Substitution rate and natural selection in parvovirus B19.

abstract：:Karrikins (KAR) are a class of signal compounds, discovered in wildfire smoke, which affect seed germination. Currently, numerous studies have focused on the model plant Arabidopsis in the KAR research field, rather than on crops. Thus the regulatory mechanisms underlying KAR regulation of crop seed germination are la...

journal_title：Scientific reports

authors： Meng Y,Chen F,Shuai H,Luo X,Ding J,Tang S,Xu S,Liu J,Liu W,Du J,Liu J,Yang F,Sun X,Yong T,Wang X,Feng Y,Shu K,Yang W

更新日期：2016-02-23 00:00:00

abstract：:Glaucoma optic neuropathy (GON) is a condition where pathogenic intraocular pressure (IOP) results in axonal damage following retinal ganglion cell (RGC) death, and further results in secondary damage of the lateral geniculate nucleus (LGN). Therapeutic targets for glaucoma thus focus on both the LGN and RGC. However,...

journal_title：Scientific reports

authors： Fujishiro T,Kawasaki H,Aihara M,Saeki T,Ymagishi R,Atarashi T,Mayama C,Araie M

更新日期：2014-10-13 00:00:00

abstract：:K-Ras is the most frequently mutated oncoprotein in human cancers, and G12D is its most prevalent mutation. To understand how G12D mutation impacts K-Ras function, we need to understand how it alters the regulation of its dynamics. Here, we present local changes in K-Ras structure, conformation and dynamics upon G12D ...

journal_title：Scientific reports

authors： Vatansever S,Erman B,Gümüş ZH

更新日期：2019-08-13 00:00:00

abstract：:There is a large body of historical documents that are too fragile to be opened or unrolled, making their contents inaccessible. Recent improvements in X-ray scanning technology and computer vision techniques make it possible to perform a "virtual" unrolling of such documents. We describe a novel technique to process ...

journal_title：Scientific reports

authors： Rosin PL,Lai YK,Liu C,Davis GR,Mills D,Tuson G,Russell Y

更新日期：2018-08-09 00:00:00

abstract：:Infertility is currently a major public health problem. Anti-sperm antibodies (ASAs) markedly reduce sperm quality, which can subsequently lead to male and/or female infertility. The accurate detection of ASAs derived from specific spermatozoa is, therefore, clinically useful. We have focused on the spermatozoa-specif...

journal_title：Scientific reports

authors： Fu J,Yao R,Luo Y,Yang D,Cao Y,Qiu Y,Song W,Miao S,Gu Y,Wang L

更新日期：2016-03-09 00:00:00

abstract：:Heterostructures of oxides have been widely investigated in optical, catalytic and electrochemical applications, because the heterostructured interfaces exhibit pronouncedly different transport, charge, and reactivity characteristics compared to the bulk of the oxides. Here we fabricated a three-dimensional (3D) heter...

journal_title：Scientific reports

authors： Zhou W,Liang F,Shao Z,Chen J,Zhu Z

更新日期：2011-01-01 00:00:00

abstract：:The importance of evaluating physical cues in cancer research is gradually being realized. Assessment of cancer cell physical appearance, or phenotype, may provide information on changes in cellular behavior, including migratory or communicative changes. These characteristics are intrinsically different between malign...

journal_title：Scientific reports

authors： Ware MJ,Tinger S,Colbert KL,Corr SJ,Rees P,Koshkina N,Curley S,Summers HD,Godin B

更新日期：2015-07-13 00:00:00

abstract：:Duchenne muscular dystrophy (DMD) is a disease marked by the development of skeletal muscle weakness and wasting. DMD results from mutations in the gene for the cytoskeletal protein dystrophin. The loss of dystrophin expression is not limited to muscle weakness but has multiple systemic consequences. Managing the nutr...

journal_title：Scientific reports

authors： Strakova J,Kamdar F,Kulhanek D,Razzoli M,Garry DJ,Ervasti JM,Bartolomucci A,Townsend D

更新日期：2018-09-11 00:00:00

abstract：:Metal nitrides have been proposed to replace noble metals in plasmonics for some specific applications. In particular, while titanium nitride (TiN) and zirconium nitride (ZrN) possess localized plasmon resonances very similar to gold in magnitude and wavelength, they benefit from a much higher sustainability to temper...

journal_title：Scientific reports

authors： Lalisse A,Tessier G,Plain J,Baffou G

更新日期：2016-12-09 00:00:00

abstract：:The global DNA methylation degree may be a ubiquitous and early biomarker to distinguish cancer cells from benign cells. However, its usefulness in clinical diagnosis was scarcely demonstrated, because the cancer cells isolated from patients were usually very rare. Even if 10 mL of peripheral blood was sampled from a ...

