving combinatorial ECM arrays seemed intuitively advantageous. We propose an alternative that suggests reducing sample size and technological burd...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18705
更新日期:2015-12-21 00:00:00
abstract::An ongoing challenge in biomedical research is the search for simple, yet robust assays using 3D cell cultures for toxicity screening. This study addresses that challenge with a novel spheroid assay, wherein spheroids, formed by magnetic 3D bioprinting, contract immediately as cells rearrange and compact the spheroid ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13987
更新日期:2015-09-14 00:00:00
abstract::Maculinea (=Phengaris) are endangered butterflies that are characterized by a very complex biological cycle. Maculinea larvae behave as obligate parasites whose survival is strictly dependent on both particular food plants and species-specific Myrmica ants. In this interaction, Maculinea caterpillars induce Myrmica wo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44514-7
更新日期:2019-05-29 00:00:00
abstract::When coming to identify new 2D materials, our intuition would suggest us to look from layered instead of 3D materials. However, since graphite can be hypothetically derived from diamond by stretching it along its [111] axis, many 3D materials can also potentially be explored as new candidates for 2D materials. Using a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24660
更新日期:2016-04-19 00:00:00
abstract::In this paper, we propose a real time, ultrahigh accuracy and full-field-of-view (RUF) algorithm for full field of view (FOV) imaging system. The proposed algorithm combines rough matching and precise matching method to stitch multiple images with the whole FOV in short time and high imaging quality. In order to verif...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69353-9
更新日期:2020-07-24 00:00:00
abstract::Nedd4-2 (NEDD4L in humans) is a ubiquitin protein ligase best known for its role in regulating ion channel internalization and turnover. Nedd4-2 deletion in mice causes perinatal lethality associated with increased epithelial sodium channel (ENaC) expression in lung and kidney. Abundant data suggest that Nedd4-2 plays...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32957
更新日期:2016-09-08 00:00:00
abstract::The 2b protein of Cucumber mosaic virus has a role in nearly all steps of the viral cycle including cell-to-cell movement, symptom induction and suppression of antiviral RNA silencing. Previous studies demonstrated the presence of 2b protein in the nucleus and in cytoplasm as well. Phosphorylation site of 2b protein i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13870-7
更新日期:2017-10-18 00:00:00
abstract::Proteins involved in genetic stability maintenance and safeguarding DNA replication act not only against cancer initiation but could also play a major role in sustaining cancer progression. Here, we report that the FANC pathway is highly expressed in metastatic melanoma harboring the oncogenic microphthalmia-associate...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36539
更新日期:2016-11-09 00:00:00
abstract::We demonstrate an experimental methodology for measuring the temporal distribution of pico-second level electron bunch with low energy using radial electric and azimuthal magnetic fields of an accelerating ([Formula: see text] mode) radio frequency (RF) cavity that is used for accelerating electron beams in a linear a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76054-w
更新日期:2020-11-03 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-58752-7
更新日期:2020-01-30 00:00:00
abstract::A polarized macrophage response into inflammatory (M1) or regenerative/anti-inflammatory (M2) phenotypes is critical in host response to multiple intracellular bacterial infections. Ehrlichia is an obligate Gram-negative intracellular bacterium that causes human monocytic ehrlichiosis (HME): a febrile illness that may...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50320-y
更新日期:2019-10-01 00:00:00
abstract::Insulin resistance (IR) has become a global epidemic that represents a serious hazard to public health. However, the precise mechanisms modulating IR have not been fully elucidated. The present study aimed to investigate the role of transcriptional factor Twist 1 in adipocyte IR and to further explore the molecular me...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30820-z
更新日期:2018-08-22 00:00:00
abstract::Alcohol and nicotine are the most widely co-abused drugs. Both modify the activity of dopaminergic (DA) neurons of the Ventral Tegmental Area (VTA) and lead to an increase in DA release in the Nucleus Accumbens, thereby affecting the reward system. Evidences support the hypothesis that distinct nicotinic acetylcholine...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45116
更新日期:2017-03-23 00:00:00
abstract::In clinical populations, olfactory abilities parallel executive function, implicating shared neuroanatomical substrates within the ventral prefrontal cortex. In healthy individuals, the relationship between olfaction and personality traits or certain cognitive and behavioural characteristics remains unexplored. We the...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34056-9
更新日期:2018-10-22 00:00:00
abstract::The high-speed liquid-jet velocity achieved using an injector strongly depends on the piston motion, physical property of the liquid, and container shape of the injector. Herein, we investigate the liquid ejection mechanism and a technique for estimating the ejection velocity of a high-speed liquid jet using a pyro je...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56511-x
更新日期:2019-12-27 00:00:00
abstract::For augmentation or reconstruction of urinary bladder after cystectomy, bladder urothelium derived from human induced pluripotent stem cells (hiPSCs) has recently received focus. However, previous studies have only shown the emergence of cells expressing some urothelial markers among derivatives of hiPSCs, and no repo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46848-8
更新日期:2019-07-19 00:00:00
abstract::Human mesenchymal stromal cells (MSCs) have served as a major cellular resource for cell-based immunomodulatory and regenerative therapies. However, genomic instability may accumulate during ex vivo expansion of MSCs, thereby increasing the potential of malignant transformation. Here, we performed whole genome sequenc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15155-5
更新日期:2017-11-06 00:00:00
abstract::Chemical conjugation is commonly used to enhance the pharmacokinetics, biodistribution, and potency of protein therapeutics, but often leads to non-specific modification or loss of bioactivity. Here, we present a simple, versatile and widely applicable method that allows exquisite N-terminal specific modification of p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18363
更新日期:2015-12-17 00:00:00