Enhanced cardiac TBC1D10C expression lowers heart rate and enhances exercise capacity and survival.

Abstract:

:TBC1D10C is a protein previously demonstrated to bind and inhibit Ras and Calcineurin. In cardiomyocytes, also CaMKII is inhibited and all three targeted enzymes are known to promote maladaptive cardiomyocyte hypertrophy. Here, in accordance with lack of Calcineurin inhibition in vivo, we did not observe a relevant anti-hypertrophic effect despite inhibition of Ras and CaMKII. However, cardiomyocyte-specific TBC1D10C overexpressing transgenic mice exhibited enhanced longevity. Ejection fraction and exercise capacity were enhanced in transgenic mice, but shortening of isolated cardiomyocytes was not increased. This suggests longevity resulted from enhanced cardiac performance but independent of cardiomyocyte contractile force. In further search for mechanisms, a transcriptome-wide analysis revealed expressional changes in several genes pertinent to control of heart rate (HR) including Hcn4, Scn10a, Sema3a and Cacna2d2. Indeed, telemetric holter recordings demonstrated slower atrial conduction and significantly lower HR. Pharmacological reduction of HR was previously demonstrated to enhance survival in mice. Thus, in addition to inhibition of stress signaling, TBC1D10C economizes generation of cardiac output via HR reduction, enhancing exercise capacity and survival. TBC1D10C may be a new target for HR reduction and longevity.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Volland C,Bremer S,Hellenkamp K,Hartmann N,Dybkova N,Khadjeh S,Kutschenko A,Liebetanz D,Wagner S,Unsöld B,Didié M,Toischer K,Sossalla S,Hasenfuß G,Seidler T

doi

10.1038/srep33853

subject

Has Abstract

pub_date

2016-09-26 00:00:00

pages

33853

issn

2045-2322

pii

srep33853

journal_volume

6

pub_type

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