Abstract:
BACKGROUND:Drug design against human immunodeficiency virus type 1 (HIV-1) integrase through its mechanistic study is of great interest in the area in biological research. The main obstacle in this area is the absence of the full-length crystal structure for HIV-1 integrase to be used as a model. A complete structure, similar to HIV-1 of a prototype foamy virus integrase in complex with DNA, including all conservative residues, is available and has been extensively used in recent investigations. OBJECTIVES:The aim of this study was to determine whether the above model is precisely representative of HIV-1 integrase. This would critically determine the success of any designed drug using the model in deactivation of integrase and AIDS treatment. MATERIALS AND METHODS:Primarily, a new structure for HIV-1 was constructed, using a crystal structure of prototype foamy virus as the starting structure. The constructed structure of HIV-1 integrase was simultaneously simulated with a prototype foamy virus integrase on a separate occasion. RESULTS:Our results indicate that the HIV-1 system behaves differently from the prototype foamy virus in terms of folding, hydration, hydrophobicity of binding site and stability. CONCLUSIONS:Based on our findings, we can conclude that HIV-1 integrase is vastly different from the prototype foamy virus integrase and does not resemble it, and the modeling output of the prototype foamy virus simulations could not be simply generalized to HIV-1 integrase. Therefore, our HIV-1 model seems to be more representative and more useful for future research.
journal_name
Jundishapur J Microbioljournal_title
Jundishapur journal of microbiologyauthors
Dayer MRdoi
10.5812/jjm.29773subject
Has Abstractpub_date
2016-02-15 00:00:00pages
e29773issue
5eissn
2008-3645issn
2008-4161journal_volume
9pub_type
杂志文章abstract:BACKGROUND:Chronic hepatitis B consists of different clinical phases. Laboratory and histological assessments can help differentiate the clinical phases of this disease and thus lead to better management. OBJECTIVES:This study was conducted to determine laboratory and histological characteristics of HBeAg-negative and...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.21444
更新日期:2015-01-14 00:00:00
abstract:BACKGROUND:Methicillin resistant coagulase-negative Staphylococci are resistant organisms causing infections associated with high morbidity and mortality. Methicillin resistant Staphylococcus epidermidis (MRSE), is especially important with respect to admitted patients with indwelling catheters and other installed inva...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.8590
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Despite the effectiveness of prophylactic antimicrobials to prevent surgical site infection the use of antibiotic prophylaxis is often inappropriate. OBJECTIVES:The current study aimed to determine the pattern of prophylactic antibiotic use in a teaching hospital affiliated to Jundishapur University of Medi...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.12251
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:At present, limited clinical data is available regarding survival rates of patients co-infected with human immunodeficiency virus (HIV)/tuberculosis (TB) in developing countries. OBJECTIVES:The present study aimed to evaluate the effect of HIV infection on the survival chances of active TB adults who disclo...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.10565
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:Against a variety of antimicrobial resistant pathogens, the scientists attempted substitution of antimicrobial medicine with various nanoparticles and plant-based antibacterial substances. OBJECTIVES:The aim of this study was to assess the antibacterial effects of silver nanoparticles solely and in combinat...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.36070
更新日期:2016-09-17 00:00:00
abstract:BACKGROUND:The sensing mechanism of glucose in Saccharomyces cerevisiae is well studied. However, such information is scarcely found in other yeast species such as Candida glabrata. OBJECTIVES:This study aimed to identify the glucose sensing pathway related genes of C. glabrata and to analyze the regulation pattern of...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.25177
更新日期:2015-11-21 00:00:00
abstract:INTRODUCTION:Acute Hepatitis A Virus (HAV) infection is common in the developing countries among children, but hydrops of gallbladder due to hepatitis A infection is an uncommon presentation. CASE PRESENTATION:A five-year-old boy was admitted in Namazi Hospital, Shiraz, Iran due to jaundice and severe abdominal pain f...
