Abstract：
:Air pollution exposure has increased extensively in recent years and there is considerable evidence that exposure to particulate matter can lead to adverse respiratory outcomes. The health impacts of exposure to air pollution during the prenatal period is especially concerning as it can impair organogenesis and organ development, which can lead to long-term complications. Exposure to air pollution during pregnancy affects respiratory health in different ways. Lung development might be impaired by air pollution indirectly by causing lower birth weight, premature birth or disturbed development of the immune system. Exposure to air pollution during pregnancy has also been linked to decreased lung function in infancy and childhood, increased respiratory symptoms, and the development of childhood asthma. In addition, impaired lung development contributes to infant mortality. The mechanisms of how prenatal air pollution affects the lungs are not fully understood, but likely involve interplay of environmental and epigenetic effects. The current epidemiological evidence on the effect of air pollution during pregnancy on lung function and children's respiratory health is summarized in this review. While evidence for the adverse effects of prenatal air pollution on lung development and health continue to mount, rigorous actions must be taken to reduce air pollution exposure and thus long-term respiratory morbidity and mortality.
journal_name
Paediatr Respir Revjournal_title
Paediatric respiratory reviewsauthors
Korten I,Ramsey K,Latzin Pdoi
10.1016/j.prrv.2016.08.008subject
Has Abstractpub_date
2017-01-01 00:00:00pages
38-46eissn
1526-0542issn
1526-0550pii
S1526-0542(16)30082-3journal_volume
21pub_type
杂志文章,评审abstract：:Since the discovery of the CF gene over a decade ago, several groups worldwide have explored the potential of gene therapy, the insertion of a normal copy of the gene into the respiratory epithelium. Both viral and synthetic gene transfer agents have been designed to this end, although problems with repeat application...
journal_title：Paediatric respiratory reviews
pub_type： 杂志文章,评审
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journal_title：Paediatric respiratory reviews
pub_type： 杂志文章,评审
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journal_title：Paediatric respiratory reviews
pub_type： 杂志文章,评审
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journal_title：Paediatric respiratory reviews
pub_type： 评论,杂志文章
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journal_title：Paediatric respiratory reviews
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journal_title：Paediatric respiratory reviews
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journal_title：Paediatric respiratory reviews
pub_type： 杂志文章,评审
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journal_title：Paediatric respiratory reviews
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journal_title：Paediatric respiratory reviews
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journal_title：Paediatric respiratory reviews
pub_type： 杂志文章
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更新日期：2011-06-01 00:00:00
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journal_title：Paediatric respiratory reviews
pub_type： 杂志文章,评审
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更新日期：2003-06-01 00:00:00
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journal_title：Paediatric respiratory reviews
pub_type： 杂志文章,评审
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更新日期：2004-01-01 00:00:00
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journal_title：Paediatric respiratory reviews
pub_type： 杂志文章,评审
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更新日期：2019-08-01 00:00:00
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journal_title：Paediatric respiratory reviews
pub_type： 杂志文章,评审
doi：10.1016/j.prrv.2017.03.008
更新日期：2018-03-01 00:00:00
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journal_title：Paediatric respiratory reviews
pub_type： 杂志文章
doi：
更新日期：2002-06-01 00:00:00
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journal_title：Paediatric respiratory reviews
pub_type： 杂志文章,评审
doi：
更新日期：2003-09-01 00:00:00
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journal_title：Paediatric respiratory reviews
pub_type： 杂志文章,评审
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journal_title：Paediatric respiratory reviews
pub_type： 杂志文章,评审
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journal_title：Paediatric respiratory reviews
pub_type： 杂志文章,评审
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journal_title：Paediatric respiratory reviews
pub_type： 杂志文章,评审
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journal_title：Paediatric respiratory reviews
pub_type： 杂志文章,评审
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journal_title：Paediatric respiratory reviews
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journal_title：Paediatric respiratory reviews
pub_type： 杂志文章,评审
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journal_title：Paediatric respiratory reviews
pub_type： 杂志文章,评审
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journal_title：Paediatric respiratory reviews
pub_type： 杂志文章,评审
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journal_title：Paediatric respiratory reviews
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journal_title：Paediatric respiratory reviews
pub_type： 杂志文章,评审
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journal_title：Paediatric respiratory reviews
pub_type： 杂志文章,评审
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更新日期：2006-01-01 00:00:00
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journal_title：Paediatric respiratory reviews
pub_type： 杂志文章,评审
doi：10.1053/prrv.2000.0121
更新日期：2001-06-01 00:00:00
