Abstract:
Objective:To assess whether receipt of antibiotics by prior hospital bed occupants is associated with increased risk for CDI in subsequent patients who occupy the same bed. Design, Setting, and Participants:This is a retrospective cohort study of adult patients hospitalized in any 1 of 4 facilities between 2010 and 2015. Patients were excluded if they had recent CDI, developed CDI within 48 hours of admission, had inadequate follow-up time, or if their prior bed occupant was in the bed for less than 24 hours. Main Outcomes and Measures:The primary exposure was receipt of non-CDI antibiotics by the prior bed occupant and the primary outcome was incident CDI in the subsequent patient to occupy the same bed. Incident CDI was defined as a positive result from a stool polymerase chain reaction for the C difficile toxin B gene followed by treatment for CDI. Demographics, comorbidities, laboratory data, and medication exposures are reported. Results:Among 100 615 pairs of patients who sequentially occupied a given hospital bed, there were 576 pairs (0.57%) in which subsequent patients developed CDI. Receipt of antibiotics in prior patients was significantly associated with incident CDI in subsequent patients (log-rank P < .01). This relationship remained unchanged after adjusting for factors known to influence risk for CDI including receipt of antibiotics by the subsequent patient (adjusted hazard ratio [aHR], 1.22; 95% CI, 1.02-1.45) and also after excluding 1497 patient pairs among whom the prior patients developed CDI (aHR, 1.20; 95% CI, 1.01-1.43). Aside from antibiotics, no other factors related to the prior bed occupants were associated with increased risk for CDI in subsequent patients. Conclusions and Relevance:Receipt of antibiotics by prior bed occupants was associated with increased risk for CDI in subsequent patients. Antibiotics can directly affect risk for CDI in patients who do not themselves receive antibiotics.
journal_name
JAMA Intern Medjournal_title
JAMA internal medicineauthors
Freedberg DE,Salmasian H,Cohen B,Abrams JA,Larson ELdoi
10.1001/jamainternmed.2016.6193subject
Has Abstractpub_date
2016-12-01 00:00:00pages
1801-1808issue
12eissn
2168-6106issn
2168-6114pii
2565687journal_volume
176pub_type
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更新日期:2016-09-01 00:00:00
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更新日期:2013-02-25 00:00:00
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更新日期:2017-03-01 00:00:00
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更新日期:2015-10-01 00:00:00
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更新日期:2013-09-23 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2017-10-01 00:00:00