当前位置： SCI文献检索 > PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA期刊下所有文献 > Stimulating S-adenosyl-l-methionine synthesis extends lifespan via activation of AMPK.

Stimulating S-adenosyl-l-methionine synthesis extends lifespan via activation of AMPK.

Abstract：

:Dietary restriction (DR), such as calorie restriction (CR) or methionine (Met) restriction, extends the lifespan of diverse model organisms. Although studies have identified several metabolites that contribute to the beneficial effects of DR, the molecular mechanism underlying the key metabolites responsible for DR regimens is not fully understood. Here we show that stimulating S-adenosyl-l-methionine (AdoMet) synthesis extended the lifespan of the budding yeast Saccharomyces cerevisiae The AdoMet synthesis-mediated beneficial metabolic effects, which resulted from consuming both Met and ATP, mimicked CR. Indeed, stimulating AdoMet synthesis activated the universal energy-sensing regulator Snf1, which is the S. cerevisiae ortholog of AMP-activated protein kinase (AMPK), resulting in lifespan extension. Furthermore, our findings revealed that S-adenosyl-l-homocysteine contributed to longevity with a higher accumulation of AdoMet only under the severe CR (0.05% glucose) conditions. Thus, our data uncovered molecular links between Met metabolites and lifespan, suggesting a unique function of AdoMet as a reservoir of Met and ATP for cell survival.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Ogawa T,Tsubakiyama R,Kanai M,Koyama T,Fujii T,Iefuji H,Soga T,Kume K,Miyakawa T,Hirata D,Mizunuma M

doi

10.1073/pnas.1604047113

subject

Has Abstract

pub_date

2016-10-18 00:00:00

pages

11913-11918

issue

42

eissn

0027-8424

issn

1091-6490

pii

1604047113

journal_volume

113

pub_type

杂志文章

相关文献

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA文献大全
  • Topological mechanics of gyroscopic metamaterials.

    abstract：:Topological mechanical metamaterials are artificial structures whose unusual properties are protected very much like their electronic and optical counterparts. Here, we present an experimental and theoretical study of an active metamaterial--composed of coupled gyroscopes on a lattice--that breaks time-reversal symmet...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1507413112

    authors： Nash LM,Kleckner D,Read A,Vitelli V,Turner AM,Irvine WT

    更新日期：2015-11-24 00:00:00

  • Hippocampal long-term depression and depotentiation are defective in mice carrying a targeted disruption of the gene encoding the RI beta subunit of cAMP-dependent protein kinase.

    abstract：:The cAMP-dependent protein kinase (PKA) has been shown to play an important role in long-term potentiation (LTP) in the hippocampus, but little is known about the function of PKA in long-term depression (LTD). We have combined pharmacologic and genetic approaches to demonstrate that PKA activity is required for both h...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.92.19.8851

    authors： Brandon EP,Zhuo M,Huang YY,Qi M,Gerhold KA,Burton KA,Kandel ER,McKnight GS,Idzerda RL

    更新日期：1995-09-12 00:00:00

  • Multiple imprinted sense and antisense transcripts, differential methylation and tandem repeats in a putative imprinting control region upstream of mouse Igf2.

    abstract：:The mouse insulin-like growth factor 2 (Igf2) locus is a complex genomic region that produces multiple transcripts from alternative promoters. Expression at this locus is regulated by parental imprinting. However, despite the existence of putative imprinting control elements in the Igf2 upstream region, imprinted tran...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.94.23.12509

    authors： Moore T,Constancia M,Zubair M,Bailleul B,Feil R,Sasaki H,Reik W

    更新日期：1997-11-11 00:00:00

  • Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic.

    abstract：:We have examined the role of cyclooxygenase 2 (COX-2) in a model of inflammation in vivo. Carrageenan administration to the subcutaneous rat air pouch induces a rapid inflammatory response characterized by high levels of prostaglandins (PGs) and leukotrienes in the fluid exudate. The time course of the induction of CO...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.91.8.3228

    authors： Masferrer JL,Zweifel BS,Manning PT,Hauser SD,Leahy KM,Smith WG,Isakson PC,Seibert K

    更新日期：1994-04-12 00:00:00

  • Success or failure of vaccination for HPV16-positive vulvar lesions correlates with kinetics and phenotype of induced T-cell responses.

    abstract：:One half of a group of 20 patients with human papillomavirus type 16 (HPV16)-induced vulvar intraepithelial neoplasia grade 3 displayed a complete regression (CR) after therapeutic vaccination with HPV16 E6/E7 synthetic long peptides. Patients with relatively larger lesions generally did not display a CR. To investiga...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1006500107

    authors： Welters MJ,Kenter GG,de Vos van Steenwijk PJ,Löwik MJ,Berends-van der Meer DM,Essahsah F,Stynenbosch LF,Vloon AP,Ramwadhdoebe TH,Piersma SJ,van der Hulst JM,Valentijn AR,Fathers LM,Drijfhout JW,Franken KL,Oostendorp J,Fle

