Abstract:
BACKGROUND:Primary immunoglobulin light chain amyloidosis (AL amyloidosis) is a plasma cell disorder which mainly affects heart, kidneys, liver, and peripheral nervous system. Cases of atypical AL amyloidosis presented as spontaneous vertebral compression fractures have been rarely reported, and data about the management and clinical outcomes of the patients are scarce. METHODS:Herein, we present 3 new cases of AL amyloidosis with spontaneous vertebral compression fracture and review 13 cases retrieved from the literature. RESULTS:Moreover, we observed overrepresentations of liver involvement and bone marrow involvement in AL amyloidosis with spontaneous vertebral compression fracture. CONCLUSION:We believe that better awareness of the rare clinical presentation as spontaneous vertebral compression fracture of AL amyloidosis can facilitate earlier diagnosis and earlier treatment.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Wu X,Feng J,Cao X,Zhang L,Zhou D,Li Jdoi
10.1097/MD.0000000000004603subject
Has Abstractpub_date
2016-09-01 00:00:00pages
e4603issue
36eissn
0025-7974issn
1536-5964pii
00005792-201609060-00019journal_volume
95pub_type
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