Allicin protects traumatic spinal cord injury through regulating the HSP70/Akt/iNOS pathway in mice.

abstract：:The early diagnosis of acute rejection is crucial for graft survival after kidney transplantation. The interferon-γ (IFNγ)-CXCR3-chemokine-dependent inflammatory loop plays a pivotal role in the recruitment of T lymphocytes during acute rejection. Previously published studies have typically focused on the CXCR3 recept...

journal_title：Molecular medicine reports

authors： Huang H,Xu X,Yao C,Cai M,Qian Y,Wang X,Shi B

更新日期：2014-01-01 00:00:00

abstract：:In the present study, a novel monoclonal antibody (MAb) specific for icariin (ICA) was prepared and characterized. A hybridoma‑secreting MAb against icariin was produced by fusing splenocytes immunized with an ICA‑bovine serum albumin conjugate with a hypoxanthine‑aminopterin‑thymidine‑sensitive mouse myeloma SP2/0 ce...

journal_title：Molecular medicine reports

authors： Cheng J,Zhang Y,Liu S,Qu B,Zhang M,Liu X,Zhao Y,Qu H

更新日期：2017-01-01 00:00:00

abstract：:Apoptosis and necroptosis occur in renal tubular epithelial cell (RTEC) death in acute kidney injury (AKI), and may be regulated by several methods. The present study identified a protective effect of necrostatin‑1 (Nec‑1) on RTECs via a flow-control-like effect. The results established a hypoxic‑ischemic injury model...

journal_title：Molecular medicine reports

authors： Luo J,Tao Y,Liang X,Chen Y,Zhang L,Jiang F,Liu S,Ye Z,Li Z,Shi W

更新日期：2017-07-01 00:00:00

abstract：:The present study aimed to identify potentially important biomarkers associated with polycystic ovary syndrome (PCOS) by integrating DNA methylation with transcriptome profiling. The transcription (E‑MTAB‑3768) and methylation (E‑MTAB‑3777) datasets were retrieved from ArrayExpress. Paired transcription and methylatio...

journal_title：Molecular medicine reports

authors： Liu L,He D,Wang Y,Sheng M

更新日期：2020-05-01 00:00:00

abstract：:Adipocytes have been demonstrated to promote the progression of various tumors through modulation of cancer cell metabolism. However, their role in lung cancer progression remains undetermined. In the present study, adipocytes and lung adenocarcinoma A549 cells were cultured in a Transwell co‑culture system. Cancer ce...

journal_title：Molecular medicine reports

authors： Li FF,Zhang H,Li JJ,Cao YN,Dong X,Gao C

更新日期：2018-08-01 00:00:00

abstract：:Oxidized low-density lipoprotein (Ox-LDL), as a strong oxidant, results in renal injury through multiple mechanisms. The aim of the present study was to determine the injury effects of Ox‑LDL and the potential protective effects of the antioxidant reagent probucol on epithelial‑mesenchymal transition (EMT) in human re...

journal_title：Molecular medicine reports

authors： Zhu BB,Wang H,Chi YF,Wang YM,Yao XM,Liu S,Qiu H,Fang J,Yin PH,Zhang XM,Peng W

更新日期：2018-01-01 00:00:00

abstract：:microRNAs (miRNAs) are small, non‑coding RNAs involved in multiple biological pathways by regulating post-transcriptional gene expression. Previously, autophagy has been reported to suppress the progression of non-small cell lung cancer (NSCLC). However, how miRNAs regulate autophagy in NSCLC remains to be elucidated....

journal_title：Molecular medicine reports

authors： Wei J,Ma Z,Li Y,Zhao B,Wang D,Jin Y,Jin Y

更新日期：2015-01-01 00:00:00

abstract：:Glioblastoma multiforme is one of the most lethal types of brain cancer. With limited success from conventional therapies, the cancer stem cell theory was developed, and investigation into microRNAs (miRs) has facilitated understanding of this theory. The present study demonstrated that miR‑141 is suppressed in sorted...

journal_title：Molecular medicine reports

authors： Gao X,Zhu X,Sun Y,Liu J

更新日期：2017-07-01 00:00:00

abstract：:In the present study, the effect of glucosamine administration (1.5 or 3 g/day) on cartilage and bone metabolism was investigated in bicycle racers, using cartilage‑ and bone‑specific biomarkers, including C‑terminal cross‑linked telopeptides of type II collagen (CTX‑II), C‑terminal...

journal_title：Molecular medicine reports

authors： Momomura R,Naito K,Igarashi M,Watari T,Terakado A,Oike S,Sakamoto K,Nagaoka I,Kaneko K

更新日期：2013-03-01 00:00:00

abstract：:Proliferative vitreoretinopathy (PVR) is one of the most common causes for failed retinal detachment surgeries. The aim of the present study was to investigate the role of insulin‑like growth factor‑binding protein‑6 (IGFBP‑6) in PVR using rat models and its effects on retinal pigment epithelial‑J (RPE‑J) cells. PVR W...