    更新日期：2010-06-29 00:00:00

  • 8-Oxoguanine-mediated transcriptional mutagenesis causes Ras activation in mammalian cells.

    abstract：:8-Oxoguanine (8OG) is efficiently bypassed by RNA polymerases in vitro and in bacterial cells in vivo, leading to mutant transcripts by directing incorporation of an incorrect nucleotide during transcription. Such transcriptional mutagenesis (TM) may produce a pool of mutant proteins. In contrast, transcription-couple...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0806464105

    authors： Saxowsky TT,Meadows KL,Klungland A,Doetsch PW

    更新日期：2008-12-02 00:00:00

  • Saccharide orientation at the cell surface affects glycolipid receptor function.

    abstract：:Three allelic variants of P-pilus-associated G-adhesins (lectins) with different cell-binding properties were recently described. Here we have analyzed Escherichia coli HB101 strains expressing the recombinant G-adhesin variants for their ability to agglutinate erythrocytes from various species as this relates to the ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.88.20.9340

    authors： Strömberg N,Nyholm PG,Pascher I,Normark S

    更新日期：1991-10-15 00:00:00

  • Protection and reactivation of oxidative phosphorylation in mitochondria by a stable free-radical prostaglandin polymer (PGBx).

    abstract：:A stable free-radical polymeric derivative of prostaglandin B1 (PGBx) has been synthesized that exhibits regenerative effects on oxidative phosphorylation in aged mitochondria. The molecular weights of the most active preparations fall between 2000 and 2600. PGBx is characterized by a single-line electron spin resonan...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.76.4.1598

    authors： Polis BD,Polis E,Kwong S

    更新日期：1979-04-01 00:00:00

  • Vasopressin induces selective desensitization of its mitogenic response in Swiss 3T3 cells.

    abstract：:Prior incubation of quiescent cultures of Swiss 3T3 cells with vasopressin leads to loss of mitogenic stimulation on its subsequent addition in the presence of a synergistic growth factor. This desensitization is selective for vasopressin, requires prolonged incubation (half-maximal desensitization after 12 hr of trea...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.80.7.1924

    authors： Collins MK,Rozengurt E

    更新日期：1983-04-01 00:00:00

  • Mononeme: a new secretory organelle in Plasmodium falciparum merozoites identified by localization of rhomboid-1 protease.

    abstract：:Compartmentalization of proteins into subcellular organelles in eukaryotic cells is a fundamental mechanism of regulating complex cellular functions. Many proteins of Plasmodium falciparum merozoites involved in invasion are compartmentalized into apical organelles. We have identified a new merozoite organelle that co...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0709999104

    authors： Singh S,Plassmeyer M,Gaur D,Miller LH

    更新日期：2007-12-11 00:00:00

  • Molecular cloning and characterization of interferon alpha/beta response element binding factors of the murine (2'-5')oligoadenylate synthetase ME-12 gene.

    abstract：:Seven clones encoding interferon response element binding factors have been isolated from a mouse fibroblast lambda gt11 cDNA library by using a 32P end-labeled tandem trimer of the mouse (2'-5')oligoadenylate synthetase gene interferon response element as a probe. Clone 16 shares strong similarity (95%) at both DNA a...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.88.1.144

    authors： Yan C,Tamm I

    更新日期：1991-01-01 00:00:00

  • Correlating structural and photochemical heterogeneity in cyanobacteriochrome NpR6012g4.

    abstract：:Phytochrome photoreceptors control plant growth, development, and the shade avoidance response that limits crop yield in high-density agricultural plantings. Cyanobacteriochromes (CBCRs) are distantly related photosensory proteins that control cyanobacterial metabolism and behavior in response to light. Photoreceptors...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1720682115

    authors： Lim S,Yu Q,Gottlieb SM,Chang CW,Rockwell NC,Martin SS,Madsen D,Lagarias JC,Larsen DS,Ames JB

    更新日期：2018-04-24 00:00:00

  • Net charge per residue modulates conformational ensembles of intrinsically disordered proteins.

    abstract：:Intrinsically disordered proteins (IDPs) adopt heterogeneous ensembles of conformations under physiological conditions. Understanding the relationship between amino acid sequence and conformational ensembles of IDPs can help clarify the role of disorder in physiological function. Recent studies revealed that polar IDP...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0911107107

    authors： Mao AH,Crick SL,Vitalis A,Chicoine CL,Pappu RV

    更新日期：2010-05-04 00:00:00

  • Ectopic expression of prion protein (PrP) in T lymphocytes or hepatocytes of PrP knockout mice is insufficient to sustain prion replication.

