Interrogating Metabolism in Brain Cancer.

Abstract:

:This article reviews existing and emerging techniques of interrogating metabolism in brain cancer from well-established proton magnetic resonance spectroscopy to the promising hyperpolarized metabolic imaging and chemical exchange saturation transfer and emerging techniques of imaging inflammation. Some of these techniques are at an early stage of development and clinical trials are in progress in patients to establish the clinical efficacy. It is likely that in vivo metabolomics and metabolic imaging is the next frontier in brain cancer diagnosis and assessing therapeutic efficacy; with the combined knowledge of genomics and proteomics a complete understanding of tumorigenesis in brain might be achieved.

authors

Salzillo TC,Hu J,Nguyen L,Whiting N,Lee J,Weygand J,Dutta P,Pudakalakatti S,Millward NZ,Gammon ST,Lang FF,Heimberger AB,Bhattacharya PK

doi

10.1016/j.mric.2016.07.003

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

687-703

issue

4

eissn

1064-9689

issn

1557-9786

pii

S1064-9689(16)30052-6

journal_volume

24

pub_type

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