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Recent Advances and Future Strategies for Immune-Checkpoint Inhibition in Small-Cell Lung Cancer.

Abstract：

:Small-cell lung cancer (SCLC) is distinguished from non-small-cell lung cancer by its rapid growth and more frequent metastases. Although patients with SCLC are highly responsive to chemotherapy and radiation therapy, long-term prognosis remains poor, with relapse and disease recurrence occurring in almost all cases. Whereas combination chemotherapies continue to be the standard of care in extensive-stage SCLC, there is value in exploring whether immune-checkpoint inhibition is an effective treatment strategy, given the durable responses in non-small-cell lung cancer. Data from SCLC trials have shown clinical activity and response to cytotoxic T-lymphocyte antigen-4 protein and programmed cell death-1 blockade, suggesting that antibodies targeting these pathways may be effective in improving survival outcome. However, data on clinical activity by programmed cell death-1 ligand expression in SCLC are not widely available. Limited data indicate that programmed cell death-1 ligand expression may not be an ideal biomarker for patient selection. Continued research is necessary to better optimize patient selection and response to therapy.

journal_name

Clin Lung Cancer

journal_title

Clinical lung cancer

authors

Chae YK,Pan A,Davis AA,Mohindra N,Matsangou M,Villaflor V,Giles F

doi

10.1016/j.cllc.2016.07.004

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

132-140

issue

2

eissn

1525-7304

issn

1938-0690

pii

S1525-7304(16)30183-8

journal_volume

18

pub_type

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