    abstract：:The cellular form of the Prion protein (PrPC) is necessary for prion replication in mice. To determine whether it is also sufficient, we expressed PrP under the control of various cell- or tissue-specific regulatory elements in PrP knockout mice. The interferon regulatory factor-1 promoter/Emu enhancer led to high PrP...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.96.7.3987

    authors： Raeber AJ,Sailer A,Hegyi I,Klein MA,Rülicke T,Fischer M,Brandner S,Aguzzi A,Weissmann C

    更新日期：1999-03-30 00:00:00

  • Bifunctional ectodermal stem cells around the nail display dual fate homeostasis and adaptive wounding response toward nail regeneration.

    abstract：:Regulation of adult stem cells (SCs) is fundamental for organ maintenance and tissue regeneration. On the body surface, different ectodermal organs exhibit distinctive modes of regeneration and the dynamics of their SC homeostasis remain to be unraveled. A slow cycling characteristic has been used to identify SCs in h...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1318848111

    authors： Leung Y,Kandyba E,Chen YB,Ruffins S,Chuong CM,Kobielak K

    更新日期：2014-10-21 00:00:00

  • Chemical and structural analysis of a photoactive vertebrate cryptochrome from pigeon.

    abstract：:Computational and biochemical studies implicate the blue-light sensor cryptochrome (CRY) as an endogenous light-dependent magnetosensor enabling migratory birds to navigate using the Earth's magnetic field. Validation of such a mechanism has been hampered by the absence of structures of vertebrate CRYs that have funct...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1907875116

    authors： Zoltowski BD,Chelliah Y,Wickramaratne A,Jarocha L,Karki N,Xu W,Mouritsen H,Hore PJ,Hibbs RE,Green CB,Takahashi JS

    更新日期：2019-09-24 00:00:00

  • Most invasive species largely conserve their climatic niche.

    abstract：:The ecological niche is a key concept for elucidating patterns of species distributions and developing strategies for conserving biodiversity. However, recent times are seeing a widespread debate whether species niches are conserved across space and time (niche conservatism hypothesis). Biological invasions represent ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.2004289117

    authors： Liu C,Wolter C,Xian W,Jeschke JM

    更新日期：2020-09-22 00:00:00

  • Identification of intracellular degradation intermediates of aldolase B by antiserum to the denatured enzyme.

    abstract：:A method has been developed that enables us to identify intracellular degradation intermediates of fructose-bisphosphate aldolase B (D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase, EC 4.1.2.13). This method is based on the use of antibody against thoroughly denatured purified aldolase. This antibody ha...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.82.18.6114

    authors： Reznick AZ,Rosenfelder L,Shpund S,Gershon D

    更新日期：1985-09-01 00:00:00

  • WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo.

    abstract：:Homeostasis of intravascular volume, Na(+), Cl(-), and K(+) is interdependent and determined by the coordinated activities of structurally diverse mediators in the distal nephron and the distal colon. The behavior of these flux pathways is regulated by the renin-angiotensin-aldosterone system; however, the mechanisms ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0611727104

    authors： Ring AM,Cheng SX,Leng Q,Kahle KT,Rinehart J,Lalioti MD,Volkman HM,Wilson FH,Hebert SC,Lifton RP

    更新日期：2007-03-06 00:00:00

  • Reduction to homozygosity involving p53 in esophageal cancers demonstrated by the polymerase chain reaction.

    abstract：:Loss of heterozygosity affecting chromosome 17p has been detected at high frequencies in a variety of human tumors, including cancers of the colon, breast, lung, and brain. One presumed target of these losses is p53, a tumor suppressor gene located on 17p. To our knowledge, loss of heterozygosity has not yet been repo...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.88.11.4976

    authors： Meltzer SJ,Yin J,Huang Y,McDaniel TK,Newkirk C,Iseri O,Vogelstein B,Resau JH

    更新日期：1991-06-01 00:00:00

  • From residue matching patterns to protein folding topographies: general model and bovine pancreatic trypsin inhibitor.

    abstract：:A coarse-grained model for protein-folding dynamics is introduced based on a discretized representation of torsional modes. The model, based on the Ramachandran map of the local torsional potential surface and the class (hydrophobic/polar/neutral) of each residue, recognizes patterns of both torsional conformations an...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.96.23.12991

    authors： Fernández A,Kostov K,Berry RS

    更新日期：1999-11-09 00:00:00

  • Globalization and the distribution of income: the economic arguments.

