Abstract:
:Antiretroviral therapy containing an integrase strand transfer inhibitor (INSTI) plus two NRTIs has become the recommended treatment for antiretroviral-naive HIV-1-infected patients in the updated guidelines. We aimed to determine the prevalence of INSTI-related mutations in Taiwan. Genotypic resistance assays were performed on plasma from ARV-naïve patients (N = 948), ARV-experienced but INSTI-naive patients (N = 359), and raltegravir-experienced patients (N = 63) from 2006 to 2015. Major INSTI mutations were defined according to the IAS-USA list and other substitutions with a Stanford HIVdb score ≧ 10 to at least one INSTI were defined as minor mutations. Of 1307 HIV-1 samples from patients never exposed to INSTIs, the overall prevalence of major resistance mutations to INSTIs was 0.9% (n = 12), with an increase to 1.2% in 2013. Of these 12 sequences, 11 harboured Q148H/K/R, one Y143R, and none N155H. Of 30 sequences (47.6%) with INSTI-resistant mutations from raltegravir-experienced patients, 17 harboured Q148H/K/R, 8 N155H, and 6 Y143C/R. Other than these major mutations, the prevalence of minor mutations were 5.3% and 38.1%, respectively, in ARV-naive and raltegravir-experienced patients. The overall prevalence of INSTI mutations remains low in Taiwan. Surveillance of INSTI resistance is warranted due to circulation of polymorphisms contributing to INSTI resistance and expected increasing use of INSTIs.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Chang SY,Lin PH,Cheng CL,Chen MY,Sun HY,Hsieh SM,Sheng WH,Su YC,Su LH,Chang SF,Liu WC,Hung CC,Chang SCdoi
10.1038/srep35779subject
Has Abstractpub_date
2016-10-25 00:00:00pages
35779issn
2045-2322pii
srep35779journal_volume
6pub_type
杂志文章abstract::Personalized medicine is a promising tool not only for prevention, screening and development of more efficient treatment strategies, but also for diminishing the side effects caused by current therapies. Deciphering gene regulation pathways provides a reliable prognostic analysis to elucidate the origin of grave disea...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41368
更新日期:2017-01-25 00:00:00
abstract::The regulation of inflammatory responses by innate immune receptors is recognized as a crucial step in the development of atherosclerosis, although the precise molecular mechanisms remain to be elucidated. This study focused on illustrating the roles of dendritic cell-specific intercellular adhesion molecule-3-grabbin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03740-7
更新日期:2017-06-12 00:00:00
abstract::In order to screen out an effective bone loss protectant from natural plant polyphenol and to elucidate the mechanism of the plant polyphenols that alleviate bone loss under simulated microgravity, the proliferation activities of 9 total polyphenol extracts from natural product (TPENP) on osteoblasts were measured. Po...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30992-8
更新日期:2018-08-24 00:00:00
abstract::Potential formula of an arbitrary resistor network has been an unsolved problem for hundreds of years, which is an interdisciplinary problem that involves many areas of natural science. A new progress has been made in this paper, which discovered the potential formula of a nonregular m × n fan network with two arbitra...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24164-x
更新日期:2018-04-11 00:00:00
abstract::Bats are an important reservoir for zoonotic viruses. To date, only three RVA strains have been reported in bats in Kenya and China. In the current study we investigated the genetic diversity of RVAs in fecal samples from 87 straw-colored fruit bats living in close contact with humans in Cameroon using viral metagenom...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34209
更新日期:2016-09-26 00:00:00
abstract::Hypoxic ischemic encephalopathy (HIE) is a major cause of neonatal mortality and morbidity. Our study sought to examine whether patterns of newborn screening analytes differed between infants with and without neonatal HIE in order to identify opportunities for potential use of these analytes for diagnosis in routine c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51919-x
更新日期:2019-10-31 00:00:00
abstract::Human African trypanosomiasis (sleeping sickness) is a neglected tropical disease caused by Trypanosoma brucei spp. The parasites are transmitted by tsetse flies and adapt to their different hosts and environments by undergoing a series of developmental changes. During differentiation, the trypanosome alters its prote...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22451
更新日期:2016-03-02 00:00:00