journal_title：Scientific reports

authors： Si X,Zhao Y,Yang C,Zhang S,Zhang X

更新日期：2015-07-03 00:00:00

abstract：:Knowing which geodynamic regimes characterised the early Earth is a fundamental question. This implies to determine when and how modern plate tectonics began. Today, the tectonic regime is dominated by mobile-lid tectonics including deep and cold subduction. However, in the early Earth (4.5 to 2 Ga) stagnant-lid tecto...

journal_title：Scientific reports

authors： François C,Debaille V,Paquette JL,Baudet D,Javaux EJ

更新日期：2018-10-18 00:00:00

abstract：:Genome editing has emerged as a technology with a potential to revolutionize plant breeding. In this study, we report on generating, in less than ten months, Tomelo, a non-transgenic tomato variety resistant to the powdery mildew fungal pathogen using the CRISPR/Cas9 technology. We used whole-genome sequencing to show...

journal_title：Scientific reports

authors： Nekrasov V,Wang C,Win J,Lanz C,Weigel D,Kamoun S

更新日期：2017-03-28 00:00:00

abstract：:Single nucleotide variations (SNVs) can result in loss or gain of protein functional sites. We analyzed the effects of SNVs on enzyme active sites, ligand binding sites, and various types of post translational modification (PTM) sites. We found that, for most types of protein functional sites, the SNV pattern differs ...

journal_title：Scientific reports

authors： Pan Y,Yan C,Hu Y,Fan Y,Pan Q,Wan Q,Torcivia-Rodriguez J,Mazumder R

更新日期：2017-02-08 00:00:00

abstract：:Studies in mice suggest that early life represents a critical time window, where antibiotics may exert profound and lasting effects on the gut microbiota and metabolism. We aimed to test the hypothesis that prenatal antibiotic exposure is associated with increased risk of childhood overweight in a population-based coh...

journal_title：Scientific reports

authors： Jess T,Morgen CS,Harpsøe MC,Sørensen TIA,Ajslev TA,Antvorskov JC,Allin KH

更新日期：2019-08-08 00:00:00

abstract：:We investigate the impact of borders on the topology of spatially embedded networks. Indeed territorial subdivisions and geographical borders significantly hamper the geographical span of networks thus playing a key role in the formation of network communities. This is especially important in scientific and technologi...

journal_title：Scientific reports

authors： Cerina F,Chessa A,Pammolli F,Riccaboni M

更新日期：2014-04-01 00:00:00

abstract：:Extensive computational modeling and simulations have been carried out, in the present study, to uncover the fundamental reaction pathway for butyrylcholinesterase (BChE)-catalyzed hydrolysis of ghrelin, demonstrating that the acylation process of BChE-catalyzed hydrolysis of ghrelin follows an unprecedented single-st...

journal_title：Scientific reports

authors： Yao J,Yuan Y,Zheng F,Zhan CG

更新日期：2016-02-29 00:00:00

abstract：:In this paper, we used a facile ball milling, microwave radiation and heating treatment method to achieve the surface modification of TiO2 with low g-C3N4 concentration, and a multilayer heterojunction composite with TiO2 as the main part and g-C3N4 as the modification agent was obtained. The obtained materials were a...

journal_title：Scientific reports

authors： Wang Y,Yu J,Peng W,Tian J,Yang C

更新日期：2019-04-11 00:00:00

abstract：:We demonstrate theoretically that photon-photon attraction can be engineered in the continuum of scattering states for pairs of photons propagating in a hollow-core photonic crystal fiber filled with cold atoms. The atoms are regularly spaced in an optical lattice configuration and the photons are resonantly tuned to ...

journal_title：Scientific reports

authors： Litinskaya M,Tignone E,Pupillo G

更新日期：2016-05-12 00:00:00

abstract：:Aerogels have numerous applications due to their high surface area and low densities. However, creating aerogels from a large variety of materials has remained an outstanding challenge. Here, we report a new methodology to enable aerogel production with a wide range of materials. The method is based on the assembly of...

journal_title：Scientific reports

authors： Jung SM,Jung HY,Dresselhaus MS,Jung YJ,Kong J

更新日期：2012-01-01 00:00:00

abstract：:Pregnancy-associated malaria (PAM) is associated with poor pregnancy outcomes. Hemoglobin S (HbS) and hemoglobin C (HbC) mutations are frequently encountered in malaria-endemic areas of Africa, where they protect children from severe and uncomplicated Plasmodium falciparum malaria. However, scant epidemiological data ...

journal_title：Scientific reports

authors： Tétard M,Milet J,Dechavanne S,Fievet N,Dorin-Semblat D,Elion J,Fairhurst RM,Deloron P,Tuikue-Ndam N,Gamain B

更新日期：2017-05-03 00:00:00

abstract：:Fatty liver (FL) disease is the most common type of chronic liver disease. We hypothesized that liver's response to the process where large droplets of triglyceride fat accumulate in liver cells is reflected also in gene pathway expression in blood. Peripheral blood genome wide gene expression analysis and ultrasonic ...