    abstract：:One of the issues currently being debated in the ongoing discussion of the pros and cons of today's globalization concerns the effects of greater world trade as well as of the changes in technology on a country's internal distribution of income, especially on skilled versus unskilled wage rates. In this article, I att...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1733335100

    authors： Jones RW

    更新日期：2003-09-16 00:00:00

  • Bacterial phytotoxin, syringomycin, induces a protein kinase-mediated phosphorylation of red beet plasma membrane polypeptides.

    abstract：:Syringomycin, a peptide toxin and a virulence factor produced by the bacterial phytopathogen Pseudomonas syringae pv. syringae, stimulated the phosphorylation of several plasma membrane polypeptides of red beet storage tissue. Among these was a 100-kDa polypeptide, which corresponds in size to the proton pump ATPase. ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.84.19.6755

    authors： Bidwai AP,Takemoto JY

    更新日期：1987-10-01 00:00:00

  • Parathyroid hormone receptors of renal cortex: specific binding of biologically active, 125I-labeled hormone and relationship to adenylate cyclase activation.

    abstract：:Biologically active (125)I-labeled bovine parathyroid hormone (prepared by electrolytic iodination) and its synthetic NH(2)-terminal (1-34) biologically active fragment bound rapidly and specifically to a purified plasma membrane preparation from bovine renal cortex. Binding of labeled intact hormone or labeled NH(2)-...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.71.3.723

    authors： Di Bella FP,Dousa TP,Miller SS,Arnaud CD

    更新日期：1974-03-01 00:00:00

  • Slowing down of North Pacific climate variability and its implications for abrupt ecosystem change.

    abstract：:Marine ecosystems are sensitive to stochastic environmental variability, with higher-amplitude, lower-frequency--i.e., "redder"--variability posing a greater threat of triggering large ecosystem changes. Here we show that fluctuations in the Pacific Decadal Oscillation (PDO) index have slowed down markedly over the ob...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1501781112

    authors： Boulton CA,Lenton TM

    更新日期：2015-09-15 00:00:00

  • Distinct neural signatures of threat learning in adolescents and adults.

    abstract：:Most teenage fears subside with age, a change that may reflect brain maturation in the service of refined fear learning. Whereas adults clearly demarcate safe situations from real dangers, attenuating fear to the former but not the latter, adolescents' immaturity in prefrontal cortex function may limit their ability t...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1005494108

    authors： Lau JY,Britton JC,Nelson EE,Angold A,Ernst M,Goldwin M,Grillon C,Leibenluft E,Lissek S,Norcross M,Shiffrin N,Pine DS

    更新日期：2011-03-15 00:00:00

  • Neural substrates of sexual arousal are not sex dependent.

    abstract：:Sexual arousal is a dynamical, highly coordinated neurophysiological process that is often induced by visual stimuli. Numerous studies have proposed that the cognitive processing stage of responding to sexual stimuli is the first stage, in which sex differences occur, and the divergence between men and women has been ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章,meta分析

    doi：10.1073/pnas.1904975116

    authors： Mitricheva E,Kimura R,Logothetis NK,Noori HR

    更新日期：2019-07-30 00:00:00

  • Regulation of hematopoiesis by the K63-specific ubiquitin-conjugating enzyme Ubc13.

    abstract：:The ubiquitin-conjugating enzyme Ubc13 mediates lysine-63-specific protein ubiquitination involved in signal transduction by immune receptors; however, the in vivo physiological functions of Ubc13 remain incompletely understood. Using Ubc13 conditional knockout mice, we show that somatic deletion of the Ubc13 gene cau...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0906547106

    authors： Wu X,Yamamoto M,Akira S,Sun SC

    更新日期：2009-12-08 00:00:00

  • Cytoplasmic poly(A) polymerases mediate cellular responses to S phase arrest.

    abstract：:The S-M checkpoint delays mitosis until DNA replication is complete; cells defective in this checkpoint lose viability when DNA replication is inhibited. This inviability can be suppressed in fission yeast by overexpression of Cid1 or the related protein Cid13. Fission yeast contain six cid1/cid13-like genes, whereas ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.192467799

    authors： Read RL,Martinho RG,Wang SW,Carr AM,Norbury CJ

    更新日期：2002-09-17 00:00:00

  • Enhanced chemistry-climate feedbacks in past greenhouse worlds.

    abstract：:Trace greenhouse gases are a fundamentally important component of Earth's global climate system sensitive to global change. However, their concentration in the pre-Pleistocene atmosphere during past warm greenhouse climates is highly uncertain because we lack suitable geochemical or biological proxies. This long-stand...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1102409108

    authors： Beerling DJ,Fox A,Stevenson DS,Valdes PJ

    更新日期：2011-06-14 00:00:00