Diversity and evolution of plant diacylglycerol acyltransferase (DGATs) unveiled by phylogenetic, gene structure and expression analyses.

abstract：:Oryza sativa, the common cultivated rice, is one of the most important crops for human consumption, but production is increasingly threatened by abiotic stresses. Although many efforts have resulted in breeding rice cultivars that are relatively tolerant to their local environments, climate changes and population incr...

journal_title：Genetics and molecular biology

authors： Menguer PK,Sperotto RA,Ricachenevsky FK

更新日期：2017-01-01 00:00:00

abstract：:In this work we describe the establishment of mesenchymal stem cells (MSCs) derived from embryonic stem cells (ESCs) and the role of bFGF in adipocyte differentiation. The totipotency of ESCs and MSCs was assessed by immunofluorescence staining and RT-PCR of totipotency factors. MSCs were successfully used to induce o...

journal_title：Genetics and molecular biology

authors： Song X,Li Y,Chen X,Yin G,Huang Q,Chen Y,Xu G,Wang L

更新日期：2014-03-01 00:00:00

abstract：:Blood methylated cell-free DNA (cfDNA) as a minimally invasive cancer biomarker has great importance in cancer management. Guanylate binding protein 2 (GBP2) has been considered as a possible controlling factor in tumor development. GBP2 gene expression and its promoter methylation status in both plasma cfDNA and tumo...

journal_title：Genetics and molecular biology

authors： Rahvar F,Salimi M,Mozdarani H

更新日期：2020-11-17 00:00:00

abstract：:Topoisomerase II inhibitors are effective chemotherapeutic agents in the treatment of cancer, in spite of being associated with the development of secondary leukemia. Our purpose was to determine the effects of etoposide on different genomic regions, aiming at discovering whether there are preferential sites which can...

journal_title：Genetics and molecular biology

authors： Brassesco MS,Montaldi AP,Sakamoto-Hojo ET

更新日期：2009-01-01 00:00:00

abstract：:Xenobiotics can trigger degranulation of eosinophils and mast cells. In this process, the cells release several substances leading to bronchial hyperactivity, the main feature of atopic asthma (AA). GSTM1 and GSTT1 genes encode enzymes involved in the inactivation of these compounds. Both genes are polymorphic in huma...

journal_title：Genetics and molecular biology

authors： Lima CS,Néri IA,Lourenço GJ,Faria IC,Ribeiro JD,Bertuzzo CS

更新日期：2010-07-01 00:00:00

abstract：:Since around 1723, on the occasion of its initial colonization by Europeans, Rondonia has received successive waves of immigrants. This has been further swelled by individuals from northeastern Brazil, who began entering at the beginning of the twentieth century. The ethnic composition varies across the state accordin...

journal_title：Genetics and molecular biology

authors： de Farias JD,Santos MG,de França AK,Delani D,Tada MS,Casseb AA,Simões AL,Engracia V

更新日期：2012-01-01 00:00:00

abstract：:Treatment of moderate and severe forms of osteogenesis imperfecta (OI) with cyclic pamidronate at the Reference Center for OI Treatment in Southern Brazil was studied. A retrospective cohort study was conducted from 2002 to 2012. Data were obtained during inpatient (drug infusion) and outpatient care. Clinical data, i...

journal_title：Genetics and molecular biology

authors： Pinheiro B,Zambrano MB,Vanz AP,Brizola E,Souza LT,Félix TM

更新日期：2019-01-01 00:00:00

abstract：:This study shows that sampling maternal DNA from hatched and abandoned eggshells is a viable noninvasive strategy for studying the genetics of rare or endangered tropical birds, as exemplified here by the Brazilian Merganser (Mergus octosetaceus). Eighteen microsatellites were isolated from enriched libraries and nine...

journal_title：Genetics and molecular biology

authors： Maia TA,Vilaça ST,Silva LRD,Santos FR,Dantas GPM

更新日期：2017-10-01 00:00:00

abstract：:DNA barcoding helps to identify species, especially when identification is based on parts of organisms or life stages such as seeds, pollen, wood, roots or juveniles. However, the implementation of this approach strongly depends on the existence of complete reference libraries of DNA sequences. If such a library is in...

journal_title：Genetics and molecular biology

authors： Lima RAF,Oliveira AA,Colletta GD,Flores TB,Coelho RLG,Dias P,Frey GP,Iribar A,Rodrigues RR,Souza VC,Chave J

更新日期：2018-07-01 00:00:00

abstract：:The arylamine N-acetyltransferase 2 (NAT2) enzymes detoxify a wide range of naturally occurring xenobiotics including carcinogens and drugs. Point mutations in the NAT2 gene result in the variant alleles M1 (NAT2 *5A), M2 (NAT2*6A), M3 (NAT2*7) and M4 (NAT2 *14A) from the wild-type WT (NAT2 *4) allele. The current stu...

