Abstract:
:Patients with senile dementia of the Alzheimer type frequently have difficulty performing visual tasks. These difficulties may be due, at least partially, to degenerative changes in both the primary visual pathway and the visual association areas. To determine whether retinal ganglion cell dysfunction contributes to visual loss in senile dementia of the Alzheimer type, we tested a group of patients with this disease (n = 13) using the pattern-reversal electroretinogram to both low (4.0 reversals per second) and high (16.0 reversals per second) temporal frequency checkerboard patterns (1.0 degree checks). Significant amplitude reductions were noted for the patients relative to age-matched control subjects (n = 30). In addition, the observed amplitude reductions were most pronounced for the high temporal frequency condition. Therefore, the results are consistent with retinal ganglion cell dysfunction and support the notion that optic nerve damage induced by senile dementia of the Alzheimer type preferentially affects the larger, faster-conducting retinal ganglion cells along with their retinocortical projections.
journal_name
Ann Neuroljournal_title
Annals of neurologyauthors
Trick GL,Barris MC,Bickler-Bluth Mdoi
10.1002/ana.410260208subject
Has Abstractpub_date
1989-08-01 00:00:00pages
226-31issue
2eissn
0364-5134issn
1531-8249journal_volume
26pub_type
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.20168
更新日期:2004-08-01 00:00:00
abstract:OBJECTIVE:To investigate whether phospholipase A2 (PLA2) plays a role in the pathogenesis of spinal cord injury (SCI). METHODS:Biochemical, Western blot, histological, immunohistochemical, electron microscopic, electrophysiological, and behavior assessments were performed to investigate (1) SCI-induced PLA2 activity, ...
journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.20798
更新日期:2006-04-01 00:00:00
abstract::Cerebral blood flow (CBF) velocity is decreased in patients with Alzheimer's disease. It is being debated whether this reflects diminished demand because of advanced neurodegeneration or that cerebral hypoperfusion contributes to dementia. We examined the relation of CBF velocity as measured with transcranial Doppler ...
journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.20493
更新日期:2005-06-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410170117
更新日期:1985-01-01 00:00:00
abstract::We examined the expression of Fas antigen and Bcl-2 protein in thymic tissue surgically resected from 10 patients with myasthenia gravis, using immunocytochemical techniques. Histologically, thymic tissues from 7 myasthenia gravis patients showed hyperplasia, while 3 other patients had thymomas. In hyperplastic thymic...
journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410390414
更新日期:1996-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-01-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
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更新日期:1991-06-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410150318
更新日期:1984-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/ana.1135
更新日期:2001-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/ana.20474
更新日期:2005-05-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410430605
更新日期:1998-06-01 00:00:00
abstract:OBJECTIVE:Autosomal-dominant lateral temporal epilepsy (ADLTE) is a genetic focal epilepsy characterized by auditory symptoms. Two genes, LGI1 and RELN, encoding secreted proteins, are implicated in the etiology of ADLTE, but half of the affected families remain genetically unsolved, and the underlying molecular mechan...
journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.25167
更新日期:2018-03-01 00:00:00
abstract::A chronic remitting-relapsing form of experimental allergic encephalomyelitis (EAE) has been produced in monkeys sensitized to homologous myelin basic protein in Freund's complete adjuvants by the technique of suboptimal treatment after the onset of disease. Not only does the clinical course resemble that of human mul...
journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410240608
更新日期:1988-12-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410100610
更新日期:1981-12-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
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pub_type: 临床试验,杂志文章
doi:10.1002/ana.410440614
更新日期:1998-12-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410220412
更新日期:1987-10-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:10.1002/ana.410160109
更新日期:1984-07-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章,随机对照试验
doi:10.1002/ana.24447
更新日期:2015-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/1531-8249(199908)46:2<243::aid-ana14>3.0.c
更新日期:1999-08-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
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更新日期:2020-12-03 00:00:00
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更新日期:2020-07-01 00:00:00
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更新日期:2014-07-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
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更新日期:2009-12-01 00:00:00
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journal_title:Annals of neurology
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更新日期:1989-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-07-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
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更新日期:1981-03-01 00:00:00
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更新日期:2002-05-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
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更新日期:1994-05-01 00:00:00
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journal_title:Annals of neurology
pub_type: 杂志文章
doi:
更新日期:2000-08-01 00:00:00