journal_title:Jundishapur journal of microbiology
pub_type:
doi:10.5812/jjm.15779
更新日期:2014-12-10 00:00:00
abstract:BACKGROUND:Coagulase-negative staphylococci (CoNS), especially Staphylococcus epidermidis, are considered as normal flora of human epithelia and also important opportunistic pathogens for nosocomial infections. S. epidermidis can also act as a reservoir for mecA, responsible for high-level resistance to methicillin and...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.11188
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Infection with non-typhoid Salmonella (NTS) is one of the most important health problems all over the world. Antimicrobial drug resistance is increasing among Salmonella infantis species. OBJECTIVES:The aim of this study was to investigate the frequency of presence of class 1 integrons in S. infantis specie...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.10019
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Magnetotactic bacteria (MTB) have the ability to biomineralize unique intracellular magnetic nanosize particles. These bacteria and their magnetosomes are under special attraction because of their great useful potential in nano-biotechnological and biomedical applications. MTB are ubiquitous in aquatic envir...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.19343
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Acinetobacter baumannii has emerged as an important nosocomial pathogen. Hospital outbreaks of extensively drug resistant (XDR) A. baumannii are a great concern. OBJECTIVES:Aims of this study were to characterize the resistance determinants and genetic relatedness of (XDR) A. baumannii isolates in hospitals...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.27021v2
更新日期:2015-07-25 00:00:00
abstract:BACKGROUND:Boletus griseipurpureus Corner, an edible mushroom, is a putative ectomycorrhizal fungus. Currently, the taxonomic boundary of this mushroom is unclear and its bitter taste makes it interesting for evaluating its antibacterial properties. OBJECTIVES:The purpose of this study was to identify the genetic vari...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.15552
更新日期:2015-03-21 00:00:00
abstract:BACKGROUND:Over the past two decades, there has been a growing trend in using oral hygienic products originating from natural resources such as essential oils (EOs) and plant extracts. Seven aromatic plants used in this study are among popular traditional Iranian medicinal plants with potential application in modern me...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.17766
更新日期:2015-02-19 00:00:00
abstract:BACKGROUND:Uropathogenic Escherichia coli (UPEC) with its virulence factors is the most prevalent cause of urinary tract infection (UTI). OBJECTIVES:This study aimed to determine the occurrence of fim, pap, sfa, and afa genes among 100 UPEC isolates collected from patients diagnosed with UTI. MATERIALS AND METHODS:A ...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.22647
更新日期:2015-08-17 00:00:00
abstract:BACKGROUND:The presence of certain oral pathogens at implant sites can hinder the osseointegration process. However, it is unclear how and by what microorganisms it happens. OBJECTIVES:This study investigated whether the presence of oral pathogens of Porphyromonas gingivalis and Prevotella intermedia individually, pla...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.8(4)2015.17920
更新日期:2015-04-18 00:00:00
abstract:BACKGROUND:Enterococci are important pathogens in nosocomial infections. Various types of antibiotics, such as aminoglycosides, are used for treatment of these infections. Enterococci can acquire resistant traits, which can lead to therapeutic problems with aminoglycosides. OBJECTIVES:This study was designed to identi...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.28923
更新日期:2016-03-12 00:00:00
abstract:BACKGROUND:The surveillance of kidney transplant patients depends on function of different immunologic markers like co-stimulatory molecules. These molecules may also be associated with post kidney transplant viral related outcomes. OBJECTIVES:The aim of this study was to investigate the possible associations between ...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.31338
更新日期:2016-02-17 00:00:00
abstract:BACKGROUND:Human cutaneous infection caused by a homogeneous group of keratinophilic fungi called dermatophytes. These fungi are the most common infectious agents in humans that are free of any population and geographic area. Microsporum canis is a cause of dermatophytosis (Tinea) in recent years in Iran and atypical s...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.8(5)2015.14874
更新日期:2015-05-31 00:00:00