journal_title：Molecular medicine reports

authors： Zhu W,Wu Y,Cui C,Zhao HM,Ba J,Chen H,Yu J

更新日期：2014-01-01 00:00:00

abstract：:Keratinocytes play an important role in the inflammatory response of the skin. UVB stimulates keratinocytes to secrete several cytokines. To our knowledge, there are no reports that have examined which layer or cell type is responsible for producing these cytokines. Thus, in this study we performed immunohistochemical...

journal_title：Molecular medicine reports

authors： Hiromi N,Nakano H,Matsuzaki Y,Sawamura D,Hanada K

更新日期：2011-07-01 00:00:00

abstract：:Neuregulin-1 (NRG-1) is a type of epidermal growth factor‑like protein primarily distributed in the nervous and cardiovascular systems. When sepsis occurs, the incidence of cardiac dysfunction in myocardial injury is high and the mechanism is complicated. It directly causes myocardial cell damage, whilst also causing ...

journal_title：Molecular medicine reports

authors： Kang W,Cheng Y,Wang X,Zhou F,Zhou C,Wang L,Zhong L

更新日期：2020-06-01 00:00:00

abstract：:Heart damage induced by chlorpromazine (CPZ) toxicity is associated with changes in the expression of various enzymes and proteins. This study aimed to investigate CPZ‑induced alterations in cardiac E-cadherin and caveolin-1 (cav-1) after CPZ administration. Male Wistar rats were randomly divided into two groups: a co...

journal_title：Molecular medicine reports

authors： Huang QY,Li XF,Liu SP

更新日期：2012-03-01 00:00:00

abstract：:Nuclear factor-κB (NF-κB) is involved in the regulation of inflammation‑associated genes. NF-κB forms dimers which bind with sequences referred to as NF-κB sites (9-11 bp). A disintegrin-like and metalloproteinase with thrombospondin type 1 motif 9 (ADAMTS9) is a type of proteoglycanase, which proteolytically cleaves ...

journal_title：Molecular medicine reports

authors： Altuntas A,Halacli SO,Cakmak O,Erden G,Akyol S,Ugurcu V,Hirohata S,Demircan K

更新日期：2015-07-01 00:00:00

abstract：:Accumulating evidence has revealed that the mammalian heart possesses a measurable capacity for renewal. Neonatal mice retain a regenerative capacity over a short time-frame (≤6 days), but this capacity is lost by 7 days of age. In the present study, differential gene expression profiling of mouse cardiac tissue was p...

journal_title：Molecular medicine reports

authors： Liu M,Zhu JG,Yu ZB,Song GX,Shen YH,Liu YQ,Zhu C,Qian LM

更新日期：2014-06-01 00:00:00

abstract：:NOVA alternative splicing regulator 1 (NOVA1) dysregulation has been detected in the gastric cancer microenvironment. Decreased NOVA1 expression has been linked to the progression and poor prognosis of gastric cancer; however, the role of NOVA1 in regulating epithelial‑mesenchymal transition (EMT) remains unclear in t...

journal_title：Molecular medicine reports

authors： Li K,Zhu X,Chen X,Wang X

更新日期：2020-03-01 00:00:00

abstract：:Cerebral ischemic injury is a major cause of death and long‑term disability worldwide that leads to neurological and behavioral deficits, and for which successful treatments are still lacking. Ras homolog family member A (RhoA) and Rho‑associated coiled‑coil containing protein kinase (ROCK) are associated with the gro...

journal_title：Molecular medicine reports

authors： Li L,Liu B

更新日期：2019-10-01 00:00:00

abstract：:Embryonic stem (ES) cells are pluripotent stem cells derived from a developmental stage of pre‑implanted embryos. The present study investigated the effect of female sex steroid hormones on the characteristics of human ES cells by using a feeder‑free culture protocol. In a feeder‑free condition without sex hormones, h...

journal_title：Molecular medicine reports

authors： Jeon SY,Hwang KA,Kim CW,Jeung EB,Choi KC

更新日期：2017-07-01 00:00:00

abstract：:Icariside II (ICAII) is a bioflavonoid compound which has demonstrated anti‑oxidative, anti‑inflammatory and anti‑apoptotic biological activities. However, to the best of our knowledge, whether ICAII can alleviate myocardial ischemia and reperfusion injury (MIRI) remains unknown. The aim of the present study was to de...

journal_title：Molecular medicine reports

authors： Guan BF,Dai XF,Huang QB,Zhao D,Shi JL,Chen C,Zhu Y,Ai F

更新日期：2020-10-01 00:00:00

abstract：:We have recently described an immune system-released activating agent (ISRAA) as a nervous system-induced factor that stimulates immune responses in the mouse spleen. However, the human ISRAA has not yet been identified. In this study, we examined the effects of the mouse ISRAA protein on human peripheral blood mononu...

