Abstract:
:Previous studies have demonstrated that patients with posttraumatic stress disorder (PTSD) caused by different types of trauma may show divergence in epidemiology, clinical manifestation and treatment outcome. However, it is still unclear whether this divergence has neuroanatomic correlates in PTSD brains. To elucidate the general and trauma-specific cortical morphometric alterations, we performed a meta-analysis of grey matter (GM) changes in PTSD (N = 246) with different traumas and trauma-exposed controls (TECs, N = 347) using anisotropic effect-size signed differential mapping and its subgroup analysis. Our results revealed general GM reduction (GMR) foci in the prefrontal-limbic-striatal system of PTSD brains when compared with those of TECs. Notably, the GMR patterns were trauma-specific. For PTSD by single-incident traumas, GMR foci were found in bilateral medial prefrontal cortex (mPFC), anterior cingulate cortex (ACC), insula, striatum, left hippocampus and amygdala; and for PTSD by prolonged traumas in the left insula, striatum, amygdala and middle temporal gyrus. Moreover, Clinician-Administered PTSD Scale scores were found to be negatively associated with the GM changes in bilateral ACC and mPFC. Our study indicates that the GMR patterns of PTSD are associated with specific traumas, suggesting a stratified diagnosis and treatment for PTSD patients.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Meng L,Jiang J,Jin C,Liu J,Zhao Y,Wang W,Li K,Gong Qdoi
10.1038/srep33748subject
Has Abstractpub_date
2016-09-21 00:00:00pages
33748issn
2045-2322pii
srep33748journal_volume
6pub_type
杂志文章,meta分析,评审abstract::Recently, long non-coding RNAs (lncRNAs) have emerged as an important class of molecules involved in many cellular processes. One of their primary functions is to shape epigenetic landscape through interactions with chromatin modifying proteins. However, mechanisms contributing to the specificity of such interactions ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41669
更新日期:2017-01-31 00:00:00
abstract::MicroRNAs (miRNAs) are proposed as potential biomarkers for the diagnosis of numerous diseases. Here, we performed a meta-analysis to evaluate the utility of faecal miRNAs as a non-invasive tool in colorectal cancer (CRC) screening. A systematic literature search, according to predetermined criteria, in five databases...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/s41598-019-45570-9
更新日期:2019-07-01 00:00:00
abstract::Cystine-knot peptides are attractive templates in drug discovery due to a number of features they possess including their 3D conformation, physicochemical stability and synthetic tractability. Yet, their cellular uptake mechanisms remain largely unexplored. Recently, we demonstrated that the cystine-knot peptide EETI-...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43285-5
更新日期:2019-05-06 00:00:00
abstract::Marine blue holes are precious geological heritages with high scientific research values. Their physical and chemical characteristics are unique because of the steep-walled structure and isolated water column which create isolated ecosystems in geographically restricted areas. The Sansha Yongle Blue Hole (SYBH) is the...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67221-0
更新日期:2020-06-24 00:00:00
abstract::Gelatin-coupled cellulose (GCC) microgel with whisker-like structure is prepared and used to incorporate into casein (CA) matrix to construct reinforced CA-based composite films by solution casting. The GCC microgel has excellent dispersibility and stability in water, which contributes to the hydrophobicity and signif...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37848-1
更新日期:2019-02-04 00:00:00
abstract::Germanium is an outstanding anode material in terms of electrochemical performance, especially rate capability, but its developments are hindered by its high price because it is rare in the crust of earth, and its huge volume variation during the lithium insertion and extraction. Introducing other cheaper elements int...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11326
更新日期:2015-06-10 00:00:00
abstract::Recently, lubricant-impregnated surfaces (LIS) have emerged as a promising condenser surface by facilitating the removal of condensates from the surface. However, LIS has the critical limitation in that lubricant oil is depleted along with the removal of condensates. Such oil depletion is significantly aggravated unde...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59683-z
更新日期:2020-02-19 00:00:00
abstract::Estuarine-coastal ecosystems are rich areas of the global ocean with elevated rates of organic matter production supporting major fisheries. Net and gross primary production (NPP, GPP) are essential properties of these ecosystems, characterized by high spatial, seasonal, and inter-annual variability associated with cl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58702-3
更新日期:2020-02-06 00:00:00
abstract::Engineered nanomaterials hold great promise for the future development of innovative products but their adverse health effects are a major concern. Recent studies have indicated that certain nanomaterials, including carbon nanotubes (CNTs), may be carcinogenic. However, the underlying mechanisms behind their potential...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12037-8
更新日期:2017-09-14 00:00:00
abstract::YPEL3 that induces cellular senescence in both normal and tumour cells of humans may show altered expression under the influence of incidental mutations. In this study, we proposed the first structure of Native YPEL3 protein and its five possible deleterious mutants-V40M, C61Y, G98R, G108S, and A131T and predicted the...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72333-8
更新日期:2020-09-17 00:00:00
abstract::Since the spring 2018, a large part of Europe has been in the midst of a record-setting drought. Using long-term observations, we demonstrate that the occurrence of the 2018-2019 (consecutive) summer drought is unprecedented in the last 250 years, and its combined impact on the growing season vegetation activities is ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68872-9
更新日期:2020-08-06 00:00:00
abstract::Subclinical hypothyroidism has been associated with dyslipidemia, hypertension, and increased risk of coronary artery disease. However, limited is known for its effect on renal function. Here we aimed to investigate whether subclinical hypothyroidism is associated with reduced estimated glomerular filtration rate (eGF...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19693-4
更新日期:2018-02-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-63859-y
更新日期:2020-04-22 00:00:00