journal_title：Genetics and molecular biology

authors： Mahasneh A,Jubaili A,El Bateiha A,Al-Ghazo M,Matalka I,Malkawi M

更新日期：2012-12-01 00:00:00

abstract：:The PPARγ nuclear receptor regulates the expression of genes involved in lipid and carbohydrate metabolism, and it has protective effects in some patients with type 2 diabetes. Nevertheless, the therapeutic value of the PPARγ nuclear receptor protein is limited due to the secondary effects of some PPARγ ligands. Becau...

journal_title：Genetics and molecular biology

authors： Lizcano F,Vargas D

更新日期：2013-03-01 00:00:00

abstract：:Ample evidence suggests that cancer is triggered by mutagenic damage and diets or supplements capable of reducing such incidences can be related to the prevention of neoplasy development or to an improvement in life quality of patients who undergo chemotherapy. This research aimed to evaluate the antimutagenic and ant...

journal_title：Genetics and molecular biology

authors： Oliveira RJ,Salles MJ,da Silva AF,Kanno TY,Lourenço AC,Leite Vda S,Matiazi HJ,Pesarini JR,Ribeiro LR,Mantovani MS

更新日期：2013-09-01 00:00:00

abstract：:The CC chemokine receptor 5 (CCR5) molecule is an important co-receptor for HIV. The effect of the CCR5*D32 allele in susceptibility to HIV infection and AIDS disease is well known. Other alleles than CCR5*D32 have not been analysed before, neither in Amerindians nor in the majority of the populations all over the wor...

journal_title：Genetics and molecular biology

authors： Boldt AB,Culpi L,Tsuneto LT,Souza IR,Kun JF,Petzl-Erler ML

更新日期：2009-01-01 00:00:00

abstract：:Phenotypic plasticity is a hallmark of the caste systems of social insects, expressed in their life history and morphological traits. These are best studied in bees. In their co-evolution with angiosperm plants, the females of corbiculate bees have acquired a specialized structure on their hind legs for collecting pol...

journal_title：Genetics and molecular biology

authors： Santos CG,Hartfelder K

更新日期：2015-07-01 00:00:00

abstract：:We genotyped 15 microsatellite loci in order to evaluate the effects of habitat fragmentation, caused by flooding of the Tucuruí reservoir, on the genetic structure of Alouatta belzebul in eastern Amazonia. The analysis included two populations sampled in 1984, representing both margins of the Tocantins river, and thr...

journal_title：Genetics and molecular biology

authors： Bastos HB,Gonçalves EC,Ferrari SF,Silva A,Schneider MP

更新日期：2010-10-01 00:00:00

abstract：:Rhagomys rufescens (Rodentia: Sigmodontinae) is an endemic species of the Atlantic forest from Southern and Southeastern Brazil. Some authors consider Rhagomys as part of the tribe Thomasomyini; but its phylogenetic relationships remain unclear. Chromosomal studies on eight specimens of Rhagomys rufescens revealed a d...

journal_title：Genetics and molecular biology

authors： Testoni AF,Althoff SL,Nascimento AP,Steiner-Souza F,Sbalqueiro IJ

更新日期：2010-07-01 00:00:00

abstract：:Splicing, the process that catalyzes intron removal and flanking exon ligation, can occur in different ways (alternative splicing) in immature RNAs transcribed from a single gene. In order to adapt to a particular context, cells modulate not only the quantity but also the quality (alternative isoforms) of their transc...

journal_title：Genetics and molecular biology

authors： Botto AEC,Muñoz JC,Giono LE,Nieto-Moreno N,Cuenca C,Kornblihtt AR,Muñoz MJ

更新日期：2020-03-27 00:00:00

abstract：:Several phylogeographic studies of seabirds have documented low genetic diversity that has been attributed to bottleneck events or individual capacity for dispersal. Few studies have been done in seabirds on the Brazilian coast and all have shown low genetic differentiation on a wide geographic scale. The Kelp Gull is...

journal_title：Genetics and molecular biology

authors： de Mendonça Dantas GP,Meyer D,Godinho R,Ferrand N,Morgante JS

更新日期：2012-12-01 00:00:00

abstract：:Alcohol dehydrogenases belong to the large superfamily of medium-chain dehydrogenases/reductases, which occur throughout the biological world and are involved with many important metabolic routes. We considered the phylogeny of 190 ADH sequences of animals, fungi, and plants. Non-class III Caenorhabditis elegans ADHs ...

journal_title：Genetics and molecular biology

authors： Thompson CE,Freitas LB,Salzano FM

更新日期：2018-01-01 00:00:00

abstract：:Diacylglycerol O-acyltransferase 1 (DGAT1) is a microsomal enzyme that catalyzes the final step of triglyceride synthesis. The DGAT1 gene is a strong functional candidate for determining milk fat content in cattle. In this work, we used PCR-SSCP (polymerase chain reaction-single-strand conformation polymorphism) and D...

journal_title：Genetics and molecular biology

authors： Raut AA,Kumar A,Kala SN,Chhokar V,Rana N,Beniwal V,Jaglan S,Samuchiwal SK,Singh JK,Mishra A