abstract:BACKGROUND:Khuzestan and other parts of Iran were involved with Influenza A (H1N1) pandemic in 2009. OBJECTIVES:The aim of this study was to describe the prevalence and mortality of H1N1 in Behbahan, a city in Khuzestan, Southwest of Iran. PATIENTS AND METHODS:The study population consisted of cases of influenza, hos...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.9263
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:Pediatric patients with neutropenia are vulnerable to invasive Candida infections. Candida is the primary cause of fungal infections, particularly in immunosuppressed patients. Candida albicans has been the most common etiologic agent of these infections, affecting 48% of patients. OBJECTIVES:The aim of thi...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.11858
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Pathogenic mycobacteria are a major cause of human morbidity and mortality. Mycobacterium tuberculosis is an etiological agent of human tuberculosis (TB). Designing new vaccines, including DNA vaccines, may be a useful strategy for preventing TB. OBJECTIVES:The purpose of this study was to design and constr...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.23560
更新日期:2015-10-26 00:00:00
abstract:BACKGROUND:The association between hepatitis C virus (HCV) infection and oral lichen planus (OLP) has been the focus of many studies. Fifteen percent of HCV infections lead to sets of extrahepatic manifestations including lichen planus (LP). The prevalence of HCV is heavily influenced by geographical location. OBJECTI...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.8(4)2015.16741
更新日期:2015-04-18 00:00:00
abstract:BACKGROUND:Toxoplasmosis is a public health problem worldwide. This complication principally affects immunodeficient patients and pregnant women. Toxoplasma gondii is an opportunistic parasite, causing severe illness among and death of high-risk individuals and treatment is becoming increasingly difficult owing to side...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.22572
更新日期:2015-09-07 00:00:00
abstract:BACKGROUND:Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterial pathogen frequently isolated in both hospital and community environments. Methicillin-resistant Staphylococcus aureus is considered a major nosocomial pathogen that causes severe morbidity and mortality. OBJECTIVES:The main objective of this ...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.26460
更新日期:2016-01-02 00:00:00
abstract:BACKGROUND:Langerhans cell histiocytosis (LCH) is a rare histiocytic proliferation of unknown etiology. It is characterized by granuloma-like proliferation of Langerhans-type dendritic cells and mainly affects young children. Although multiple investigators have suggested the possible role of viruses, such as Epstein-B...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.27219
更新日期:2015-12-26 00:00:00
abstract:CONTEXT:Acne vulgaris affects about 85% of teenagers and may continue to adulthood. There are about two million visits to physicians per year for teenagers and the direct cost of acne treatment in the US exceeds $1 billion per year. EVIDENCE ACQUISITION:A wide variety of treatment regimens exist for acne vulgaris incl...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章,评审
doi:10.5812/jjm.25580
更新日期:2015-11-21 00:00:00
abstract:BACKGROUND:Acinetobacter baumannii has emerged as a highly troublesome pathogen and a leading cause of mortality and morbidity among hospitalized burn patients. OBJECTIVES:The aims of this study were to determine the frequency of the AdeABC genes and the role of the efflux pump (s) in the imipenem resistance of A. bau...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.19048
更新日期:2015-10-12 00:00:00
abstract:BACKGROUND:Resistant Pseudomonas aeruginosa is a serious concern for antimicrobial therapy, as the common isolates exhibit variable grades of resistance, involving beta-lactamase enzymes, beside native defense mechanisms. OBJECTIVES:The present study was designed to determine the occurrence of Metallo-β- Lactamases (M...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.30257
更新日期:2016-10-02 00:00:00
abstract:BACKGROUND:Escherichia coli and Klebsiella pneumoniae are common human pathogens that cause a wide spectrum of infections. Antimicrobial resistance is a basic obstacle in the management of these infections which has different patterns in various regions. OBJECTIVES:In this study, the antibiotic resistance patterns and...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.27517
更新日期:2015-10-25 00:00:00
abstract:BACKGROUND:Anabolic-androgenic steroids (AAS) abuse by the athletes has dramatically increased during the recent decades. These substances might increase the skin lipids and enhance the cutaneous microbial proliferation. OBJECTIVES:The current study aimed to investigate the potential side effects of AAS on the bacteri...
journal_title:Jundishapur journal of microbiology
pub_type: 杂志文章
doi:10.5812/jjm.12269
更新日期:2014-12-06 00:00:00