abstract::In this paper we applied transfer learning techniques for image recognition, automatic categorization, and labeling of nanoscience images obtained by scanning electron microscope (SEM). Roughly 20,000 SEM images were manually classified into 10 categories to form a labeled training set, which can be used as a referenc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13565-z
更新日期:2017-10-16 00:00:00
abstract::There has been much interest recently in the discovery of thermally induced magnetisation switching using femtosecond laser excitation, where a ferrimagnetic system can be switched deterministically without an applied magnetic field. Experimental results suggest that the reversal occurs due to intrinsic material prope...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03262
更新日期:2013-11-20 00:00:00
abstract::Toll-like receptors (TLRs), as innate immunity sensors, play critical roles in immune responses. Six SNPs of TLR3, TLR7, and TLR8 were genotyped to determine their associations with systemic lupus erythematosus (SLE) and clinical manifestations of SLE. TLR7 SNP rs3853839 was independently associated with SLE susceptib...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03792
更新日期:2014-01-21 00:00:00
abstract::Cardiac fibroblasts are present throughout the myocardium and are enriched in the microenvironment surrounding the ventricular conduction system (VCS). Several forms of arrhythmias are linked to VCS abnormalities, but it is still unclear whether VCS malformations are cardiomyocyte autonomous or could be linked to cros...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73159-0
更新日期:2020-09-30 00:00:00
abstract::In this paper, the effects of random errors on the oscillating behaviors have been studied theoretically and numerically in a prototypical coupled nonlinear oscillator. Two kinds of noises have been employed respectively to represent the measurement errors accompanied with the parameter specifying the distance from a ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42715
更新日期:2017-02-15 00:00:00
abstract::The accurate calculation of decimal fractions is still a challenge for the binary-coded computations that rely on von Neumann paradigm. Here, we report a kind of memristive abacus based on synaptic Ag-Ge-Se device, in which the memristive long-term potentiation and depression are caused by a chemically driven phase tr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01230
更新日期:2013-01-01 00:00:00
abstract::Graphite's capacity of intercalating lithium in rechargeable batteries is limited (theoretically, 372 mAh g-1) due to low diffusion within commensurately-stacked graphene layers. Graphene foam with highly enriched incommensurately-stacked layers was grown and applied as an active electrode in rechargeable batteries. A...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39944
更新日期:2017-01-06 00:00:00
abstract::Models of biological processes are often subject to different sources of noise. Developing an understanding of the combined effects of different types of uncertainty is an open challenge. In this paper, we study a variant of the susceptible-infective-recovered model of epidemic spread, which combines both agent-to-age...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12606-x
更新日期:2017-10-11 00:00:00
abstract::The influence of the growth conditions of multilayer CdTe/ZnTe quantum dots (QDs) on Si substrate upon their carrier dynamics is studied using intensity integration and broadening photoluminescence. The unusual temperature dependence of the line broadening is explained using a model for interband transitions that invo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08267
更新日期:2015-02-05 00:00:00
abstract::We describe here a partial skull with associated mandible of a large felid from Monte Argentario, Italy (Early Pleistocene; ~1.5 million years). Propagation x-ray phase-contrast synchrotron microtomography of the specimen, still partially embedded in the rock matrix, allows ascribing it reliably to Acinonyx pardinensi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26698-6
更新日期:2018-05-29 00:00:00
abstract::This study compared effects of five hypoxia-inducible factor (HIF) prolyl hydroxylases (PHD) inhibitors on PC12 cells and primary rat neurons following oxygen-glucose deprivation (OGD). At 100 µM, the PHD inhibitors did not cause cytotoxicity and apoptosis. MTT activity was only significantly reduced by FG4592 or Baye...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58482-w
更新日期:2020-01-31 00:00:00
abstract::Detection dogs, specially trained domestic dogs (Canis familiaris), have become a valuable, noninvasive, conservation tool because they remove the dependence of attracting species to a particular location. Further, detection dogs locate samples independent of appearance, composition, or visibility allowing researchers...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32244-1
更新日期:2018-09-14 00:00:00
abstract::Although the anxiolytic-like effects of Xiaoyaosan, a Chinese herbal formula, have been described in many previous studies, its underlying mechanism remains undefined. The cytokine tumour necrosis factor-α (TNF-α) and its closely associated janus kinase 2 (JAK2)-signal transducer and activator of transcription (STAT3)...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00496-y
更新日期:2017-03-23 00:00:00
abstract::Although redox reactions are recognized to fractionate iron (Fe) isotopes, the dominant mechanisms controlling the Fe isotope fractionation and notably the role of organic matter (OM) are still debated. Here, we demonstrate how binding to organic ligands governs Fe isotope fractionation beyond that arising from redox ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-81494-z
更新日期:2021-01-21 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-64342-4
更新日期:2020-05-08 00:00:00
abstract::In addition to its role in sister chromatid cohesion, genome stability and integrity, the cohesin complex is involved in gene transcription. Mutations in core cohesin subunits SMC1A, SMC3 and RAD21, or their regulators NIPBL and HDAC8, cause Cornelia de Lange syndrome (CdLS). Recent evidence reveals that gene expressi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16803
更新日期:2015-11-19 00:00:00
abstract::This observational study investigated the impact of hyponatremia resolution on the results of a comprehensive geriatric assessment (CGA) in 150 patients with age ≥70 years and serum sodium <130 mEq/L. The test battery including Barthel index of Activities of Daily Living (ADL) and various tests of neurocognitive funct...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49054-8
更新日期:2019-08-29 00:00:00