abstract::We have developed sensitive detection of cancer biomarker vascular endothelial growth factor (VEGF) using the p-n heterojunction comprised of p-type BiOI nanoflakes (NFs) array and n-type TiO2 nanotubes (NTs) array. Due to the unique arrayed structure and the synergy effect of photoelectrochemistry in the formed p-n j...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04426
更新日期:2014-03-21 00:00:00
abstract::Rotator cuff tears are common and are associated with shoulder pain, disability, and dysfunction. Previous studies that have reported different arthroscopic techniques are controversial. A network meta-analysis with indirect and direct evidence was performed to compare the effectiveness of arthroscopic techniques for ...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/s41598-019-40641-3
更新日期:2019-03-11 00:00:00
abstract::Mammalian cytokinetic abscission is mediated by the ESCRT membrane fission machinery. While much has been clarified on the topology and kinetics of abscission through high-resolution microscopy, key questions regarding the mechanism of abscission remain open. Here we apply cryogenic soft-X-ray tomography to elucidate ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27629
更新日期:2016-06-10 00:00:00
abstract::It has been suggested that orthographic transparency and age changes may affect the relationship between visual attention span (VAS) deficit and reading difficulty. The present study explored the developmental trend of VAS in children with developmental dyslexia (DD) in Chinese, a logographic language with a deep orth...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21578-5
更新日期:2018-02-16 00:00:00
abstract::Peripheral artery disease (PAD) is a major cause of acute and chronic illness, with extremely poor prognosis that remains underdiagnosed and undertreated. Trimethylamine-N-Oxide (TMAO), a gut derived metabolite, has been associated with atherosclerotic burden. We determined plasma levels of TMAO by mass spectrometry a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52082-z
更新日期:2019-10-30 00:00:00
abstract::As part of an ongoing study of new insulin mimetic agents from medicinal plants, the 70% EtOH extract of Symplocos cochinchinensis was found to have a stimulatory effect on glucose uptake in 3T3-L1 adipocyte cells. The intensive targeted isolation of this active extract resulted in ten new hydroxyoleoside-type compoun...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-38013-4
更新日期:2019-02-19 00:00:00
abstract::Triterpenic acids (TAs), a large group of natural compounds with diverse biological activity, are produced by several plant taxa. Betulinic, oleanolic, and ursolic acids are the most medicinally important TAs and are mainly found in plants of the mint family. Metabolic engineering is strongly dependent on identifying ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-52090-z
更新日期:2019-11-01 00:00:00
abstract::Previous studies demonstrated distinct neural correlates underpinning impaired self-regulation (dysregulation) between individuals with autism spectrum disorder (ASD) and typically developing controls (TDC). However, the impacts of dysregulation on white matter (WM) microstructural property in ASD and TDC remain uncle...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70836-y
更新日期:2020-08-14 00:00:00
abstract::In this study, we describe a web-based resource, developed for assisting the scientific community in designing an effective therapeutics against the Ebola virus. Firstly, we predicted and identified experimentally validated epitopes in each of the antigens/proteins of the five known ebolaviruses. Secondly, we generate...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep24782
更新日期:2016-04-26 00:00:00
abstract::Medicinal plants are considered as one of the ideal sources for cancer therapy due to their bioactive contents and low toxicity to humans. Vernonia genus is one of the common medicinal plants, which has wide spread usage in food and medicine. However, there are limited studies to explore its anticancer properties. In ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23255
更新日期:2016-03-24 00:00:00
abstract::Several studies have shown that dysmenorrhea increased the risk of depression. However, the association between dysmenorrhea and postpartum depression (PPD) is unclear. The purpose of this study is to evaluate the effects of dysmenorrhea on the development of PPD among Chinese women. A case-control study was performed...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53059-8
更新日期:2019-11-12 00:00:00
abstract::Global climate change has resulted in a warmer Arctic, with projections indicating accelerated modifications to permafrost in the near future. The thermal, hydrological, and mechanical physics of permafrost thaw have been hypothesized to couple in a complex fashion but data collection efforts to study these feedbacks ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29292-y