更新日期：2012-07-01 00:00:00

abstract：:Up-regulation of human endogenous retroviruses (HERVs) is associated with many diseases, including cancer. In this study, an H family HERV (HERV-H)-related gene was identified and characterized. Its spliced transcript lacks protein-coding capacity and may belong to the emerging class of noncoding RNAs (ncRNAs). The 1....

journal_title：Genetics and molecular biology

authors： Liang Q,Ding J,Zheng S

更新日期：2009-10-01 00:00:00

abstract：:Oral Lichen Planus (OLP) is an oral inflammatory condition, mediated by host immune system reaction, presenting basal membrane damages with inflammatory lesions in the mouth and/or skin. In this study, the role of functional polymorphisms in the MBL2 gene, encoding for Mannose-Binding Protein C (MBP-C), a member of th...

journal_title：Genetics and molecular biology

authors： Polesello V,Segat L,Biasotto M,Ottaviani G,Gobbo M,Di Lenarda R,Crovella S,Zupin L

更新日期：2019-01-01 00:00:00

abstract：:Breast cancer (BC) is the most prevalent type worldwide, besides being one of the most common causes of death among women. It has been suggested that sporadic BC is most likely caused by low-penetrance genes, including those involved in DNA repair mechanisms. Furthermore, the accumulation of DNA damage may contribute ...

journal_title：Genetics and molecular biology

authors： Santos RA,Teixeira AC,Mayorano MB,Carrara HH,Andrade JM,Takahashi CS

更新日期：2010-10-01 00:00:00

abstract：:The allelic frequencies of 12 short tandem repeat loci were obtained from a sample of 307 unrelated individuals living in Macapá, a city in the northern Amazon region, Brazil. These loci are the most commonly used in forensics and paternity testing. Based on the allele frequency obtained for the population of Macapá, ...

journal_title：Genetics and molecular biology

authors： da Costa Francez PA,Rodrigues EM,Frazão GF,Dos Reis Borges ND,Dos Santos SE

更新日期：2011-01-01 00:00:00

abstract：:A wide array of molecular markers has been used to investigate the genetic diversity among common bean species. However, the best combination of markers for studying such diversity among common bean cultivars has yet to be determined. Few reports have examined the genetic diversity of the carioca bean, commercially on...

journal_title：Genetics and molecular biology

authors： Küpper Cardoso Perseguini JM,Chioratto AF,Zucchi MI,Colombo CA,Carbonell SA,Costa Mondego JM,Gazaffi R,Franco Garcia AA,de Campos T,de Souza AP,Rubiano LB

更新日期：2011-01-01 00:00:00

abstract：:Screening of mutations that cause β-thalassaemia in the Bangladeshi population led to the identification of a patient with a combination of two rare mutations, Hb Monroe and HBB: -92 C > G. The β-thalassaemia major male individual was transfusion-dependent and had an atypical β-globin gene cluster haplotype. Of the tw...

journal_title：Genetics and molecular biology

authors： Moosa MM,Ayub MI,Bashar AE,Sarwardi G,Khan W,Khan H,Yeasmin S

更新日期：2011-07-01 00:00:00

abstract：:Despite their ecological and economical importance, fishes of the family Ariidae are still genetically and cytogenetically poorly studied. Among the 133 known species of ariids, only eight have been karyotyped. Cytogenetic analyses performed on Genidens barbus and Sciades herzbergii revealed that both species have 2n ...

journal_title：Genetics and molecular biology

authors： Nirchio M,Martinez ER,Foresti F,Oliveira C

更新日期：2010-04-01 00:00:00

abstract：:Now a days, an important and interesting alternative in the control of tick-infestation in cattle is to select resistant animals, and identify the respective quantitative trait loci (QTLs) and DNA markers, for posterior use in breeding programs. The number of ticks/animal is characterized as a discrete-counting trait,...

journal_title：Genetics and molecular biology

authors： Silva FF,Tunin KP,Rosa GJ,da Silva MV,Azevedo AL,da Silva Verneque R,Machado MA,Packer IU

更新日期：2011-10-01 00:00:00

abstract：:The D-genome progenitor of wheat (Triticum aestivum), Aegilops tauschii, possesses numerous genes for resistance to abiotic stresses, including drought. Therefore, information on the genetic architecture of A. tauschii can aid the development of drought-resistant wheat varieties. Here, we evaluated 13 traits in 373 A....

journal_title：Genetics and molecular biology

authors： Qin P,Lin Y,Hu Y,Liu K,Mao S,Li Z,Wang J,Liu Y,Wei Y,Zheng Y

更新日期：2016-07-01 00:00:00

abstract：:Cytogenetic studies in birds are still scarce compared to other vertebrates. Woodcreepers (Dendrocolaptidae) are part of a highly specialized group within the Suboscines of the New World. They are forest birds exclusive to the Neotropical region and similar to woodpeckers, at a comparable evolutionary stage. This pape...

journal_title：Genetics and molecular biology

authors： de Oliveira Barbosa M,da Silva RR,de Sena Correia VC,Dos Santos LP,Garnero Adel V,Gunski RJ

更新日期：2013-03-01 00:00:00