journal_title：Scientific reports

authors： Taipale T,Seppälä I,Raitoharju E,Mononen N,Lyytikäinen LP,Illig T,Waldenberger M,Juonala M,Hutri-Kähönen N,Oksala N,Kähönen M,Raitakari O,Lehtimäki T

更新日期：2018-07-09 00:00:00

abstract：:Phelan-McDermid Syndrome (PMS), which is defined by a deletion within 22q13, demonstrates significant phenotypic variation. Given that six mitochondrial genes are located within 22q13, including complex I and IV genes, we hypothesize that mitochondrial complex activity abnormalities may explain phenotypic variation in...

journal_title：Scientific reports

authors： Frye RE,Cox D,Slattery J,Tippett M,Kahler S,Granpeesheh D,Damle S,Legido A,Goldenthal MJ

更新日期：2016-01-29 00:00:00

abstract：:Misfolding and aggregation of prion protein (PrP) causes neurodegenerative diseases like Creutzfeldt-Jakob disease (CJD) and scrapie. Besides the consensus that spontaneous conversion of normal cellular PrPC into misfolded and aggregating PrPSc is the central event in prion disease, an alternative hypothesis suggests ...

journal_title：Scientific reports

authors： Czech A,Konarev PV,Goebel I,Svergun DI,Wills PR,Ignatova Z

更新日期：2019-02-21 00:00:00

abstract：:Disease associated genetic variations often cause intracellular enzyme inactivation, dysregulation and instability. However, allosteric communication of mutational effects to distant functional sites leading to loss-of-function remains poorly understood. We characterize here interdomain site-to-site communication by w...

journal_title：Scientific reports

authors： Medina-Carmona E,Neira JL,Salido E,Fuchs JE,Palomino-Morales R,Timson DJ,Pey AL

更新日期：2017-03-14 00:00:00

abstract：:The Next-Generation Sequencing (NGS) platforms provide a major approach to obtaining millions of short reads from samples. NGS has been used in a wide range of analyses, such as for determining genome sequences, analyzing evolutionary processes, identifying gene expression and resolving metagenomic analyses. Usually, ...

journal_title：Scientific reports

authors： Gaia ASC,de Sá PHCG,de Oliveira MS,Veras AAO

更新日期：2019-08-12 00:00:00

abstract：:The decomposition of methane (CH4) is a catalytically important reaction in the production of syngas that is used to make a wide spectrum of hydrocarbons and alcohols, and a principal carbon deposition pathway in methane reforming. Literatures suggest that stepped Ni surface is uniquely selective toward methane decomp...

journal_title：Scientific reports

authors： Arevalo RL,Aspera SM,Escaño MCS,Nakanishi H,Kasai H

更新日期：2017-10-25 00:00:00

abstract：:The molecular dissociation constant, Kd, is a well-established parameter to quantitate the affinity of protein-protein or other molecular interactions. Recently, we reported the theoretical basis and experimental procedure for Kd determination using a quantitative FRET method. Here we report a new development of Kd de...

journal_title：Scientific reports

authors： Jiang L,Xiong Z,Song Y,Lu Y,Chen Y,Schultz JS,Li J,Liao J

更新日期：2019-02-14 00:00:00

abstract：:Impaired wound healing is an immense medical challenge, and while autologous skin grafting remains the "gold-standard" therapeutic option for repairing wounds that cannot be closed by primary or secondary intention, it is limited by substantial donor site morbidity. We previously developed the alternative approach of ...

journal_title：Scientific reports

authors： Fuchs C,Pham L,Henderson J,Stalnaker KJ,Anderson RR,Tam J

更新日期：2021-01-18 00:00:00

abstract：:CD4(+)CD25(+) T cells are critical for maintenance of immunologic self-tolerance. We measured the number of CD4(+)CD25(+) cells in the patients with primary malignant hypertension related kidney injury, to explore the molecular pathogenesis of this disease. We selected 30 patients with primary malignant hypertension r...

journal_title：Scientific reports

authors： Huang H,Luo Y,Liang Y,Long X,Peng Y,Liu Z,Wen X,Jia M,Tian R,Bai C,Li C,He F,Lin Q,Wang X,Dong X

更新日期：2016-06-09 00:00:00

abstract：:BK virus (BKV) is a polyomavirus that cause of allograft dysfunction among kidney transplant recipients. The role of BKV infection in non-renal solid organ transplant recipients is not well understood neither for the relationship between various BKV strains with occurrence of BKV viral viruria. This study aimed to und...

journal_title：Scientific reports

authors： Wang RY,Li YJ,Lee WC,Wu HH,Lin CY,Lee CC,Chen YC,Hung CC,Yang CW,Tian YC

更新日期：2016-06-24 00:00:00