更新日期:2018-07-19 00:00:00
abstract::Extreme weather events and pest outbreaks decrease rice yields and increase their variability, presenting challenges for the agricultural agenda to increase rice productivity and yield stability in Asia. The integration of azolla, fish and ducks has been shown to create robust systems that maintain high yields under h...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32915-z
更新日期:2018-10-03 00:00:00
abstract::We report the transient memory device by means of a water soluble SSG (solid sodium with glycerine) paper. This material has a hydroscopic property hence it can be soluble in water. In terms of physical security of memory devices, prompt abrogation of a memory device which stored a large number of data is crucial when...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38324
更新日期:2016-12-05 00:00:00
abstract::Boreal forests play critical roles in global carbon, water and energy cycles. Recent studies suggest drought is causing a decline in boreal spruce growth, leading to predictions of widespread mortality and a shift in dominant vegetation type in interior Alaska. We took advantage of a large set of tree cores collected ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15644-7
更新日期:2017-11-10 00:00:00
abstract::The prediction of infarction volume after stroke onset depends on the shape of the growth dynamics of the infarction. To understand growth patterns that predict lesion volume changes, we studied currently available models described in literature and compared the models with Adaptive Neuro-Fuzzy Inference System [ANFIS...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08044-4
更新日期:2017-08-08 00:00:00
abstract::Undulator based synchrotron light sources and Free Electron Lasers (FELs) are valuable modern probes of matter with high temporal and spatial resolution. Laser Plasma Accelerators (LPAs), delivering GeV electron beams in few centimeters, are good candidates for future compact light sources. However the barriers set by...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55209-4
更新日期:2019-12-13 00:00:00
abstract::Triple-negative breast cancers (TNBC) are unlikely to respond to hormonal therapies and anti-HER2-targeted therapies. TNBCs overexpress EGFR and exhibit constitutive activation of the PI3K/AKT/mTOR signalling pathway. We hypothesized that simultaneously blocking EGFR and mTOR could be a potential therapeutic strategy ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63310-2
更新日期:2020-04-14 00:00:00
abstract::This paper studies the social acceptability and feasibility of a focused protection strategy against coronavirus disease 2019 (COVID-19). We propose a control scheme to develop herd immunity while satisfying the following two basic requirements for a viable policy option. The first requirement is social acceptability:...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81630-9
更新日期:2021-01-21 00:00:00
abstract::EhV-ATPase is an ATP-driven Na+ pump in the eubacteria Enterococcus hirae (Eh). Here, we present the first entire structure of detergent-solubilized EhV-ATPase by single-particle cryo-electron microscopy (cryo-EM) using Zernike phase plate. The cryo-EM map dominantly showed one of three catalytic conformations in this...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33977-9
更新日期:2018-10-23 00:00:00
abstract::The Goos-Hänchen (GH) shifts in the reflected light are investigated both for p and s polarized partial coherent light beams incident on epsilon-near-zero (ENZ) metamaterials. In contrary to the coherent counterparts, the magnitude of GH shift becomes non-zero for p polarized partial coherent light beam; while GH shif...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26504
更新日期:2016-05-23 00:00:00
abstract::Based on density functional theory and non-equilibrium Green's function formalism, we explore the effect of Fe atom in Au-Fe@C20-Au monomer and dimer systems in comparison with the C20 fullerene molecular junctions. We calculate the spin-dependent transmission coefficient, spin polarization and also their spin thermoe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-78111-w
更新日期:2020-12-03 00:00:00
abstract::Recently, graphene nanomesh (GNM) has attracted great attentions due to its unique porous structure, abundant active sites, finite band gap and possesses potential applications in the fields of electronics, gas sensor/storage, catalysis, etc. Therefore, diverse GNMs with different physical and chemical properties are ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32310
更新日期:2016-08-26 00:00:00