journal_title：Molecular medicine reports

authors： Taha S,Fathallah MD,Bakhiet M

更新日期：2014-07-01 00:00:00

abstract：:Intrauterine adhesions (IUA) may be caused by endometrial stromal cell proliferation, increases in myofibroblasts or increases in extracellular matrix secretion. However, the specific mechanisms underlying the development of IUA have yet to be elucidated. The present study identified that angiotensin (Ang) II is capab...

journal_title：Molecular medicine reports

authors： Shan T,Zhang L,Zhao C,Chen W,Zhang Y,Li G

更新日期：2014-06-01 00:00:00

abstract：:Endometriosis is an enigmatic condition with an unknown etiology and a poorly understood pathogenesis. It is considered to appear from the interplay of many genetic and environmental factors, affecting up to 10% of women and represents a major cause of pain and infertility. The familial association of endometriosis, a...

journal_title：Molecular medicine reports

authors： Albertsen HM,Matalliotaki C,Matalliotakis M,Zervou MI,Matalliotakis I,Spandidos DA,Chettier R,Ward K,Goulielmos GN

更新日期：2019-03-01 00:00:00

abstract：:MicroRN-143 (miR‑143) has been previously reported to be downregulated in specific types of cancer, including colorectal, bladder, oral squamous cell, pituitary, cervical, nasopharyngeal, lymphoma and prostate cancer. In the present study, the effects of miR-143 on prostate cancer cell migration and invasion were exam...

journal_title：Molecular medicine reports

authors： Wu D,Huang P,Wang L,Zhou Y,Pan H,Qu P

更新日期：2013-08-01 00:00:00

abstract：:To identify novel candidate genes associated with osteoporosis, RNA‑sequence analysis of human mesenchymal stem cells (hMSCs) from patients with osteoporosis (G3) and osteopenia (G2), and healthy controls (G1) was performed. Differentially expressed genes (DEGs) from among the three groups were identified. DEGs were s...

journal_title：Molecular medicine reports

authors： Song I,Choi YJ,Jin Y,Kim JW,Koh JT,Ji HM,Jeong SY,Won YY,Kim W,Chung YS

更新日期：2017-10-01 00:00:00

abstract：:Portal hypertension (PHT) is one of the most severe consequences of liver cirrhosis. Carvedilol is a first‑line pharmacological treatment of PHT. However, the antifibrogenic effects of carvedilol on liver cirrhosis and the intrinsic mechanisms underlying these effects have not been thoroughly investigated. The present...

journal_title：Molecular medicine reports

authors： Ling L,Li G,Wang G,Meng D,Li Z,Zhang C

更新日期：2019-08-01 00:00:00

abstract：:As one of main active ingredients of salvia miltiorrhizae, which is a traditional Chinese medicine, tanshinone IIA is the basis of its pharmacological activities. In the present study, the effect of tanshinone IIA on weakening spastic cerebral palsy (SCP) in neonatal rats was investigated. Radial arm water maze and ho...

journal_title：Molecular medicine reports

authors： Zhang WL,Cao YA,Xia J,Tian L,Yang L,Peng CS

更新日期：2018-01-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) and Angiotensin II (Ang-II) are important in glomerulosclerosis, which is one of the main causes of chronic kidney disease. Previous studies have demonstrated that angiotensin type 1 receptor blocker (ARB) can inhibit the synthesis of VEGF mediated by Ang‑II and can effectivel...

journal_title：Molecular medicine reports

authors： Liu X,Zhang H,Wang Q,Yu K,Wang R,Sun J

更新日期：2015-09-01 00:00:00

abstract：:Dyslipidemia is an important risk factor for myocardial infarction (MI). We previously showed that gene polymorphisms associated with MI differed among individuals with different lipid profiles. We also showed that rs6929846 of BTN2A1 and rs2569512 of ILF3 were significantly associated with MI in Japanese individuals....

journal_title：Molecular medicine reports

authors： Yoshida T,Kato K,Oguri M,Horibe H,Kawamiya T,Yokoi K,Fujimaki T,Watanabe S,Satoh K,Aoyagi Y,Tanaka M,Yoshida H,Shinkai S,Nozawa Y,Yamada Y

更新日期：2011-05-01 00:00:00

abstract：:Inflammatory and immune responses, as well as melatonin secretion, are affected by circadian regulation. Abnormal circadian rhythm of melatonin release has been reported to be associated with the later stages of sepsis; however, its role in the early stages of sepsis is unclear. We studied 11 septic and 11 non-septic ...

journal_title：Molecular medicine reports

authors： Li CX,Liang DD,Xie GH,Cheng BL,Chen QX,Wu SJ,Wang JL,Cho W,Fang XM

更新日期：2013-04-01 00:00:00

abstract：:The present study aimed to determine the potential molecular mechanisms underlying p21 (RAC1)‑activated kinase 7 (PAK7) expression in glioblastoma (GBM) and evaluate candidate prognosis biomarkers for GBM. Gene expression data from patients with GBM, including 144 tumor samples and 5 normal brain samples, were downloa...

journal_title：Molecular medicine reports

authors： Wang X,Liu S,Shao Z,Zhang P

更新日期：2020-08-01 00:00:00